JP2002527149A5 - - Google Patents
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- Publication number
- JP2002527149A5 JP2002527149A5 JP2000575563A JP2000575563A JP2002527149A5 JP 2002527149 A5 JP2002527149 A5 JP 2002527149A5 JP 2000575563 A JP2000575563 A JP 2000575563A JP 2000575563 A JP2000575563 A JP 2000575563A JP 2002527149 A5 JP2002527149 A5 JP 2002527149A5
- Authority
- JP
- Japan
- Prior art keywords
- solution
- red blood
- blood cells
- hemolysate
- hemoglobin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000034 method Methods 0.000 description 29
- 239000000243 solution Substances 0.000 description 15
- 210000003743 erythrocyte Anatomy 0.000 description 13
- 102000001554 Hemoglobins Human genes 0.000 description 11
- 108010054147 Hemoglobins Proteins 0.000 description 11
- 239000000815 hypotonic solution Substances 0.000 description 8
- 239000008280 blood Substances 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 6
- 230000002934 lysing effect Effects 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 238000005406 washing Methods 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 238000002955 isolation Methods 0.000 description 3
- 210000002381 plasma Anatomy 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 230000000415 inactivating effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000005416 organic matter Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10431998P | 1998-10-15 | 1998-10-15 | |
| US60/104,319 | 1998-10-15 | ||
| US12218099P | 1999-03-01 | 1999-03-01 | |
| US60/122,180 | 1999-03-01 | ||
| PCT/US1999/024149 WO2000021591A1 (en) | 1998-10-15 | 1999-10-15 | Method for production of stroma-free hemoglobin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002527149A JP2002527149A (ja) | 2002-08-27 |
| JP2002527149A5 true JP2002527149A5 (cg-RX-API-DMAC10.html) | 2007-03-08 |
Family
ID=26801402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000575563A Withdrawn JP2002527149A (ja) | 1998-10-15 | 1999-10-15 | 無ストロマヘモグロビンの産生のための方法 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1121165A1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP2002527149A (cg-RX-API-DMAC10.html) |
| KR (1) | KR20010099700A (cg-RX-API-DMAC10.html) |
| CN (1) | CN1332646A (cg-RX-API-DMAC10.html) |
| AU (1) | AU771465B2 (cg-RX-API-DMAC10.html) |
| BR (1) | BR9915734A (cg-RX-API-DMAC10.html) |
| CA (1) | CA2346825C (cg-RX-API-DMAC10.html) |
| MX (1) | MXPA01003836A (cg-RX-API-DMAC10.html) |
| WO (1) | WO2000021591A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080138790A1 (en) * | 2004-04-13 | 2008-06-12 | Winslow Robert M | Methods and Compositions for Simultaneously Isolating Hemoglobin from Red Blood Cells and Inactivating Viruses |
| JP2006021121A (ja) | 2004-07-08 | 2006-01-26 | Hitachi Koki Co Ltd | 遠心分離機 |
| ITLU20070013A1 (it) * | 2007-06-22 | 2008-12-23 | Kedrion Spa | Processo per la purificazione di emoglobina umana apirogena e virus inattivata. |
| JP5456689B2 (ja) * | 2007-12-07 | 2014-04-02 | ミルテンイ バイオテック ゲーエムベーハー | 試料を少なくとも２つの成分に分離する遠心分離機 |
| CA2791122C (en) * | 2010-02-25 | 2019-08-27 | Sangart, Inc. | Methods for preparing peg-hemoglobin conjugates using reduced reactant ratios |
| US20150273132A1 (en) * | 2012-11-05 | 2015-10-01 | Haemonetics Corporation | System and Method for Continuous Separation of Whole Blood |
| CN103091149B (zh) * | 2013-01-10 | 2015-08-05 | 济南金域医学检验中心有限公司 | 血红蛋白电泳液的制备方法 |
| CN104955834A (zh) | 2013-02-26 | 2015-09-30 | Emd密理博公司 | 利用活性炭通过调整溶液条件来从蛋白混合物选择性地去除蛋白 |
| WO2015158776A1 (en) * | 2014-04-15 | 2015-10-22 | Boehringer Ingelheim International Gmbh | Methods, apparatuses, and systems for continuously inactivating a virus during manufacture of a biological product |
| CN111801412A (zh) * | 2018-03-02 | 2020-10-20 | 赛默电子Led有限公司 | 用于分离生物悬浮液的一次性离心容器和使用方法 |
| CN109298171B (zh) * | 2018-11-15 | 2022-06-28 | 武汉中生毓晋生物医药有限责任公司 | 醛化红细胞中内毒素的去除方法与应用 |
| CO2023018740A1 (es) * | 2023-12-29 | 2025-07-07 | Lifefactors S A S | Sistema de separación de componentes plasmáticos por descongelamiento controlado mediante unos mecanismos integrados de transferencia térmica controlada y sedimentación acelerada en unos medios continuos |
| CN119746044A (zh) * | 2025-03-06 | 2025-04-04 | 润方（北京）生物医药研究院有限公司 | 血红蛋白氧载体在制备抗病毒药物中的应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4303193A (en) | 1979-01-22 | 1981-12-01 | Haemonetics Corporation | Apparatus for separating blood into components thereof |
| US4401652A (en) * | 1980-12-31 | 1983-08-30 | Allied Corporation | Process for the preparation of stroma-free hemoglobin solutions |
| US5464814A (en) * | 1986-06-20 | 1995-11-07 | Northfield Laboratories, Inc. | Acellular red blood cell substitute |
| CA1312009C (en) | 1986-11-10 | 1992-12-29 | Carl W. Rausch | Extra pure semi-synthetic blood substitute |
| JPH02121931A (ja) * | 1988-10-29 | 1990-05-09 | Res Inst For Prod Dev | 濃縮ヘモグロビンの製造方法 |
| US5646252A (en) * | 1992-02-10 | 1997-07-08 | Staat Der Nederlanden, De Minister Van Defensie, Voor Deze: Het Hoofd Van De Afdeling Militair Geneeskundig Beleid | Hemoglobin composition and preparation thereof |
| US5676644A (en) | 1995-06-07 | 1997-10-14 | Cobe Laboratories, Inc. | Extracorporeal blood processing methods and apparatus |
| US5814601A (en) | 1997-02-28 | 1998-09-29 | The Regents Of The University Of California | Methods and compositions for optimization of oxygen transport by cell-free systems |
-
1999
- 1999-10-15 EP EP99954950A patent/EP1121165A1/en not_active Withdrawn
- 1999-10-15 MX MXPA01003836A patent/MXPA01003836A/es unknown
- 1999-10-15 KR KR1020017004781A patent/KR20010099700A/ko not_active Withdrawn
- 1999-10-15 CN CN99813429A patent/CN1332646A/zh active Pending
- 1999-10-15 BR BR9915734-9A patent/BR9915734A/pt not_active IP Right Cessation
- 1999-10-15 WO PCT/US1999/024149 patent/WO2000021591A1/en not_active Ceased
- 1999-10-15 CA CA002346825A patent/CA2346825C/en not_active Expired - Fee Related
- 1999-10-15 AU AU11170/00A patent/AU771465B2/en not_active Ceased
- 1999-10-15 JP JP2000575563A patent/JP2002527149A/ja not_active Withdrawn
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