JP2002525286A5 - - Google Patents

Info

Publication number

JP2002525286A5

JP2002525286A5 JP2000571055A JP2000571055A JP2002525286A5 JP 2002525286 A5 JP2002525286 A5 JP 2002525286A5 JP 2000571055 A JP2000571055 A JP 2000571055A JP 2000571055 A JP2000571055 A JP 2000571055A JP 2002525286 A5 JP2002525286 A5 JP 2002525286A5

Authority

JP

Japan

Prior art keywords

compound

formula

compound according

group

carbon atoms

Prior art date

1999-08-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 150000001875 compounds Chemical class 0.000 description 21
• 125000004432 carbon atom Chemical group C* 0.000 description 8
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 7
• 125000000217 alkyl group Chemical group 0.000 description 5
• 238000000034 method Methods 0.000 description 4
• -1 nitro, amino Chemical group 0.000 description 4
• 229910052717 sulfur Inorganic materials 0.000 description 4
• 125000001475 halogen functional group Chemical group 0.000 description 3
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 3
• 229910052760 oxygen Inorganic materials 0.000 description 3
• 125000003118 aryl group Chemical group 0.000 description 2
• 239000003814 drug Substances 0.000 description 2
• GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 description 1
• 208000035143 Bacterial infection Diseases 0.000 description 1
• 101150065749 Churc1 gene Proteins 0.000 description 1
• 208000030852 Parasitic disease Diseases 0.000 description 1
• 102100038239 Protein Churchill Human genes 0.000 description 1
• 208000036142 Viral infection Diseases 0.000 description 1
• 239000002253 acid Substances 0.000 description 1
• 125000003545 alkoxy group Chemical group 0.000 description 1
• 125000002877 alkyl aryl group Chemical group 0.000 description 1
• 125000003710 aryl alkyl group Chemical group 0.000 description 1
• 230000001580 bacterial effect Effects 0.000 description 1
• 208000022362 bacterial infectious disease Diseases 0.000 description 1
• CREMABGTGYGIQB-UHFFFAOYSA-N carbon carbon Chemical compound C.C CREMABGTGYGIQB-UHFFFAOYSA-N 0.000 description 1
• 239000011203 carbon fibre reinforced carbon Substances 0.000 description 1
• 239000003085 diluting agent Substances 0.000 description 1
• 201000010099 disease Diseases 0.000 description 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
• 239000003937 drug carrier Substances 0.000 description 1
• 125000000524 functional group Chemical group 0.000 description 1
• 125000005843 halogen group Chemical group 0.000 description 1
• 125000005842 heteroatom Chemical group 0.000 description 1
• 125000005647 linker group Chemical group 0.000 description 1
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
• 230000003071 parasitic effect Effects 0.000 description 1
• 239000008194 pharmaceutical composition Substances 0.000 description 1
• 125000006239 protecting group Chemical group 0.000 description 1
• 108090000623 proteins and genes Proteins 0.000 description 1
• 238000012216 screening Methods 0.000 description 1
• 239000007787 solid Substances 0.000 description 1
• 238000002560 therapeutic procedure Methods 0.000 description 1
• 238000010200 validation analysis Methods 0.000 description 1
• 230000009385 viral infection Effects 0.000 description 1
• 229910052727 yttrium Inorganic materials 0.000 description 1