JP2002527354A5 - - Google Patents
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- Publication number
- JP2002527354A5 JP2002527354A5 JP2000549631A JP2000549631A JP2002527354A5 JP 2002527354 A5 JP2002527354 A5 JP 2002527354A5 JP 2000549631 A JP2000549631 A JP 2000549631A JP 2000549631 A JP2000549631 A JP 2000549631A JP 2002527354 A5 JP2002527354 A5 JP 2002527354A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- peptide according
- diseases
- peptide
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 description 10
- 125000003275 alpha amino acid group Chemical group 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 4
- 230000007170 pathology Effects 0.000 description 4
- 238000002054 transplantation Methods 0.000 description 4
- 108090001005 Interleukin-6 Proteins 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 239000002243 precursor Substances 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 208000023275 Autoimmune disease Diseases 0.000 description 2
- 208000020084 Bone disease Diseases 0.000 description 2
- 208000018084 Bone neoplasm Diseases 0.000 description 2
- 239000005557 antagonist Substances 0.000 description 2
- 208000014951 hematologic disease Diseases 0.000 description 2
- 208000026278 immune system disease Diseases 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 108010067902 Peptide Library Proteins 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98108997.2 | 1998-05-18 | ||
| EP98108997A EP0972780A1 (en) | 1998-05-18 | 1998-05-18 | Il-6 antagonist peptides |
| PCT/EP1999/003421 WO1999060013A2 (en) | 1998-05-18 | 1999-05-18 | Il-6 antagonist peptides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002527354A JP2002527354A (ja) | 2002-08-27 |
| JP2002527354A5 true JP2002527354A5 (enExample) | 2006-05-18 |
| JP4468578B2 JP4468578B2 (ja) | 2010-05-26 |
Family
ID=8231951
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000549631A Expired - Fee Related JP4468578B2 (ja) | 1998-05-18 | 1999-05-18 | Ｉｌ−６アンタゴニストペプチド |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6599875B1 (enExample) |
| EP (2) | EP0972780A1 (enExample) |
| JP (1) | JP4468578B2 (enExample) |
| AT (1) | ATE347563T1 (enExample) |
| AU (1) | AU749616B2 (enExample) |
| CA (2) | CA2690399C (enExample) |
| CY (1) | CY1105865T1 (enExample) |
| DE (1) | DE69934308T2 (enExample) |
| DK (1) | DK1078001T3 (enExample) |
| ES (1) | ES2273492T3 (enExample) |
| IL (2) | IL139575A0 (enExample) |
| PT (1) | PT1078001E (enExample) |
| SI (1) | SI1078001T1 (enExample) |
| WO (1) | WO1999060013A2 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0972780A1 (en) * | 1998-05-18 | 2000-01-19 | Applied Research Systems ARS Holding N.V. | Il-6 antagonist peptides |
| US7488590B2 (en) | 1998-10-23 | 2009-02-10 | Amgen Inc. | Modified peptides as therapeutic agents |
| ATE348163T1 (de) | 1998-10-23 | 2007-01-15 | Amgen Inc | Thrombopoietin substitute |
| JP2008505928A (ja) | 2004-07-08 | 2008-02-28 | アムジェン インコーポレーテッド | 治療用ペプチド |
| US20070036788A1 (en) * | 2004-09-22 | 2007-02-15 | Ahmed Sheriff | Use of a compound for reducing the biological effectiveness of il-6 |
| DK1797127T3 (en) | 2004-09-24 | 2017-10-02 | Amgen Inc | Modified Fc molecules |
| US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
| JP5754875B2 (ja) | 2006-04-07 | 2015-07-29 | 国立大学法人大阪大学 | 筋再生促進剤 |
| JO3324B1 (ar) | 2006-04-21 | 2019-03-13 | Amgen Inc | مركبات علاجية مجففة بالتبريد تتعلق بالعصارة الهضمية |
| ES2564392T3 (es) | 2007-01-23 | 2016-03-22 | Shinshu University | Inhibidores de IL-6 para el tratamiento de rechazo crónico |
| US10717781B2 (en) | 2008-06-05 | 2020-07-21 | National Cancer Center | Neuroinvasion inhibitor |
| CN102292449B (zh) | 2008-11-25 | 2016-03-30 | 奥尔德生物制药公司 | 预防或治疗血栓形成的il-6拮抗剂 |
| ES2932398T3 (es) | 2010-05-28 | 2023-01-18 | Chugai Pharmaceutical Co Ltd | Potenciador de la respuesta de las células T antitumorales |
| EP2643016A2 (en) | 2010-11-23 | 2013-10-02 | Alder Biopharmaceuticals, Inc. | Anti-il-6 antibodies for the treatment of anemia |
| WO2015089217A2 (en) | 2013-12-10 | 2015-06-18 | Bionz, Llc | Methods of developing selective peptide antagonists |
| CN103501805B (zh) * | 2011-01-18 | 2018-09-14 | 比奥尼斯有限责任公司 | 调节γ-C-细胞因子活性的组合物及方法 |
| US9327023B2 (en) | 2011-10-25 | 2016-05-03 | The Regents Of The University Of Michigan | HER2 targeting agent treatment in non-HER2-amplified cancers having HER2 expressing cancer stem cells |
| CN103923182A (zh) * | 2014-01-17 | 2014-07-16 | 南通诚信氨基酸有限公司 | 白介素-6多肽抑制剂及其应用 |
| PT3359556T (pt) | 2015-10-09 | 2021-08-30 | Bioniz Llc | Modulação da atividade de citocinas gama-c |
| JP7185884B2 (ja) | 2017-05-02 | 2022-12-08 | 国立研究開発法人国立精神・神経医療研究センター | Ｉｌ－６及び好中球の関連する疾患の治療効果の予測及び判定方法 |
| WO2019078344A1 (ja) | 2017-10-20 | 2019-04-25 | 学校法人兵庫医科大学 | 抗ｉｌ－６受容体抗体を含有する術後の癒着を抑制するための医薬組成物 |
| JP2022527972A (ja) | 2019-04-02 | 2022-06-07 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 前悪性病変を有する患者において癌を予測及び予防する方法 |
| CN113874075A (zh) | 2019-05-03 | 2021-12-31 | 比奥尼斯有限责任公司 | 调节γC-细胞因子信号传导对于治疗脱发和脱发相关病症的影响 |
| CN116003530B (zh) * | 2022-12-27 | 2023-12-15 | 西湖大学 | 一种针对白细胞介素-6的d-蛋白抑制剂及其应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4420782C1 (de) * | 1994-06-15 | 1995-08-17 | Fluegge Ulf Ingo Prof Dr | DNA-Sequenz, kodierend einen 2-Oxoglutarat/Malat-Translokator, Plasmide, Bakterien, Hefen und Pflanzen enthaltend diesen Transporter |
| ATE217344T1 (de) * | 1994-09-21 | 2002-05-15 | Cytogen Corp | Antigen bindende peptide (abtides) aus peptidbibliotheken |
| AU3204895A (en) * | 1995-02-01 | 1996-08-21 | University Of Massachusetts Medical Center | Methods of selecting a random peptide that binds to a target protein |
| RU2205874C2 (ru) * | 1995-05-11 | 2003-06-10 | Апплайд Резеч Системз Арс Холдинг Н.В. | Нуклеотидная последовательность, способная ингибировать активность il-6, плазмидный вектор для трансфекции в клетки млекопитающих, нуклеотидная последовательность, используемая при терапии, фармацевтическая композиция (варианты) |
| DE19628873A1 (de) * | 1995-07-17 | 1997-01-23 | Fraunhofer Ges Forschung | Cyclitol |
| AU709585B2 (en) * | 1995-09-28 | 1999-09-02 | Yeda Research And Development Co. Ltd. | Synthetic peptides that inhibit IL-6 activity |
| AU3193097A (en) * | 1996-06-20 | 1998-01-07 | Koster, Henk W. | Il-6 and il-6-receptor derived peptides having il-6 antagonistic or agonistic activity |
| EP0972780A1 (en) * | 1998-05-18 | 2000-01-19 | Applied Research Systems ARS Holding N.V. | Il-6 antagonist peptides |
-
1998
- 1998-05-18 EP EP98108997A patent/EP0972780A1/en not_active Withdrawn
-
1999
- 1999-05-18 WO PCT/EP1999/003421 patent/WO1999060013A2/en not_active Ceased
- 1999-05-18 JP JP2000549631A patent/JP4468578B2/ja not_active Expired - Fee Related
- 1999-05-18 IL IL13957599A patent/IL139575A0/xx active IP Right Grant
- 1999-05-18 DE DE69934308T patent/DE69934308T2/de not_active Expired - Lifetime
- 1999-05-18 CA CA2690399A patent/CA2690399C/en not_active Expired - Fee Related
- 1999-05-18 CA CA2332817A patent/CA2332817C/en not_active Expired - Fee Related
- 1999-05-18 AU AU43627/99A patent/AU749616B2/en not_active Ceased
- 1999-05-18 DK DK99926326T patent/DK1078001T3/da active
- 1999-05-18 SI SI9930940T patent/SI1078001T1/sl unknown
- 1999-05-18 ES ES99926326T patent/ES2273492T3/es not_active Expired - Lifetime
- 1999-05-18 PT PT99926326T patent/PT1078001E/pt unknown
- 1999-05-18 EP EP99926326A patent/EP1078001B1/en not_active Expired - Lifetime
- 1999-05-18 AT AT99926326T patent/ATE347563T1/de active
-
2000
- 2000-11-09 IL IL139575A patent/IL139575A/en not_active IP Right Cessation
- 2000-11-20 US US09/715,923 patent/US6599875B1/en not_active Expired - Lifetime
-
2003
- 2003-02-04 US US10/357,479 patent/US6838433B2/en not_active Expired - Lifetime
-
2006
- 2006-12-20 CY CY20061101820T patent/CY1105865T1/el unknown
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