JP2002529240A - リポソーム生成のための方法および装置 - Google Patents

リポソーム生成のための方法および装置

Info

Publication number
JP2002529240A
JP2002529240A JP2000582143A JP2000582143A JP2002529240A JP 2002529240 A JP2002529240 A JP 2002529240A JP 2000582143 A JP2000582143 A JP 2000582143A JP 2000582143 A JP2000582143 A JP 2000582143A JP 2002529240 A JP2002529240 A JP 2002529240A
Authority
JP
Japan
Prior art keywords
lipid
phase
manifold
vesicle
aqueous phase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2000582143A
Other languages
English (en)
Japanese (ja)
Inventor
マーティン ティー． ベーカー，
ウィリアム エイ． ヘリオット，
Original Assignee
オプタイム セラピュウティクス， インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by オプタイム セラピュウティクス， インコーポレイテッド filed Critical オプタイム セラピュウティクス， インコーポレイテッド
Publication of JP2002529240A publication Critical patent/JP2002529240A/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B01F23/411—Emulsifying using electrical or magnetic fields, heat or vibrations
    • B01F23/4111—Emulsifying using electrical or magnetic fields, heat or vibrations using vibrations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B01F23/4105—Methods of emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80—Mixing plants; Combinations of mixers
    • B01F33/82—Combinations of dissimilar mixers
    • B01F33/821—Combinations of dissimilar mixers with consecutive receptacles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/21—Measuring
    • B01F35/213—Measuring of the properties of the mixtures, e.g. temperature, density or colour
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/22—Control or regulation
    • B01F35/221—Control or regulation of operational parameters, e.g. level of material in the mixer, temperature or pressure
    • B01F35/2215—Temperature
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/80—Forming a predetermined ratio of the substances to be mixed
    • B01F35/83—Forming a predetermined ratio of the substances to be mixed by controlling the ratio of two or more flows, e.g. using flow sensing or flow controlling devices
    • B01F35/831—Forming a predetermined ratio of the substances to be mixed by controlling the ratio of two or more flows, e.g. using flow sensing or flow controlling devices using one or more pump or other dispensing mechanisms for feeding the flows in predetermined proportion, e.g. one of the pumps being driven by one of the flows
    • B01F35/8311—Forming a predetermined ratio of the substances to be mixed by controlling the ratio of two or more flows, e.g. using flow sensing or flow controlling devices using one or more pump or other dispensing mechanisms for feeding the flows in predetermined proportion, e.g. one of the pumps being driven by one of the flows with means for controlling the motor driving the pumps or the other dispensing mechanisms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0436—Operational information
    • B01F2215/0468—Numerical pressure values
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0436—Operational information
    • B01F2215/0472—Numerical temperature values
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2000582143A 1998-11-13 1999-11-12 リポソーム生成のための方法および装置 Withdrawn JP2002529240A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10835598P 1998-11-13 1998-11-13
US60/108,355 1998-11-13
PCT/US1999/026738 WO2000029103A1 (en) 1998-11-13 1999-11-12 Method and apparatus for liposome production

Publications (1)

Publication Number Publication Date
JP2002529240A true JP2002529240A (ja) 2002-09-10

Family

ID=22321729

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000582143A Withdrawn JP2002529240A (ja) 1998-11-13 1999-11-12 リポソーム生成のための方法および装置

Country Status (9)

Country Link
US (3) US6534018B1 (cg-RX-API-DMAC7.html)
EP (1) EP1146959B1 (cg-RX-API-DMAC7.html)
JP (1) JP2002529240A (cg-RX-API-DMAC7.html)
AT (1) ATE397488T1 (cg-RX-API-DMAC7.html)
AU (1) AU756196B2 (cg-RX-API-DMAC7.html)
CA (1) CA2350430C (cg-RX-API-DMAC7.html)
DE (1) DE69938875D1 (cg-RX-API-DMAC7.html)
IL (1) IL143104A (cg-RX-API-DMAC7.html)
WO (1) WO2000029103A1 (cg-RX-API-DMAC7.html)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002535268A (ja) * 1999-01-25 2002-10-22 オプティム セラピューティクス， インコーポレイテッド リポソーム処方物
JP2003504390A (ja) * 1999-07-15 2003-02-04 イネックス ファーマスーティカルズ コーポレイション 脂質小胞の製造のための方法および装置
JP2017520551A (ja) * 2014-07-02 2017-07-27 シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド メッセンジャーｒｎａのカプセル化
JP2022506097A (ja) * 2018-10-26 2022-01-17 ユニバーシティ オブ コネチカット ナノ粒子に対する内部修飾および外部修飾の連続処理システムおよび方法

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EP1334765B1 (en) * 2000-10-13 2010-06-30 National Institute of Advanced Industrial Science and Technology Process for producing liposome
EP1203614A1 (de) * 2000-11-03 2002-05-08 Polymun Scientific Immunbiologische Forschung GmbH Verfahren und Vorrichtung zur Herstellung von Lipidvesikeln

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JP2002535268A (ja) * 1999-01-25 2002-10-22 オプティム セラピューティクス， インコーポレイテッド リポソーム処方物
JP2003504390A (ja) * 1999-07-15 2003-02-04 イネックス ファーマスーティカルズ コーポレイション 脂質小胞の製造のための方法および装置
JP2017520551A (ja) * 2014-07-02 2017-07-27 シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド メッセンジャーｒｎａのカプセル化
JP2021008517A (ja) * 2014-07-02 2021-01-28 シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド メッセンジャーｒｎａのカプセル化
JP2023144134A (ja) * 2014-07-02 2023-10-06 トランスレイト バイオ， インコーポレイテッド メッセンジャーｒｎａのカプセル化
JP7549098B2 (ja) 2014-07-02 2024-09-10 トランスレイト バイオ， インコーポレイテッド メッセンジャーｒｎａのカプセル化
JP2024161144A (ja) * 2014-07-02 2024-11-15 トランスレイト バイオ， インコーポレイテッド メッセンジャーｒｎａのカプセル化
JP2022506097A (ja) * 2018-10-26 2022-01-17 ユニバーシティ オブ コネチカット ナノ粒子に対する内部修飾および外部修飾の連続処理システムおよび方法
US12434208B2 (en) 2018-10-26 2025-10-07 University Of Connecticut Continuous processing system and methods for internal and external modifications to nanoparticles

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EP1146959B1 (en) 2008-06-04
US20030124033A1 (en) 2003-07-03
US20050196435A1 (en) 2005-09-08
US6855277B2 (en) 2005-02-15
EP1146959A4 (en) 2004-12-29
DE69938875D1 (cg-RX-API-DMAC7.html) 2008-07-17
AU756196B2 (en) 2003-01-09
WO2000029103A1 (en) 2000-05-25
CA2350430A1 (en) 2000-05-25
IL143104A0 (en) 2002-04-21
CA2350430C (en) 2008-06-03
EP1146959A1 (en) 2001-10-24
ATE397488T1 (de) 2008-06-15
IL143104A (en) 2005-09-25
AU1476800A (en) 2000-06-05

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