JP2003534287A5 - - Google Patents
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- Publication number
- JP2003534287A5 JP2003534287A5 JP2001585794A JP2001585794A JP2003534287A5 JP 2003534287 A5 JP2003534287 A5 JP 2003534287A5 JP 2001585794 A JP2001585794 A JP 2001585794A JP 2001585794 A JP2001585794 A JP 2001585794A JP 2003534287 A5 JP2003534287 A5 JP 2003534287A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- composition
- peptide antagonist
- composition according
- diabetes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 description 19
- 229940083963 Peptide antagonist Drugs 0.000 description 7
- 125000003275 alpha amino acid group Chemical group 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 102100025255 Haptoglobin Human genes 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 108010027843 zonulin Proteins 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20530500P | 2000-05-19 | 2000-05-19 | |
| US60/205,305 | 2000-05-19 | ||
| PCT/US2001/005825 WO2001089551A1 (en) | 2000-05-19 | 2001-03-21 | Method of use of peptide antagonists of zonulin to prevent or delay the onset of diabetes |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007302283A Division JP2008074869A (ja) | 2000-05-19 | 2007-11-21 | 糖尿病発症を予防または遅延させるためのゾヌリンのペプチドアンタゴニストの使用方法 |
| JP2011169654A Division JP2011213742A (ja) | 2000-05-19 | 2011-08-02 | 糖尿病発症を予防または遅延させるためのゾヌリンのペプチドアンタゴニストの使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003534287A JP2003534287A (ja) | 2003-11-18 |
| JP2003534287A5 true JP2003534287A5 (enExample) | 2007-12-06 |
Family
ID=22761653
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001585794A Pending JP2003534287A (ja) | 2000-05-19 | 2001-03-21 | 糖尿病発症を予防または遅延させるためのゾヌリンのペプチドアンタゴニストの使用方法 |
| JP2007302283A Pending JP2008074869A (ja) | 2000-05-19 | 2007-11-21 | 糖尿病発症を予防または遅延させるためのゾヌリンのペプチドアンタゴニストの使用方法 |
| JP2011169654A Pending JP2011213742A (ja) | 2000-05-19 | 2011-08-02 | 糖尿病発症を予防または遅延させるためのゾヌリンのペプチドアンタゴニストの使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007302283A Pending JP2008074869A (ja) | 2000-05-19 | 2007-11-21 | 糖尿病発症を予防または遅延させるためのゾヌリンのペプチドアンタゴニストの使用方法 |
| JP2011169654A Pending JP2011213742A (ja) | 2000-05-19 | 2011-08-02 | 糖尿病発症を予防または遅延させるためのゾヌリンのペプチドアンタゴニストの使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (6) | US7026294B2 (enExample) |
| EP (1) | EP1282432B1 (enExample) |
| JP (3) | JP2003534287A (enExample) |
| AT (1) | ATE438405T1 (enExample) |
| AU (1) | AU2001249067A1 (enExample) |
| CA (1) | CA2409771C (enExample) |
| DE (1) | DE60139466D1 (enExample) |
| WO (1) | WO2001089551A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6458925B1 (en) * | 1998-08-03 | 2002-10-01 | University Of Maryland, Baltimore | Peptide antagonists of zonulin and methods for use of the same |
| JP2003534287A (ja) * | 2000-05-19 | 2003-11-18 | ユニバーシティ・オブ・メリーランド， ボルティモア | 糖尿病発症を予防または遅延させるためのゾヌリンのペプチドアンタゴニストの使用方法 |
| CA2531491A1 (en) * | 2003-07-15 | 2005-02-03 | University Of Maryland, Baltimore | Agonist polypeptide of receptor for zot and zonulin |
| US20090176244A1 (en) * | 2005-05-13 | 2009-07-09 | Bai Julio | Methods and compositions for the diagnosis of crohn's disease |
| TW200716159A (en) * | 2005-06-09 | 2007-05-01 | Univ Maryland | Method of use of antagonists of zonulin to prevent the loss of or to regenerate pancreatic cells |
| AU2012203787B2 (en) * | 2006-02-09 | 2014-07-10 | Alba Therapeutics Corporation | Formulations for a Tight Junction Effector |
| BRPI0707616A2 (pt) | 2006-02-09 | 2011-05-10 | Alba Therapuetics Corp | formulaÇÕes para um efetor de junÇço oclusiva |
| US20090069247A1 (en) * | 2006-10-06 | 2009-03-12 | Blake Paterson | Use of tight junction antagonists to treat inflammatory bowel disease |
| US8034776B2 (en) * | 2006-10-26 | 2011-10-11 | Alba Therapeutics Corporation | Materials and methods for the treatment of celiac disease |
| EP2091551B1 (en) * | 2006-11-03 | 2020-01-15 | Alba Therapeutics Corporation | Method of treating asthma |
| AT504214B1 (de) * | 2007-01-03 | 2008-04-15 | Bernhard Hans Peter Dipl Ing D | Verfahren zur dynamischen, datenabhängigen bestimmung und anwendung von berechtigungen in hierarchischen und relationalen umgebungen |
| US8728491B2 (en) * | 2007-05-07 | 2014-05-20 | Alba Therapeutics Corporation | Transcutaneous delivery of therapeutic agents |
| WO2009006246A1 (en) * | 2007-06-29 | 2009-01-08 | Alea Therapeutics Corp. | Use of tight junction antagonists in the treatment of acute long injury and acute respiratory distress syndrome |
| WO2009015382A2 (en) | 2007-07-26 | 2009-01-29 | Alba Therapeutics Corporation | Novel peptides that enhance tight junction permeability |
| US9051349B2 (en) | 2007-11-21 | 2015-06-09 | Alba Therapeutics Corporation | Larazotide acetate compositions |
| EP2062909A1 (en) * | 2007-11-21 | 2009-05-27 | SOLVAY (Société Anonyme) | Peptide production and purification process |
| WO2009137436A2 (en) * | 2008-05-05 | 2009-11-12 | Alba Therapeutics Corporation | Peptide conjugates |
| US8957032B2 (en) | 2008-05-06 | 2015-02-17 | Alba Therapeutics Corporation | Inhibition of gliadin peptides |
| KR20190121785A (ko) | 2017-02-10 | 2019-10-28 | 이노베이트 바이오파마슈티컬스, 인코포레이티드 | 장 상피의 투과성과 관련된 질환을 치료하기 위한 조성물 및 방법 |
| KR20180107341A (ko) * | 2017-03-16 | 2018-10-02 | 차의과학대학교 산학협력단 | 칼륨 경쟁적 위산분비억제제를 유효성분을 함유하는 장 누수 증후군 치료 및 예방용 조성물 |
| WO2019165346A1 (en) | 2018-02-23 | 2019-08-29 | Innovate Biopharmaceuticals, Inc. | Compounds and methods for treating tight junction permeability |
| US20210069286A1 (en) * | 2018-04-09 | 2021-03-11 | 9 Meters Biopharma, Inc. | Compositions and methods for treating or preventing hyperglycemia, insulin resistance, and associated organ damage |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5936065A (en) * | 1993-12-06 | 1999-08-10 | Cytel Corporation | CS-1 peptidomimetics, compositions and methods of using the same |
| US6057294A (en) * | 1995-01-16 | 2000-05-02 | Northern Sydney Area Health Service Of Pacific Highway | Peptide |
| US5665389A (en) | 1995-05-24 | 1997-09-09 | University Of Maryland At Baltimore | Oral dosage composition for intestinal delivery and method of treating diabetes |
| AU739130B2 (en) * | 1996-06-11 | 2001-10-04 | Northern Sydney And Central Coast Area Health Service | T cell antigen receptor peptides |
| US5945510A (en) * | 1997-05-21 | 1999-08-31 | University Of Maryland, Baltimore | Substantially pure zonulin, a physiological modulator of mammalian tight junctions |
| US6458925B1 (en) | 1998-08-03 | 2002-10-01 | University Of Maryland, Baltimore | Peptide antagonists of zonulin and methods for use of the same |
| JP2003534287A (ja) * | 2000-05-19 | 2003-11-18 | ユニバーシティ・オブ・メリーランド， ボルティモア | 糖尿病発症を予防または遅延させるためのゾヌリンのペプチドアンタゴニストの使用方法 |
| US7025294B2 (en) * | 2003-05-20 | 2006-04-11 | Carter Day International, Inc. | Hammermill with stub shaft rotor apparatus and method |
| BRPI0707616A2 (pt) * | 2006-02-09 | 2011-05-10 | Alba Therapuetics Corp | formulaÇÕes para um efetor de junÇço oclusiva |
| US20090069247A1 (en) * | 2006-10-06 | 2009-03-12 | Blake Paterson | Use of tight junction antagonists to treat inflammatory bowel disease |
| US8034776B2 (en) * | 2006-10-26 | 2011-10-11 | Alba Therapeutics Corporation | Materials and methods for the treatment of celiac disease |
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2001
- 2001-03-21 JP JP2001585794A patent/JP2003534287A/ja active Pending
- 2001-03-21 AU AU2001249067A patent/AU2001249067A1/en not_active Abandoned
- 2001-03-21 US US10/275,877 patent/US7026294B2/en not_active Expired - Lifetime
- 2001-03-21 CA CA002409771A patent/CA2409771C/en not_active Expired - Lifetime
- 2001-03-21 AT AT01922244T patent/ATE438405T1/de not_active IP Right Cessation
- 2001-03-21 DE DE60139466T patent/DE60139466D1/de not_active Expired - Lifetime
- 2001-03-21 EP EP01922244A patent/EP1282432B1/en not_active Expired - Lifetime
- 2001-03-21 WO PCT/US2001/005825 patent/WO2001089551A1/en not_active Ceased
-
2006
- 2006-02-03 US US11/346,395 patent/US7531512B2/en not_active Expired - Fee Related
-
2007
- 2007-11-21 JP JP2007302283A patent/JP2008074869A/ja active Pending
-
2008
- 2008-06-30 US US12/165,088 patent/US20080269136A1/en not_active Abandoned
-
2009
- 2009-08-05 US US12/536,158 patent/US8183211B2/en not_active Expired - Fee Related
-
2011
- 2011-08-02 JP JP2011169654A patent/JP2011213742A/ja active Pending
-
2012
- 2012-05-01 US US13/461,343 patent/US20130157943A1/en not_active Abandoned
-
2013
- 2013-11-01 US US14/070,212 patent/US20140128321A1/en not_active Abandoned