JP2002512976A5 - - Google Patents
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- Publication number
- JP2002512976A5 JP2002512976A5 JP2000545556A JP2000545556A JP2002512976A5 JP 2002512976 A5 JP2002512976 A5 JP 2002512976A5 JP 2000545556 A JP2000545556 A JP 2000545556A JP 2000545556 A JP2000545556 A JP 2000545556A JP 2002512976 A5 JP2002512976 A5 JP 2002512976A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- lhrh antagonist
- lhrh
- antagonist
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000009472 formulation Methods 0.000 description 36
- 239000000203 mixture Substances 0.000 description 36
- 238000000034 method Methods 0.000 description 19
- 239000002474 gonadorelin antagonist Substances 0.000 description 17
- 229940124041 Luteinizing hormone releasing hormone (LHRH) antagonist Drugs 0.000 description 14
- 208000033830 Hot Flashes Diseases 0.000 description 8
- 206010060800 Hot flush Diseases 0.000 description 8
- 201000000079 gynecomastia Diseases 0.000 description 5
- DCXYFEDJOCDNAF-UWTATZPHSA-N D-Asparagine Chemical compound OC(=O)[C@H](N)CC(N)=O DCXYFEDJOCDNAF-UWTATZPHSA-N 0.000 description 3
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 description 2
- 230000009245 menopause Effects 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 102000007698 Alcohol dehydrogenase Human genes 0.000 description 1
- 108010021809 Alcohol dehydrogenase Proteins 0.000 description 1
- 206010007270 Carcinoid syndrome Diseases 0.000 description 1
- 101000904173 Homo sapiens Progonadoliberin-1 Proteins 0.000 description 1
- 102100024028 Progonadoliberin-1 Human genes 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 101000996723 Sus scrofa Gonadotropin-releasing hormone receptor Proteins 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- XLXSAKCOAKORKW-UHFFFAOYSA-N gonadorelin Chemical compound C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 XLXSAKCOAKORKW-UHFFFAOYSA-N 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 229960001603 tamoxifen Drugs 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6714098A | 1998-04-27 | 1998-04-27 | |
| US09/067,140 | 1998-04-27 | ||
| PCT/US1999/009081 WO1999055358A1 (en) | 1998-04-27 | 1999-04-27 | Methods for treating hot flashes and gynaecomastia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002512976A JP2002512976A (ja) | 2002-05-08 |
| JP2002512976A5 true JP2002512976A5 (enExample) | 2006-06-15 |
Family
ID=22073965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000545556A Withdrawn JP2002512976A (ja) | 1998-04-27 | 1999-04-27 | のぼせおよび女性化乳房を処置するための方法 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1073454A4 (enExample) |
| JP (1) | JP2002512976A (enExample) |
| KR (1) | KR20010043014A (enExample) |
| CN (1) | CN1307481A (enExample) |
| AU (1) | AU770565B2 (enExample) |
| CA (1) | CA2329941A1 (enExample) |
| NZ (1) | NZ507504A (enExample) |
| WO (1) | WO1999055358A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070185032A1 (en) * | 1996-12-11 | 2007-08-09 | Praecis Pharmaceuticals, Inc. | Pharmaceutical formulations for sustained drug delivery |
| EP1330257B1 (en) * | 2000-10-30 | 2005-08-31 | University Of Zurich | Gnrh analogues for treatment of urinary incontinence |
| CA2481391A1 (en) * | 2002-04-12 | 2003-10-23 | Takeda Pharmaceutical Company Limited | Preventives/remedies for hotflash |
| US20060193825A1 (en) * | 2003-04-29 | 2006-08-31 | Praecis Phamaceuticals, Inc. | Pharmaceutical formulations for sustained drug delivery |
| WO2007021970A2 (en) * | 2005-08-15 | 2007-02-22 | Praecis Pharmaceuticals, Inc. | Stable pharmaceutical formulations and methods of use thereof |
| TW201244733A (en) | 2011-03-31 | 2012-11-16 | Shiseido Co Ltd | Hot flash suppressant |
| US9188731B2 (en) | 2012-05-18 | 2015-11-17 | Reald Inc. | Directional backlight |
| WO2013173786A1 (en) | 2012-05-18 | 2013-11-21 | Reald Inc. | Directional backlight |
| EP4123348B1 (en) | 2012-05-18 | 2024-04-10 | RealD Spark, LLC | Controlling light sources of a directional backlight |
| US9235057B2 (en) | 2012-05-18 | 2016-01-12 | Reald Inc. | Polarization recovery in a directional display device |
| US9678267B2 (en) | 2012-05-18 | 2017-06-13 | Reald Spark, Llc | Wide angle imaging directional backlights |
| JP2016529764A (ja) | 2013-06-17 | 2016-09-23 | リアルディー インコーポレイテッド | 指向性バックライトの光源の制御 |
| WO2015057625A1 (en) | 2013-10-14 | 2015-04-23 | Reald Inc. | Control of directional display |
| CN106062620B (zh) | 2013-10-14 | 2020-02-07 | 瑞尔D斯帕克有限责任公司 | 用于定向背光源的光输入 |
| CN106662773B (zh) | 2014-06-26 | 2021-08-06 | 瑞尔D 斯帕克有限责任公司 | 定向防窥显示器 |
| US9835792B2 (en) | 2014-10-08 | 2017-12-05 | Reald Spark, Llc | Directional backlight |
| US10356383B2 (en) | 2014-12-24 | 2019-07-16 | Reald Spark, Llc | Adjustment of perceived roundness in stereoscopic image of a head |
| US10459152B2 (en) | 2015-04-13 | 2019-10-29 | Reald Spark, Llc | Wide angle imaging directional backlights |
| CN108351951B (zh) | 2015-10-26 | 2023-02-07 | 瑞尔D斯帕克有限责任公司 | 智能隐私系统、设备及其方法 |
| WO2017083526A1 (en) | 2015-11-10 | 2017-05-18 | Reald Inc. | Distortion matching polarization conversion systems and methods thereof |
| EP3374822B1 (en) | 2015-11-13 | 2023-12-27 | RealD Spark, LLC | Surface features for imaging directional backlights |
| CN114143495B (zh) | 2016-01-05 | 2025-07-15 | 瑞尔D斯帕克有限责任公司 | 多视角图像的注视校正 |
| WO2022060673A1 (en) | 2020-09-16 | 2022-03-24 | Reald Spark, Llc | Vehicle external illumination device |
| US11966049B2 (en) | 2022-08-02 | 2024-04-23 | Reald Spark, Llc | Pupil tracking near-eye display |
| US12282168B2 (en) | 2022-08-11 | 2025-04-22 | Reald Spark, Llc | Anamorphic directional illumination device with selective light-guiding |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3724520C2 (de) * | 1986-07-31 | 1996-01-11 | Madaus Ag | Neue 3-Aryl-3-Cycloalkyl-piperidin-2,6-dion-Derivate |
| EP0301850A3 (en) * | 1987-07-31 | 1990-10-31 | Syntex (U.S.A.) Inc. | Lhrh antagonist analogs and 19-nor-progestational steroids for therapy |
| US4992421A (en) * | 1988-04-19 | 1991-02-12 | Abbott Laboratories | Luteinizing hormone releasing hormone antagonist |
| ATE144538T1 (de) * | 1991-04-25 | 1996-11-15 | Romano Deghenghi | Lhrh-antagonisten |
| US5843901A (en) * | 1995-06-07 | 1998-12-01 | Advanced Research & Technology Institute | LHRH antagonist peptides |
-
1999
- 1999-04-27 EP EP99920059A patent/EP1073454A4/en not_active Withdrawn
- 1999-04-27 CN CN99807942A patent/CN1307481A/zh active Pending
- 1999-04-27 WO PCT/US1999/009081 patent/WO1999055358A1/en not_active Ceased
- 1999-04-27 KR KR1020007011870A patent/KR20010043014A/ko not_active Ceased
- 1999-04-27 AU AU37642/99A patent/AU770565B2/en not_active Ceased
- 1999-04-27 JP JP2000545556A patent/JP2002512976A/ja not_active Withdrawn
- 1999-04-27 NZ NZ507504A patent/NZ507504A/en unknown
- 1999-04-27 CA CA002329941A patent/CA2329941A1/en not_active Abandoned
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