IL139575A0 - Il-6 antagonist peptides and pharmaceutical compositions containing them - Google Patents
Il-6 antagonist peptides and pharmaceutical compositions containing themInfo
- Publication number
- IL139575A0 IL139575A0 IL13957599A IL13957599A IL139575A0 IL 139575 A0 IL139575 A0 IL 139575A0 IL 13957599 A IL13957599 A IL 13957599A IL 13957599 A IL13957599 A IL 13957599A IL 139575 A0 IL139575 A0 IL 139575A0
- Authority
- IL
- Israel
- Prior art keywords
- seq
- pharmaceutical compositions
- antagonist peptides
- compositions containing
- present
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 239000005557 antagonist Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 101150101999 IL6 gene Proteins 0.000 title 1
- 102000004889 Interleukin-6 Human genes 0.000 abstract 2
- 108090001005 Interleukin-6 Proteins 0.000 abstract 2
- 108010067902 Peptide Library Proteins 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000010396 two-hybrid screening Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5412—IL-6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98108997A EP0972780A1 (en) | 1998-05-18 | 1998-05-18 | Il-6 antagonist peptides |
| PCT/EP1999/003421 WO1999060013A2 (en) | 1998-05-18 | 1999-05-18 | Il-6 antagonist peptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL139575A0 true IL139575A0 (en) | 2002-02-10 |
Family
ID=8231951
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13957599A IL139575A0 (en) | 1998-05-18 | 1999-05-18 | Il-6 antagonist peptides and pharmaceutical compositions containing them |
| IL139575A IL139575A (en) | 1998-05-18 | 2000-11-09 | Il-6 antagonist peptides and pharmaceutical compositions containing them |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL139575A IL139575A (en) | 1998-05-18 | 2000-11-09 | Il-6 antagonist peptides and pharmaceutical compositions containing them |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6599875B1 (enExample) |
| EP (2) | EP0972780A1 (enExample) |
| JP (1) | JP4468578B2 (enExample) |
| AT (1) | ATE347563T1 (enExample) |
| AU (1) | AU749616B2 (enExample) |
| CA (2) | CA2332817C (enExample) |
| CY (1) | CY1105865T1 (enExample) |
| DE (1) | DE69934308T2 (enExample) |
| DK (1) | DK1078001T3 (enExample) |
| ES (1) | ES2273492T3 (enExample) |
| IL (2) | IL139575A0 (enExample) |
| PT (1) | PT1078001E (enExample) |
| SI (1) | SI1078001T1 (enExample) |
| WO (1) | WO1999060013A2 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0972780A1 (en) * | 1998-05-18 | 2000-01-19 | Applied Research Systems ARS Holding N.V. | Il-6 antagonist peptides |
| US7488590B2 (en) | 1998-10-23 | 2009-02-10 | Amgen Inc. | Modified peptides as therapeutic agents |
| ME00238B (me) | 1998-10-23 | 2011-02-10 | Kirin Amgen Inc | Mimičko vezivanje dimernog trombopoitetinskog peptida za mp1 receptor sa trombopoietičkom aktivnošću |
| MX2007000216A (es) | 2004-07-08 | 2007-03-15 | Amgen Inc | Peptidos terapeuticos. |
| US20070036788A1 (en) * | 2004-09-22 | 2007-02-15 | Ahmed Sheriff | Use of a compound for reducing the biological effectiveness of il-6 |
| WO2006036834A2 (en) | 2004-09-24 | 2006-04-06 | Amgen Inc. | MODIFIED Fc MOLECULES |
| US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
| CN101495146B (zh) | 2006-04-07 | 2012-10-17 | 国立大学法人大阪大学 | 肌肉再生促进剂 |
| JO3324B1 (ar) | 2006-04-21 | 2019-03-13 | Amgen Inc | مركبات علاجية مجففة بالتبريد تتعلق بالعصارة الهضمية |
| ES2564392T3 (es) | 2007-01-23 | 2016-03-22 | Shinshu University | Inhibidores de IL-6 para el tratamiento de rechazo crónico |
| JP5544290B2 (ja) | 2008-06-05 | 2014-07-09 | 独立行政法人国立がん研究センター | 神経浸潤抑制剤 |
| WO2010065077A2 (en) | 2008-11-25 | 2010-06-10 | Alder Biopharmaceuticals, Inc. | Antagonists of il-6 to prevent or treat thrombosis |
| EP4115906A1 (en) | 2010-05-28 | 2023-01-11 | Chugai Seiyaku Kabushiki Kaisha | Antitumor t cell response enhancer |
| AU2011332817A1 (en) | 2010-11-23 | 2013-06-13 | Alder Biopharmaceuticals, Inc. | Anti-IL-6 antibodies for the treatment of anemia |
| RS60050B1 (sr) | 2011-01-18 | 2020-04-30 | Bioniz Llc | Kompozicije za modulaciju aktivnosti gama-c-citokina |
| WO2015089217A2 (en) | 2013-12-10 | 2015-06-18 | Bionz, Llc | Methods of developing selective peptide antagonists |
| WO2013063229A1 (en) | 2011-10-25 | 2013-05-02 | The Regents Of The University Of Michigan | Her2 targeting agent treatment in non-her2-amplified cancers having her2 expressing cancer stem cells |
| CN103923182A (zh) * | 2014-01-17 | 2014-07-16 | 南通诚信氨基酸有限公司 | 白介素-6多肽抑制剂及其应用 |
| KR102654684B1 (ko) | 2015-10-09 | 2024-04-04 | 바이오니즈 테라퓨틱스, 아이엔씨. | 감마-ｃ-사이토카인 활성의 조정 |
| WO2018203545A1 (ja) | 2017-05-02 | 2018-11-08 | 国立研究開発法人国立精神・神経医療研究センター | Ｉｌ－６及び好中球の関連する疾患の治療効果の予測及び判定方法 |
| EP3698808B1 (en) | 2017-10-20 | 2025-01-01 | Hyogo College Of Medicine | Anti-il-6 receptor antibody-containing medicinal composition for preventing post-surgical adhesion |
| US20220177978A1 (en) | 2019-04-02 | 2022-06-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of predicting and preventing cancer in patients having premalignant lesions |
| WO2020227019A1 (en) | 2019-05-03 | 2020-11-12 | Bioniz, Llc | Modulating the effects of gamma-c-cytokine signaling for the treatment of alopecia and alopecia associated disorders |
| CN116003530B (zh) * | 2022-12-27 | 2023-12-15 | 西湖大学 | 一种针对白细胞介素-6的d-蛋白抑制剂及其应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4420782C1 (de) * | 1994-06-15 | 1995-08-17 | Fluegge Ulf Ingo Prof Dr | DNA-Sequenz, kodierend einen 2-Oxoglutarat/Malat-Translokator, Plasmide, Bakterien, Hefen und Pflanzen enthaltend diesen Transporter |
| ATE217344T1 (de) * | 1994-09-21 | 2002-05-15 | Cytogen Corp | Antigen bindende peptide (abtides) aus peptidbibliotheken |
| WO1996023899A1 (en) * | 1995-02-01 | 1996-08-08 | University Of Massachusetts Medical Center | Methods of selecting a random peptide that binds to a target protein |
| AU715125B2 (en) * | 1995-05-11 | 2000-01-20 | Merck Serono Sa | IL-6 activity inhibitor |
| WO1997004101A2 (de) * | 1995-07-17 | 1997-02-06 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Enzym geeignet zur oxidation von cyclitolen und ihren derivaten |
| AU709585B2 (en) * | 1995-09-28 | 1999-09-02 | Yeda Research And Development Co. Ltd. | Synthetic peptides that inhibit IL-6 activity |
| AU3193097A (en) * | 1996-06-20 | 1998-01-07 | Koster, Henk W. | Il-6 and il-6-receptor derived peptides having il-6 antagonistic or agonistic activity |
| EP0972780A1 (en) * | 1998-05-18 | 2000-01-19 | Applied Research Systems ARS Holding N.V. | Il-6 antagonist peptides |
-
1998
- 1998-05-18 EP EP98108997A patent/EP0972780A1/en not_active Withdrawn
-
1999
- 1999-05-18 AT AT99926326T patent/ATE347563T1/de active
- 1999-05-18 CA CA2332817A patent/CA2332817C/en not_active Expired - Fee Related
- 1999-05-18 SI SI9930940T patent/SI1078001T1/sl unknown
- 1999-05-18 DK DK99926326T patent/DK1078001T3/da active
- 1999-05-18 JP JP2000549631A patent/JP4468578B2/ja not_active Expired - Fee Related
- 1999-05-18 CA CA2690399A patent/CA2690399C/en not_active Expired - Fee Related
- 1999-05-18 EP EP99926326A patent/EP1078001B1/en not_active Expired - Lifetime
- 1999-05-18 IL IL13957599A patent/IL139575A0/xx active IP Right Grant
- 1999-05-18 PT PT99926326T patent/PT1078001E/pt unknown
- 1999-05-18 DE DE69934308T patent/DE69934308T2/de not_active Expired - Lifetime
- 1999-05-18 WO PCT/EP1999/003421 patent/WO1999060013A2/en not_active Ceased
- 1999-05-18 AU AU43627/99A patent/AU749616B2/en not_active Ceased
- 1999-05-18 ES ES99926326T patent/ES2273492T3/es not_active Expired - Lifetime
-
2000
- 2000-11-09 IL IL139575A patent/IL139575A/en not_active IP Right Cessation
- 2000-11-20 US US09/715,923 patent/US6599875B1/en not_active Expired - Lifetime
-
2003
- 2003-02-04 US US10/357,479 patent/US6838433B2/en not_active Expired - Lifetime
-
2006
- 2006-12-20 CY CY20061101820T patent/CY1105865T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL139575A (en) | 2008-03-20 |
| CA2690399C (en) | 2015-01-20 |
| EP1078001B1 (en) | 2006-12-06 |
| US6599875B1 (en) | 2003-07-29 |
| DE69934308D1 (de) | 2007-01-18 |
| US20030186876A1 (en) | 2003-10-02 |
| CA2332817A1 (en) | 1999-11-25 |
| EP0972780A1 (en) | 2000-01-19 |
| ATE347563T1 (de) | 2006-12-15 |
| AU749616B2 (en) | 2002-06-27 |
| WO1999060013A2 (en) | 1999-11-25 |
| DE69934308T2 (de) | 2007-03-29 |
| EP1078001A2 (en) | 2001-02-28 |
| SI1078001T1 (sl) | 2007-04-30 |
| CA2690399A1 (en) | 1999-11-25 |
| CA2332817C (en) | 2010-08-31 |
| ES2273492T3 (es) | 2007-05-01 |
| US6838433B2 (en) | 2005-01-04 |
| WO1999060013A3 (en) | 2000-03-09 |
| JP2002527354A (ja) | 2002-08-27 |
| CY1105865T1 (el) | 2011-02-02 |
| PT1078001E (pt) | 2007-01-31 |
| AU4362799A (en) | 1999-12-06 |
| DK1078001T3 (da) | 2007-02-19 |
| JP4468578B2 (ja) | 2010-05-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed |