ZA200104142B - Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses. - Google Patents

Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses. Download PDF

Info

Publication number
ZA200104142B
ZA200104142B ZA200104142A ZA200104142A ZA200104142B ZA 200104142 B ZA200104142 B ZA 200104142B ZA 200104142 A ZA200104142 A ZA 200104142A ZA 200104142 A ZA200104142 A ZA 200104142A ZA 200104142 B ZA200104142 B ZA 200104142B
Authority
ZA
South Africa
Prior art keywords
carbon atoms
phenyl
alkyl
hydrogen
acetamide
Prior art date
Application number
ZA200104142A
Other languages
English (en)
Inventor
Jonathan David Bloom
Russel George Dushin
Bryan Mark O'hara
Martin Joseph Digrandi
Stanley Albert Lang
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of ZA200104142B publication Critical patent/ZA200104142B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/22—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
ZA200104142A 1998-12-09 2001-05-21 Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses. ZA200104142B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20831698A 1998-12-09 1998-12-09

Publications (1)

Publication Number Publication Date
ZA200104142B true ZA200104142B (en) 2002-10-25

Family

ID=22774137

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200104142A ZA200104142B (en) 1998-12-09 2001-05-21 Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses.

Country Status (15)

Country Link
EP (1) EP1137633A2 (fr)
JP (1) JP2002531544A (fr)
KR (1) KR20010087413A (fr)
CN (1) CN1333750A (fr)
AU (1) AU3111200A (fr)
BR (1) BR9916041A (fr)
CA (1) CA2350899A1 (fr)
CZ (1) CZ20012060A3 (fr)
EA (1) EA200100640A1 (fr)
HU (1) HUP0104944A3 (fr)
IL (1) IL143204A0 (fr)
NO (1) NO20012834L (fr)
PL (1) PL349131A1 (fr)
WO (1) WO2000034237A2 (fr)
ZA (1) ZA200104142B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6166028A (en) * 1998-12-09 2000-12-26 American Home Products Corporation Diaminopuridine-containing thiourea inhibitors of herpes viruses
US6844367B1 (en) 1999-09-17 2005-01-18 Millennium Pharmaceuticals, Inc. Benzamides and related inhibitors of factor Xa
DE60115394T2 (de) 2000-02-29 2006-10-19 Millennium Pharmaceuticals, Inc., Cambridge Benzamide und ähnliche inhibitoren vom faktor xa
CA2503445C (fr) * 2002-10-24 2012-07-31 Merck Patent Gesellschaft Mit Beschraenkter Haftung Derives de methylene uree
US7220768B2 (en) * 2003-02-11 2007-05-22 Wyeth Holdings Corp. Isoxazole-containing thiourea inhibitors useful for treatment of varicella zoster virus
AU2004263900A1 (en) 2003-08-08 2005-02-17 Arriva Pharmaceuticals, Inc. Methods of protein production in yeast
US8158814B2 (en) 2003-08-29 2012-04-17 Mitsui Chemicals, Inc. Insecticide for agricultural or horticultural use and method of use thereof
WO2005086915A2 (fr) 2004-03-09 2005-09-22 Arriva Pharmaceuticals, Inc. Traitement de la bronchopneumopathie chronique obstructive par inhalation a faible dose d'inhibiteur de protease
US20100093864A1 (en) * 2006-10-13 2010-04-15 Lica Pharmaceuticals Anti-infective thiourea compounds
ATE544749T1 (de) 2006-11-02 2012-02-15 Millennium Pharm Inc Verfahren zur synthetisierung pharmazeutischer salze aus einem faktor-xa-hemmer
CN108619123A (zh) * 2018-03-13 2018-10-09 武汉威立得生物医药有限公司 Tenovin-1在制备防治人类疱疹病毒感染药物中的应用
WO2019193541A1 (fr) * 2018-04-06 2019-10-10 Glaxosmithkline Intellectual Property Development Limited Dérivés de cycle aromatiques bicycliques de formule (i) utilisés en tant qu'inhibiteurs d'atf4
CN112807294B (zh) * 2019-11-18 2023-09-05 武汉大学 一种酰基硫脲类化合物在制备治疗或预防单纯疱疹病毒i型感染药物中的应用
WO2022150962A1 (fr) * 2021-01-12 2022-07-21 Westlake Pharmaceutical (Hangzhou) Co., Ltd. Inhibiteurs de protéase, leur préparation et leurs utilisations

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2243370T3 (es) * 1997-04-10 2005-12-01 PHARMACIA & UPJOHN COMPANY LLC Composiciones poliaromaticas para el tratamiento de infecciones por virus herpes.

Also Published As

Publication number Publication date
NO20012834D0 (no) 2001-06-08
AU3111200A (en) 2000-06-26
HUP0104944A2 (hu) 2002-04-29
CN1333750A (zh) 2002-01-30
CZ20012060A3 (cs) 2001-11-14
JP2002531544A (ja) 2002-09-24
BR9916041A (pt) 2001-12-04
PL349131A1 (en) 2002-07-01
IL143204A0 (en) 2002-04-21
NO20012834L (no) 2001-08-07
CA2350899A1 (fr) 2000-06-15
EP1137633A2 (fr) 2001-10-04
EA200100640A1 (ru) 2001-12-24
WO2000034237A2 (fr) 2000-06-15
HUP0104944A3 (en) 2003-03-28
KR20010087413A (ko) 2001-09-15
WO2000034237A3 (fr) 2000-11-23

Similar Documents

Publication Publication Date Title
EP0243670B1 (fr) Composés de purine et pyrimidine et leur usage comme agents antiviraux
ZA200104142B (en) Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses.
FI106461B (fi) Menetelmä terapeuttisesti käyttökelpoisten enantiomeeristen yhdisteiden valmistamiseksi sekä menetelmässä käyttökelpoinen välituote
DK168323B1 (da) Anvendelse af visse pyrimidinnucleosider til fremstilling af et lægemiddel mod VZV-infektioner; hidtil ukendte pyrimidinnucleosider, sådanne forbindelser til anvendelse i human terapi samt fremgangsmåde til fremstilling af forbindelserne
AU636108B2 (en) Therapeutic 6-substituted purine carbocyclic nucleosides and pharmaceutically acceptable derivatives thereof
US4548819A (en) Derivatives of 9-(2-hydroxyethoxymethyl) guanine
US4957924A (en) Therapeutic valine esters of acyclovir and pharmaceutically acceptable salts thereof
SK95193A3 (en) Antiviral nucleoside combination
FI93546B (fi) Menetelmä terapeuttisesti käyttökelpoisten dideoksikarbosyklisten nukleosidianalogien valmistamiseksi
RU2642463C2 (ru) Циклопропанкарбоксилатные эфиры пуриновых аналогов
DK159683B (da) 9-(4-hydroxybutyl)-guaninderivat, farmaceutisk praeparat indeholdende en saadan forbindelse og anvendelse af den til fremstilling af et laegemiddel
ZA200104322B (en) Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing a substituted phenylenediamine group.
WO1997034894A1 (fr) Derives de la naphthyridine et leurs analogues inhibiteurs du cytomegalovirus
Shigeta et al. Synthesis and antiherpesvirus activities of 5-alkyl-2-thiopyrimidine nucleoside analogues
ZA200104376B (en) Alpha-methybenzyl-containing thiourea inhibitors of herpes viruses containing a phenylenediamine groups.
US5153352A (en) Process for preparation of intermediates of carbocyclic nucleoside analogs
TWI385172B (zh) 新穎化合物
ZA200104373B (en) Thiourea inhibitors of herpes viruses.
ZA200104318B (en) Thiourea inhibitors of herpes viruses.
US6274589B1 (en) L-β-dioxolane uridine analogs and their pharmaceutical compositions
WO2022165162A1 (fr) Inhibiteurs sélectifs de kinases dépendantes des cyclines et leurs procédés d'utilisation thérapeutique
EP0479822B1 (fr) Nucleosides therapeutiques
US7220768B2 (en) Isoxazole-containing thiourea inhibitors useful for treatment of varicella zoster virus
US5028596A (en) 1-(β-D-arabinofuranosyl)-5-propynyluracil for treatment of VZV infections
PH26589A (en) Esters of 5-propynyl pyrimidine nucleosides