ZA200106995B - Peptidyl heterocyclic ketones useful as tryptase inhibitors. - Google Patents
Peptidyl heterocyclic ketones useful as tryptase inhibitors. Download PDFInfo
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- ZA200106995B ZA200106995B ZA200106995A ZA200106995A ZA200106995B ZA 200106995 B ZA200106995 B ZA 200106995B ZA 200106995 A ZA200106995 A ZA 200106995A ZA 200106995 A ZA200106995 A ZA 200106995A ZA 200106995 B ZA200106995 B ZA 200106995B
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- South Africa
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- amino
- substituents
- substituted
- nitro
- perfluoro
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Molecular Biology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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- Pulmonology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
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- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| US11760299P | 1999-01-27 | 1999-01-27 |
Publications (1)
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| ZA200106995B true ZA200106995B (en) | 2002-11-25 |
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| ZA200106995A ZA200106995B (en) | 1999-01-27 | 2001-08-23 | Peptidyl heterocyclic ketones useful as tryptase inhibitors. |
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Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6346510B1 (en) | 1995-10-23 | 2002-02-12 | The Children's Medical Center Corporation | Therapeutic antiangiogenic endostatin compositions |
| DE60120661T2 (de) * | 2000-03-27 | 2007-07-05 | Applied Research Systems Ars Holding N.V. | Pharmazeutisch wirksame pyrrolidin-derivate als bax-inhibitoren |
| DK1268419T3 (da) * | 2000-03-27 | 2006-10-02 | Applied Research Systems | Farmaceutisk aktive pyrrolidinderivater som BAX-inhibitorer |
| US6960597B2 (en) * | 2000-06-30 | 2005-11-01 | Orth-Mcneil Pharmaceutical, Inc. | Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists |
| US6589978B2 (en) * | 2000-06-30 | 2003-07-08 | Hoffman-La Roche Inc. | 1-sulfonyl pyrrolidine derivatives |
| US6797461B2 (en) * | 2000-10-27 | 2004-09-28 | Promega Corporation | Tryptase substrates and assay for tryptase activity using same |
| CA2433713A1 (en) * | 2001-01-05 | 2002-07-18 | Kyowa Hakko Kogyo Co., Ltd. | Preventives for arthritis |
| JP2004518688A (ja) | 2001-01-30 | 2004-06-24 | ブリストル−マイヤーズ スクイブ カンパニー | ファクターＸａ阻害剤のスルホンアミドラクタムおよびその方法 |
| GB0103765D0 (en) * | 2001-02-15 | 2001-04-04 | Affitech As | Assay |
| EP1455765A2 (en) * | 2001-12-13 | 2004-09-15 | Kowa Company Ltd. | Use of protease-activated receptor-2 inhibitor in the manufacture of a medicament for treating delayed hypersensitivity |
| WO2003101381A2 (en) * | 2002-05-29 | 2003-12-11 | Merck & Co., Inc. | 1,2 diamido cycloalkyl sodium channel blockers |
| DE10249304B4 (de) * | 2002-10-22 | 2006-09-28 | Cytec Surface Specialties Germany Gmbh & Co. Kg | Wäßrige Beschichtungsmittel |
| US7205384B2 (en) | 2003-08-05 | 2007-04-17 | Ortho-Mcneil Pharmaceutical Inc. | Process for preparing peptidyl heterocyclic ketone derivatives |
| US20050176755A1 (en) * | 2003-10-31 | 2005-08-11 | Dyatkin Alexey B. | Aza-bridged-bicyclic amino acid derivatives as alpha4 integrin antagonists |
| ATE371649T1 (de) * | 2004-02-10 | 2007-09-15 | Janssen Pharmaceutica Nv | Pyridazinonharnstoffe als antagonisten von a4- integrinen |
| JP2008510726A (ja) * | 2004-08-20 | 2008-04-10 | エントレメッド インコーポレイテッド | プロテイナーゼ活性化受容体アンタゴニストを含む組成物および方法 |
| GB0507577D0 (en) * | 2005-04-14 | 2005-05-18 | Novartis Ag | Organic compounds |
| JP5270538B2 (ja) * | 2006-05-23 | 2013-08-21 | アイアールエム・リミテッド・ライアビリティ・カンパニー | チャネル活性化プロテアーゼ阻害剤としての化合物および組成物 |
| CA2651762A1 (en) * | 2006-05-23 | 2007-11-29 | Irm Llc | Compounds and compositions as channel activating protease inhibitors |
| KR101131238B1 (ko) | 2007-02-09 | 2012-03-30 | 아이알엠 엘엘씨 | 채널 활성화 프로테아제 억제제로서의 화합물 및 조성물 |
| AU2008214217B2 (en) * | 2007-02-09 | 2011-10-13 | Irm Llc | Compounds and compositions as channel activating protease inhibitors |
| MX2009008493A (es) * | 2007-02-09 | 2009-08-20 | Irm Llc | Compuestos y composiciones como inhibidores de la proteasa activadora de canal. |
| ES2351323B1 (es) * | 2009-06-26 | 2011-10-05 | Institut Univ. De Ciència I Tecnologia, S.A. | Bibliotecas de n-fenil-1-sulfonil-2-pirrolidinacarboxamidas para el descubrimiento de farmacos. |
| EP2714716B1 (en) | 2011-06-02 | 2018-04-11 | Socpra Sciences Santé Et Humaines S.E.C. | Matriptase inhibitors and uses thereof against orthomyxoviridae infections |
| CN103145598B (zh) * | 2011-12-07 | 2014-10-15 | 北京京卫顺康医药科技发展有限公司 | 一种奥沙西罗晶体及含有该晶体的组合物 |
| HRP20181197T1 (hr) * | 2013-10-29 | 2018-11-30 | Biomarin Pharmaceutical Inc. | Derivati n-(1-hidroksi-3-(pirolidinil)propan-2-il)pirolidin-3-karboksamida kao inhibitori glukozilceramid sintaze |
| PT3204352T (pt) | 2014-10-06 | 2020-09-23 | Cortexyme Inc | Inibidores de lisina-gingipaína |
| WO2016144654A1 (en) * | 2015-03-09 | 2016-09-15 | Washington University | Inhibitors of growth factor activation enzymes |
| CA3004095A1 (en) | 2015-11-09 | 2017-05-18 | Cortexyme, Inc. | Inhibitors of arginine gingipain |
| ES2992410T3 (es) | 2016-09-16 | 2024-12-12 | Lighthouse Pharmaceuticals Inc | Inhibidores cetónicos de la lisina gingipaína |
| CN110944637A (zh) * | 2017-05-10 | 2020-03-31 | 库特克希米公司 | 氨基吡啶化合物及其制备方法和使用方法 |
| EP4159211A4 (en) * | 2021-07-15 | 2024-10-30 | National Center for Global Health and Medicine | ASSOCIATED WITH PHYSIOLOGICAL ACTIVITY SUCH AS ANTIVIRAL ACTIVITY |
Family Cites Families (18)
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| US5525623A (en) * | 1993-03-12 | 1996-06-11 | Arris Pharmaceutical Corporation | Compositions and methods for the treatment of immunomediated inflammatory disorders |
| JPH0820597A (ja) | 1994-07-07 | 1996-01-23 | Meiji Seika Kaisha Ltd | トロンビン阻害作用を有する複素環カルボニル化合物 |
| JPH10513151A (ja) | 1994-12-22 | 1998-12-15 | バイオケム ファーマ インコーポレイテッド | トロンビン阻害剤としての複素環式ケトアルギニンペプチド |
| WO1996019483A1 (en) | 1994-12-22 | 1996-06-27 | Biochem Pharma Inc. | Low molecular weight bicyclic thrombin inhibitors |
| WO1996030396A1 (en) | 1995-03-24 | 1996-10-03 | Molecumetics Ltd. | β-SHEET MIMETICS AND USE THEREOF AS PROTEASE INHIBITORS |
| EP0815123B1 (en) | 1995-03-24 | 2001-10-04 | Molecumetics, Ltd. | Beta-sheet mimetics and use thereof as protease inhibitors |
| GB9510264D0 (en) | 1995-05-22 | 1995-07-19 | Iaf Biochem Int | Low molecular weight bicyclic-urea type thrombin inhibitors |
| US5827860A (en) * | 1995-06-07 | 1998-10-27 | Ortho Pharmaceutical Corporation | Peptidyl heterocycles useful in the treatment of thrombin related disorders |
| US5827866A (en) | 1995-06-07 | 1998-10-27 | Ortho Pharmaceutical Corporation | Peptidyl heterocycles useful in the treatment of thrombin related disorders |
| US5523308A (en) | 1995-06-07 | 1996-06-04 | Costanzo; Michael J. | Peptidyl heterocycles useful in the treatment of thrombin related disorders |
| US6069130A (en) | 1995-06-07 | 2000-05-30 | Cor Therapeutics, Inc. | Ketoheterocyclic inhibitors of factor Xa |
| IL119466A (en) * | 1995-11-03 | 2001-08-26 | Akzo Nobel Nv | Thrombin inhibitors, their preparation and pharmaceutical compositions containing them |
| CA2262900A1 (en) | 1996-08-05 | 1998-02-12 | Molecumetics Ltd. | Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors |
| AU4172397A (en) | 1996-09-06 | 1998-03-26 | Biochem Pharma Inc. | Lactam inhibitors of thrombin |
| US5827886A (en) * | 1997-05-07 | 1998-10-27 | Thione International, Inc. | Composition for relief of arthritis-induced symptoms |
| US8039026B1 (en) | 1997-07-28 | 2011-10-18 | Johnson & Johnson Consumer Companies, Inc | Methods for treating skin pigmentation |
| WO1999026925A1 (en) | 1997-11-26 | 1999-06-03 | Yoshitomi Pharmaceutical Industries, Ltd. | Tryptase inhibitors comprising heterocyclic amide compounds |
| CA2314899A1 (en) | 1997-12-16 | 1999-06-24 | Johnson & Johnson Consumer Companies, Inc. | Compositions and methods for regulating phagocytosis and icam-1 expression |
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| JP2002535394A (ja) | 2002-10-22 |
| EP1147097A1 (en) | 2001-10-24 |
| US7132418B2 (en) | 2006-11-07 |
| WO2000044733A1 (en) | 2000-08-03 |
| IL144577A0 (en) | 2002-05-23 |
| HUP0201295A3 (en) | 2002-10-28 |
| KR20010110422A (ko) | 2001-12-13 |
| AR022427A1 (es) | 2002-09-04 |
| NO20013666D0 (no) | 2001-07-26 |
| SK10742001A3 (sk) | 2002-08-06 |
| EE200100391A (et) | 2002-10-15 |
| BR0007778A (pt) | 2002-06-04 |
| CN1353701A (zh) | 2002-06-12 |
| TR200102766T2 (tr) | 2001-12-21 |
| HUP0201295A2 (en) | 2002-09-28 |
| YU61401A (sh) | 2005-07-19 |
| HRP20010601A2 (en) | 2002-08-31 |
| NO20013666L (no) | 2001-09-26 |
| US6469036B1 (en) | 2002-10-22 |
| EA200100815A1 (ru) | 2002-08-29 |
| CA2361479A1 (en) | 2000-08-03 |
| BG105762A (en) | 2002-03-29 |
| CZ20012722A3 (cs) | 2002-08-14 |
| TWI229669B (en) | 2005-03-21 |
| AU3208500A (en) | 2000-08-18 |
| US20030008829A1 (en) | 2003-01-09 |
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