ATE329606T1 - Peptidantagonisten von zonulin und methoden zu deren verwendung - Google Patents

Peptidantagonisten von zonulin und methoden zu deren verwendung

Info

Publication number
ATE329606T1
ATE329606T1 AT99940809T AT99940809T ATE329606T1 AT E329606 T1 ATE329606 T1 AT E329606T1 AT 99940809 T AT99940809 T AT 99940809T AT 99940809 T AT99940809 T AT 99940809T AT E329606 T1 ATE329606 T1 AT E329606T1
Authority
AT
Austria
Prior art keywords
peptide antagonists
zonulin
methods
peptide
opening
Prior art date
Application number
AT99940809T
Other languages
German (de)
English (en)
Inventor
Alessio Fasano
Original Assignee
Univ Maryland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Maryland filed Critical Univ Maryland
Application granted granted Critical
Publication of ATE329606T1 publication Critical patent/ATE329606T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4716—Muscle proteins, e.g. myosin, actin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT99940809T 1998-08-03 1999-07-28 Peptidantagonisten von zonulin und methoden zu deren verwendung ATE329606T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/127,815 US6458925B1 (en) 1998-08-03 1998-08-03 Peptide antagonists of zonulin and methods for use of the same

Publications (1)

Publication Number Publication Date
ATE329606T1 true ATE329606T1 (de) 2006-07-15

Family

ID=22432094

Family Applications (2)

Application Number Title Priority Date Filing Date
AT99940809T ATE329606T1 (de) 1998-08-03 1999-07-28 Peptidantagonisten von zonulin und methoden zu deren verwendung
AT06006483T ATE480252T1 (de) 1998-08-03 1999-07-28 Peptidantagonist von zonulin und dessen verwendung

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT06006483T ATE480252T1 (de) 1998-08-03 1999-07-28 Peptidantagonist von zonulin und dessen verwendung

Country Status (18)

Country Link
US (10) US6458925B1 (enExample)
EP (2) EP1698345B1 (enExample)
JP (1) JP4822585B2 (enExample)
KR (1) KR100610389B1 (enExample)
CN (2) CN1217697C (enExample)
AT (2) ATE329606T1 (enExample)
AU (1) AU745507B2 (enExample)
CA (1) CA2338005C (enExample)
DE (2) DE69942753D1 (enExample)
DK (1) DK1102596T3 (enExample)
ES (1) ES2267282T3 (enExample)
HU (1) HU228079B1 (enExample)
IL (2) IL141082A0 (enExample)
NO (1) NO326552B1 (enExample)
NZ (1) NZ509579A (enExample)
RU (1) RU2214267C2 (enExample)
WO (1) WO2000007609A1 (enExample)
ZA (1) ZA200100829B (enExample)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458925B1 (en) * 1998-08-03 2002-10-01 University Of Maryland, Baltimore Peptide antagonists of zonulin and methods for use of the same
DE60139466D1 (de) * 2000-05-19 2009-09-17 Univ Maryland Behandlung von diabetes
JP2005526772A (ja) * 2002-03-15 2005-09-08 リテック 消化機能病理を処置するための組成物
FR2844201A1 (fr) * 2002-09-06 2004-03-12 Rytek Compositions pour le traitement de pathologies fonctionnelles digestives
JP2007534621A (ja) * 2003-07-15 2007-11-29 ユニバーシティ オブ メリーランド， ボルチモア Ｚｏｔおよびゾニューリンに対するレセプターのアゴニストペプチド
US7067385B2 (en) 2003-09-04 2006-06-27 Micron Technology, Inc. Support for vertically oriented capacitors during the formation of a semiconductor device
US7125781B2 (en) * 2003-09-04 2006-10-24 Micron Technology, Inc. Methods of forming capacitor devices
US20080038843A1 (en) * 2006-08-11 2008-02-14 University Of Maryland - Baltimore Method of diagnosing celiac disease
US7387939B2 (en) * 2004-07-19 2008-06-17 Micron Technology, Inc. Methods of forming semiconductor structures and capacitor devices
US7202127B2 (en) * 2004-08-27 2007-04-10 Micron Technology, Inc. Methods of forming a plurality of capacitors
US7439152B2 (en) * 2004-08-27 2008-10-21 Micron Technology, Inc. Methods of forming a plurality of capacitors
US20060046055A1 (en) 2004-08-30 2006-03-02 Nan Ya Plastics Corporation Superfine fiber containing grey dope dyed component and the fabric made of the same
US7547945B2 (en) 2004-09-01 2009-06-16 Micron Technology, Inc. Transistor devices, transistor structures and semiconductor constructions
US7320911B2 (en) * 2004-12-06 2008-01-22 Micron Technology, Inc. Methods of forming pluralities of capacitors
FR2879100B1 (fr) 2004-12-09 2007-07-06 Lionel Bueno Compositions pour le traitement des pathologies oculaires de surface et de la retine
AR053661A1 (es) * 2005-01-14 2007-05-16 Univ Maryland Peptido para entregar vacunas via mucosas
US7557015B2 (en) * 2005-03-18 2009-07-07 Micron Technology, Inc. Methods of forming pluralities of capacitors
GB2425654B (en) * 2005-04-29 2010-03-17 Seiko Epson Corp A method of fabricating a heterojunction of organic semiconducting polymers
EP1722466A1 (en) * 2005-05-13 2006-11-15 STMicroelectronics S.r.l. Method and relative circuit for generating a control voltage of a synchronous rectifier
US7544563B2 (en) 2005-05-18 2009-06-09 Micron Technology, Inc. Methods of forming a plurality of capacitors
US7517753B2 (en) * 2005-05-18 2009-04-14 Micron Technology, Inc. Methods of forming pluralities of capacitors
AR057058A1 (es) * 2005-06-09 2007-11-14 Alba Therapeutics Corp Metodo para usar antagonistas de zonulina para prevenir la perdida o para regenerar celulas pancreaticas
US7282401B2 (en) 2005-07-08 2007-10-16 Micron Technology, Inc. Method and apparatus for a self-aligned recessed access device (RAD) transistor gate
US7199005B2 (en) * 2005-08-02 2007-04-03 Micron Technology, Inc. Methods of forming pluralities of capacitors
US7867851B2 (en) 2005-08-30 2011-01-11 Micron Technology, Inc. Methods of forming field effect transistors on substrates
US7700441B2 (en) 2006-02-02 2010-04-20 Micron Technology, Inc. Methods of forming field effect transistors, methods of forming field effect transistor gates, methods of forming integrated circuitry comprising a transistor gate array and circuitry peripheral to the gate array, and methods of forming integrated circuitry comprising a transistor gate array including first gates and second grounded isolation gates
BRPI0707616A2 (pt) * 2006-02-09 2011-05-10 Alba Therapuetics Corp formulaÇÕes para um efetor de junÇço oclusiva
US7557013B2 (en) 2006-04-10 2009-07-07 Micron Technology, Inc. Methods of forming a plurality of capacitors
US7602001B2 (en) 2006-07-17 2009-10-13 Micron Technology, Inc. Capacitorless one transistor DRAM cell, integrated circuitry comprising an array of capacitorless one transistor DRAM cells, and method of forming lines of capacitorless one transistor DRAM cells
US7772632B2 (en) 2006-08-21 2010-08-10 Micron Technology, Inc. Memory arrays and methods of fabricating memory arrays
US7589995B2 (en) 2006-09-07 2009-09-15 Micron Technology, Inc. One-transistor memory cell with bias gate
US20090069247A1 (en) * 2006-10-06 2009-03-12 Blake Paterson Use of tight junction antagonists to treat inflammatory bowel disease
US7902081B2 (en) 2006-10-11 2011-03-08 Micron Technology, Inc. Methods of etching polysilicon and methods of forming pluralities of capacitors
US8034776B2 (en) * 2006-10-26 2011-10-11 Alba Therapeutics Corporation Materials and methods for the treatment of celiac disease
WO2008073627A2 (en) 2006-11-03 2008-06-19 Alba Therapeutics Corporation Method of diagnosing and treating asthma
US7785962B2 (en) 2007-02-26 2010-08-31 Micron Technology, Inc. Methods of forming a plurality of capacitors
US8728491B2 (en) * 2007-05-07 2014-05-20 Alba Therapeutics Corporation Transcutaneous delivery of therapeutic agents
WO2008150981A2 (en) * 2007-05-30 2008-12-11 Alba Therapeutics Corporation Novel short peptides that inhibit the opening of mammalian tight junctions
US7923373B2 (en) 2007-06-04 2011-04-12 Micron Technology, Inc. Pitch multiplication using self-assembling materials
WO2008154493A2 (en) * 2007-06-07 2008-12-18 Alba Therapeutics Corporation Novel peptides that inhibit the opening of mammalian tight junctions
WO2008154350A2 (en) * 2007-06-08 2008-12-18 Alba Therapeutics Corporation Use of tight junction agonists to suppress immune responses
US20110201543A1 (en) * 2007-06-29 2011-08-18 Blake Paterson Use of tight junction antagonists in the treatment of acute lung injury and acute respiratory distress
WO2009015382A2 (en) 2007-07-26 2009-01-29 Alba Therapeutics Corporation Novel peptides that enhance tight junction permeability
US7682924B2 (en) 2007-08-13 2010-03-23 Micron Technology, Inc. Methods of forming a plurality of capacitors
US8785374B2 (en) * 2007-10-19 2014-07-22 Alba Therapeutics Corporation Inhibitors of mammalian tight junction opening
US9051349B2 (en) 2007-11-21 2015-06-09 Alba Therapeutics Corporation Larazotide acetate compositions
EP2062909A1 (en) * 2007-11-21 2009-05-27 SOLVAY (Société Anonyme) Peptide production and purification process
WO2009110947A2 (en) * 2007-12-19 2009-09-11 Alba Therapeutics Corporation Compositions and methods for inhibiting cytokine production
US8388851B2 (en) 2008-01-08 2013-03-05 Micron Technology, Inc. Capacitor forming methods
US8274777B2 (en) 2008-04-08 2012-09-25 Micron Technology, Inc. High aspect ratio openings
US8957032B2 (en) * 2008-05-06 2015-02-17 Alba Therapeutics Corporation Inhibition of gliadin peptides
US7759193B2 (en) 2008-07-09 2010-07-20 Micron Technology, Inc. Methods of forming a plurality of capacitors
JP2012529508A (ja) * 2009-06-10 2012-11-22 ユニバーシティ オブ メリーランド，ボルチモア 腸透過性のｅｇｆｒおよびｐａｒ２調節
RU2410765C1 (ru) * 2009-07-21 2011-01-27 Государственное образовательное учреждение высшего профессионального образования "Северо-Осетинская государственная медицинская академия" Федерального агентства по здравоохранению и социальному развитию Способ профилактики токсического действия никеля у экспериментальных животных при хроническом отравлении
RU2412489C1 (ru) * 2009-09-01 2011-02-20 Государственное образовательное учреждение высшего профессионального образования "Северо-Осетинская государственная медицинская академия" Федерального агентства по здравоохранению и социальному развитию Способ профилактики хронической токсической кардиопатии у экспериментальных животных
US8518788B2 (en) 2010-08-11 2013-08-27 Micron Technology, Inc. Methods of forming a plurality of capacitors
US9076680B2 (en) 2011-10-18 2015-07-07 Micron Technology, Inc. Integrated circuitry, methods of forming capacitors, and methods of forming integrated circuitry comprising an array of capacitors and circuitry peripheral to the array
US8946043B2 (en) 2011-12-21 2015-02-03 Micron Technology, Inc. Methods of forming capacitors
DK3677252T3 (da) 2012-03-19 2023-10-02 Cidara Therapeutics Inc Doseringsregimer for echinocandin-klasse forbindelser
US8652926B1 (en) 2012-07-26 2014-02-18 Micron Technology, Inc. Methods of forming capacitors
EP3896082A1 (en) * 2013-11-05 2021-10-20 Bio-Rad Laboratories, Inc. Pre-haptoglobin-2 monoclonal antibodies and uses thereof
CN106456549A (zh) * 2014-04-04 2017-02-22 阿尔巴医疗公司 利用拉瑞唑来治疗乳糜泻的方法
MX2019009586A (es) 2017-02-10 2019-11-11 Innovate Biopharmaceuticals Inc Composiciones y metodos para tratar enfermedades asociadas con la permeabilidad del epitelio intestinal.
WO2019165346A1 (en) 2018-02-23 2019-08-29 Innovate Biopharmaceuticals, Inc. Compounds and methods for treating tight junction permeability
CN117597137A (zh) 2021-04-19 2024-02-23 伊布里斯有限责任公司 用于治疗儿童（mis-c）和成人（mis-a）多系统炎症综合征的连蛋白拮抗剂
CN118873629B (zh) * 2024-09-27 2024-12-10 北京大学口腔医学院 醋酸拉唑肽在制备促进成骨药物中的用途

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US667048A (en) * 1900-07-06 1901-01-29 Edson F Whitman Torpedo-projectile.
US2419898A (en) 1943-12-10 1947-04-29 Int Harvester Co Shelled corn saver for husking devices
US5395750A (en) * 1992-02-28 1995-03-07 Hoffmann-La Roche Inc. Methods for producing proteins which bind to predetermined antigens
WO1994011505A1 (en) * 1992-11-10 1994-05-26 Washington University Pars planitis specific polypeptides
WO1994011508A2 (en) * 1992-11-13 1994-05-26 Cancer Research Fund Of Contra Costa Polypeptides with specificity for neoplasias, kit, and diagnostic, vaccination, and therapeutic methods
DE69332930T2 (de) * 1992-11-16 2004-02-26 Cancer Research Fund Of Contra Costa, Walnut Creek Peptide mit breiter neoplastischer spezifizität
JP2996864B2 (ja) * 1994-03-30 2000-01-11 寳酒造株式会社 抗体可変領域ｄｎａ
US5665389A (en) 1995-05-24 1997-09-09 University Of Maryland At Baltimore Oral dosage composition for intestinal delivery and method of treating diabetes
KR19990087802A (ko) * 1996-03-15 1999-12-27 길리스 스티브 전립선암의 면역치료 및 면역진단을 위한 화합물 및 방법
US5912323A (en) * 1997-02-20 1999-06-15 University Of Maryland, Baltimore Zonula occludens toxin receptors
US5945510A (en) * 1997-05-21 1999-08-31 University Of Maryland, Baltimore Substantially pure zonulin, a physiological modulator of mammalian tight junctions
US6506577B1 (en) * 1998-03-19 2003-01-14 The Regents Of The University Of California Synthesis and crosslinking of catechol containing copolypeptides
US6458925B1 (en) 1998-08-03 2002-10-01 University Of Maryland, Baltimore Peptide antagonists of zonulin and methods for use of the same
RU2214271C2 (ru) * 1998-09-14 2003-10-20 Юниверсити Оф Мэриленд, Балтимор Способ применения zot или зонулина для ингибирования антиген-специфической пролиферации лимфоцитов
DE60139466D1 (de) * 2000-05-19 2009-09-17 Univ Maryland Behandlung von diabetes
US8034776B2 (en) * 2006-10-26 2011-10-11 Alba Therapeutics Corporation Materials and methods for the treatment of celiac disease

Also Published As

Publication number Publication date
EP1102596A1 (en) 2001-05-30
NO326552B1 (no) 2009-01-05
US6936689B2 (en) 2005-08-30
US20050209161A1 (en) 2005-09-22
DE69942753D1 (de) 2010-10-21
NO20010567D0 (no) 2001-02-02
CN1217697C (zh) 2005-09-07
US20140128328A1 (en) 2014-05-08
JP2002524393A (ja) 2002-08-06
EP1698345A2 (en) 2006-09-06
KR20010072245A (ko) 2001-07-31
ZA200100829B (en) 2002-06-26
US7531504B2 (en) 2009-05-12
HUP0103321A3 (en) 2006-01-30
DE69931929T2 (de) 2007-02-08
US20060276399A1 (en) 2006-12-07
DE69931929D1 (de) 2006-07-27
DK1102596T3 (da) 2006-10-09
CN1679915A (zh) 2005-10-12
HUP0103321A2 (hu) 2001-12-28
HK1082210A1 (zh) 2006-06-02
KR100610389B1 (ko) 2006-08-09
CA2338005A1 (en) 2000-02-17
HU228079B1 (en) 2012-10-29
EP1102596A4 (en) 2002-08-14
US6670448B2 (en) 2003-12-30
CA2338005C (en) 2012-05-29
NO20010567L (no) 2001-04-02
US20020115825A1 (en) 2002-08-22
ATE480252T1 (de) 2010-09-15
RU2214267C2 (ru) 2003-10-20
US20080051349A1 (en) 2008-02-28
EP1698345A3 (en) 2006-09-13
IL141082A0 (en) 2002-02-10
AU745507B2 (en) 2002-03-21
CN1313772A (zh) 2001-09-19
NZ509579A (en) 2003-07-25
EP1102596B1 (en) 2006-06-14
AU5459099A (en) 2000-02-28
US7189696B2 (en) 2007-03-13
JP4822585B2 (ja) 2011-11-24
US7582603B2 (en) 2009-09-01
US20130190247A1 (en) 2013-07-25
US20110183923A1 (en) 2011-07-28
US6458925B1 (en) 2002-10-01
US20040082512A1 (en) 2004-04-29
EP1698345B1 (en) 2010-09-08
CN100348266C (zh) 2007-11-14
ES2267282T3 (es) 2007-03-01
WO2000007609A1 (en) 2000-02-17
IL141082A (en) 2012-09-24
US20090082279A1 (en) 2009-03-26

Similar Documents

Publication Publication Date Title
ATE329606T1 (de) Peptidantagonisten von zonulin und methoden zu deren verwendung
TR199801255T2 (xx) Vitronektin resept�r antagonistleri.
ATE416772T1 (de) Biphenylsulfonamide als zweifach aktive rezeptor antagonisten von angiotensin und endothelin
TR199801253T2 (xx) Vitronektin resept�r� antagonistleri.
TR200101398T2 (tr) Pirolidin türevleri-CCR-3 reseptörü antagonistleri.
DK0914331T3 (da) Neuroaktive peptider
DE69616480D1 (de) Piperidinderivate als neurokininantagonisten
ATE280826T1 (de) Cc-chemokinzeptor c-c ckr-5, dessen derivate und verwendungen
EP0584082A4 (en) Domains of extracellular region of human platelet derived growth factor receptor polypeptides
DE69939327D1 (de) Funktionelle antagonisten von hedgehog-aktivität
DK0982988T3 (da) I det væsentlige rent zonulin, en fysiologisk modulator af mammale tight junctions
ATE98376T1 (de) Synthetische htlv-iii-peptid-zusammensetzungen und ihre verwendung.
TR200002896T2 (tr) Kalsilitik Bileşimler
AU1667500A (en) N-(2-phenyl-4-piperidinybutyl)-5,6,7,8-tetrahydro-1-naphthal necarboxamides and their use as neurokinin 1 (nk1) and/or neurokinin 2 (nk2) receptor antagonists
CO5460266A1 (es) Novedosos analogos de la somatostatina
TR200102041T2 (tr) Progesteron reseptör bağlama aktif maddeleri olarak ikameli 2-arilimino heterosaykıllar
TR199900363T2 (xx) NK1 ve NK2 antagonistleri olarak asilaminoalkenilen-amid t�revleri.
DE69427484D1 (de) Angiotensin ii rezeptor typ i spezifische monoklonale antikörper und hybridoma
EA200000198A1 (ru) 2-ациламинопропанамины в качестве антагонистов рецепторов тахикининов
TR200002072T2 (tr) Spiropiperidin türevleri
TR199800152T1 (xx) Endotelin Resept�r Antagonistleri
DE69938130D1 (de) Neue peptide
MX9603045A (es) Antagonistas de los receptores endoteliales.
DE69526738D1 (de) Endothelin-rezeptor-antagonisten
TR200100354T2 (tr) NK-2 Antagonist hareketine sahip monosiklik bileşimler ve oluşumlar.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1102596

Country of ref document: EP