JP2003534287A - 糖尿病発症を予防または遅延させるためのゾヌリンのペプチドアンタゴニストの使用方法 - Google Patents
糖尿病発症を予防または遅延させるためのゾヌリンのペプチドアンタゴニストの使用方法Info
- Publication number
- JP2003534287A JP2003534287A JP2001585794A JP2001585794A JP2003534287A JP 2003534287 A JP2003534287 A JP 2003534287A JP 2001585794 A JP2001585794 A JP 2001585794A JP 2001585794 A JP2001585794 A JP 2001585794A JP 2003534287 A JP2003534287 A JP 2003534287A
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- Prior art keywords
- diabetes
- seq
- zonulin
- peptide antagonist
- rats
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/843—Digestive system
- Y10S530/844—Stomach; intestine
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Nutrition Science (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20530500P | 2000-05-19 | 2000-05-19 | |
| US60/205,305 | 2000-05-19 | ||
| PCT/US2001/005825 WO2001089551A1 (en) | 2000-05-19 | 2001-03-21 | Method of use of peptide antagonists of zonulin to prevent or delay the onset of diabetes |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007302283A Division JP2008074869A (ja) | 2000-05-19 | 2007-11-21 | 糖尿病発症を予防または遅延させるためのゾヌリンのペプチドアンタゴニストの使用方法 |
| JP2011169654A Division JP2011213742A (ja) | 2000-05-19 | 2011-08-02 | 糖尿病発症を予防または遅延させるためのゾヌリンのペプチドアンタゴニストの使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003534287A true JP2003534287A (ja) | 2003-11-18 |
| JP2003534287A5 JP2003534287A5 (enExample) | 2007-12-06 |
Family
ID=22761653
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001585794A Pending JP2003534287A (ja) | 2000-05-19 | 2001-03-21 | 糖尿病発症を予防または遅延させるためのゾヌリンのペプチドアンタゴニストの使用方法 |
| JP2007302283A Pending JP2008074869A (ja) | 2000-05-19 | 2007-11-21 | 糖尿病発症を予防または遅延させるためのゾヌリンのペプチドアンタゴニストの使用方法 |
| JP2011169654A Pending JP2011213742A (ja) | 2000-05-19 | 2011-08-02 | 糖尿病発症を予防または遅延させるためのゾヌリンのペプチドアンタゴニストの使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007302283A Pending JP2008074869A (ja) | 2000-05-19 | 2007-11-21 | 糖尿病発症を予防または遅延させるためのゾヌリンのペプチドアンタゴニストの使用方法 |
| JP2011169654A Pending JP2011213742A (ja) | 2000-05-19 | 2011-08-02 | 糖尿病発症を予防または遅延させるためのゾヌリンのペプチドアンタゴニストの使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (6) | US7026294B2 (enExample) |
| EP (1) | EP1282432B1 (enExample) |
| JP (3) | JP2003534287A (enExample) |
| AT (1) | ATE438405T1 (enExample) |
| AU (1) | AU2001249067A1 (enExample) |
| CA (1) | CA2409771C (enExample) |
| DE (1) | DE60139466D1 (enExample) |
| WO (1) | WO2001089551A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009527468A (ja) * | 2006-02-09 | 2009-07-30 | アルバ セラピューティクス コーポレーション | タイトジャンクション・エフェクター用製剤 |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6458925B1 (en) * | 1998-08-03 | 2002-10-01 | University Of Maryland, Baltimore | Peptide antagonists of zonulin and methods for use of the same |
| WO2001089551A1 (en) * | 2000-05-19 | 2001-11-29 | University Of Maryland, Baltimore | Method of use of peptide antagonists of zonulin to prevent or delay the onset of diabetes |
| AU2004259705B2 (en) * | 2003-07-15 | 2009-04-23 | University Of Maryland, Baltimore | Agonist polypeptide of receptor for zot and zonulin |
| US20090176244A1 (en) * | 2005-05-13 | 2009-07-09 | Bai Julio | Methods and compositions for the diagnosis of crohn's disease |
| TW200716159A (en) * | 2005-06-09 | 2007-05-01 | Univ Maryland | Method of use of antagonists of zonulin to prevent the loss of or to regenerate pancreatic cells |
| AU2012203787B2 (en) * | 2006-02-09 | 2014-07-10 | Alba Therapeutics Corporation | Formulations for a Tight Junction Effector |
| WO2008043107A2 (en) * | 2006-10-06 | 2008-04-10 | Alba Therapeutics Corporation | Use of tight junction antagonists to treat inflammatory bowel disease |
| WO2008052185A2 (en) * | 2006-10-26 | 2008-05-02 | Alba Therapeutics Corp | Materials and methods for the treatment of celiac disease |
| EP2091551B1 (en) * | 2006-11-03 | 2020-01-15 | Alba Therapeutics Corporation | Method of treating asthma |
| AT504214B1 (de) * | 2007-01-03 | 2008-04-15 | Bernhard Hans Peter Dipl Ing D | Verfahren zur dynamischen, datenabhängigen bestimmung und anwendung von berechtigungen in hierarchischen und relationalen umgebungen |
| US8728491B2 (en) * | 2007-05-07 | 2014-05-20 | Alba Therapeutics Corporation | Transcutaneous delivery of therapeutic agents |
| US20110201543A1 (en) * | 2007-06-29 | 2011-08-18 | Blake Paterson | Use of tight junction antagonists in the treatment of acute lung injury and acute respiratory distress |
| US8198233B2 (en) | 2007-07-26 | 2012-06-12 | Alba Therapeutics Corporation | Synthetic peptides that enhance tight junction permeability |
| US9051349B2 (en) | 2007-11-21 | 2015-06-09 | Alba Therapeutics Corporation | Larazotide acetate compositions |
| EP2062909A1 (en) | 2007-11-21 | 2009-05-27 | SOLVAY (Société Anonyme) | Peptide production and purification process |
| WO2009137436A2 (en) * | 2008-05-05 | 2009-11-12 | Alba Therapeutics Corporation | Peptide conjugates |
| US8957032B2 (en) | 2008-05-06 | 2015-02-17 | Alba Therapeutics Corporation | Inhibition of gliadin peptides |
| US20190358288A1 (en) | 2017-02-10 | 2019-11-28 | Innovate Biopharmaceuticals, Inc. | Compositions and methods for treating or preventing environmental enteropathy |
| KR20180107341A (ko) * | 2017-03-16 | 2018-10-02 | 차의과학대학교 산학협력단 | 칼륨 경쟁적 위산분비억제제를 유효성분을 함유하는 장 누수 증후군 치료 및 예방용 조성물 |
| WO2019165346A1 (en) | 2018-02-23 | 2019-08-29 | Innovate Biopharmaceuticals, Inc. | Compounds and methods for treating tight junction permeability |
| US20210069286A1 (en) * | 2018-04-09 | 2021-03-11 | 9 Meters Biopharma, Inc. | Compositions and methods for treating or preventing hyperglycemia, insulin resistance, and associated organ damage |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998052415A1 (en) * | 1997-05-21 | 1998-11-26 | University Of Maryland, Baltimore | Substantially pure zonulin, a physiological modulator of mammalian tight junctions |
| WO2000007609A1 (en) * | 1998-08-03 | 2000-02-17 | University Of Maryland, Baltimore | Peptide antagonists of zonulin and methods for use of the same |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5936065A (en) * | 1993-12-06 | 1999-08-10 | Cytel Corporation | CS-1 peptidomimetics, compositions and methods of using the same |
| ES2168456T3 (es) * | 1995-01-16 | 2002-06-16 | North Sydney Area Health Serv | Peptidos que afectan a los linfocitos t. |
| US5665389A (en) * | 1995-05-24 | 1997-09-09 | University Of Maryland At Baltimore | Oral dosage composition for intestinal delivery and method of treating diabetes |
| ATE408617T1 (de) * | 1996-06-11 | 2008-10-15 | Northern Sydney And Central Co | T zell antigen rezeptor peptide |
| WO2001089551A1 (en) * | 2000-05-19 | 2001-11-29 | University Of Maryland, Baltimore | Method of use of peptide antagonists of zonulin to prevent or delay the onset of diabetes |
| US7025294B2 (en) * | 2003-05-20 | 2006-04-11 | Carter Day International, Inc. | Hammermill with stub shaft rotor apparatus and method |
| CN101420850A (zh) * | 2006-02-09 | 2009-04-29 | 阿尔巴医疗公司 | 紧密连接效应子的制剂 |
| WO2008043107A2 (en) * | 2006-10-06 | 2008-04-10 | Alba Therapeutics Corporation | Use of tight junction antagonists to treat inflammatory bowel disease |
| WO2008052185A2 (en) * | 2006-10-26 | 2008-05-02 | Alba Therapeutics Corp | Materials and methods for the treatment of celiac disease |
-
2001
- 2001-03-21 WO PCT/US2001/005825 patent/WO2001089551A1/en not_active Ceased
- 2001-03-21 DE DE60139466T patent/DE60139466D1/de not_active Expired - Lifetime
- 2001-03-21 AT AT01922244T patent/ATE438405T1/de not_active IP Right Cessation
- 2001-03-21 AU AU2001249067A patent/AU2001249067A1/en not_active Abandoned
- 2001-03-21 CA CA002409771A patent/CA2409771C/en not_active Expired - Lifetime
- 2001-03-21 JP JP2001585794A patent/JP2003534287A/ja active Pending
- 2001-03-21 US US10/275,877 patent/US7026294B2/en not_active Expired - Lifetime
- 2001-03-21 EP EP01922244A patent/EP1282432B1/en not_active Expired - Lifetime
-
2006
- 2006-02-03 US US11/346,395 patent/US7531512B2/en not_active Expired - Fee Related
-
2007
- 2007-11-21 JP JP2007302283A patent/JP2008074869A/ja active Pending
-
2008
- 2008-06-30 US US12/165,088 patent/US20080269136A1/en not_active Abandoned
-
2009
- 2009-08-05 US US12/536,158 patent/US8183211B2/en not_active Expired - Fee Related
-
2011
- 2011-08-02 JP JP2011169654A patent/JP2011213742A/ja active Pending
-
2012
- 2012-05-01 US US13/461,343 patent/US20130157943A1/en not_active Abandoned
-
2013
- 2013-11-01 US US14/070,212 patent/US20140128321A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998052415A1 (en) * | 1997-05-21 | 1998-11-26 | University Of Maryland, Baltimore | Substantially pure zonulin, a physiological modulator of mammalian tight junctions |
| WO2000007609A1 (en) * | 1998-08-03 | 2000-02-17 | University Of Maryland, Baltimore | Peptide antagonists of zonulin and methods for use of the same |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009527468A (ja) * | 2006-02-09 | 2009-07-30 | アルバ セラピューティクス コーポレーション | タイトジャンクション・エフェクター用製剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| ATE438405T1 (de) | 2009-08-15 |
| US20060128626A1 (en) | 2006-06-15 |
| US8183211B2 (en) | 2012-05-22 |
| WO2001089551A1 (en) | 2001-11-29 |
| EP1282432A4 (en) | 2005-06-08 |
| US20140128321A1 (en) | 2014-05-08 |
| EP1282432A1 (en) | 2003-02-12 |
| US20050065074A1 (en) | 2005-03-24 |
| CA2409771C (en) | 2008-12-02 |
| DE60139466D1 (de) | 2009-09-17 |
| CA2409771A1 (en) | 2001-11-29 |
| EP1282432B1 (en) | 2009-08-05 |
| US7531512B2 (en) | 2009-05-12 |
| US20080269136A1 (en) | 2008-10-30 |
| JP2011213742A (ja) | 2011-10-27 |
| JP2008074869A (ja) | 2008-04-03 |
| US20100087380A1 (en) | 2010-04-08 |
| US20130157943A1 (en) | 2013-06-20 |
| AU2001249067A1 (en) | 2001-12-03 |
| US7026294B2 (en) | 2006-04-11 |
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