AU1458500A - Variable heavy chain and variable light chain regions of antibodies to human platelet glycoprotein IB alpha - Google Patents
Variable heavy chain and variable light chain regions of antibodies to human platelet glycoprotein IB alphaInfo
- Publication number
- AU1458500A AU1458500A AU14585/00A AU1458500A AU1458500A AU 1458500 A AU1458500 A AU 1458500A AU 14585/00 A AU14585/00 A AU 14585/00A AU 1458500 A AU1458500 A AU 1458500A AU 1458500 A AU1458500 A AU 1458500A
- Authority
- AU
- Australia
- Prior art keywords
- seq
- amino acid
- fragment
- antibody
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 210000004623 platelet-rich plasma Anatomy 0.000 description 1
- 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000011533 pre-incubation Methods 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000001742 protein purification Methods 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 230000004043 responsiveness Effects 0.000 description 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
- 239000002336 ribonucleotide Substances 0.000 description 1
- 125000002652 ribonucleotide group Chemical group 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 229920002477 rna polymer Polymers 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000012086 standard solution Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 102000027257 transmembrane receptors Human genes 0.000 description 1
- 108091008578 transmembrane receptors Proteins 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10627598P | 1998-10-30 | 1998-10-30 | |
| US60106275 | 1998-10-30 | ||
| PCT/US1999/025495 WO2000026667A1 (en) | 1998-10-30 | 1999-10-29 | Variable heavy chain and variable light chain regions of antibodies to human platelet glycoprotein ib alpha |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU1458500A true AU1458500A (en) | 2000-05-22 |
Family
ID=22310524
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU14585/00A Abandoned AU1458500A (en) | 1998-10-30 | 1999-10-29 | Variable heavy chain and variable light chain regions of antibodies to human platelet glycoprotein IB alpha |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1051620B1 (enExample) |
| JP (1) | JP2002529054A (enExample) |
| AT (1) | ATE329263T1 (enExample) |
| AU (1) | AU1458500A (enExample) |
| CA (1) | CA2317808A1 (enExample) |
| DE (1) | DE69931756T2 (enExample) |
| IL (1) | IL137121A0 (enExample) |
| WO (1) | WO2000026667A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9918788D0 (en) | 1999-08-10 | 1999-10-13 | Leuven K U Res & Dev | Antithrombotic effect of platelet glycoprotein 1b blocking monoclonal Fab fragments |
| DE10019967A1 (de) * | 2000-04-20 | 2001-10-25 | Fenning Biomed Gmbh Dr | Antikörper gegen natives gp96, deren Herstellung und Verwendung |
| US7521053B2 (en) | 2001-10-11 | 2009-04-21 | Amgen Inc. | Angiopoietin-2 specific binding agents |
| US7658924B2 (en) | 2001-10-11 | 2010-02-09 | Amgen Inc. | Angiopoietin-2 specific binding agents |
| WO2004003144A2 (en) | 2002-07-01 | 2004-01-08 | Human Genome Sciences, Inc. | Antibodies that specifically bind to reg iv |
| EP1539236A4 (en) * | 2002-07-03 | 2007-07-18 | Univ Pennsylvania | COMPOSITIONS, METHODS, AND KITS RELATED TO ANTI-BLOOD PLAYBACK AUTOANTIC BODIES AND INHIBITORS THEREOF |
| AU2003298112A1 (en) * | 2002-11-13 | 2004-06-03 | Micromet Ag | Method for identifying antigen specific b cells |
| RU2006102570A (ru) * | 2003-06-30 | 2007-08-20 | Био-Текнолоджи Дженерал(Израиль) Лтд. (IL) | Антитела и их применение |
| EP1749536A1 (en) * | 2005-08-03 | 2007-02-07 | Thrombotargets Europe, S.L. | Activated factor X stimulants as new antihemorrhagic agents for topical use |
| JO2913B1 (en) | 2008-02-20 | 2015-09-15 | امجين إنك, | Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses |
| EP2186829B1 (en) * | 2008-11-14 | 2014-12-31 | Canadian Blood Services | Antibodies against GPIbalpha |
| CN102905727B (zh) * | 2009-10-30 | 2016-12-07 | 詹森生物科技公司 | Il-17a拮抗剂 |
| KR20220127250A (ko) * | 2019-12-10 | 2022-09-19 | 씨씨오에이 테라퓨틱스 (항저우) 컴퍼니 리미티드 | 인간화 항-당단백질 ib알파(gpibalpha) 항체 |
| US20230055143A1 (en) * | 2019-12-20 | 2023-02-23 | Medimmune, Llc | Compositions and Methods of Treating Cancer with Chimeric Antigen Receptors Targeting Glypican 3 |
| WO2021262880A2 (en) * | 2020-06-23 | 2021-12-30 | Kadmon Corporation, Llc | Anti-pd-1 antibodies and fusion proteins |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5877155A (en) * | 1995-03-17 | 1999-03-02 | The Research Foundation Of State University Of New York | Mimotopes and anti-mimotopes of human platelet glycoprotein Ib/IX |
| US5817748A (en) * | 1995-03-17 | 1998-10-06 | The Research Foundation Of State University Of New York | Mimotopes of human Platelet glycoprotein Ib/IX |
-
1999
- 1999-10-29 DE DE69931756T patent/DE69931756T2/de not_active Expired - Lifetime
- 1999-10-29 EP EP99971513A patent/EP1051620B1/en not_active Expired - Lifetime
- 1999-10-29 AU AU14585/00A patent/AU1458500A/en not_active Abandoned
- 1999-10-29 WO PCT/US1999/025495 patent/WO2000026667A1/en not_active Ceased
- 1999-10-29 JP JP2000579997A patent/JP2002529054A/ja active Pending
- 1999-10-29 CA CA002317808A patent/CA2317808A1/en not_active Abandoned
- 1999-10-29 AT AT99971513T patent/ATE329263T1/de not_active IP Right Cessation
- 1999-10-29 IL IL13712199A patent/IL137121A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000026667A1 (en) | 2000-05-11 |
| EP1051620A1 (en) | 2000-11-15 |
| JP2002529054A (ja) | 2002-09-10 |
| ATE329263T1 (de) | 2006-06-15 |
| WO2000026667A9 (en) | 2001-04-12 |
| CA2317808A1 (en) | 2000-05-11 |
| DE69931756T2 (de) | 2007-05-24 |
| DE69931756D1 (de) | 2006-07-20 |
| IL137121A0 (en) | 2001-06-14 |
| EP1051620A4 (en) | 2005-01-12 |
| EP1051620B1 (en) | 2006-06-07 |
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