JP2002535334A - 縮合ヘテロ環状化合物及びこれを神経変性疾患の治療に使用する方法 - Google Patents

縮合ヘテロ環状化合物及びこれを神経変性疾患の治療に使用する方法

Info

Publication number
JP2002535334A
JP2002535334A JP2000594813A JP2000594813A JP2002535334A JP 2002535334 A JP2002535334 A JP 2002535334A JP 2000594813 A JP2000594813 A JP 2000594813A JP 2000594813 A JP2000594813 A JP 2000594813A JP 2002535334 A JP2002535334 A JP 2002535334A
Authority
JP
Japan
Prior art keywords
alkyl
group
disease
hydrogen
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000594813A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002535334A5 (enExample
Inventor
ペータース・ダン
グレンボルグ・メッテ
メルラー・アルネ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NTG Nordic Transport Group AS
Original Assignee
Neurosearch AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch AS filed Critical Neurosearch AS
Publication of JP2002535334A publication Critical patent/JP2002535334A/ja
Publication of JP2002535334A5 publication Critical patent/JP2002535334A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2000594813A 1999-01-19 2000-01-13 縮合ヘテロ環状化合物及びこれを神経変性疾患の治療に使用する方法 Pending JP2002535334A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA199900061 1999-01-19
DK199900061 1999-01-19
PCT/DK2000/000012 WO2000043397A1 (en) 1999-01-19 2000-01-13 Fused heterocyclic compounds and their use in the treatment of neurodegenerative diseases

Publications (2)

Publication Number Publication Date
JP2002535334A true JP2002535334A (ja) 2002-10-22
JP2002535334A5 JP2002535334A5 (enExample) 2007-02-22

Family

ID=8089290

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000594813A Pending JP2002535334A (ja) 1999-01-19 2000-01-13 縮合ヘテロ環状化合物及びこれを神経変性疾患の治療に使用する方法

Country Status (10)

Country Link
US (1) US6576641B2 (enExample)
EP (1) EP1147113B1 (enExample)
JP (1) JP2002535334A (enExample)
CN (1) CN1147490C (enExample)
AT (1) ATE328887T1 (enExample)
AU (1) AU776276B2 (enExample)
CA (1) CA2353903A1 (enExample)
DE (1) DE60028538T2 (enExample)
NZ (1) NZ512289A (enExample)
WO (1) WO2000043397A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1432708B1 (en) * 2001-09-24 2005-11-30 Bayer Pharmaceuticals Corporation Preparation and use of 1,5,6,7-tetrahydropyrrolo 3,2-c]pyridine derivatives for treatment of obesity
KR100553398B1 (ko) * 2004-03-12 2006-02-16 한미약품 주식회사 티에노[3,2-ｃ]피리딘 유도체의 제조 방법 및 이에사용되는 중간체
CN104193761B (zh) 2009-12-04 2017-10-17 桑诺维恩药品公司 多环化合物及其使用方法
BR112019001407A2 (pt) 2016-07-29 2019-07-09 Sunovion Pharmaceuticals Inc. compostos e composições e usos dos mesmos
SG10202100724UA (en) 2016-07-29 2021-03-30 Sunovion Pharmaceuticals Inc Compounds and compositions and uses thereof
EP3582815A1 (en) 2017-02-16 2019-12-25 Sunovion Pharmaceuticals Inc. Methods of treating schizophrenia
MX2020000523A (es) 2017-08-02 2020-08-20 Sunovion Pharmaceuticals Inc Compuestos de isocromano y usos de los mismos.
SG11202007823PA (en) 2018-02-16 2020-09-29 Sunovion Pharmaceuticals Inc Salts, crystal forms, and production methods thereof
JP7703449B2 (ja) 2019-03-14 2025-07-07 スミトモ・ファーマ・アメリカ・インコーポレイテッド イソクロマニル化合物の塩およびその結晶体、ならびにそれらの製造方法、治療用途および医薬組成物
KR20230003503A (ko) 2020-04-14 2023-01-06 선오비온 파마슈티컬스 인코포레이티드 신경학적 및 정신의학적 장애의 치료를 위한 (S)-(4,5-디히드로-7H-티에노[2,3-c]피란-7-일)-N-메틸메탄아민
KR20240101561A (ko) 2021-10-14 2024-07-02 인사이트 코포레이션 Kras의 저해제로서의 퀴놀린 화합물

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5441332A (en) * 1977-06-22 1979-04-02 Sentore Deechiyuude Puuru Rand Treating composition of sickle shaped erythrocyte disease
JPS61106577A (ja) * 1984-09-27 1986-05-24 シンセラボ フロ−〔３，２−ｃ〕ピリジン誘導体、その製造法およびそれを含有する医薬組成物
JPH02115185A (ja) * 1988-09-07 1990-04-27 Synthelabo Sa ４，５，６，７―テトラヒドロフロピリジン誘導体の肥満症治療用医薬への応用
JPH03130288A (ja) * 1989-09-22 1991-06-04 Fujisawa Pharmaceut Co Ltd 二環式アミン化合物およびその製造法
WO1997010218A1 (en) * 1995-09-11 1997-03-20 Hoechst Marion Roussel, Inc. Cyclic nitrones and pharmaceutical compositions containing them

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2566775B1 (fr) 1984-06-27 1986-10-31 Synthelabo Derives de tetrahydro-4,5,6,7 furo ou 1h-pyrrolo(2,3-c)pyridine, leur preparation et leur application en therapeutique
FR2652579B1 (fr) * 1989-10-02 1992-01-24 Sanofi Sa Derives d'hydroxy-2 thiophene et furanne condenses avec un cycle azote, sur procede de preparation et leur application en therapeutique.
FI101150B (fi) * 1991-09-09 1998-04-30 Sankyo Co Menetelmä lääkeaineina käyttökelpoisten tetrahydrotienopyridiinin johd annaisten valmistamiseksi
AU3619795A (en) * 1994-10-11 1996-05-02 Takeda Chemical Industries Ltd. Substituted heterobicyclic alkyl amines and their use as squalene oxide cyclase inhibitors

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5441332A (en) * 1977-06-22 1979-04-02 Sentore Deechiyuude Puuru Rand Treating composition of sickle shaped erythrocyte disease
JPS61106577A (ja) * 1984-09-27 1986-05-24 シンセラボ フロ−〔３，２−ｃ〕ピリジン誘導体、その製造法およびそれを含有する医薬組成物
JPH02115185A (ja) * 1988-09-07 1990-04-27 Synthelabo Sa ４，５，６，７―テトラヒドロフロピリジン誘導体の肥満症治療用医薬への応用
JPH03130288A (ja) * 1989-09-22 1991-06-04 Fujisawa Pharmaceut Co Ltd 二環式アミン化合物およびその製造法
WO1997010218A1 (en) * 1995-09-11 1997-03-20 Hoechst Marion Roussel, Inc. Cyclic nitrones and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
US20020013336A1 (en) 2002-01-31
CN1147490C (zh) 2004-04-28
DE60028538T2 (de) 2007-06-21
CA2353903A1 (en) 2000-07-27
US6576641B2 (en) 2003-06-10
AU776276B2 (en) 2004-09-02
WO2000043397A1 (en) 2000-07-27
AU3033300A (en) 2000-08-07
EP1147113A1 (en) 2001-10-24
EP1147113B1 (en) 2006-06-07
ATE328887T1 (de) 2006-06-15
DE60028538D1 (de) 2006-07-20
CN1336929A (zh) 2002-02-20
NZ512289A (en) 2003-06-30

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