DK1313462T3 - Anvendelse af asiatisk syre eller asiaticosid til behandling af cancer - Google Patents
Anvendelse af asiatisk syre eller asiaticosid til behandling af cancerInfo
- Publication number
- DK1313462T3 DK1313462T3 DK01920974T DK01920974T DK1313462T3 DK 1313462 T3 DK1313462 T3 DK 1313462T3 DK 01920974 T DK01920974 T DK 01920974T DK 01920974 T DK01920974 T DK 01920974T DK 1313462 T3 DK1313462 T3 DK 1313462T3
- Authority
- DK
- Denmark
- Prior art keywords
- asiaticoside
- cancer
- treatment
- asian acid
- acid
- Prior art date
Links
- WYQVAPGDARQUBT-FGWHUCSPSA-N Madecassol Chemical compound O([C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)O)OC[C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)[C@]12CC[C@H]([C@@H]([C@H]1C=1[C@@]([C@@]3(CC[C@H]4[C@](C)(CO)[C@@H](O)[C@H](O)C[C@]4(C)[C@H]3CC=1)C)(C)CC2)C)C)[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O WYQVAPGDARQUBT-FGWHUCSPSA-N 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- WYQVAPGDARQUBT-XCWYDTOWSA-N asiaticoside Natural products O=C(O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]2[C@H](O)[C@H](O)[C@H](O[C@H]3[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O3)[C@@H](CO)O2)O1)[C@@]12[C@@H]([C@@H](C)[C@H](C)CC1)C=1[C@](C)([C@@]3(C)[C@@H]([C@@]4(C)[C@H]([C@@](CO)(C)[C@@H](O)[C@H](O)C4)CC3)CC=1)CC2 WYQVAPGDARQUBT-XCWYDTOWSA-N 0.000 title abstract 2
- 229940022757 asiaticoside Drugs 0.000 title abstract 2
- QCYLIQBVLZBPNK-UHFFFAOYSA-N asiaticoside A Natural products O1C(C(=O)C(C)C)=CC(C)C(C2(C(OC(C)=O)CC34C5)C)C1CC2(C)C3CCC(C1(C)C)C45CCC1OC1OCC(O)C(O)C1O QCYLIQBVLZBPNK-UHFFFAOYSA-N 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- JXSVIVRDWWRQRT-UYDOISQJSA-N asiatic acid Chemical compound C1[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C)[C@H](C)[C@H]5C4=CC[C@@H]3[C@]21C JXSVIVRDWWRQRT-UYDOISQJSA-N 0.000 abstract 1
- 229940011658 asiatic acid Drugs 0.000 abstract 1
- LBGFKBYMNRAMFC-PYSQTNCISA-N asiatic acid Natural products C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]5CC[C@@]34C)[C@]2(C)[C@H]1C)C(=O)O LBGFKBYMNRAMFC-PYSQTNCISA-N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- CLXOLTFMHAXJST-UHFFFAOYSA-N esculentic acid Natural products C12CC=C3C4CC(C)(C(O)=O)CCC4(C(O)=O)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(CO)C CLXOLTFMHAXJST-UHFFFAOYSA-N 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/739—Lipopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7012—Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MYPI20003987A MY138883A (en) | 2000-08-29 | 2000-08-29 | Use of asiatic acid for treatment of cencer |
| PCT/US2001/040103 WO2002017904A1 (en) | 2000-08-29 | 2001-02-14 | Use of asiatic acid or asiaticoside for treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1313462T3 true DK1313462T3 (da) | 2009-03-30 |
Family
ID=19749475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK01920974T DK1313462T3 (da) | 2000-08-29 | 2001-02-14 | Anvendelse af asiatisk syre eller asiaticosid til behandling af cancer |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20040097463A1 (enExample) |
| EP (1) | EP1313462B1 (enExample) |
| JP (2) | JP2004507496A (enExample) |
| AT (1) | ATE415962T1 (enExample) |
| AU (1) | AU2001247968A1 (enExample) |
| DE (1) | DE60136826D1 (enExample) |
| DK (1) | DK1313462T3 (enExample) |
| MY (1) | MY138883A (enExample) |
| WO (1) | WO2002017904A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030144312A1 (en) * | 2001-10-30 | 2003-07-31 | Schoenhard Grant L. | Inhibitors of ABC drug transporters in multidrug resistant cancer cells |
| KR100571886B1 (ko) | 2004-02-23 | 2006-04-17 | 학교법인 영남학원 | 아시아틱산을 포함하는 피부암 예방 또는 치료용 조성물 |
| EP1737493B1 (en) | 2004-02-25 | 2011-06-29 | Dana-Farber Cancer Institute, Inc. | Inhibitors of insulin-like growth factor receptor -1 for inhibiting tumor cell growth |
| WO2006012015A2 (en) * | 2004-06-29 | 2006-02-02 | Oregon Health And Science University | Methods and compositions for nerve regeneration |
| US20070010459A1 (en) * | 2005-01-14 | 2007-01-11 | Ying Liu | Application of asiatic acid and its derivatives to treat pulmonary fibrosis |
| CA2595749A1 (en) * | 2005-01-27 | 2006-08-03 | Research Development Foundation | Combination therapy with triterpenoid compounds and proteasome inhibitors |
| WO2009089365A2 (en) * | 2008-01-11 | 2009-07-16 | Shanghai Institute Of Pharmaceutical Industry (Sipi) | Therapeutic formulations based on asiatic acid and selected salts thereof |
| ES2836128T3 (es) | 2008-04-16 | 2021-06-24 | Univ Johns Hopkins | Método para determinar variantes del receptor de andrógenos en cáncer de próstata |
| US8835506B2 (en) | 2008-06-05 | 2014-09-16 | Stc.Unm | Methods and related compositions for the treatment of cancer |
| KR101808750B1 (ko) | 2009-12-21 | 2017-12-13 | 피렐리 타이어 소시에떼 퍼 아찌오니 | 타이어를 제조하는 공정 및 장치 |
| CA2802154C (en) | 2010-06-10 | 2017-02-28 | Indus Biotech Private Limited | A method for preparation of highly pure asiaticoside composition from centella asiatica and a method of use thereof |
| WO2012104241A1 (de) * | 2011-01-31 | 2012-08-09 | LUCOLAS-M.D. Ltd | Kombinationen von aromatase inhibitoren und antioxidanzien |
| US20140194368A1 (en) * | 2013-01-04 | 2014-07-10 | Beech Tree Labs, Inc. | Method of Treating Cancer by Administration of Low Levels of Heat Shock Protein 70 (HSP70) |
| KR20150127720A (ko) | 2013-03-14 | 2015-11-17 | 유니버시티 오브 매릴랜드, 발티모어 | 안드로겐 수용체 하향 조절제 및 그의 용도 |
| CN110251675A (zh) | 2013-05-03 | 2019-09-20 | 西莱克塔生物科技公司 | 降低或预防响应于非变应原性抗原的过敏反应的致耐受性合成纳米载体 |
| WO2015023710A1 (en) | 2013-08-12 | 2015-02-19 | Tokai Pharmaceuticals, Inc. | Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies |
| WO2015179404A1 (en) | 2014-05-19 | 2015-11-26 | The Johns Hopkins University | Methods for identifying androgen receptor splice variants in subjects having castration resistant prostate cancer |
| US11345956B2 (en) | 2014-08-25 | 2022-05-31 | The Johns Hopkins University | Methods and compositions related to prostate cancer therapeutics |
| EP3124047A1 (en) * | 2015-07-28 | 2017-02-01 | Merz Pharma GmbH & Co. KGaA | Pentacyclic triterpenoids for injection lipolysis |
| US20180228815A1 (en) * | 2016-11-09 | 2018-08-16 | The Chinese University Of Hong Kong | Naringenin and asiatic acid combination treatment of cancers |
| ES3036482T3 (en) | 2017-03-11 | 2025-09-19 | Cartesian Therapeutics Inc | Methods and compositions related to combined treatment with anti-inflammatories and synthetic nanocarriers comprising an immunosuppressant |
| WO2019200585A1 (en) * | 2018-04-19 | 2019-10-24 | The Chinese University Of Hong Kong | Naringenin and asiatic acid combination treatment of cancers |
| WO2020078454A1 (en) * | 2018-10-18 | 2020-04-23 | Sinomab Bioscience Limited | Method of modulating autoimmunity by disrupting cis‐ligand binding of siglec type antigens |
| CN109528735B (zh) * | 2019-01-30 | 2021-03-12 | 中国药科大学 | 积雪草苷在制备治疗皮肤癌药物中的新用途 |
| AU2020287627A1 (en) | 2019-06-04 | 2021-11-18 | Selecta Biosciences, Inc. | Formulations and doses of PEGylated uricase |
| CN110200981A (zh) * | 2019-06-06 | 2019-09-06 | 中国药科大学 | 五环三萜皂苷的医药用途及其药物组合物 |
| US20240034788A1 (en) * | 2020-08-20 | 2024-02-01 | The Board Of Trustees Of The Leland Stanford Junior University | Abscopal therapy for cancer |
| US20250275978A1 (en) * | 2024-03-04 | 2025-09-04 | Cardiff Oncology, Inc. | Use of onvansertib as monotherapy and in combination with cetuximab in treating ras wild-type colorectal cancer |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB923414A (en) * | 1960-04-13 | 1963-04-10 | Laroche Navarron Lab | Therapeutic compositions comprising asiatic and arjunolic acids |
| IT1203515B (it) * | 1987-02-26 | 1989-02-15 | Indena Spa | Complessi di saponine con fosfolipidi e composizioni farmaceutiche e cosmetiche che li contengono |
| EP0383171A3 (en) * | 1989-02-11 | 1991-07-24 | Hoechst Aktiengesellschaft | 2,3,23-trihydroxy-urs-12-ene derivatives for treating cognitive disorders |
| FR2714598B1 (fr) * | 1993-12-30 | 1996-02-09 | Oreal | Composition amincissante à deux types de liposomes pour traitement topique, son utilisation. |
| JPH08133952A (ja) * | 1994-11-07 | 1996-05-28 | Shiseido Co Ltd | 皮膚外用剤 |
| WO1998023575A1 (en) * | 1996-11-27 | 1998-06-04 | Dong Kook Pharmaceutical Co., Ltd. | Asiatic acid derivatives having modified a-ring |
| IT1288257B1 (it) * | 1996-11-29 | 1998-09-11 | Paoli Ambrosi Gianfranco De | Composizione per uso cosmetico,farmaceutico o dietetico a base di un aminozucchero e/o di un acido poliidrossilico |
| FR2763336B1 (fr) * | 1997-05-14 | 1999-08-06 | Lvmh Rech | Esters de tocopherol et leurs utilisations en cosmetique et pharmacie |
| RU2007101074A (ru) * | 2004-06-14 | 2008-07-20 | Зозер Б. САЛАМА (DE) | Фармацевтическая противораковая композиция пролина или его производных и противоопухолевого антитела |
-
2000
- 2000-08-29 MY MYPI20003987A patent/MY138883A/en unknown
-
2001
- 2001-02-14 AU AU2001247968A patent/AU2001247968A1/en not_active Abandoned
- 2001-02-14 AT AT01920974T patent/ATE415962T1/de not_active IP Right Cessation
- 2001-02-14 EP EP01920974A patent/EP1313462B1/en not_active Expired - Lifetime
- 2001-02-14 JP JP2002522878A patent/JP2004507496A/ja active Pending
- 2001-02-14 DK DK01920974T patent/DK1313462T3/da active
- 2001-02-14 US US10/362,720 patent/US20040097463A1/en not_active Abandoned
- 2001-02-14 WO PCT/US2001/040103 patent/WO2002017904A1/en not_active Ceased
- 2001-02-14 DE DE60136826T patent/DE60136826D1/de not_active Expired - Lifetime
-
2011
- 2011-11-24 JP JP2011256721A patent/JP5421340B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2001247968A1 (en) | 2002-03-13 |
| JP2012092110A (ja) | 2012-05-17 |
| MY138883A (en) | 2009-08-28 |
| US20040097463A1 (en) | 2004-05-20 |
| EP1313462B1 (en) | 2008-12-03 |
| ATE415962T1 (de) | 2008-12-15 |
| WO2002017904A1 (en) | 2002-03-07 |
| JP5421340B2 (ja) | 2014-02-19 |
| JP2004507496A (ja) | 2004-03-11 |
| DE60136826D1 (de) | 2009-01-15 |
| EP1313462A1 (en) | 2003-05-28 |
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