JPH10507207A - エストロゲン欠乏を正すための新規なホルモン医薬及びその使用 - Google Patents
エストロゲン欠乏を正すための新規なホルモン医薬及びその使用Info
- Publication number
- JPH10507207A JPH10507207A JP9507406A JP50740697A JPH10507207A JP H10507207 A JPH10507207 A JP H10507207A JP 9507406 A JP9507406 A JP 9507406A JP 50740697 A JP50740697 A JP 50740697A JP H10507207 A JPH10507207 A JP H10507207A
- Authority
- JP
- Japan
- Prior art keywords
- estrogen
- estradiol
- progestogen
- mixture
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. 閉経期婦人におけるエストロゲン欠乏を治療するためのエストロゲン−プ ロゲストーゲン混合物の使用であって、月の全期間を通して、エストロゲン単独 の、エストロゲン/プロゲストーゲン組合せの、そして最後にプラセボの経口に よる投与を含む使用。 2. 該エストロゲンが17β−エストラジオールである、請求項1の混合物の 使用。 3. 該プロゲストーゲンが酢酸ノメゲストロールである、請求項1の混合物の 使用。 4. 該エストロゲン単独が17β−エストラジオールの錠の形で10日間投与さ れるものである、請求項1又は2のエストロゲン−プロゲストーゲン混合物の使 用。 5. エストロゲンとプロゲストーゲンの該組合せが14日間連続して投与される ものである、請求項1乃至3の何れかのエストロゲン−プロゲストーゲン混合物 の使用。 6. 該プラセボ錠が6日間連続して投与されるものである、請求項1のエスト ロゲン−プロゲストーゲン混合物の使用。 7. 該17β−エストラジオールが単位投与量当たり1乃至3mgの範囲の投 与量で存在するものである、請求項1のエストロゲン組成物。 8. 17β−エストラジオールが1乃至3mgの範囲の投与量で存在しそして 酢酸ノメゲストロール1.5 乃至6mgの範囲の投与量で存在するものである、請 求項1のエストロゲン−プロゲストーゲン組成物。 9. 17β−エストラジオールが1乃至2mgの範囲の投与量、より好ましく は1.5 mgの投与量で存在するものである、請求項7の組成物。 10. 17β−エストラジオールが1乃至2mgの範囲の投与量で存在しそし て酢酸ノメゲストロールが2.5 乃至5mgの範囲の投与量で存在する、請求項7 又は8の組成物。 11. 請求項7のエストロゲン組成物の製造のための方法であって、エストラ ジオールを親水性結合剤中に分散させ次いで不活性な希釈剤及び圧縮のための結 合剤を加え、固まりを造粒し、顆粒を乾燥させ、そしてこれを粉砕することより なり、この混合物が酢酸ノメゲストロール及び、17β−エストラジオール及び 酢酸ノメゲストロールを含有する錠剤を形成するために圧縮のための添加剤が加 えられてよいものである、方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9509364A FR2737411B1 (fr) | 1995-08-01 | 1995-08-01 | Nouveaux medicaments hormonaux et leur utilisation pour la correction des carences estrogeniques |
FR95/09364 | 1995-08-01 | ||
PCT/IB1996/000754 WO1997004784A1 (fr) | 1995-08-01 | 1996-07-29 | Nouveaux medicaments hormonaux et leur utilisation pour la correction des carences estrogeniques |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH10507207A true JPH10507207A (ja) | 1998-07-14 |
Family
ID=9481610
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9507406A Ceased JPH10507207A (ja) | 1995-08-01 | 1996-07-29 | エストロゲン欠乏を正すための新規なホルモン医薬及びその使用 |
Country Status (31)
Country | Link |
---|---|
US (1) | US5891867A (ja) |
EP (1) | EP0783310B1 (ja) |
JP (1) | JPH10507207A (ja) |
KR (1) | KR100450649B1 (ja) |
CN (1) | CN1138547C (ja) |
AP (1) | AP829A (ja) |
AR (1) | AR004502A1 (ja) |
AT (1) | ATE225659T1 (ja) |
AU (1) | AU722355B2 (ja) |
BR (1) | BR9606549A (ja) |
CA (1) | CA2201368C (ja) |
CZ (1) | CZ289706B6 (ja) |
DE (1) | DE69624214T2 (ja) |
DK (1) | DK0783310T3 (ja) |
DZ (1) | DZ2078A1 (ja) |
ES (1) | ES2184880T3 (ja) |
FR (1) | FR2737411B1 (ja) |
HK (1) | HK1005227A1 (ja) |
HU (1) | HU229843B1 (ja) |
IL (1) | IL120558A (ja) |
MA (1) | MA23946A1 (ja) |
MX (1) | MX9702381A (ja) |
MY (1) | MY117307A (ja) |
NO (1) | NO312996B1 (ja) |
OA (1) | OA10411A (ja) |
PT (1) | PT783310E (ja) |
RU (1) | RU2188641C2 (ja) |
TN (1) | TNSN96101A1 (ja) |
TW (1) | TW473390B (ja) |
WO (1) | WO1997004784A1 (ja) |
ZA (1) | ZA966545B (ja) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001030355A1 (fr) * | 1999-10-25 | 2001-05-03 | Laboratoire Theramex | Medicament contraceptif a base d'un progestatif et d'un estrogene et son mode de preparation |
FR2754179B1 (fr) * | 1996-10-08 | 1998-12-24 | Theramex | Nouvelle composition hormononale et son utilisation |
US6787531B1 (en) * | 1999-08-31 | 2004-09-07 | Schering Ag | Pharmaceutical composition for use as a contraceptive |
WO2001030356A1 (fr) | 1999-10-25 | 2001-05-03 | Laboratoire Theramex | Composition hormonale a base d'un progestatif et d'un estrogene et son utilisation |
US20020132801A1 (en) * | 2001-01-11 | 2002-09-19 | Schering Aktiengesellschaft | Drospirenone for hormone replacement therapy |
FR2814074B1 (fr) * | 2000-09-15 | 2003-03-07 | Theramex | Nouvelles compositions estro-progestatives topiques a effet systemique |
US20020151732A1 (en) * | 2001-01-05 | 2002-10-17 | Claes Ohlsson | Estrogen receptors |
AU2002309919B2 (en) * | 2001-05-16 | 2008-04-10 | Barr Laboratories, Inc. | Treatment of conditions relating to hormone deficiencies by administration of progestins |
BRPI0214716B8 (pt) * | 2001-12-05 | 2021-05-25 | Teva Womens Health Inc | kit, preparos, e uso de estrogênio e progestina na fabricação de um medicamento para uso na prevenção de gravidez |
US7008979B2 (en) * | 2002-04-30 | 2006-03-07 | Hydromer, Inc. | Coating composition for multiple hydrophilic applications |
CN101001631B (zh) * | 2003-07-16 | 2014-08-06 | 特卫华妇女健康有限公司 | 利用连续给予雌激素的避孕方案的激素治疗方法 |
US20070111975A1 (en) * | 2004-10-07 | 2007-05-17 | Duramed Pharmaceuticals, Inc. | Methods of Hormonal Treatment Utilizing Ascending-Dose Extended Cycle Regimens |
US8022053B2 (en) * | 2004-11-02 | 2011-09-20 | Bayer Schering Pharma Aktiengesellschaft | Oral solid dosage forms containing a low dose of estradiol |
PE20081895A1 (es) * | 2007-03-26 | 2009-01-26 | Theramex | Regimen anticonceptivo oral |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4390531A (en) * | 1981-08-10 | 1983-06-28 | Syntex Pharmaceuticals International Ltd. | Method of contraception using peak progestogen dosage |
US4826831A (en) * | 1983-08-05 | 1989-05-02 | Pre Jay Holdings Limited | Method of hormonal treatment for menopausal or post-menopausal disorders involving continuous administration of progestogens and estrogens |
FR2695826B1 (fr) * | 1992-09-21 | 1995-01-06 | Theramex | Nouvelles compositions pharmaceutiques à base de dérivés de nomégestrol et leurs procédés d'obtention. |
-
1995
- 1995-08-01 FR FR9509364A patent/FR2737411B1/fr not_active Expired - Fee Related
-
1996
- 1996-07-22 MA MA24321A patent/MA23946A1/fr unknown
- 1996-07-26 MY MYPI96003099A patent/MY117307A/en unknown
- 1996-07-29 BR BR9606549A patent/BR9606549A/pt not_active Application Discontinuation
- 1996-07-29 EP EP96923018A patent/EP0783310B1/fr not_active Expired - Lifetime
- 1996-07-29 KR KR1019970702125A patent/KR100450649B1/ko not_active IP Right Cessation
- 1996-07-29 ES ES96923018T patent/ES2184880T3/es not_active Expired - Lifetime
- 1996-07-29 JP JP9507406A patent/JPH10507207A/ja not_active Ceased
- 1996-07-29 CZ CZ1997967A patent/CZ289706B6/cs not_active IP Right Cessation
- 1996-07-29 DK DK96923018T patent/DK0783310T3/da active
- 1996-07-29 CN CNB96191100XA patent/CN1138547C/zh not_active Expired - Lifetime
- 1996-07-29 WO PCT/IB1996/000754 patent/WO1997004784A1/fr not_active Application Discontinuation
- 1996-07-29 CA CA2201368A patent/CA2201368C/fr not_active Expired - Lifetime
- 1996-07-29 RU RU97108279/14A patent/RU2188641C2/ru active
- 1996-07-29 DE DE69624214T patent/DE69624214T2/de not_active Expired - Lifetime
- 1996-07-29 MX MX9702381A patent/MX9702381A/es active IP Right Grant
- 1996-07-29 AU AU63674/96A patent/AU722355B2/en not_active Expired
- 1996-07-29 AT AT96923018T patent/ATE225659T1/de active
- 1996-07-29 AP APAP/P/1997/000979A patent/AP829A/en active
- 1996-07-29 US US08/817,329 patent/US5891867A/en not_active Expired - Lifetime
- 1996-07-29 HU HU9900612A patent/HU229843B1/hu unknown
- 1996-07-29 PT PT96923018T patent/PT783310E/pt unknown
- 1996-07-29 IL IL12055896A patent/IL120558A/en not_active IP Right Cessation
- 1996-07-30 DZ DZ960122A patent/DZ2078A1/fr active
- 1996-07-31 AR ARP960103818A patent/AR004502A1/es not_active Application Discontinuation
- 1996-08-01 TN TNTNSN96101A patent/TNSN96101A1/fr unknown
- 1996-08-01 ZA ZA966545A patent/ZA966545B/xx unknown
- 1996-09-24 TW TW085111673A patent/TW473390B/zh not_active IP Right Cessation
-
1997
- 1997-03-26 NO NO19971449A patent/NO312996B1/no not_active IP Right Cessation
- 1997-04-01 OA OA60985A patent/OA10411A/fr unknown
-
1998
- 1998-05-25 HK HK98104497A patent/HK1005227A1/xx not_active IP Right Cessation
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20070320 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20070615 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20070807 |
|
A313 | Final decision of rejection without a dissenting response from the applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A313 Effective date: 20071226 |
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A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20080205 |