JP2002531544A - アセトアミド及び置換されたアセトアミドを含有するヘルペスウイルスのチオ尿素インヒビター - Google Patents

アセトアミド及び置換されたアセトアミドを含有するヘルペスウイルスのチオ尿素インヒビター

Info

Publication number
JP2002531544A
JP2002531544A JP2000586685A JP2000586685A JP2002531544A JP 2002531544 A JP2002531544 A JP 2002531544A JP 2000586685 A JP2000586685 A JP 2000586685A JP 2000586685 A JP2000586685 A JP 2000586685A JP 2002531544 A JP2002531544 A JP 2002531544A
Authority
JP
Japan
Prior art keywords
phenyl
thioureido
carbon atoms
chloro
fluoro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000586685A
Other languages
English (en)
Japanese (ja)
Inventor
ブルーム，ジヨナサン・デイビツド
デイグランデイ，マーテイン・ジヨセフ
ダシン，ラツセル・ジヨージ
ラング，スタンリー・アルバート
オハラ，ブライアン・マーク
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth LLC filed Critical Wyeth LLC
Publication of JP2002531544A publication Critical patent/JP2002531544A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/22—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
JP2000586685A 1998-12-09 1999-12-06 アセトアミド及び置換されたアセトアミドを含有するヘルペスウイルスのチオ尿素インヒビター Pending JP2002531544A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20831698A 1998-12-09 1998-12-09
US09/208,316 1998-12-09
PCT/US1999/028844 WO2000034237A2 (fr) 1998-12-09 1999-12-06 Inhibiteurs des virus de l'herpes a base de thio-urees contenant des acetamides et des acetamides substitues

Publications (1)

Publication Number Publication Date
JP2002531544A true JP2002531544A (ja) 2002-09-24

Family

ID=22774137

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000586685A Pending JP2002531544A (ja) 1998-12-09 1999-12-06 アセトアミド及び置換されたアセトアミドを含有するヘルペスウイルスのチオ尿素インヒビター

Country Status (15)

Country Link
EP (1) EP1137633A2 (fr)
JP (1) JP2002531544A (fr)
KR (1) KR20010087413A (fr)
CN (1) CN1333750A (fr)
AU (1) AU3111200A (fr)
BR (1) BR9916041A (fr)
CA (1) CA2350899A1 (fr)
CZ (1) CZ20012060A3 (fr)
EA (1) EA200100640A1 (fr)
HU (1) HUP0104944A3 (fr)
IL (1) IL143204A0 (fr)
NO (1) NO20012834L (fr)
PL (1) PL349131A1 (fr)
WO (1) WO2000034237A2 (fr)
ZA (1) ZA200104142B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006506454A (ja) * 2002-10-24 2006-02-23 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング メチレン尿素誘導体

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6166028A (en) * 1998-12-09 2000-12-26 American Home Products Corporation Diaminopuridine-containing thiourea inhibitors of herpes viruses
US6844367B1 (en) 1999-09-17 2005-01-18 Millennium Pharmaceuticals, Inc. Benzamides and related inhibitors of factor Xa
DE60115394T2 (de) 2000-02-29 2006-10-19 Millennium Pharmaceuticals, Inc., Cambridge Benzamide und ähnliche inhibitoren vom faktor xa
US7220768B2 (en) * 2003-02-11 2007-05-22 Wyeth Holdings Corp. Isoxazole-containing thiourea inhibitors useful for treatment of varicella zoster virus
AU2004263900A1 (en) 2003-08-08 2005-02-17 Arriva Pharmaceuticals, Inc. Methods of protein production in yeast
US8158814B2 (en) 2003-08-29 2012-04-17 Mitsui Chemicals, Inc. Insecticide for agricultural or horticultural use and method of use thereof
WO2005086915A2 (fr) 2004-03-09 2005-09-22 Arriva Pharmaceuticals, Inc. Traitement de la bronchopneumopathie chronique obstructive par inhalation a faible dose d'inhibiteur de protease
US20100093864A1 (en) * 2006-10-13 2010-04-15 Lica Pharmaceuticals Anti-infective thiourea compounds
ATE544749T1 (de) 2006-11-02 2012-02-15 Millennium Pharm Inc Verfahren zur synthetisierung pharmazeutischer salze aus einem faktor-xa-hemmer
CN108619123A (zh) * 2018-03-13 2018-10-09 武汉威立得生物医药有限公司 Tenovin-1在制备防治人类疱疹病毒感染药物中的应用
WO2019193541A1 (fr) * 2018-04-06 2019-10-10 Glaxosmithkline Intellectual Property Development Limited Dérivés de cycle aromatiques bicycliques de formule (i) utilisés en tant qu'inhibiteurs d'atf4
CN112807294B (zh) * 2019-11-18 2023-09-05 武汉大学 一种酰基硫脲类化合物在制备治疗或预防单纯疱疹病毒i型感染药物中的应用
WO2022150962A1 (fr) * 2021-01-12 2022-07-21 Westlake Pharmaceutical (Hangzhou) Co., Ltd. Inhibiteurs de protéase, leur préparation et leurs utilisations

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2243370T3 (es) * 1997-04-10 2005-12-01 PHARMACIA & UPJOHN COMPANY LLC Composiciones poliaromaticas para el tratamiento de infecciones por virus herpes.

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006506454A (ja) * 2002-10-24 2006-02-23 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング メチレン尿素誘導体
JP2010254714A (ja) * 2002-10-24 2010-11-11 Merck Patent Gmbh メチレン尿素誘導体
JP4690889B2 (ja) * 2002-10-24 2011-06-01 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング メチレン尿素誘導体

Also Published As

Publication number Publication date
NO20012834D0 (no) 2001-06-08
AU3111200A (en) 2000-06-26
HUP0104944A2 (hu) 2002-04-29
CN1333750A (zh) 2002-01-30
CZ20012060A3 (cs) 2001-11-14
BR9916041A (pt) 2001-12-04
PL349131A1 (en) 2002-07-01
IL143204A0 (en) 2002-04-21
NO20012834L (no) 2001-08-07
ZA200104142B (en) 2002-10-25
CA2350899A1 (fr) 2000-06-15
EP1137633A2 (fr) 2001-10-04
EA200100640A1 (ru) 2001-12-24
WO2000034237A2 (fr) 2000-06-15
HUP0104944A3 (en) 2003-03-28
KR20010087413A (ko) 2001-09-15
WO2000034237A3 (fr) 2000-11-23

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