RU2214267C2 - Пептидный антагонист зонулина - Google Patents

Пептидный антагонист зонулина Download PDF

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Publication number
RU2214267C2
RU2214267C2 RU2001106615/14A RU2001106615A RU2214267C2 RU 2214267 C2 RU2214267 C2 RU 2214267C2 RU 2001106615/14 A RU2001106615/14 A RU 2001106615/14A RU 2001106615 A RU2001106615 A RU 2001106615A RU 2214267 C2 RU2214267 C2 RU 2214267C2
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RU
Russia
Prior art keywords
seq
zonuline
peptide antagonist
contacts
antagonists
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Application number
RU2001106615/14A
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English (en)
Russian (ru)
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RU2001106615A (ru
Inventor
Алессио ФАЗАНО
Original Assignee
Юниверсити Оф Мэриленд, Балтимор
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Publication of RU2001106615A publication Critical patent/RU2001106615A/ru
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4716—Muscle proteins, e.g. myosin, actin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
RU2001106615/14A 1998-08-03 1999-07-28 Пептидный антагонист зонулина RU2214267C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/127,815 1998-08-03
US09/127,815 US6458925B1 (en) 1998-08-03 1998-08-03 Peptide antagonists of zonulin and methods for use of the same

Publications (2)

Publication Number Publication Date
RU2001106615A RU2001106615A (ru) 2003-02-20
RU2214267C2 true RU2214267C2 (ru) 2003-10-20

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU2001106615/14A RU2214267C2 (ru) 1998-08-03 1999-07-28 Пептидный антагонист зонулина

Country Status (18)

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US (10) US6458925B1 (enExample)
EP (2) EP1698345B1 (enExample)
JP (1) JP4822585B2 (enExample)
KR (1) KR100610389B1 (enExample)
CN (2) CN100348266C (enExample)
AT (2) ATE329606T1 (enExample)
AU (1) AU745507B2 (enExample)
CA (1) CA2338005C (enExample)
DE (2) DE69942753D1 (enExample)
DK (1) DK1102596T3 (enExample)
ES (1) ES2267282T3 (enExample)
HU (1) HU228079B1 (enExample)
IL (2) IL141082A0 (enExample)
NO (1) NO326552B1 (enExample)
NZ (1) NZ509579A (enExample)
RU (1) RU2214267C2 (enExample)
WO (1) WO2000007609A1 (enExample)
ZA (1) ZA200100829B (enExample)

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US6458925B1 (en) * 1998-08-03 2002-10-01 University Of Maryland, Baltimore Peptide antagonists of zonulin and methods for use of the same
CA2409771C (en) * 2000-05-19 2008-12-02 University Of Maryland, Baltimore Method of use of peptide antagonists of zonulin to prevent or delay the onset of diabetes
FR2844201A1 (fr) * 2002-09-06 2004-03-12 Rytek Compositions pour le traitement de pathologies fonctionnelles digestives
EP1485074A2 (fr) * 2002-03-15 2004-12-15 Rytek Compositions pour le traitement de pathologies fonctionnelles digestives
KR20080056318A (ko) * 2003-07-15 2008-06-20 유니버시티 오브 메릴랜드, 볼티모어 Ｚｏｔ 및 조눌린에 대한 수용체의 작용제 폴리펩티드
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US7202127B2 (en) * 2004-08-27 2007-04-10 Micron Technology, Inc. Methods of forming a plurality of capacitors
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US7517753B2 (en) * 2005-05-18 2009-04-14 Micron Technology, Inc. Methods of forming pluralities of capacitors
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US7199005B2 (en) * 2005-08-02 2007-04-03 Micron Technology, Inc. Methods of forming pluralities of capacitors
US7867851B2 (en) 2005-08-30 2011-01-11 Micron Technology, Inc. Methods of forming field effect transistors on substrates
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US7557013B2 (en) 2006-04-10 2009-07-07 Micron Technology, Inc. Methods of forming a plurality of capacitors
US7602001B2 (en) * 2006-07-17 2009-10-13 Micron Technology, Inc. Capacitorless one transistor DRAM cell, integrated circuitry comprising an array of capacitorless one transistor DRAM cells, and method of forming lines of capacitorless one transistor DRAM cells
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US20090069247A1 (en) * 2006-10-06 2009-03-12 Blake Paterson Use of tight junction antagonists to treat inflammatory bowel disease
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Also Published As

Publication number Publication date
CN1217697C (zh) 2005-09-07
US7531504B2 (en) 2009-05-12
DE69942753D1 (de) 2010-10-21
EP1102596A4 (en) 2002-08-14
US20050209161A1 (en) 2005-09-22
US20110183923A1 (en) 2011-07-28
US6670448B2 (en) 2003-12-30
US7189696B2 (en) 2007-03-13
IL141082A (en) 2012-09-24
HK1082210A1 (zh) 2006-06-02
EP1698345A2 (en) 2006-09-06
ES2267282T3 (es) 2007-03-01
HUP0103321A3 (en) 2006-01-30
AU5459099A (en) 2000-02-28
CA2338005C (en) 2012-05-29
CN100348266C (zh) 2007-11-14
EP1102596B1 (en) 2006-06-14
JP4822585B2 (ja) 2011-11-24
IL141082A0 (en) 2002-02-10
WO2000007609A1 (en) 2000-02-17
KR100610389B1 (ko) 2006-08-09
KR20010072245A (ko) 2001-07-31
AU745507B2 (en) 2002-03-21
US20040082512A1 (en) 2004-04-29
EP1102596A1 (en) 2001-05-30
HUP0103321A2 (hu) 2001-12-28
US6936689B2 (en) 2005-08-30
US20140128328A1 (en) 2014-05-08
ATE329606T1 (de) 2006-07-15
CN1679915A (zh) 2005-10-12
US20060276399A1 (en) 2006-12-07
US20130190247A1 (en) 2013-07-25
DK1102596T3 (da) 2006-10-09
US20020115825A1 (en) 2002-08-22
NO20010567L (no) 2001-04-02
NO20010567D0 (no) 2001-02-02
EP1698345A3 (en) 2006-09-13
US20090082279A1 (en) 2009-03-26
JP2002524393A (ja) 2002-08-06
US6458925B1 (en) 2002-10-01
ATE480252T1 (de) 2010-09-15
HU228079B1 (en) 2012-10-29
EP1698345B1 (en) 2010-09-08
CN1313772A (zh) 2001-09-19
NO326552B1 (no) 2009-01-05
DE69931929T2 (de) 2007-02-08
US7582603B2 (en) 2009-09-01
US20080051349A1 (en) 2008-02-28
CA2338005A1 (en) 2000-02-17
ZA200100829B (en) 2002-06-26
NZ509579A (en) 2003-07-25
DE69931929D1 (de) 2006-07-27

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