JP2004507496A5 - - Google Patents

Info

Publication number

JP2004507496A5

JP2004507496A5 JP2002522878A JP2002522878A JP2004507496A5 JP 2004507496 A5 JP2004507496 A5 JP 2004507496A5 JP 2002522878 A JP2002522878 A JP 2002522878A JP 2002522878 A JP2002522878 A JP 2002522878A JP 2004507496 A5 JP2004507496 A5 JP 2004507496A5

Authority

JP

Japan

Prior art keywords

asiaticoside

acid

composition

cancer

isolated

Prior art date

2001-02-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• WYQVAPGDARQUBT-XCWYDTOWSA-N asiaticoside Natural products O=C(O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]2[C@H](O)[C@H](O)[C@H](O[C@H]3[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O3)[C@@H](CO)O2)O1)[C@@]12[C@@H]([C@@H](C)[C@H](C)CC1)C=1[C@](C)([C@@]3(C)[C@@H]([C@@]4(C)[C@H]([C@@](CO)(C)[C@@H](O)[C@H](O)C4)CC3)CC=1)CC2 WYQVAPGDARQUBT-XCWYDTOWSA-N 0.000 description 11
• WYQVAPGDARQUBT-FGWHUCSPSA-N Madecassol Chemical group O([C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)O)OC[C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)[C@]12CC[C@H]([C@@H]([C@H]1C=1[C@@]([C@@]3(CC[C@H]4[C@](C)(CO)[C@@H](O)[C@H](O)C[C@]4(C)[C@H]3CC=1)C)(C)CC2)C)C)[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O WYQVAPGDARQUBT-FGWHUCSPSA-N 0.000 description 9
• 239000002253 acid Substances 0.000 description 9
• 229940022757 asiaticoside Drugs 0.000 description 9
• QCYLIQBVLZBPNK-UHFFFAOYSA-N asiaticoside A Natural products O1C(C(=O)C(C)C)=CC(C)C(C2(C(OC(C)=O)CC34C5)C)C1CC2(C)C3CCC(C1(C)C)C45CCC1OC1OCC(O)C(O)C1O QCYLIQBVLZBPNK-UHFFFAOYSA-N 0.000 description 9
• 239000000203 mixture Substances 0.000 description 8
• 238000000034 method Methods 0.000 description 6
• 206010028980 Neoplasm Diseases 0.000 description 5
• 201000011510 cancer Diseases 0.000 description 5
• 210000004027 cell Anatomy 0.000 description 5
• 230000001093 anti-cancer Effects 0.000 description 3
• 230000004663 cell proliferation Effects 0.000 description 3
• 239000000825 pharmaceutical preparation Substances 0.000 description 3
• 230000006907 apoptotic process Effects 0.000 description 2
• JXSVIVRDWWRQRT-UYDOISQJSA-N asiatic acid Chemical compound C1[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C)[C@H](C)[C@H]5C4=CC[C@@H]3[C@]21C JXSVIVRDWWRQRT-UYDOISQJSA-N 0.000 description 2
• 229940011658 asiatic acid Drugs 0.000 description 2
• LBGFKBYMNRAMFC-PYSQTNCISA-N asiatic acid Natural products C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]5CC[C@@]34C)[C@]2(C)[C@H]1C)C(=O)O LBGFKBYMNRAMFC-PYSQTNCISA-N 0.000 description 2
• 150000001875 compounds Chemical class 0.000 description 2
• CLXOLTFMHAXJST-UHFFFAOYSA-N esculentic acid Natural products C12CC=C3C4CC(C)(C(O)=O)CCC4(C(O)=O)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(CO)C CLXOLTFMHAXJST-UHFFFAOYSA-N 0.000 description 2
• 230000002401 inhibitory effect Effects 0.000 description 2
• 150000007513 acids Chemical class 0.000 description 1
• 230000005907 cancer growth Effects 0.000 description 1
• 230000010261 cell growth Effects 0.000 description 1
• 239000003937 drug carrier Substances 0.000 description 1
• 210000002919 epithelial cell Anatomy 0.000 description 1
• 239000008194 pharmaceutical composition Substances 0.000 description 1
• 208000024891 symptom Diseases 0.000 description 1
• 238000007910 systemic administration Methods 0.000 description 1