JP2002524393A5 - - Google Patents
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- Publication number
- JP2002524393A5 JP2002524393A5 JP2000563294A JP2000563294A JP2002524393A5 JP 2002524393 A5 JP2002524393 A5 JP 2002524393A5 JP 2000563294 A JP2000563294 A JP 2000563294A JP 2000563294 A JP2000563294 A JP 2000563294A JP 2002524393 A5 JP2002524393 A5 JP 2002524393A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- composition
- condition
- peptide antagonist
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 description 16
- 229940083963 Peptide antagonist Drugs 0.000 description 7
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 4
- 125000003275 alpha amino acid group Chemical group 0.000 description 4
- 210000001578 tight junction Anatomy 0.000 description 4
- 239000003053 toxin Substances 0.000 description 4
- 231100000765 toxin Toxicity 0.000 description 4
- 108700012359 toxins Proteins 0.000 description 4
- 239000005557 antagonist Substances 0.000 description 3
- 210000000936 intestine Anatomy 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 102100025255 Haptoglobin Human genes 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 108010027843 zonulin Proteins 0.000 description 2
- -1 Amino Chemical group 0.000 description 1
- 208000037157 Azotemia Diseases 0.000 description 1
- 201000006474 Brain Ischemia Diseases 0.000 description 1
- 206010048962 Brain oedema Diseases 0.000 description 1
- 206010008120 Cerebral ischaemia Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 206010064147 Gastrointestinal inflammation Diseases 0.000 description 1
- 208000035895 Guillain-Barré syndrome Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 201000009906 Meningitis Diseases 0.000 description 1
- 206010049567 Miller Fisher syndrome Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 102000000591 Tight Junction Proteins Human genes 0.000 description 1
- 108010002321 Tight Junction Proteins Proteins 0.000 description 1
- 208000030886 Traumatic Brain injury Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000008499 blood brain barrier function Effects 0.000 description 1
- 210000001218 blood-brain barrier Anatomy 0.000 description 1
- 208000006752 brain edema Diseases 0.000 description 1
- 208000029028 brain injury Diseases 0.000 description 1
- 206010008118 cerebral infarction Diseases 0.000 description 1
- 206010014599 encephalitis Diseases 0.000 description 1
- 201000002491 encephalomyelitis Diseases 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000009529 traumatic brain injury Effects 0.000 description 1
- 208000009852 uremia Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/127,815 US6458925B1 (en) | 1998-08-03 | 1998-08-03 | Peptide antagonists of zonulin and methods for use of the same |
| US09/127,815 | 1998-08-03 | ||
| PCT/US1999/016683 WO2000007609A1 (en) | 1998-08-03 | 1999-07-28 | Peptide antagonists of zonulin and methods for use of the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002524393A JP2002524393A (ja) | 2002-08-06 |
| JP2002524393A5 true JP2002524393A5 (enExample) | 2006-09-14 |
| JP4822585B2 JP4822585B2 (ja) | 2011-11-24 |
Family
ID=22432094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000563294A Expired - Lifetime JP4822585B2 (ja) | 1998-08-03 | 1999-07-28 | ゾヌリンのペプチドアンタゴニストおよびその使用方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (10) | US6458925B1 (enExample) |
| EP (2) | EP1698345B1 (enExample) |
| JP (1) | JP4822585B2 (enExample) |
| KR (1) | KR100610389B1 (enExample) |
| CN (2) | CN100348266C (enExample) |
| AT (2) | ATE329606T1 (enExample) |
| AU (1) | AU745507B2 (enExample) |
| CA (1) | CA2338005C (enExample) |
| DE (2) | DE69942753D1 (enExample) |
| DK (1) | DK1102596T3 (enExample) |
| ES (1) | ES2267282T3 (enExample) |
| HU (1) | HU228079B1 (enExample) |
| IL (2) | IL141082A0 (enExample) |
| NO (1) | NO326552B1 (enExample) |
| NZ (1) | NZ509579A (enExample) |
| RU (1) | RU2214267C2 (enExample) |
| WO (1) | WO2000007609A1 (enExample) |
| ZA (1) | ZA200100829B (enExample) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6458925B1 (en) * | 1998-08-03 | 2002-10-01 | University Of Maryland, Baltimore | Peptide antagonists of zonulin and methods for use of the same |
| JP2003534287A (ja) * | 2000-05-19 | 2003-11-18 | ユニバーシティ・オブ・メリーランド， ボルティモア | 糖尿病発症を予防または遅延させるためのゾヌリンのペプチドアンタゴニストの使用方法 |
| FR2844201A1 (fr) * | 2002-09-06 | 2004-03-12 | Rytek | Compositions pour le traitement de pathologies fonctionnelles digestives |
| WO2003077893A2 (fr) * | 2002-03-15 | 2003-09-25 | Rytek | Compositions pour le traitement de pathologies fonctionnelles digestives |
| CA2531491A1 (en) * | 2003-07-15 | 2005-02-03 | University Of Maryland, Baltimore | Agonist polypeptide of receptor for zot and zonulin |
| US7125781B2 (en) * | 2003-09-04 | 2006-10-24 | Micron Technology, Inc. | Methods of forming capacitor devices |
| US7067385B2 (en) * | 2003-09-04 | 2006-06-27 | Micron Technology, Inc. | Support for vertically oriented capacitors during the formation of a semiconductor device |
| US20080038843A1 (en) * | 2006-08-11 | 2008-02-14 | University Of Maryland - Baltimore | Method of diagnosing celiac disease |
| US7387939B2 (en) * | 2004-07-19 | 2008-06-17 | Micron Technology, Inc. | Methods of forming semiconductor structures and capacitor devices |
| US7439152B2 (en) * | 2004-08-27 | 2008-10-21 | Micron Technology, Inc. | Methods of forming a plurality of capacitors |
| US7202127B2 (en) * | 2004-08-27 | 2007-04-10 | Micron Technology, Inc. | Methods of forming a plurality of capacitors |
| US20060046055A1 (en) | 2004-08-30 | 2006-03-02 | Nan Ya Plastics Corporation | Superfine fiber containing grey dope dyed component and the fabric made of the same |
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| FR2879100B1 (fr) | 2004-12-09 | 2007-07-06 | Lionel Bueno | Compositions pour le traitement des pathologies oculaires de surface et de la retine |
| TW200637573A (en) * | 2005-01-14 | 2006-11-01 | Univ Maryland | Peptide for delivery of mucosal vaccines |
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| TW200716159A (en) * | 2005-06-09 | 2007-05-01 | Univ Maryland | Method of use of antagonists of zonulin to prevent the loss of or to regenerate pancreatic cells |
| US7282401B2 (en) | 2005-07-08 | 2007-10-16 | Micron Technology, Inc. | Method and apparatus for a self-aligned recessed access device (RAD) transistor gate |
| US7199005B2 (en) * | 2005-08-02 | 2007-04-03 | Micron Technology, Inc. | Methods of forming pluralities of capacitors |
| US7867851B2 (en) | 2005-08-30 | 2011-01-11 | Micron Technology, Inc. | Methods of forming field effect transistors on substrates |
| US7700441B2 (en) | 2006-02-02 | 2010-04-20 | Micron Technology, Inc. | Methods of forming field effect transistors, methods of forming field effect transistor gates, methods of forming integrated circuitry comprising a transistor gate array and circuitry peripheral to the gate array, and methods of forming integrated circuitry comprising a transistor gate array including first gates and second grounded isolation gates |
| BRPI0707616A2 (pt) | 2006-02-09 | 2011-05-10 | Alba Therapuetics Corp | formulaÇÕes para um efetor de junÇço oclusiva |
| US7557013B2 (en) | 2006-04-10 | 2009-07-07 | Micron Technology, Inc. | Methods of forming a plurality of capacitors |
| US7602001B2 (en) | 2006-07-17 | 2009-10-13 | Micron Technology, Inc. | Capacitorless one transistor DRAM cell, integrated circuitry comprising an array of capacitorless one transistor DRAM cells, and method of forming lines of capacitorless one transistor DRAM cells |
| US7772632B2 (en) | 2006-08-21 | 2010-08-10 | Micron Technology, Inc. | Memory arrays and methods of fabricating memory arrays |
| US7589995B2 (en) | 2006-09-07 | 2009-09-15 | Micron Technology, Inc. | One-transistor memory cell with bias gate |
| US20090069247A1 (en) * | 2006-10-06 | 2009-03-12 | Blake Paterson | Use of tight junction antagonists to treat inflammatory bowel disease |
| US7902081B2 (en) | 2006-10-11 | 2011-03-08 | Micron Technology, Inc. | Methods of etching polysilicon and methods of forming pluralities of capacitors |
| US8034776B2 (en) * | 2006-10-26 | 2011-10-11 | Alba Therapeutics Corporation | Materials and methods for the treatment of celiac disease |
| EP2091551B1 (en) | 2006-11-03 | 2020-01-15 | Alba Therapeutics Corporation | Method of treating asthma |
| US7785962B2 (en) | 2007-02-26 | 2010-08-31 | Micron Technology, Inc. | Methods of forming a plurality of capacitors |
| US8728491B2 (en) * | 2007-05-07 | 2014-05-20 | Alba Therapeutics Corporation | Transcutaneous delivery of therapeutic agents |
| WO2008150981A2 (en) * | 2007-05-30 | 2008-12-11 | Alba Therapeutics Corporation | Novel short peptides that inhibit the opening of mammalian tight junctions |
| US7923373B2 (en) | 2007-06-04 | 2011-04-12 | Micron Technology, Inc. | Pitch multiplication using self-assembling materials |
| WO2008154493A2 (en) * | 2007-06-07 | 2008-12-18 | Alba Therapeutics Corporation | Novel peptides that inhibit the opening of mammalian tight junctions |
| WO2008154350A2 (en) * | 2007-06-08 | 2008-12-18 | Alba Therapeutics Corporation | Use of tight junction agonists to suppress immune responses |
| WO2009006246A1 (en) * | 2007-06-29 | 2009-01-08 | Alea Therapeutics Corp. | Use of tight junction antagonists in the treatment of acute long injury and acute respiratory distress syndrome |
| WO2009015382A2 (en) | 2007-07-26 | 2009-01-29 | Alba Therapeutics Corporation | Novel peptides that enhance tight junction permeability |
| US7682924B2 (en) | 2007-08-13 | 2010-03-23 | Micron Technology, Inc. | Methods of forming a plurality of capacitors |
| WO2009052489A2 (en) * | 2007-10-19 | 2009-04-23 | Alba Therapeutics Corporation | Novel inhibitors of mammalian tight junction opening |
| EP2062909A1 (en) * | 2007-11-21 | 2009-05-27 | SOLVAY (Société Anonyme) | Peptide production and purification process |
| US9051349B2 (en) | 2007-11-21 | 2015-06-09 | Alba Therapeutics Corporation | Larazotide acetate compositions |
| WO2009110947A2 (en) * | 2007-12-19 | 2009-09-11 | Alba Therapeutics Corporation | Compositions and methods for inhibiting cytokine production |
| US8388851B2 (en) | 2008-01-08 | 2013-03-05 | Micron Technology, Inc. | Capacitor forming methods |
| US8274777B2 (en) | 2008-04-08 | 2012-09-25 | Micron Technology, Inc. | High aspect ratio openings |
| US8957032B2 (en) * | 2008-05-06 | 2015-02-17 | Alba Therapeutics Corporation | Inhibition of gliadin peptides |
| US7759193B2 (en) | 2008-07-09 | 2010-07-20 | Micron Technology, Inc. | Methods of forming a plurality of capacitors |
| CN102481362A (zh) * | 2009-06-10 | 2012-05-30 | 马里兰巴尔的摩大学 | 表皮生长因子受体(egfr)与蛋白酶活化受体2(par2)对肠道通透性的调节 |
| RU2410765C1 (ru) * | 2009-07-21 | 2011-01-27 | Государственное образовательное учреждение высшего профессионального образования "Северо-Осетинская государственная медицинская академия" Федерального агентства по здравоохранению и социальному развитию | Способ профилактики токсического действия никеля у экспериментальных животных при хроническом отравлении |
| RU2412489C1 (ru) * | 2009-09-01 | 2011-02-20 | Государственное образовательное учреждение высшего профессионального образования "Северо-Осетинская государственная медицинская академия" Федерального агентства по здравоохранению и социальному развитию | Способ профилактики хронической токсической кардиопатии у экспериментальных животных |
| US8518788B2 (en) | 2010-08-11 | 2013-08-27 | Micron Technology, Inc. | Methods of forming a plurality of capacitors |
| US9076680B2 (en) | 2011-10-18 | 2015-07-07 | Micron Technology, Inc. | Integrated circuitry, methods of forming capacitors, and methods of forming integrated circuitry comprising an array of capacitors and circuitry peripheral to the array |
| US8946043B2 (en) | 2011-12-21 | 2015-02-03 | Micron Technology, Inc. | Methods of forming capacitors |
| SI3677252T1 (sl) | 2012-03-19 | 2024-02-29 | Cidara Therapeutics, Inc. | Sheme odmerjanja za spojine iz razreda ehinokandinov |
| US8652926B1 (en) | 2012-07-26 | 2014-02-18 | Micron Technology, Inc. | Methods of forming capacitors |
| WO2015069718A2 (en) | 2013-11-05 | 2015-05-14 | Bio-Rad Laboratories, Inc. | Pre-haptoglobin-2 monoclonal antibodies and uses thereof |
| WO2015154010A1 (en) * | 2014-04-04 | 2015-10-08 | Perrow Wendy | Methods of treating celiac disease with larazotide |
| KR20190121785A (ko) | 2017-02-10 | 2019-10-28 | 이노베이트 바이오파마슈티컬스, 인코포레이티드 | 장 상피의 투과성과 관련된 질환을 치료하기 위한 조성물 및 방법 |
| WO2019165346A1 (en) | 2018-02-23 | 2019-08-29 | Innovate Biopharmaceuticals, Inc. | Compounds and methods for treating tight junction permeability |
| CN117597137A (zh) | 2021-04-19 | 2024-02-23 | 伊布里斯有限责任公司 | 用于治疗儿童（mis-c）和成人（mis-a）多系统炎症综合征的连蛋白拮抗剂 |
| CN118873629B (zh) * | 2024-09-27 | 2024-12-10 | 北京大学口腔医学院 | 醋酸拉唑肽在制备促进成骨药物中的用途 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US667048A (en) * | 1900-07-06 | 1901-01-29 | Edson F Whitman | Torpedo-projectile. |
| US2419898A (en) | 1943-12-10 | 1947-04-29 | Int Harvester Co | Shelled corn saver for husking devices |
| US5395750A (en) * | 1992-02-28 | 1995-03-07 | Hoffmann-La Roche Inc. | Methods for producing proteins which bind to predetermined antigens |
| WO1994011505A1 (en) * | 1992-11-10 | 1994-05-26 | Washington University | Pars planitis specific polypeptides |
| AU5615594A (en) * | 1992-11-13 | 1994-06-08 | Cancer Research Fund Of Contra Costa | Polypeptides with specificity for neoplasias, kit, and diagnostic, vaccination, and therapeutic methods |
| EP0674710B1 (en) * | 1992-11-16 | 2003-05-02 | Cancer Research Fund Of Contra Costa | Peptides with broad neoplastic specificity |
| JP2996864B2 (ja) * | 1994-03-30 | 2000-01-11 | 寳酒造株式会社 | 抗体可変領域ｄｎａ |
| US5665389A (en) | 1995-05-24 | 1997-09-09 | University Of Maryland At Baltimore | Oral dosage composition for intestinal delivery and method of treating diabetes |
| EP0914335A2 (en) * | 1996-03-15 | 1999-05-12 | Corixa Corporation | Compounds and methods for immunotherapy and immunodiagnosis of prostate cancer |
| US5912323A (en) * | 1997-02-20 | 1999-06-15 | University Of Maryland, Baltimore | Zonula occludens toxin receptors |
| US5945510A (en) * | 1997-05-21 | 1999-08-31 | University Of Maryland, Baltimore | Substantially pure zonulin, a physiological modulator of mammalian tight junctions |
| US6506577B1 (en) * | 1998-03-19 | 2003-01-14 | The Regents Of The University Of California | Synthesis and crosslinking of catechol containing copolypeptides |
| US6458925B1 (en) * | 1998-08-03 | 2002-10-01 | University Of Maryland, Baltimore | Peptide antagonists of zonulin and methods for use of the same |
| RU2214271C2 (ru) * | 1998-09-14 | 2003-10-20 | Юниверсити Оф Мэриленд, Балтимор | Способ применения zot или зонулина для ингибирования антиген-специфической пролиферации лимфоцитов |
| JP2003534287A (ja) * | 2000-05-19 | 2003-11-18 | ユニバーシティ・オブ・メリーランド， ボルティモア | 糖尿病発症を予防または遅延させるためのゾヌリンのペプチドアンタゴニストの使用方法 |
| US8034776B2 (en) * | 2006-10-26 | 2011-10-11 | Alba Therapeutics Corporation | Materials and methods for the treatment of celiac disease |
-
1998
- 1998-08-03 US US09/127,815 patent/US6458925B1/en not_active Expired - Lifetime
-
1999
- 1999-07-28 KR KR1020017001503A patent/KR100610389B1/ko not_active Expired - Lifetime
- 1999-07-28 AT AT99940809T patent/ATE329606T1/de active
- 1999-07-28 JP JP2000563294A patent/JP4822585B2/ja not_active Expired - Lifetime
- 1999-07-28 DE DE69942753T patent/DE69942753D1/de not_active Expired - Lifetime
- 1999-07-28 DK DK99940809T patent/DK1102596T3/da active
- 1999-07-28 ES ES99940809T patent/ES2267282T3/es not_active Expired - Lifetime
- 1999-07-28 CN CNB2005100077127A patent/CN100348266C/zh not_active Expired - Lifetime
- 1999-07-28 AU AU54590/99A patent/AU745507B2/en not_active Expired
- 1999-07-28 WO PCT/US1999/016683 patent/WO2000007609A1/en not_active Ceased
- 1999-07-28 RU RU2001106615/14A patent/RU2214267C2/ru active
- 1999-07-28 AT AT06006483T patent/ATE480252T1/de not_active IP Right Cessation
- 1999-07-28 CA CA2338005A patent/CA2338005C/en not_active Expired - Lifetime
- 1999-07-28 CN CN998100315A patent/CN1217697C/zh not_active Expired - Lifetime
- 1999-07-28 IL IL14108299A patent/IL141082A0/xx unknown
- 1999-07-28 HU HU0103321A patent/HU228079B1/hu unknown
- 1999-07-28 EP EP06006483A patent/EP1698345B1/en not_active Expired - Lifetime
- 1999-07-28 DE DE69931929T patent/DE69931929T2/de not_active Expired - Lifetime
- 1999-07-28 EP EP99940809A patent/EP1102596B1/en not_active Expired - Lifetime
- 1999-07-28 NZ NZ509579A patent/NZ509579A/en not_active IP Right Cessation
-
2001
- 2001-01-24 IL IL141082A patent/IL141082A/en not_active IP Right Cessation
- 2001-01-30 ZA ZA2001/00829A patent/ZA200100829B/en unknown
- 2001-02-02 NO NO20010567A patent/NO326552B1/no not_active IP Right Cessation
-
2002
- 2002-03-13 US US10/095,450 patent/US6670448B2/en not_active Expired - Lifetime
-
2003
- 2003-08-27 US US10/648,642 patent/US6936689B2/en not_active Expired - Lifetime
-
2005
- 2005-03-09 US US11/074,727 patent/US7189696B2/en not_active Expired - Fee Related
-
2006
- 2006-08-08 US US11/500,429 patent/US7531504B2/en not_active Expired - Fee Related
-
2007
- 2007-08-21 US US11/842,763 patent/US7582603B2/en not_active Expired - Fee Related
- 2007-08-21 US US11/842,738 patent/US20090082279A1/en not_active Abandoned
-
2010
- 2010-10-20 US US12/908,709 patent/US20110183923A1/en not_active Abandoned
-
2013
- 2013-01-09 US US13/737,517 patent/US20130190247A1/en not_active Abandoned
- 2013-11-01 US US14/070,208 patent/US20140128328A1/en not_active Abandoned
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