JP2002532498A5 - - Google Patents
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- Publication number
- JP2002532498A5 JP2002532498A5 JP2000588174A JP2000588174A JP2002532498A5 JP 2002532498 A5 JP2002532498 A5 JP 2002532498A5 JP 2000588174 A JP2000588174 A JP 2000588174A JP 2000588174 A JP2000588174 A JP 2000588174A JP 2002532498 A5 JP2002532498 A5 JP 2002532498A5
- Authority
- JP
- Japan
- Prior art keywords
- heart
- occlusion
- experimetria
- racemate
- chest
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 210000000038 chest Anatomy 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- 230000036772 blood pressure Effects 0.000 description 2
- 210000004351 coronary vessel Anatomy 0.000 description 2
- 208000031225 myocardial ischemia Diseases 0.000 description 2
- 208000001778 Coronary Occlusion Diseases 0.000 description 1
- 206010011086 Coronary artery occlusion Diseases 0.000 description 1
- 206010061216 Infarction Diseases 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 230000004872 arterial blood pressure Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000008753 endothelial function Effects 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000007574 infarction Effects 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 229960001412 pentobarbital Drugs 0.000 description 1
- WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000010410 reperfusion Effects 0.000 description 1
- 238000011699 spontaneously hypertensive rat Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9802897 | 1998-12-14 | ||
| HU9802897A HU226617B1 (en) | 1998-12-14 | 1998-12-14 | Optically active pyridyl-4h-1,2,4-oxadiazine derivatives, and pharmaceutical composition containing the compound as active ingredient |
| PCT/HU1999/000095 WO2000035914A1 (en) | 1998-12-14 | 1999-12-07 | Optically active pyridyl-4h-1,2,4-oxadiazine derivative and its use in the treatment of vascular diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011128516A Division JP5620340B2 (ja) | 1998-12-14 | 2011-06-08 | 光学活性ピリジル−４ｈ−１，２，４−オキサジアジン誘導体およびその血管疾患の治療における使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002532498A JP2002532498A (ja) | 2002-10-02 |
| JP2002532498A5 true JP2002532498A5 (https=) | 2007-02-08 |
Family
ID=10991166
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000588174A Withdrawn JP2002532498A (ja) | 1998-12-14 | 1999-12-07 | 光学活性ピリジル−４ｈ−１，２，４−オキサジアジン誘導体およびその血管疾患の治療における使用 |
| JP2011128516A Expired - Lifetime JP5620340B2 (ja) | 1998-12-14 | 2011-06-08 | 光学活性ピリジル−４ｈ−１，２，４−オキサジアジン誘導体およびその血管疾患の治療における使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011128516A Expired - Lifetime JP5620340B2 (ja) | 1998-12-14 | 2011-06-08 | 光学活性ピリジル−４ｈ−１，２，４−オキサジアジン誘導体およびその血管疾患の治療における使用 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6384029B1 (https=) |
| EP (1) | EP1147105B1 (https=) |
| JP (2) | JP2002532498A (https=) |
| KR (1) | KR100661774B1 (https=) |
| AT (1) | ATE266027T1 (https=) |
| AU (1) | AU765336B2 (https=) |
| BG (1) | BG65179B1 (https=) |
| BR (1) | BR9913982A (https=) |
| CA (1) | CA2340734C (https=) |
| CZ (1) | CZ300764B6 (https=) |
| DE (1) | DE69917074T2 (https=) |
| DK (1) | DK1147105T3 (https=) |
| EE (1) | EE04551B1 (https=) |
| ES (1) | ES2219091T3 (https=) |
| HR (1) | HRP20010133B1 (https=) |
| HU (1) | HU226617B1 (https=) |
| IL (1) | IL141515A (https=) |
| NO (1) | NO317649B1 (https=) |
| PL (1) | PL196584B1 (https=) |
| PT (1) | PT1147105E (https=) |
| RS (1) | RS50129B (https=) |
| RU (1) | RU2222538C2 (https=) |
| SI (1) | SI1147105T1 (https=) |
| SK (1) | SK285582B6 (https=) |
| UA (1) | UA70340C2 (https=) |
| WO (1) | WO2000035914A1 (https=) |
| ZA (1) | ZA200101182B (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003057664A1 (en) | 2002-01-11 | 2003-07-17 | Biorex Kutató És Fejlesztö Rt. | Carboxamidine derivatives and their use in the treatment of vascular diseases |
| KR100678577B1 (ko) * | 2006-09-11 | 2007-02-06 | 조만규 | 가정용 분전함 |
| AU2009262670B2 (en) | 2008-06-26 | 2013-06-20 | Zevra Denmark A/S | Use of Hsp70 as a regulator of enzymatic activity |
| US20110224200A1 (en) | 2008-11-18 | 2011-09-15 | Shin-Ichiro Hirai | Therapeutic agent for chorioretinal degenerative disease containing pyridine-3-carbaldehyde 0-(piperidin-1-yl-propyl)-oxime derivative as active ingredient |
| CA2817773A1 (en) | 2010-11-30 | 2012-06-07 | Orphazyme Aps | Methods for increasing intracellular activity of hsp70 |
| HUP1100534A2 (en) | 2011-09-26 | 2013-04-29 | Balazs Dr Hazay | Pharmaceutical composition for the treatment of muscle atrophy |
| AU2015317447B2 (en) | 2014-09-15 | 2021-02-25 | Zevra Denmark A/S | Arimoclomol formulation |
| US10898476B2 (en) | 2016-04-13 | 2021-01-26 | Orphazyme A/S | Heat shock proteins and cholesterol homeostasis |
| DK3782624T3 (da) | 2016-04-29 | 2025-12-15 | Zevra Denmark As | Arimoclomol til behandling af glucocerebrosidase-associerede lidelser |
| MX2019013835A (es) | 2017-05-24 | 2020-07-14 | Orphazyme As | Inductores de proteinas de choque termico y trastornos frontotemporales. |
| SG11202011592SA (en) | 2018-05-28 | 2020-12-30 | Orphazyme As | Hsp70 protein levels in pbmc samples as biomarker for disease |
| KR20230128462A (ko) | 2020-11-19 | 2023-09-05 | 제브라 덴마크 에이/에스 | 아리모클로몰 시트레이트 및 이의 중간체를 제조하기 위한 공정 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT395853B (de) * | 1991-01-31 | 1993-03-25 | Chem Pharm Forsch Gmbh | Neue imidazolderivate, verfahren zu ihrer herstellung und ihre verwendung |
| HU222994B1 (hu) * | 1995-11-02 | 2004-01-28 | BIOREX Kutató és Fejlesztő Rt. | Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására |
| EP0858413B1 (en) * | 1995-11-03 | 2003-05-21 | Summit Packaging Systems Limited | Apparatus for dispensing and filling bags at a checkout counter of a supermarket |
| UA64716C2 (en) * | 1996-08-09 | 2004-03-15 | Pharmaceuticals for therapy or prevention of illnesses connected with dysfunction of vascular endothelial cells |
-
1998
- 1998-12-14 HU HU9802897A patent/HU226617B1/hu not_active IP Right Cessation
-
1999
- 1999-07-12 UA UA2001063850A patent/UA70340C2/uk unknown
- 1999-12-07 RU RU2001118854/04A patent/RU2222538C2/ru not_active IP Right Cessation
- 1999-12-07 EE EEP200100188A patent/EE04551B1/xx not_active IP Right Cessation
- 1999-12-07 AT AT99961225T patent/ATE266027T1/de active
- 1999-12-07 SI SI9930566T patent/SI1147105T1/xx unknown
- 1999-12-07 DK DK99961225T patent/DK1147105T3/da active
- 1999-12-07 DE DE69917074T patent/DE69917074T2/de not_active Expired - Lifetime
- 1999-12-07 CZ CZ20011550A patent/CZ300764B6/cs not_active IP Right Cessation
- 1999-12-07 EP EP99961225A patent/EP1147105B1/en not_active Expired - Lifetime
- 1999-12-07 CA CA002340734A patent/CA2340734C/en not_active Expired - Lifetime
- 1999-12-07 PL PL346767A patent/PL196584B1/pl not_active IP Right Cessation
- 1999-12-07 JP JP2000588174A patent/JP2002532498A/ja not_active Withdrawn
- 1999-12-07 HR HR20010133A patent/HRP20010133B1/xx not_active IP Right Cessation
- 1999-12-07 PT PT99961225T patent/PT1147105E/pt unknown
- 1999-12-07 SK SK234-2001A patent/SK285582B6/sk not_active IP Right Cessation
- 1999-12-07 WO PCT/HU1999/000095 patent/WO2000035914A1/en not_active Ceased
- 1999-12-07 US US09/762,949 patent/US6384029B1/en not_active Expired - Lifetime
- 1999-12-07 ES ES99961225T patent/ES2219091T3/es not_active Expired - Lifetime
- 1999-12-07 KR KR1020017002870A patent/KR100661774B1/ko not_active Expired - Fee Related
- 1999-12-07 RS YUP-250/01A patent/RS50129B/sr unknown
- 1999-12-07 IL IL14151599A patent/IL141515A/xx not_active IP Right Cessation
- 1999-12-07 BR BR9913982-0A patent/BR9913982A/pt not_active Application Discontinuation
- 1999-12-07 AU AU17906/00A patent/AU765336B2/en not_active Expired
-
2001
- 2001-02-12 ZA ZA200101182A patent/ZA200101182B/en unknown
- 2001-03-14 BG BG105342A patent/BG65179B1/bg unknown
- 2001-05-10 NO NO20012310A patent/NO317649B1/no not_active IP Right Cessation
-
2011
- 2011-06-08 JP JP2011128516A patent/JP5620340B2/ja not_active Expired - Lifetime
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