CA2350430C - Method and apparatus for liposome production - Google Patents
Method and apparatus for liposome production Download PDFInfo
- Publication number
- CA2350430C CA2350430C CA002350430A CA2350430A CA2350430C CA 2350430 C CA2350430 C CA 2350430C CA 002350430 A CA002350430 A CA 002350430A CA 2350430 A CA2350430 A CA 2350430A CA 2350430 C CA2350430 C CA 2350430C
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- lipid
- manifold
- phase
- mixing
- inlet
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/41—Emulsifying
- B01F23/4105—Methods of emulsifying
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/41—Emulsifying
- B01F23/411—Emulsifying using electrical or magnetic fields, heat or vibrations
- B01F23/4111—Emulsifying using electrical or magnetic fields, heat or vibrations using vibrations
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/82—Combinations of dissimilar mixers
- B01F33/821—Combinations of dissimilar mixers with consecutive receptacles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/20—Measuring; Control or regulation
- B01F35/21—Measuring
- B01F35/213—Measuring of the properties of the mixtures, e.g. temperature, density or colour
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/20—Measuring; Control or regulation
- B01F35/22—Control or regulation
- B01F35/221—Control or regulation of operational parameters, e.g. level of material in the mixer, temperature or pressure
- B01F35/2215—Temperature
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/80—Forming a predetermined ratio of the substances to be mixed
- B01F35/83—Forming a predetermined ratio of the substances to be mixed by controlling the ratio of two or more flows, e.g. using flow sensing or flow controlling devices
- B01F35/831—Forming a predetermined ratio of the substances to be mixed by controlling the ratio of two or more flows, e.g. using flow sensing or flow controlling devices using one or more pump or other dispensing mechanisms for feeding the flows in predetermined proportion, e.g. one of the pumps being driven by one of the flows
- B01F35/8311—Forming a predetermined ratio of the substances to be mixed by controlling the ratio of two or more flows, e.g. using flow sensing or flow controlling devices using one or more pump or other dispensing mechanisms for feeding the flows in predetermined proportion, e.g. one of the pumps being driven by one of the flows with means for controlling the motor driving the pumps or the other dispensing mechanisms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2215/00—Auxiliary or complementary information in relation with mixing
- B01F2215/04—Technical information in relation with mixing
- B01F2215/0413—Numerical information
- B01F2215/0436—Operational information
- B01F2215/0468—Numerical pressure values
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2215/00—Auxiliary or complementary information in relation with mixing
- B01F2215/04—Technical information in relation with mixing
- B01F2215/0413—Numerical information
- B01F2215/0436—Operational information
- B01F2215/0472—Numerical temperature values
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10835598P | 1998-11-13 | 1998-11-13 | |
| US60/108,355 | 1998-11-13 | ||
| PCT/US1999/026738 WO2000029103A1 (en) | 1998-11-13 | 1999-11-12 | Method and apparatus for liposome production |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2350430A1 CA2350430A1 (en) | 2000-05-25 |
| CA2350430C true CA2350430C (en) | 2008-06-03 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002350430A Expired - Lifetime CA2350430C (en) | 1998-11-13 | 1999-11-12 | Method and apparatus for liposome production |
Country Status (9)
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|---|---|
| US (3) | US6534018B1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1146959B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2002529240A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE397488T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU756196B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2350430C (cg-RX-API-DMAC7.html) |
| DE (1) | DE69938875D1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL143104A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2000029103A1 (cg-RX-API-DMAC7.html) |
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| EP0943242A1 (en) * | 1998-02-26 | 1999-09-22 | Puratos N.V. | Granulated bread improver for the preparation of bakery products |
| US6855296B1 (en) * | 1998-11-13 | 2005-02-15 | Optime Therapeutics, Inc. | Method and apparatus for liposome production |
| WO2000042990A1 (en) * | 1999-01-25 | 2000-07-27 | Optime Therapeutics, Inc. | Liposome formulations |
| AU769357B2 (en) * | 1999-07-15 | 2004-01-22 | University Of British Columbia, The | Methods for preparation of lipid-encapsulated therapeutic agents |
| US20020119188A1 (en) * | 2000-02-08 | 2002-08-29 | Susan Niemiec | Method of manufacturing liposomes |
| DE60138934D1 (de) * | 2000-02-25 | 2009-07-23 | Hitachi Ltd | Mischvorrichtung für Analysenautomat |
| EP1203614A1 (de) * | 2000-11-03 | 2002-05-08 | Polymun Scientific Immunbiologische Forschung GmbH | Verfahren und Vorrichtung zur Herstellung von Lipidvesikeln |
| ES2354607T3 (es) * | 2002-06-28 | 2011-03-16 | Protiva Biotherapeutics Inc. | Procedimiento y aparato para producir liposomas. |
| US7718189B2 (en) | 2002-10-29 | 2010-05-18 | Transave, Inc. | Sustained release of antiinfectives |
| US7879351B2 (en) | 2002-10-29 | 2011-02-01 | Transave, Inc. | High delivery rates for lipid based drug formulations, and methods of treatment thereof |
| KR101424980B1 (ko) | 2002-10-29 | 2014-08-01 | 인스메드 인코포레이티드 | 항감염제의 지속적인 방출 |
| FR2854072B1 (fr) * | 2003-04-23 | 2006-08-04 | Centre Nat Rech Scient | Vecteur pour administration par voie orale |
| ATE489182T1 (de) * | 2004-03-23 | 2010-12-15 | Sintokogio Ltd | Vorrichtung zur herstellung einer gussform und metallformeinheit für den einsatz darin |
| TW201204410A (en) * | 2004-04-01 | 2012-02-01 | Oncothyreon Inc | Mucinous glycoprotein (MUC-1) vaccine |
| DE102004018283A1 (de) * | 2004-04-15 | 2005-11-03 | Wacker-Chemie Gmbh | Verfahren zur kontinuierlichen Herstellung von Silicon Emulsionen |
| EP1857112B1 (en) * | 2005-03-09 | 2013-05-15 | Sunstar Inc. | Anticancer composition comprising liposomes containing phytosterols |
| CN101267805A (zh) * | 2005-07-27 | 2008-09-17 | 普洛体维生物治疗公司 | 制造脂质体的系统和方法 |
| DK1962805T3 (en) | 2005-12-08 | 2016-09-26 | Insmed Inc | Lipid-based compositions of the anti-infective agents for the treatment of lung infections |
| US7740152B2 (en) | 2006-03-06 | 2010-06-22 | The Coca-Cola Company | Pump system with calibration curve |
| US10631558B2 (en) | 2006-03-06 | 2020-04-28 | The Coca-Cola Company | Methods and apparatuses for making compositions comprising an acid and an acid degradable component and/or compositions comprising a plurality of selectable components |
| US9146564B2 (en) | 2006-03-06 | 2015-09-29 | Deka Products Limited Partnership | Product dispensing system |
| US11906988B2 (en) | 2006-03-06 | 2024-02-20 | Deka Products Limited Partnership | Product dispensing system |
| US11214476B2 (en) | 2006-03-06 | 2022-01-04 | Deka Products Limited Partnership | System and method for generating a drive signal |
| WO2008016691A2 (en) * | 2006-08-01 | 2008-02-07 | Covaris, Inc. | Methods and apparatus for treating samples with acoustic energy |
| US8071127B2 (en) * | 2006-10-24 | 2011-12-06 | Aradigm Corporation | Dual action, inhaled formulations providing both an immediate and sustained release profile |
| US8119156B2 (en) | 2006-10-24 | 2012-02-21 | Aradigm Corporation | Dual action, inhaled formulations providing both an immediate and sustained release profile |
| US8268347B1 (en) | 2006-10-24 | 2012-09-18 | Aradigm Corporation | Dual action, inhaled formulations providing both an immediate and sustained release profile |
| US7985058B2 (en) * | 2007-01-12 | 2011-07-26 | Mark Gray | Method and apparatus for making uniformly sized particles |
| WO2008137717A1 (en) | 2007-05-04 | 2008-11-13 | Transave, Inc. | Compositions of multicationic drugs for reducing interactions with polyanionic biomolecules and methods and uses thereof |
| US9119783B2 (en) | 2007-05-07 | 2015-09-01 | Insmed Incorporated | Method of treating pulmonary disorders with liposomal amikacin formulations |
| US9333214B2 (en) | 2007-05-07 | 2016-05-10 | Insmed Incorporated | Method for treating pulmonary disorders with liposomal amikacin formulations |
| US9114081B2 (en) | 2007-05-07 | 2015-08-25 | Insmed Incorporated | Methods of treating pulmonary disorders with liposomal amikacin formulations |
| CA2710983A1 (en) * | 2007-12-27 | 2009-10-01 | The Ohio State University Research Foundation | Lipid nanoparticle compositions and methods of making and using the same |
| US9445975B2 (en) | 2008-10-03 | 2016-09-20 | Access Business Group International, Llc | Composition and method for preparing stable unilamellar liposomal suspension |
| US20110221082A1 (en) * | 2008-10-10 | 2011-09-15 | Hashimoto Electronic Industry Co., Ltd. | Liposome manufacturing device |
| WO2010044399A1 (ja) * | 2008-10-14 | 2010-04-22 | 株式会社リポソーム工学研究所 | 多機能リポソーム自動製造装置 |
| EP3243504A1 (en) | 2009-01-29 | 2017-11-15 | Arbutus Biopharma Corporation | Improved lipid formulation |
| CA2754043A1 (en) | 2009-03-12 | 2010-09-16 | Alnylam Pharmaceuticals, Inc. | Lipid formulated compositions and methods for inhibiting expression of eg5 and vegf genes |
| US8883202B2 (en) | 2009-05-05 | 2014-11-11 | Tekmira Pharmaceuticals Corporation | Lipid compositions |
| EP3504967A1 (en) | 2009-05-05 | 2019-07-03 | Arbutus Biopharma Corporation | Methods of delivering oligonucleotides to immune cells |
| LT2440183T (lt) | 2009-06-10 | 2018-08-10 | Arbutus Biopharma Corporation | Patobulinta lipido kompozicija |
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1999
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- 1999-11-12 WO PCT/US1999/026738 patent/WO2000029103A1/en not_active Ceased
- 1999-11-12 IL IL14310499A patent/IL143104A/xx not_active IP Right Cessation
- 1999-11-12 AU AU14768/00A patent/AU756196B2/en not_active Expired
- 1999-11-12 CA CA002350430A patent/CA2350430C/en not_active Expired - Lifetime
- 1999-11-12 AT AT99972124T patent/ATE397488T1/de not_active IP Right Cessation
- 1999-11-12 JP JP2000582143A patent/JP2002529240A/ja not_active Withdrawn
- 1999-11-12 US US09/439,619 patent/US6534018B1/en not_active Expired - Lifetime
- 1999-11-12 EP EP99972124A patent/EP1146959B1/en not_active Expired - Lifetime
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2002
- 2002-11-15 US US10/298,143 patent/US6855277B2/en not_active Expired - Lifetime
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2005
- 2005-01-05 US US11/030,583 patent/US20050196435A1/en not_active Abandoned
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| US6534018B1 (en) | 2003-03-18 |
| JP2002529240A (ja) | 2002-09-10 |
| EP1146959B1 (en) | 2008-06-04 |
| US20030124033A1 (en) | 2003-07-03 |
| US20050196435A1 (en) | 2005-09-08 |
| US6855277B2 (en) | 2005-02-15 |
| EP1146959A4 (en) | 2004-12-29 |
| DE69938875D1 (cg-RX-API-DMAC7.html) | 2008-07-17 |
| AU756196B2 (en) | 2003-01-09 |
| WO2000029103A1 (en) | 2000-05-25 |
| CA2350430A1 (en) | 2000-05-25 |
| IL143104A0 (en) | 2002-04-21 |
| EP1146959A1 (en) | 2001-10-24 |
| ATE397488T1 (de) | 2008-06-15 |
| IL143104A (en) | 2005-09-25 |
| AU1476800A (en) | 2000-06-05 |
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