JP2002529054A - ヒト血小板糖タンパク質ｉｂアルファに対する抗体の可変重鎖領域及び可変軽鎖領域 - Google Patents

ヒト血小板糖タンパク質ｉｂアルファに対する抗体の可変重鎖領域及び可変軽鎖領域

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Publication number
JP2002529054A
JP2002529054A JP2000579997A JP2000579997A JP2002529054A JP 2002529054 A JP2002529054 A JP 2002529054A JP 2000579997 A JP2000579997 A JP 2000579997A JP 2000579997 A JP2000579997 A JP 2000579997A JP 2002529054 A JP2002529054 A JP 2002529054A
Authority
JP
Japan
Prior art keywords
seq
amino acid
chain region
antibody
acid sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000579997A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002529054A5 (enExample
Inventor
エル．ミラー ジョナサン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of JP2002529054A publication Critical patent/JP2002529054A/ja
Publication of JP2002529054A5 publication Critical patent/JP2002529054A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2000579997A 1998-10-30 1999-10-29 ヒト血小板糖タンパク質ｉｂアルファに対する抗体の可変重鎖領域及び可変軽鎖領域 Pending JP2002529054A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10627598P 1998-10-30 1998-10-30
US60/106,275 1998-10-30
PCT/US1999/025495 WO2000026667A1 (en) 1998-10-30 1999-10-29 Variable heavy chain and variable light chain regions of antibodies to human platelet glycoprotein ib alpha

Publications (2)

Publication Number Publication Date
JP2002529054A true JP2002529054A (ja) 2002-09-10
JP2002529054A5 JP2002529054A5 (enExample) 2006-12-07

Family

ID=22310524

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000579997A Pending JP2002529054A (ja) 1998-10-30 1999-10-29 ヒト血小板糖タンパク質ｉｂアルファに対する抗体の可変重鎖領域及び可変軽鎖領域

Country Status (8)

Country Link
EP (1) EP1051620B1 (enExample)
JP (1) JP2002529054A (enExample)
AT (1) ATE329263T1 (enExample)
AU (1) AU1458500A (enExample)
CA (1) CA2317808A1 (enExample)
DE (1) DE69931756T2 (enExample)
IL (1) IL137121A0 (enExample)
WO (1) WO2000026667A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006500008A (ja) * 2002-07-03 2006-01-05 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア 抗血小板自己抗体およびそのインヒビターに関連する組成物、方法およびキット

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9918788D0 (en) 1999-08-10 1999-10-13 Leuven K U Res & Dev Antithrombotic effect of platelet glycoprotein 1b blocking monoclonal Fab fragments
DE10019967A1 (de) * 2000-04-20 2001-10-25 Fenning Biomed Gmbh Dr Antikörper gegen natives gp96, deren Herstellung und Verwendung
US7521053B2 (en) 2001-10-11 2009-04-21 Amgen Inc. Angiopoietin-2 specific binding agents
US7658924B2 (en) 2001-10-11 2010-02-09 Amgen Inc. Angiopoietin-2 specific binding agents
WO2004003144A2 (en) 2002-07-01 2004-01-08 Human Genome Sciences, Inc. Antibodies that specifically bind to reg iv
AU2003298112A1 (en) * 2002-11-13 2004-06-03 Micromet Ag Method for identifying antigen specific b cells
RU2006102570A (ru) * 2003-06-30 2007-08-20 Био-Текнолоджи Дженерал(Израиль) Лтд. (IL) Антитела и их применение
EP1749536A1 (en) * 2005-08-03 2007-02-07 Thrombotargets Europe, S.L. Activated factor X stimulants as new antihemorrhagic agents for topical use
JO2913B1 (en) 2008-02-20 2015-09-15 امجين إنك, Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses
EP2186829B1 (en) * 2008-11-14 2014-12-31 Canadian Blood Services Antibodies against GPIbalpha
CN102905727B (zh) * 2009-10-30 2016-12-07 詹森生物科技公司 Il-17a拮抗剂
KR20220127250A (ko) * 2019-12-10 2022-09-19 씨씨오에이 테라퓨틱스 (항저우) 컴퍼니 리미티드 인간화 항-당단백질 ib알파(gpibalpha) 항체
US20230055143A1 (en) * 2019-12-20 2023-02-23 Medimmune, Llc Compositions and Methods of Treating Cancer with Chimeric Antigen Receptors Targeting Glypican 3
WO2021262880A2 (en) * 2020-06-23 2021-12-30 Kadmon Corporation, Llc Anti-pd-1 antibodies and fusion proteins

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997018236A1 (en) * 1995-11-13 1997-05-22 The Research Foundation Of State University Of New York MIMOTOPES AND ANTI-MIMOTOPES OF HUMAN PLATELET GLYCOPROTEIN Ib/IX
US5817748A (en) * 1995-03-17 1998-10-06 The Research Foundation Of State University Of New York Mimotopes of human Platelet glycoprotein Ib/IX

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817748A (en) * 1995-03-17 1998-10-06 The Research Foundation Of State University Of New York Mimotopes of human Platelet glycoprotein Ib/IX
WO1997018236A1 (en) * 1995-11-13 1997-05-22 The Research Foundation Of State University Of New York MIMOTOPES AND ANTI-MIMOTOPES OF HUMAN PLATELET GLYCOPROTEIN Ib/IX

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JPN6009041574, "Ｔｈｅ ＥＭＢＯ Ｊｏｕｒｎａｌ", １９９４， Ｖｏｌ．１３， Ｎｏ．３， ｐｐ．６９２−６９８ *
JPN6009041579, "Ｔｈｅ ＥＭＢＯ Ｊｏｕｒｎａｌ", １９９４， Ｖｏｌ．１３， Ｎｏ．１４， ｐｐ．３２４５−３２６０ *
JPN6009041582, "Ｊｏｕｒｎａｌ ｏｆ Ｂｉｏｌｏｇｉｃａｌ Ｃｈｅｍｉｓｔｒｙ", １９９３， Ｖｏｌ．２６８， Ｎｏ．１１， ｐｐ．８３７６−８３８２ *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006500008A (ja) * 2002-07-03 2006-01-05 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア 抗血小板自己抗体およびそのインヒビターに関連する組成物、方法およびキット

Also Published As

Publication number Publication date
WO2000026667A1 (en) 2000-05-11
EP1051620A1 (en) 2000-11-15
ATE329263T1 (de) 2006-06-15
WO2000026667A9 (en) 2001-04-12
AU1458500A (en) 2000-05-22
CA2317808A1 (en) 2000-05-11
DE69931756T2 (de) 2007-05-24
DE69931756D1 (de) 2006-07-20
IL137121A0 (en) 2001-06-14
EP1051620A4 (en) 2005-01-12
EP1051620B1 (en) 2006-06-07

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