CA2332817C - Il-6 antagonist peptides - Google Patents
Il-6 antagonist peptides Download PDFInfo
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- CA2332817C CA2332817C CA2332817A CA2332817A CA2332817C CA 2332817 C CA2332817 C CA 2332817C CA 2332817 A CA2332817 A CA 2332817A CA 2332817 A CA2332817 A CA 2332817A CA 2332817 C CA2332817 C CA 2332817C
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- 230000008827 biological function Effects 0.000 description 1
- UDSAIICHUKSCKT-UHFFFAOYSA-N bromophenol blue Chemical compound C1=C(Br)C(O)=C(Br)C=C1C1(C=2C=C(Br)C(O)=C(Br)C=2)C2=CC=CC=C2S(=O)(=O)O1 UDSAIICHUKSCKT-UHFFFAOYSA-N 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
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- FSXRLASFHBWESK-UHFFFAOYSA-N dipeptide phenylalanyl-tyrosine Natural products C=1C=C(O)C=CC=1CC(C(O)=O)NC(=O)C(N)CC1=CC=CC=C1 FSXRLASFHBWESK-UHFFFAOYSA-N 0.000 description 1
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- 238000000605 extraction Methods 0.000 description 1
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- 108010055341 glutamyl-glutamic acid Proteins 0.000 description 1
- 230000009036 growth inhibition Effects 0.000 description 1
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- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 description 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 description 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 description 1
- 102000052611 human IL6 Human genes 0.000 description 1
- 102000055886 human lamin C Human genes 0.000 description 1
- 108700018816 human lamin C Proteins 0.000 description 1
- 229910000040 hydrogen fluoride Inorganic materials 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
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- 150000002500 ions Chemical class 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 108010073472 leucyl-prolyl-proline Proteins 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- XIXADJRWDQXREU-UHFFFAOYSA-M lithium acetate Chemical compound [Li+].CC([O-])=O XIXADJRWDQXREU-UHFFFAOYSA-M 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
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- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
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- 238000007911 parenteral administration Methods 0.000 description 1
- 108010069653 peptide E (adrenal medulla) Proteins 0.000 description 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000029279 positive regulation of transcription, DNA-dependent Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 229960004919 procaine Drugs 0.000 description 1
- 239000000047 product Substances 0.000 description 1
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- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
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- 239000002464 receptor antagonist Substances 0.000 description 1
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- 108010026333 seryl-proline Proteins 0.000 description 1
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- 230000011664 signaling Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 239000001226 triphosphate Substances 0.000 description 1
- 235000011178 triphosphate Nutrition 0.000 description 1
- 125000002264 triphosphate group Chemical class [H]OP(=O)(O[H])OP(=O)(O[H])OP(=O)(O[H])O* 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5412—IL-6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2690399A CA2690399C (en) | 1998-05-18 | 1999-05-18 | Il-6 antagonist peptides |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98108997.2 | 1998-05-18 | ||
| EP98108997A EP0972780A1 (en) | 1998-05-18 | 1998-05-18 | Il-6 antagonist peptides |
| PCT/EP1999/003421 WO1999060013A2 (en) | 1998-05-18 | 1999-05-18 | Il-6 antagonist peptides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2690399A Division CA2690399C (en) | 1998-05-18 | 1999-05-18 | Il-6 antagonist peptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2332817A1 CA2332817A1 (en) | 1999-11-25 |
| CA2332817C true CA2332817C (en) | 2010-08-31 |
Family
ID=8231951
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2690399A Expired - Fee Related CA2690399C (en) | 1998-05-18 | 1999-05-18 | Il-6 antagonist peptides |
| CA2332817A Expired - Fee Related CA2332817C (en) | 1998-05-18 | 1999-05-18 | Il-6 antagonist peptides |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2690399A Expired - Fee Related CA2690399C (en) | 1998-05-18 | 1999-05-18 | Il-6 antagonist peptides |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6599875B1 (enExample) |
| EP (2) | EP0972780A1 (enExample) |
| JP (1) | JP4468578B2 (enExample) |
| AT (1) | ATE347563T1 (enExample) |
| AU (1) | AU749616B2 (enExample) |
| CA (2) | CA2690399C (enExample) |
| CY (1) | CY1105865T1 (enExample) |
| DE (1) | DE69934308T2 (enExample) |
| DK (1) | DK1078001T3 (enExample) |
| ES (1) | ES2273492T3 (enExample) |
| IL (2) | IL139575A0 (enExample) |
| PT (1) | PT1078001E (enExample) |
| SI (1) | SI1078001T1 (enExample) |
| WO (1) | WO1999060013A2 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0972780A1 (en) * | 1998-05-18 | 2000-01-19 | Applied Research Systems ARS Holding N.V. | Il-6 antagonist peptides |
| DK1783222T3 (da) | 1998-10-23 | 2012-07-09 | Kirin Amgen Inc | Dimere trombopoietiske peptidomimetika, der binder til MPL-receptor og har trombopoietisk aktivitet |
| US7488590B2 (en) | 1998-10-23 | 2009-02-10 | Amgen Inc. | Modified peptides as therapeutic agents |
| EP1773400A2 (en) | 2004-07-08 | 2007-04-18 | Amgen Inc. | Therapeutic peptides |
| US20070036788A1 (en) * | 2004-09-22 | 2007-02-15 | Ahmed Sheriff | Use of a compound for reducing the biological effectiveness of il-6 |
| MX2007003320A (es) | 2004-09-24 | 2007-05-18 | Amgen Inc | Moleculas fc modificadas. |
| US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
| WO2007116962A1 (ja) | 2006-04-07 | 2007-10-18 | Osaka University | 筋再生促進剤 |
| US9283260B2 (en) | 2006-04-21 | 2016-03-15 | Amgen Inc. | Lyophilized therapeutic peptibody formulations |
| ES2564392T3 (es) | 2007-01-23 | 2016-03-22 | Shinshu University | Inhibidores de IL-6 para el tratamiento de rechazo crónico |
| KR101665729B1 (ko) | 2008-06-05 | 2016-10-12 | 국립연구개발법인 고쿠리츠간켄큐센터 | 신경침윤 억제제 |
| KR20110112307A (ko) | 2008-11-25 | 2011-10-12 | 앨더 바이오파마슈티컬즈, 인코포레이티드 | 알부민을 상승시키고 및／또는 ｃｒｐ를 낮추는 ｉｌ６의 길항제 |
| PL2578231T3 (pl) | 2010-05-28 | 2023-01-16 | Chugai Seiyaku Kabushiki Kaisha | Środek wzmacniający przeciwnowotworową odpowiedź limfocytów t |
| CA2818813C (en) | 2010-11-23 | 2020-10-06 | Alder Biopharmaceuticals, Inc. | Anti-il-6 antibodies for the treatment of oral mucositis |
| WO2015089217A2 (en) | 2013-12-10 | 2015-06-18 | Bionz, Llc | Methods of developing selective peptide antagonists |
| ES2778053T3 (es) * | 2011-01-18 | 2020-08-07 | Bioniz Llc | Composiciones para modular la actividad de la citocina gamma-c |
| US9327023B2 (en) | 2011-10-25 | 2016-05-03 | The Regents Of The University Of Michigan | HER2 targeting agent treatment in non-HER2-amplified cancers having HER2 expressing cancer stem cells |
| CN103923182A (zh) * | 2014-01-17 | 2014-07-16 | 南通诚信氨基酸有限公司 | 白介素-6多肽抑制剂及其应用 |
| KR102654684B1 (ko) | 2015-10-09 | 2024-04-04 | 바이오니즈 테라퓨틱스, 아이엔씨. | 감마-ｃ-사이토카인 활성의 조정 |
| EP3620531A4 (en) | 2017-05-02 | 2021-03-17 | National Center of Neurology and Psychiatry | METHOD OF PREDICTION AND EVALUATION OF THERAPEUTIC EFFECT IN DISEASES RELATING TO IL-6 AND NEUTROPHILS |
| WO2019078344A1 (ja) | 2017-10-20 | 2019-04-25 | 学校法人兵庫医科大学 | 抗ｉｌ－６受容体抗体を含有する術後の癒着を抑制するための医薬組成物 |
| EP3947737A2 (en) | 2019-04-02 | 2022-02-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of predicting and preventing cancer in patients having premalignant lesions |
| US12030936B2 (en) | 2019-05-03 | 2024-07-09 | Bioniz Therapeutics, Inc. | Modulating the effects of gamma-c-cytokine signaling for the treatment of alopecia and alopecia associated disorders |
| CN116003530B (zh) * | 2022-12-27 | 2023-12-15 | 西湖大学 | 一种针对白细胞介素-6的d-蛋白抑制剂及其应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4420782C1 (de) * | 1994-06-15 | 1995-08-17 | Fluegge Ulf Ingo Prof Dr | DNA-Sequenz, kodierend einen 2-Oxoglutarat/Malat-Translokator, Plasmide, Bakterien, Hefen und Pflanzen enthaltend diesen Transporter |
| JPH10506463A (ja) * | 1994-09-21 | 1998-06-23 | サイトーゲン コーポレーション | ペプチドライブラリー由来の抗原結合性ペプチド（アブチド） |
| WO1996023899A1 (en) * | 1995-02-01 | 1996-08-08 | University Of Massachusetts Medical Center | Methods of selecting a random peptide that binds to a target protein |
| US6004813A (en) * | 1995-05-11 | 1999-12-21 | Applied Research Systems Ars Holding N.V. | Il-6 activity inhibitor |
| AU6731896A (en) * | 1995-07-17 | 1997-02-18 | Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Cyclitol |
| WO1997013781A2 (en) * | 1995-09-28 | 1997-04-17 | Yeda Research And Development Co. Ltd. | Synthetic peptides that inhibit il-6 activity |
| WO1997048728A1 (en) * | 1996-06-20 | 1997-12-24 | Koster, Henk, Wilhelmus | Il-6 and il-6-receptor derived peptides having il-6 antagonistic or agonistic activity |
| EP0972780A1 (en) * | 1998-05-18 | 2000-01-19 | Applied Research Systems ARS Holding N.V. | Il-6 antagonist peptides |
-
1998
- 1998-05-18 EP EP98108997A patent/EP0972780A1/en not_active Withdrawn
-
1999
- 1999-05-18 SI SI9930940T patent/SI1078001T1/sl unknown
- 1999-05-18 EP EP99926326A patent/EP1078001B1/en not_active Expired - Lifetime
- 1999-05-18 IL IL13957599A patent/IL139575A0/xx active IP Right Grant
- 1999-05-18 DK DK99926326T patent/DK1078001T3/da active
- 1999-05-18 AU AU43627/99A patent/AU749616B2/en not_active Ceased
- 1999-05-18 CA CA2690399A patent/CA2690399C/en not_active Expired - Fee Related
- 1999-05-18 AT AT99926326T patent/ATE347563T1/de active
- 1999-05-18 CA CA2332817A patent/CA2332817C/en not_active Expired - Fee Related
- 1999-05-18 PT PT99926326T patent/PT1078001E/pt unknown
- 1999-05-18 ES ES99926326T patent/ES2273492T3/es not_active Expired - Lifetime
- 1999-05-18 WO PCT/EP1999/003421 patent/WO1999060013A2/en not_active Ceased
- 1999-05-18 DE DE69934308T patent/DE69934308T2/de not_active Expired - Lifetime
- 1999-05-18 JP JP2000549631A patent/JP4468578B2/ja not_active Expired - Fee Related
-
2000
- 2000-11-09 IL IL139575A patent/IL139575A/en not_active IP Right Cessation
- 2000-11-20 US US09/715,923 patent/US6599875B1/en not_active Expired - Lifetime
-
2003
- 2003-02-04 US US10/357,479 patent/US6838433B2/en not_active Expired - Lifetime
-
2006
- 2006-12-20 CY CY20061101820T patent/CY1105865T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US6838433B2 (en) | 2005-01-04 |
| EP1078001B1 (en) | 2006-12-06 |
| DK1078001T3 (da) | 2007-02-19 |
| CY1105865T1 (el) | 2011-02-02 |
| IL139575A (en) | 2008-03-20 |
| JP4468578B2 (ja) | 2010-05-26 |
| CA2690399C (en) | 2015-01-20 |
| JP2002527354A (ja) | 2002-08-27 |
| WO1999060013A3 (en) | 2000-03-09 |
| DE69934308T2 (de) | 2007-03-29 |
| CA2690399A1 (en) | 1999-11-25 |
| US6599875B1 (en) | 2003-07-29 |
| EP1078001A2 (en) | 2001-02-28 |
| IL139575A0 (en) | 2002-02-10 |
| PT1078001E (pt) | 2007-01-31 |
| AU4362799A (en) | 1999-12-06 |
| CA2332817A1 (en) | 1999-11-25 |
| US20030186876A1 (en) | 2003-10-02 |
| DE69934308D1 (de) | 2007-01-18 |
| EP0972780A1 (en) | 2000-01-19 |
| ATE347563T1 (de) | 2006-12-15 |
| AU749616B2 (en) | 2002-06-27 |
| WO1999060013A2 (en) | 1999-11-25 |
| ES2273492T3 (es) | 2007-05-01 |
| SI1078001T1 (sl) | 2007-04-30 |
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