JP2002527459A - 粘膜表面を水和する方法 - Google Patents
粘膜表面を水和する方法Info
- Publication number
- JP2002527459A JP2002527459A JP2000576801A JP2000576801A JP2002527459A JP 2002527459 A JP2002527459 A JP 2002527459A JP 2000576801 A JP2000576801 A JP 2000576801A JP 2000576801 A JP2000576801 A JP 2000576801A JP 2002527459 A JP2002527459 A JP 2002527459A
- Authority
- JP
- Japan
- Prior art keywords
- lower alkyl
- group
- phenyl
- carrier moiety
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims abstract description 72
- 150000001875 compounds Chemical class 0.000 claims abstract description 48
- -1 phenamyl Chemical compound 0.000 claims abstract description 36
- 239000003195 sodium channel blocking agent Substances 0.000 claims abstract description 36
- 229940125794 sodium channel blocker Drugs 0.000 claims abstract description 34
- 150000003839 salts Chemical class 0.000 claims abstract description 23
- 239000000018 receptor agonist Substances 0.000 claims abstract description 17
- 229940044601 receptor agonist Drugs 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- BGGCAGOTBOAZPU-UHFFFAOYSA-N n-(diaminomethylidene)pyrazine-2-carboxamide;sodium Chemical compound [Na].NC(N)=NC(=O)C1=CN=CC=N1 BGGCAGOTBOAZPU-UHFFFAOYSA-N 0.000 claims abstract description 16
- 230000028327 secretion Effects 0.000 claims abstract description 11
- 230000009103 reabsorption Effects 0.000 claims abstract description 10
- 230000000887 hydrating effect Effects 0.000 claims abstract description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims abstract description 8
- 102000009027 Albumins Human genes 0.000 claims abstract description 7
- 108010088751 Albumins Proteins 0.000 claims abstract description 7
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 7
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 7
- 125000000217 alkyl group Chemical group 0.000 claims description 134
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 56
- 229910052739 hydrogen Inorganic materials 0.000 claims description 48
- 239000001257 hydrogen Substances 0.000 claims description 46
- 125000004432 carbon atom Chemical group C* 0.000 claims description 39
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 32
- 239000000203 mixture Substances 0.000 claims description 31
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 15
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 15
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- 125000005059 halophenyl group Chemical group 0.000 claims description 12
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- 125000005843 halogen group Chemical group 0.000 claims description 11
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- 125000004799 bromophenyl group Chemical group 0.000 claims description 10
- 125000000068 chlorophenyl group Chemical group 0.000 claims description 10
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 10
- 229910052757 nitrogen Inorganic materials 0.000 claims description 10
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 10
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- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims description 4
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- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 claims description 4
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- 125000003884 phenylalkyl group Chemical group 0.000 claims description 3
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 2
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- 150000004676 glycans Chemical class 0.000 claims 3
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- 229910052760 oxygen Inorganic materials 0.000 claims 2
- VDRMSHBDXWSTNR-UHFFFAOYSA-N [Na].NC(=N)N Chemical compound [Na].NC(=N)N VDRMSHBDXWSTNR-UHFFFAOYSA-N 0.000 claims 1
- XSDQTOBWRPYKKA-UHFFFAOYSA-N amiloride Chemical compound NC(=N)NC(=O)C1=NC(Cl)=C(N)N=C1N XSDQTOBWRPYKKA-UHFFFAOYSA-N 0.000 abstract description 12
- KXDROGADUISDGY-UHFFFAOYSA-N Benzamil hydrochloride Chemical compound C=1C=CC=CC=1CN=C(N)NC(=O)C1=NC(Cl)=C(N)N=C1N KXDROGADUISDGY-UHFFFAOYSA-N 0.000 abstract description 9
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- A61P11/02—Nasal agents, e.g. decongestants
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- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Otolaryngology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10499998P | 1998-10-20 | 1998-10-20 | |
| US60/104,999 | 1998-10-20 | ||
| PCT/US1999/024546 WO2000023023A1 (en) | 1998-10-20 | 1999-10-20 | Methods of hydrating mucosal surfaces |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002527459A true JP2002527459A (ja) | 2002-08-27 |
| JP2002527459A5 JP2002527459A5 (https=) | 2005-12-22 |
Family
ID=22303527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000576801A Pending JP2002527459A (ja) | 1998-10-20 | 1999-10-20 | 粘膜表面を水和する方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6264975B1 (https=) |
| EP (1) | EP1143896B1 (https=) |
| JP (1) | JP2002527459A (https=) |
| AT (1) | ATE347880T1 (https=) |
| AU (1) | AU757139B2 (https=) |
| CA (1) | CA2346656A1 (https=) |
| DE (1) | DE69934435T2 (https=) |
| WO (1) | WO2000023023A1 (https=) |
Cited By (2)
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| JP2008179653A (ja) * | 2004-04-01 | 2008-08-07 | Cardiome Pharma Corp | Ｐｅｇ化イオンチャネル調節化合物 |
| WO2010131486A1 (en) * | 2009-05-15 | 2010-11-18 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal pharmaceutical compositions with improved pharmacokinetics |
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| EP1143896B1 (en) * | 1998-10-20 | 2006-12-13 | The University of North Carolina at Chapel Hill | Methods of hydrating the nasal mucosal surface |
| JP4969002B2 (ja) * | 1999-06-08 | 2012-07-04 | ユニバーシテイ・オブ・アイオワ・リサーチ・フアウンデーシヨン | ｒＡＡＶ形質導入を増加するための化合物および方法 |
| KR20020038694A (ko) * | 1999-07-19 | 2002-05-23 | 프란시스 제이 메이어 | 소듐 채널 차단제의 콘쥬게이트 및 그 이용방법 |
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| WO2003038089A1 (fr) * | 2001-11-02 | 2003-05-08 | Ngk Insulators, Ltd. | Compositions de solution de sonde, puce reactive faisant appel auxdites compositions et son procede de production |
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| US7098189B2 (en) * | 2002-12-16 | 2006-08-29 | Kimberly-Clark Worldwide, Inc. | Wound and skin care compositions |
| GB0303506D0 (en) * | 2003-02-14 | 2003-03-19 | Novartis Ag | Organic compounds |
| WO2004073729A1 (ja) | 2003-02-21 | 2004-09-02 | Translational Research Ltd. | 薬物の経鼻投与用組成物 |
| CA2519287A1 (en) | 2003-03-27 | 2004-10-14 | Bioactis Limited | Powder medicine applicator for nasal cavity |
| JP2007524379A (ja) * | 2003-03-31 | 2007-08-30 | ユニバーシテイ・オブ・アイオワ・リサーチ・フアウンデーシヨン | 上皮ナトリウムチャンネル関連障害のＰｈａｒｍｉｃｏ−遺伝子治療 |
| ES2432529T3 (es) | 2003-08-18 | 2013-12-04 | Parion Sciences, Inc. | Bloqueadores del canal de sodio de pirazinoilguanidina rematada |
| US20050090505A1 (en) * | 2003-08-18 | 2005-04-28 | Johnson Michael R. | Methods of reducing risk of infection from pathogens |
| US7745442B2 (en) | 2003-08-20 | 2010-06-29 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens |
| US20090253714A1 (en) * | 2003-08-20 | 2009-10-08 | Johnson Michael R | Methods of reducing risk of infection from pathogens |
| US7754897B2 (en) | 2005-06-15 | 2010-07-13 | Cardiome Pharma Corp. | Synthetic processes for the preparation of aminocyclohexyl ether compounds |
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| US7705036B2 (en) | 2004-04-01 | 2010-04-27 | Cardiome Pharma Corp. | Deuterated aminocyclohexyl ether compounds and processes for preparing same |
| MXPA06011419A (es) | 2004-04-01 | 2007-04-20 | Cardiome Pharma Corp | Profarmacos de compuestos moduladores de canales ionicos y usos de los mismos. |
| US7485666B2 (en) * | 2004-06-17 | 2009-02-03 | Kimberly-Clark Worldwide, Inc. | Vaginal health products |
| WO2006016530A1 (ja) | 2004-08-10 | 2006-02-16 | Translational Research, Ltd. | 速効性でかつ高い吸収性を可能とする経鼻投与用組成物 |
| US7956059B2 (en) | 2004-08-18 | 2011-06-07 | Parion Sciences, Inc. | Aliphatic amide and ester pyrazinoylguanidine sodium channel blockers |
| US7115561B2 (en) * | 2004-09-22 | 2006-10-03 | Patterson James A | Medicament composition and method of administration |
| EP1828099B1 (en) | 2004-11-18 | 2020-01-22 | Correvio International Sàrl | Synthetic process for aminocyclohexyl ether compounds |
| WO2006082588A2 (en) * | 2005-02-07 | 2006-08-10 | Pharmalight Inc. | Method and device for ophthalmic administration of active pharmaceutical ingredients |
| AU2007243184A1 (en) * | 2006-04-28 | 2007-11-08 | University Of Iowa Research Foundation | Methods and compounds to modulate parvovirus transduction of mammalian cells or to alter virus infection, method to identify a viral receptor or co-receptor |
| EA200970258A1 (ru) * | 2006-09-07 | 2009-08-28 | Пэрион Сайенсиз, Инк. | Способ усиления гидратации слизистой оболочки и клиренса слизистой оболочки обработкой блокаторами натриевых каналов и осмолитами |
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| WO2016130498A1 (en) | 2015-02-10 | 2016-08-18 | Massachusetts Institute Of Technology | Isolated mucins and different microoorganisms, and methods of use |
| WO2017139381A1 (en) | 2016-02-08 | 2017-08-17 | University Of Iowa Research Foundation | Methods to produce chimeric adeno-associated virus/bocavirus parvovirus |
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| US11142775B2 (en) | 2017-01-13 | 2021-10-12 | University Of Iowa Research Foundation | Bocaparvovirus small noncoding RNA and uses thereof |
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| US5635160A (en) * | 1995-06-07 | 1997-06-03 | The University Of North Carolina At Chapel Hill | Dinucleotides useful for the treatment of cystic fibrosis and for hydrating mucus secretions |
| EP1143896B1 (en) * | 1998-10-20 | 2006-12-13 | The University of North Carolina at Chapel Hill | Methods of hydrating the nasal mucosal surface |
-
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- 1999-10-20 EP EP99970585A patent/EP1143896B1/en not_active Expired - Lifetime
- 1999-10-20 CA CA002346656A patent/CA2346656A1/en not_active Abandoned
- 1999-10-20 JP JP2000576801A patent/JP2002527459A/ja active Pending
- 1999-10-20 US US09/421,705 patent/US6264975B1/en not_active Expired - Fee Related
- 1999-10-20 DE DE69934435T patent/DE69934435T2/de not_active Expired - Lifetime
- 1999-10-20 AU AU12141/00A patent/AU757139B2/en not_active Ceased
- 1999-10-20 WO PCT/US1999/024546 patent/WO2000023023A1/en not_active Ceased
- 1999-10-20 AT AT99970585T patent/ATE347880T1/de not_active IP Right Cessation
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2001
- 2001-02-20 US US09/789,256 patent/US7056524B2/en not_active Expired - Fee Related
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008179653A (ja) * | 2004-04-01 | 2008-08-07 | Cardiome Pharma Corp | Ｐｅｇ化イオンチャネル調節化合物 |
| WO2010131486A1 (en) * | 2009-05-15 | 2010-11-18 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal pharmaceutical compositions with improved pharmacokinetics |
| JP2012526726A (ja) * | 2009-05-15 | 2012-11-01 | 株式会社新日本科学 | 薬物動態が改善された鼻腔内用薬学的組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| DE69934435T2 (de) | 2007-09-27 |
| AU757139B2 (en) | 2003-02-06 |
| EP1143896B1 (en) | 2006-12-13 |
| EP1143896A4 (en) | 2004-11-24 |
| DE69934435D1 (de) | 2007-01-25 |
| US6264975B1 (en) | 2001-07-24 |
| US20010034349A1 (en) | 2001-10-25 |
| EP1143896A1 (en) | 2001-10-17 |
| US7056524B2 (en) | 2006-06-06 |
| AU1214100A (en) | 2000-05-08 |
| WO2000023023A1 (en) | 2000-04-27 |
| ATE347880T1 (de) | 2007-01-15 |
| CA2346656A1 (en) | 2000-04-27 |
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