JP2002518473A5 - - Google Patents
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- Publication number
- JP2002518473A5 JP2002518473A5 JP2000555864A JP2000555864A JP2002518473A5 JP 2002518473 A5 JP2002518473 A5 JP 2002518473A5 JP 2000555864 A JP2000555864 A JP 2000555864A JP 2000555864 A JP2000555864 A JP 2000555864A JP 2002518473 A5 JP2002518473 A5 JP 2002518473A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- group
- molecular weight
- polythiol
- atomic mass
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 description 33
- 238000000034 method Methods 0.000 description 24
- 125000003396 thiol group Chemical class [H]S* 0.000 description 14
- 239000003795 chemical substances by application Substances 0.000 description 11
- 229920006295 polythiol Polymers 0.000 description 11
- HRKQOINLCJTGBK-UHFFFAOYSA-N dihydroxidosulfur Chemical compound OSO HRKQOINLCJTGBK-UHFFFAOYSA-N 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 4
- 125000003158 alcohol group Chemical group 0.000 description 4
- 125000001931 aliphatic group Chemical group 0.000 description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
- 125000000962 organic group Chemical group 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 229920001184 polypeptide Polymers 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- -1 16A compound Chemical class 0.000 description 2
- ZIIQCSMRQKCOCT-UHFFFAOYSA-N 2-acetamido-3-methyl-3-nitrososulfanylbutanoic acid Chemical group CC(=O)NC(C(O)=O)C(C)(C)SN=O ZIIQCSMRQKCOCT-UHFFFAOYSA-N 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 229920005862 polyol Polymers 0.000 description 2
- 150000003077 polyols Chemical class 0.000 description 2
- 230000000249 desinfective effect Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/103,227 US6207855B1 (en) | 1998-06-23 | 1998-06-23 | Stable no-delivering compounds |
| US09/103,227 | 1998-06-23 | ||
| PCT/US1999/013963 WO1999067210A1 (en) | 1998-06-23 | 1999-06-21 | Stable no-delivering compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002518473A JP2002518473A (ja) | 2002-06-25 |
| JP2002518473A5 true JP2002518473A5 (https=) | 2006-08-10 |
Family
ID=22294054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000555864A Pending JP2002518473A (ja) | 1998-06-23 | 1999-06-21 | 安定なｎｏ−送達化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (6) | US6207855B1 (https=) |
| EP (1) | EP1089969B1 (https=) |
| JP (1) | JP2002518473A (https=) |
| AU (1) | AU4580599A (https=) |
| CA (1) | CA2335989A1 (https=) |
| DE (1) | DE69942338D1 (https=) |
| WO (1) | WO1999067210A1 (https=) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6207855B1 (en) | 1998-06-23 | 2001-03-27 | Duke University Medical Center | Stable no-delivering compounds |
| TWI243672B (en) * | 1999-06-01 | 2005-11-21 | Astrazeneca Ab | New use of compounds as antibacterial agents |
| CA2403818A1 (en) * | 2000-03-20 | 2001-09-27 | Novovascular, Inc. | Matrices containing nitric oxide donors and reducing agents and their use |
| WO2003026717A1 (en) * | 2001-09-26 | 2003-04-03 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Nitric oxide-releasing coated medical devices and method of preparing same |
| EP1545798A4 (en) * | 2002-08-02 | 2006-06-14 | Us Gov Health & Human Serv | NETWORKED NITROGEN OXIDE RELEASING POLYAMINE-COATED SUBSTRATES, THESE COMPOSITIONS AND MANUFACTURING PROCESSES DAF R |
| US8017074B2 (en) * | 2004-01-07 | 2011-09-13 | Noxilizer, Inc. | Sterilization system and device |
| EP1701747B1 (en) | 2004-01-07 | 2014-03-12 | Noxilizer, Inc. | Sterilisation method |
| US7569559B2 (en) * | 2004-02-09 | 2009-08-04 | Noxilizer, Inc. | Nitric oxide-releasing molecules |
| EP1750782A1 (en) * | 2004-04-29 | 2007-02-14 | Cube Medical A/S | A balloon for use in angioplasty with an outer layer of nanofibers |
| US7968575B2 (en) * | 2004-05-05 | 2011-06-28 | Renopharm Ltd. | Nitric oxide donors and uses thereof |
| US8134010B2 (en) * | 2004-05-05 | 2012-03-13 | Renopharm Ltd. | Thiazole-based nitric oxide donors having aryl substituent(s) and uses thereof |
| GB0419416D0 (en) * | 2004-09-01 | 2004-10-06 | Inst Of Ex Botany Ascr | 4-Arylazo-3,5-Diamino-Pyrazole compounds and use thereof |
| DE102004043279A1 (de) * | 2004-09-08 | 2006-03-23 | Theo Woike | Verfahren und Vorrichtung zum biologischen, medizinischen und pharmazeutischen Gebrauch des Nitrosylmoleküls NO durch optische Anregung von metastabilen Zuständen in Nitrosylkomplexen |
| ES2731298T3 (es) | 2005-05-27 | 2019-11-14 | Univ North Carolina Chapel Hill | Partículas de liberación de óxido nítrico para agentes terapéuticos de óxido nítrico y aplicaciones biomédicas |
| US7968533B2 (en) * | 2006-03-07 | 2011-06-28 | Duke University | Ethyl nitrite as a gastrointestinal smooth muscle relaxant and diagnostic and therapeutic uses thereof |
| US11229746B2 (en) | 2006-06-22 | 2022-01-25 | Excelsior Medical Corporation | Antiseptic cap |
| US9259535B2 (en) | 2006-06-22 | 2016-02-16 | Excelsior Medical Corporation | Antiseptic cap equipped syringe |
| US7875671B2 (en) | 2006-08-03 | 2011-01-25 | Bridgestone Corporation | Process for preparing filler-dispersed polymeric compositions |
| US8063165B2 (en) | 2007-06-18 | 2011-11-22 | Bridgestone Corporation | Functional polymers prepared with sulfur-containing initiators |
| WO2009050527A1 (en) | 2007-10-17 | 2009-04-23 | Biotech Hungary Kutató És Fejlesztési Kft. | Pharmaceutical composition comprising s-nitrosoglutathione and polysaccharide |
| US7910574B2 (en) * | 2007-12-11 | 2011-03-22 | Illinois State University | Treatments for the control of schistosomiasis |
| US20090170933A1 (en) * | 2007-12-26 | 2009-07-02 | Cook Incorporated | Method for removing a medical device from a spasmodic constriction in a bodily passageway |
| AU2009244790B2 (en) * | 2008-05-09 | 2013-09-12 | Duke University | Treatment for diseases relying on discovery that thioredoxin mediates nitric oxide release in cells |
| EP2334279A4 (en) * | 2008-10-16 | 2013-03-20 | Novan Inc | STAIN OXIDE RELEASING PARTICLES FOR MOUTH CARE APPLICATIONS |
| US9078992B2 (en) | 2008-10-27 | 2015-07-14 | Pursuit Vascular, Inc. | Medical device for applying antimicrobial to proximal end of catheter |
| US9849276B2 (en) | 2011-07-12 | 2017-12-26 | Pursuit Vascular, Inc. | Method of delivering antimicrobial to a catheter |
| WO2010096766A1 (en) | 2009-02-23 | 2010-08-26 | Noxilizer, Inc. | Device and method for gas sterilization |
| US8137396B2 (en) | 2009-05-20 | 2012-03-20 | 480 Biomedical, Inc | Medical implant |
| US9265633B2 (en) | 2009-05-20 | 2016-02-23 | 480 Biomedical, Inc. | Drug-eluting medical implants |
| US8992601B2 (en) | 2009-05-20 | 2015-03-31 | 480 Biomedical, Inc. | Medical implants |
| US9309347B2 (en) | 2009-05-20 | 2016-04-12 | Biomedical, Inc. | Bioresorbable thermoset polyester/urethane elastomers |
| US20110319987A1 (en) | 2009-05-20 | 2011-12-29 | Arsenal Medical | Medical implant |
| US8888840B2 (en) * | 2009-05-20 | 2014-11-18 | Boston Scientific Scimed, Inc. | Drug eluting medical implant |
| WO2011022652A1 (en) | 2009-08-21 | 2011-02-24 | Novan, Inc. | Topical gels |
| CA2771389C (en) | 2009-08-21 | 2019-04-09 | Novan, Inc. | Wound dressings, methods of using the same and methods of forming the same |
| US8372133B2 (en) | 2009-10-05 | 2013-02-12 | 480 Biomedical, Inc. | Polymeric implant delivery system |
| BR112012008508A2 (pt) * | 2009-10-13 | 2017-06-13 | Novan Inc | revestimento de sol-gel, substrato, método para produzir um revestimento de sol-gel |
| KR101830872B1 (ko) | 2009-12-22 | 2018-02-26 | 가부시키가이샤 브리지스톤 | 개선된 비닐 개질제 조성물 및 그러한 조성물의 이용 방법 |
| WO2011082098A1 (en) | 2009-12-30 | 2011-07-07 | The Rockefeller University | Lysine and arginine methyltransferase inhibitors for treating cancer |
| US8591876B2 (en) | 2010-12-15 | 2013-11-26 | Novan, Inc. | Methods of decreasing sebum production in the skin |
| BR112013016433B1 (pt) | 2010-12-30 | 2021-02-23 | Bridgestone Corporation | processo para produzir polímeros funcionalizados com aminosilano, polímero telequélico produzido a partir deste processo e composição de borracha para uso em pneus |
| WO2012118829A2 (en) | 2011-02-28 | 2012-09-07 | Novan, Inc. | Tertiary s-nitrosothiol-modified nitricoxide-releasing xerogels and methods of using the same |
| US10166381B2 (en) | 2011-05-23 | 2019-01-01 | Excelsior Medical Corporation | Antiseptic cap |
| TWI585115B (zh) | 2011-12-15 | 2017-06-01 | 普利司通股份有限公司 | 經穩定之多價陰離子聚合反應引發劑及其製備方法 |
| JP6334514B2 (ja) | 2012-05-01 | 2018-05-30 | 株式会社ブリヂストン | オルガノホスフィン官能基を有するポリジエンおよびジエンコポリマー |
| JP2017501289A (ja) | 2013-12-12 | 2017-01-12 | ファイアストン ポリマーズ エルエルシー | 官能化ポリマーを含むポリマー組成物の製造方法 |
| ES2755352T3 (es) | 2014-05-02 | 2020-04-22 | Excelsior Medical Corp | Paquete en tira para tapón antiséptico |
| DK3294404T3 (da) | 2015-05-08 | 2025-09-08 | Icu Medical Inc | Medicinske konnektorer konfigureret til at modtage emittere af terapeutiske midler |
| US10519266B2 (en) | 2015-09-23 | 2019-12-31 | Bridgestone Corporation | Polydienes and diene copolymers using 1,1-bis(hydrocarbylthio)hydrocarbyl-1-ene compounds |
| WO2018067838A1 (en) * | 2016-10-07 | 2018-04-12 | The University Of North Carolina At Chapel Hill | S-nitrosothiol-mediated hyperbranched polyesters |
| PL3525865T3 (pl) | 2016-10-14 | 2023-02-06 | Icu Medical, Inc. | Nasadki dezynfekcyjne dla łączników medycznych |
| WO2018127819A1 (en) | 2017-01-03 | 2018-07-12 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing alginates as biodegradable antibacterial scaffolds and methods pertaining thereto |
| JP7403152B2 (ja) | 2017-03-28 | 2023-12-22 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 生分解可能な抗菌性スキャフォールドとしての一酸化窒素放出性ポリアミノグリコシドおよびそれに関する方法背景 |
| WO2018204206A2 (en) | 2017-05-01 | 2018-11-08 | Icu Medical, Inc. | Medical fluid connectors and methods for providing additives in medical fluid lines |
| EP3710514B1 (en) | 2017-11-15 | 2023-06-07 | The University of North Carolina at Chapel Hill | Nitric oxide-releasing hyperbranched compounds as antibacterial scaffolds and methods pertaining thereto |
| CA3091458A1 (en) | 2018-03-06 | 2019-09-12 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing cyclodextrins as biodegradable antibacterial scaffolds and methods pertaining thereto |
| US11541220B2 (en) | 2018-11-07 | 2023-01-03 | Icu Medical, Inc. | Needleless connector with antimicrobial properties |
| US11534595B2 (en) | 2018-11-07 | 2022-12-27 | Icu Medical, Inc. | Device for delivering an antimicrobial composition into an infusion device |
| US11541221B2 (en) | 2018-11-07 | 2023-01-03 | Icu Medical, Inc. | Tubing set with antimicrobial properties |
| US11517732B2 (en) | 2018-11-07 | 2022-12-06 | Icu Medical, Inc. | Syringe with antimicrobial properties |
| US11400195B2 (en) | 2018-11-07 | 2022-08-02 | Icu Medical, Inc. | Peritoneal dialysis transfer set with antimicrobial properties |
| JP2022513096A (ja) | 2018-11-21 | 2022-02-07 | アイシーユー・メディカル・インコーポレーテッド | リング及びインサートを有するキャップを備える抗菌装置 |
| CN113383019B (zh) | 2018-12-28 | 2023-11-17 | 北卡罗来纳大学教堂山分校 | 一氧化氮释放型抗菌聚合物和由其制成的支架和其相关方法 |
| JP2024500319A (ja) | 2020-12-07 | 2024-01-09 | アイシーユー・メディカル・インコーポレーテッド | 腹膜透析キャップ、システム、及び方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5025001A (en) | 1988-06-15 | 1991-06-18 | Brigham And Women's Hospital | S-nitroso derivatives of ACE inhibitors and the use thereof |
| DE69008454T2 (de) | 1989-08-07 | 1994-08-25 | Takeda Chemical Industries Ltd | Nitrolsothiolderivate, ihre Herstellung und Verwendung. |
| US5380758A (en) * | 1991-03-29 | 1995-01-10 | Brigham And Women's Hospital | S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof |
| IL101406A (en) | 1991-03-29 | 1998-02-08 | Brigham & Womens Hospital | Pharmaceutical compositions containing s-nitrosothiol derivatives |
| US5385937A (en) | 1991-04-10 | 1995-01-31 | Brigham & Women's Hospital | Nitrosation of homocysteine as a method for treating homocysteinemia |
| US5650447A (en) | 1992-08-24 | 1997-07-22 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Nitric oxide-releasing polymers to treat restenosis and related disorders |
| DE69433478T2 (de) | 1993-09-17 | 2004-11-25 | Brigham And Women's Hospital, Boston | Verwendung von stickoxid-addukten zur verhütung von thrombosen auf artifiziellen und vaskulären oberflächen |
| US5583101A (en) | 1994-07-15 | 1996-12-10 | Harvard College | Use of nitrogen oxide species and adducts to inhibit skeletal muscle contraction |
| WO1996003139A1 (en) | 1994-07-27 | 1996-02-08 | Duke University | Use of nitric oxide or nitric oxide adducts to preserve platelets |
| US5612314A (en) | 1995-04-21 | 1997-03-18 | Brigham & Women's Hospital | Nitrosylated neuropeptides |
| US5770645A (en) | 1996-08-02 | 1998-06-23 | Duke University Medical Center | Polymers for delivering nitric oxide in vivo |
| US6207855B1 (en) | 1998-06-23 | 2001-03-27 | Duke University Medical Center | Stable no-delivering compounds |
-
1998
- 1998-06-23 US US09/103,227 patent/US6207855B1/en not_active Expired - Lifetime
-
1999
- 1999-06-21 EP EP99928821A patent/EP1089969B1/en not_active Expired - Lifetime
- 1999-06-21 JP JP2000555864A patent/JP2002518473A/ja active Pending
- 1999-06-21 DE DE69942338T patent/DE69942338D1/de not_active Expired - Lifetime
- 1999-06-21 WO PCT/US1999/013963 patent/WO1999067210A1/en not_active Ceased
- 1999-06-21 AU AU45805/99A patent/AU4580599A/en not_active Abandoned
- 1999-06-21 CA CA002335989A patent/CA2335989A1/en not_active Abandoned
-
2000
- 2000-11-29 US US09/725,603 patent/US6359167B2/en not_active Expired - Lifetime
-
2001
- 2001-12-18 US US10/026,851 patent/US6488951B2/en not_active Expired - Fee Related
-
2002
- 2002-08-12 US US10/217,580 patent/US6583311B2/en not_active Expired - Fee Related
-
2003
- 2003-03-11 US US10/387,116 patent/US7015347B2/en not_active Expired - Lifetime
-
2006
- 2006-03-14 US US11/376,756 patent/US7745656B2/en not_active Expired - Fee Related
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