JP2002535394A5 - - Google Patents

Download PDF

Info

Publication number
JP2002535394A5
JP2002535394A5 JP2000595989A JP2000595989A JP2002535394A5 JP 2002535394 A5 JP2002535394 A5 JP 2002535394A5 JP 2000595989 A JP2000595989 A JP 2000595989A JP 2000595989 A JP2000595989 A JP 2000595989A JP 2002535394 A5 JP2002535394 A5 JP 2002535394A5
Authority
JP
Japan
Prior art keywords
alkyl
amino
amide
perfluoro
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2000595989A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002535394A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2000/000883 external-priority patent/WO2000044733A1/en
Publication of JP2002535394A publication Critical patent/JP2002535394A/ja
Publication of JP2002535394A5 publication Critical patent/JP2002535394A5/ja
Withdrawn legal-status Critical Current

Links

JP2000595989A 1999-01-27 2000-01-13 トリプターゼインヒビターとして有用なペプチジル複素環式ケトン Withdrawn JP2002535394A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11760299P 1999-01-27 1999-01-27
US60/117,602 1999-01-27
PCT/US2000/000883 WO2000044733A1 (en) 1999-01-27 2000-01-13 Peptidyl heterocyclic ketones useful as tryptase inhibitors

Publications (2)

Publication Number Publication Date
JP2002535394A JP2002535394A (ja) 2002-10-22
JP2002535394A5 true JP2002535394A5 (https=) 2007-02-15

Family

ID=22373811

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000595989A Withdrawn JP2002535394A (ja) 1999-01-27 2000-01-13 トリプターゼインヒビターとして有用なペプチジル複素環式ケトン

Country Status (24)

Country Link
US (2) US6469036B1 (https=)
EP (1) EP1147097A1 (https=)
JP (1) JP2002535394A (https=)
KR (1) KR20010110422A (https=)
CN (1) CN1353701A (https=)
AR (1) AR022427A1 (https=)
AU (1) AU3208500A (https=)
BG (1) BG105762A (https=)
BR (1) BR0007778A (https=)
CA (1) CA2361479A1 (https=)
CZ (1) CZ20012722A3 (https=)
EA (1) EA200100815A1 (https=)
EE (1) EE200100391A (https=)
HK (1) HK1038561A1 (https=)
HR (1) HRP20010601A2 (https=)
HU (1) HUP0201295A3 (https=)
IL (1) IL144577A0 (https=)
NO (1) NO20013666L (https=)
SK (1) SK10742001A3 (https=)
TR (1) TR200102766T2 (https=)
TW (1) TWI229669B (https=)
WO (1) WO2000044733A1 (https=)
YU (1) YU61401A (https=)
ZA (1) ZA200106995B (https=)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
DE60120661T2 (de) * 2000-03-27 2007-07-05 Applied Research Systems Ars Holding N.V. Pharmazeutisch wirksame pyrrolidin-derivate als bax-inhibitoren
DK1268419T3 (da) * 2000-03-27 2006-10-02 Applied Research Systems Farmaceutisk aktive pyrrolidinderivater som BAX-inhibitorer
US6960597B2 (en) * 2000-06-30 2005-11-01 Orth-Mcneil Pharmaceutical, Inc. Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists
US6589978B2 (en) * 2000-06-30 2003-07-08 Hoffman-La Roche Inc. 1-sulfonyl pyrrolidine derivatives
US6797461B2 (en) * 2000-10-27 2004-09-28 Promega Corporation Tryptase substrates and assay for tryptase activity using same
CA2433713A1 (en) * 2001-01-05 2002-07-18 Kyowa Hakko Kogyo Co., Ltd. Preventives for arthritis
JP2004518688A (ja) 2001-01-30 2004-06-24 ブリストル−マイヤーズ　スクイブ　カンパニー ファクターＸａ阻害剤のスルホンアミドラクタムおよびその方法
GB0103765D0 (en) * 2001-02-15 2001-04-04 Affitech As Assay
EP1455765A2 (en) * 2001-12-13 2004-09-15 Kowa Company Ltd. Use of protease-activated receptor-2 inhibitor in the manufacture of a medicament for treating delayed hypersensitivity
WO2003101381A2 (en) * 2002-05-29 2003-12-11 Merck & Co., Inc. 1,2 diamido cycloalkyl sodium channel blockers
DE10249304B4 (de) * 2002-10-22 2006-09-28 Cytec Surface Specialties Germany Gmbh & Co. Kg Wäßrige Beschichtungsmittel
US7205384B2 (en) 2003-08-05 2007-04-17 Ortho-Mcneil Pharmaceutical Inc. Process for preparing peptidyl heterocyclic ketone derivatives
US20050176755A1 (en) * 2003-10-31 2005-08-11 Dyatkin Alexey B. Aza-bridged-bicyclic amino acid derivatives as alpha4 integrin antagonists
ATE371649T1 (de) * 2004-02-10 2007-09-15 Janssen Pharmaceutica Nv Pyridazinonharnstoffe als antagonisten von a4- integrinen
JP2008510726A (ja) * 2004-08-20 2008-04-10 エントレメッド インコーポレイテッド プロテイナーゼ活性化受容体アンタゴニストを含む組成物および方法
GB0507577D0 (en) * 2005-04-14 2005-05-18 Novartis Ag Organic compounds
JP5270538B2 (ja) * 2006-05-23 2013-08-21 アイアールエム・リミテッド・ライアビリティ・カンパニー チャネル活性化プロテアーゼ阻害剤としての化合物および組成物
CA2651762A1 (en) * 2006-05-23 2007-11-29 Irm Llc Compounds and compositions as channel activating protease inhibitors
KR101131238B1 (ko) 2007-02-09 2012-03-30 아이알엠 엘엘씨 채널 활성화 프로테아제 억제제로서의 화합물 및 조성물
AU2008214217B2 (en) * 2007-02-09 2011-10-13 Irm Llc Compounds and compositions as channel activating protease inhibitors
MX2009008493A (es) * 2007-02-09 2009-08-20 Irm Llc Compuestos y composiciones como inhibidores de la proteasa activadora de canal.
ES2351323B1 (es) * 2009-06-26 2011-10-05 Institut Univ. De Ciència I Tecnologia, S.A. Bibliotecas de n-fenil-1-sulfonil-2-pirrolidinacarboxamidas para el descubrimiento de farmacos.
EP2714716B1 (en) 2011-06-02 2018-04-11 Socpra Sciences Santé Et Humaines S.E.C. Matriptase inhibitors and uses thereof against orthomyxoviridae infections
CN103145598B (zh) * 2011-12-07 2014-10-15 北京京卫顺康医药科技发展有限公司 一种奥沙西罗晶体及含有该晶体的组合物
HRP20181197T1 (hr) * 2013-10-29 2018-11-30 Biomarin Pharmaceutical Inc. Derivati n-(1-hidroksi-3-(pirolidinil)propan-2-il)pirolidin-3-karboksamida kao inhibitori glukozilceramid sintaze
PT3204352T (pt) 2014-10-06 2020-09-23 Cortexyme Inc Inibidores de lisina-gingipaína
WO2016144654A1 (en) * 2015-03-09 2016-09-15 Washington University Inhibitors of growth factor activation enzymes
CA3004095A1 (en) 2015-11-09 2017-05-18 Cortexyme, Inc. Inhibitors of arginine gingipain
ES2992410T3 (es) 2016-09-16 2024-12-12 Lighthouse Pharmaceuticals Inc Inhibidores cetónicos de la lisina gingipaína
CN110944637A (zh) * 2017-05-10 2020-03-31 库特克希米公司 氨基吡啶化合物及其制备方法和使用方法
EP4159211A4 (en) * 2021-07-15 2024-10-30 National Center for Global Health and Medicine ASSOCIATED WITH PHYSIOLOGICAL ACTIVITY SUCH AS ANTIVIRAL ACTIVITY

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5525623A (en) * 1993-03-12 1996-06-11 Arris Pharmaceutical Corporation Compositions and methods for the treatment of immunomediated inflammatory disorders
JPH0820597A (ja) 1994-07-07 1996-01-23 Meiji Seika Kaisha Ltd トロンビン阻害作用を有する複素環カルボニル化合物
JPH10513151A (ja) 1994-12-22 1998-12-15 バイオケム ファーマ インコーポレイテッド トロンビン阻害剤としての複素環式ケトアルギニンペプチド
WO1996019483A1 (en) 1994-12-22 1996-06-27 Biochem Pharma Inc. Low molecular weight bicyclic thrombin inhibitors
WO1996030396A1 (en) 1995-03-24 1996-10-03 Molecumetics Ltd. β-SHEET MIMETICS AND USE THEREOF AS PROTEASE INHIBITORS
EP0815123B1 (en) 1995-03-24 2001-10-04 Molecumetics, Ltd. Beta-sheet mimetics and use thereof as protease inhibitors
GB9510264D0 (en) 1995-05-22 1995-07-19 Iaf Biochem Int Low molecular weight bicyclic-urea type thrombin inhibitors
US5827860A (en) * 1995-06-07 1998-10-27 Ortho Pharmaceutical Corporation Peptidyl heterocycles useful in the treatment of thrombin related disorders
US5827866A (en) 1995-06-07 1998-10-27 Ortho Pharmaceutical Corporation Peptidyl heterocycles useful in the treatment of thrombin related disorders
US5523308A (en) 1995-06-07 1996-06-04 Costanzo; Michael J. Peptidyl heterocycles useful in the treatment of thrombin related disorders
US6069130A (en) 1995-06-07 2000-05-30 Cor Therapeutics, Inc. Ketoheterocyclic inhibitors of factor Xa
IL119466A (en) * 1995-11-03 2001-08-26 Akzo Nobel Nv Thrombin inhibitors, their preparation and pharmaceutical compositions containing them
CA2262900A1 (en) 1996-08-05 1998-02-12 Molecumetics Ltd. Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors
AU4172397A (en) 1996-09-06 1998-03-26 Biochem Pharma Inc. Lactam inhibitors of thrombin
US5827886A (en) * 1997-05-07 1998-10-27 Thione International, Inc. Composition for relief of arthritis-induced symptoms
US8039026B1 (en) 1997-07-28 2011-10-18 Johnson & Johnson Consumer Companies, Inc Methods for treating skin pigmentation
WO1999026925A1 (en) 1997-11-26 1999-06-03 Yoshitomi Pharmaceutical Industries, Ltd. Tryptase inhibitors comprising heterocyclic amide compounds
CA2314899A1 (en) 1997-12-16 1999-06-24 Johnson & Johnson Consumer Companies, Inc. Compositions and methods for regulating phagocytosis and icam-1 expression

Similar Documents

Publication Publication Date Title
JP2002535394A5 (https=)
TWI336696B (en) Thiazole derivatives
JP2015535252A5 (https=)
AU2005210004B2 (en) Novel inhibitors of glutaminyl cyclase
CA3172387A1 (en) Indazole based compounds and associated methods of use
WO2020041331A1 (en) Proteolysis targeting chimeric (protac) compound with e3 ubiquitin ligase binding activity and targeting alpha-synuclein protein for treating neurodegenerative diseases
RU2437882C2 (ru) Производные имидазолидинона
RU98100420A (ru) Пептидильные гетероциклы, используемые при лечении тромбин ассоциированных заболеваний
IL307911A (en) New inhibitors
CA2446136A1 (en) Pyruvate derivatives
JP2021535134A5 (https=)
IL300175A (en) Methods of treating mutant lymphomas
JP2013515038A5 (https=)
CA2543452A1 (en) Therapeutic agent for keratoconjunctival disorder
CN1353701A (zh) 用作类胰蛋白酶抑制剂的肽基杂环酮类化合物
JP2005524628A5 (https=)
HRP20100522T1 (hr) Piridin karboksamidi kao inhibitori 11-beta-hsd1
ZA200508608B (en) Derivatives of 2-acylamino-4-phenylthiazole, preparation method thereof and application of same in therapeutics
RU2010106854A (ru) Производные 2-аза-бицикло[3.3.0]октана
JP2006502963A5 (https=)
JP2001507679A (ja) セリンプロテアーゼ阻害剤
HRP20211678T1 (hr) N-supstituirani derivati indola kao modulatori receptora pge2
RU2006137655A (ru) Производные тетрагидрокарбазолов
WO2004087138A1 (en) Method for treating vascular hyperpermeable disease
HRP20140588T1 (hr) Spojevi kondenziranog prstena i njihova uporaba