JP2002516283A5 - - Google Patents
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- Publication number
- JP2002516283A5 JP2002516283A5 JP2000550490A JP2000550490A JP2002516283A5 JP 2002516283 A5 JP2002516283 A5 JP 2002516283A5 JP 2000550490 A JP2000550490 A JP 2000550490A JP 2000550490 A JP2000550490 A JP 2000550490A JP 2002516283 A5 JP2002516283 A5 JP 2002516283A5
- Authority
- JP
- Japan
- Prior art keywords
- manufacture
- compound
- formula
- pharmaceutically acceptable
- medicament
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 239000000651 prodrug Substances 0.000 description 4
- 229940002612 prodrug Drugs 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 108010057466 NF-kappa B Proteins 0.000 description 3
- 102000003945 NF-kappa B Human genes 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 208000037803 restenosis Diseases 0.000 description 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 description 1
- 208000036487 Arthropathies Diseases 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 208000012659 Joint disease Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 description 1
- 206010040070 Septic Shock Diseases 0.000 description 1
- 206010052779 Transplant rejections Diseases 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 description 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 230000000495 immunoinflammatory effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000004770 neurodegeneration Effects 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000036303 septic shock Effects 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9801154 | 1998-05-27 | ||
| ES009801154A ES2136581B1 (es) | 1998-05-27 | 1998-05-27 | Uso de derivados del acido-2-hidroxi-4-trifluorometilbenzoico para la preparacion de medicamentos utiles para inhibir el factor de transcripcion nuclear nf-kb. |
| PCT/ES1999/000154 WO1999061030A1 (es) | 1998-05-27 | 1999-05-26 | USO DE DERIVADOS DEL ACIDO 2-HIDROXI-4-TRIFLUOROMETILBENZOICO COMO INHIBIDORES DE LA ACTIVACION DEL FACTOR DE TRANSCRIPCION NUCLEAR NF-λB |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002516283A JP2002516283A (ja) | 2002-06-04 |
| JP2002516283A5 true JP2002516283A5 (https=) | 2006-07-27 |
Family
ID=8304002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000550490A Pending JP2002516283A (ja) | 1998-05-27 | 1999-05-26 | 核転写因子ＮＦ−κＢの活性化の阻害剤としての２−ヒドロキシ−４−トリフルオロメチル安息香酸誘導体の使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6414025B1 (https=) |
| EP (2) | EP1082962B1 (https=) |
| JP (1) | JP2002516283A (https=) |
| KR (2) | KR100762156B1 (https=) |
| AT (1) | ATE245987T1 (https=) |
| AU (1) | AU3828699A (https=) |
| BR (1) | BR9911598A (https=) |
| CA (1) | CA2332863A1 (https=) |
| DE (1) | DE69910019T2 (https=) |
| DK (1) | DK1082962T3 (https=) |
| ES (2) | ES2136581B1 (https=) |
| NO (1) | NO20005981L (https=) |
| PT (1) | PT1082962E (https=) |
| WO (1) | WO1999061030A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2154242B1 (es) * | 1999-09-03 | 2001-10-16 | Uriach & Cia Sa J | Nuevos sistemas polimericos biocompatibles portadores de triflusal o htb. |
| US20040101488A1 (en) * | 2000-03-24 | 2004-05-27 | Balaram Ghosh | Method for the prevention of septic shock lethality using curcumin |
| ES2190373B1 (es) * | 2001-12-07 | 2004-10-16 | J. URIACH & CIA, S.A. | Uso del acido 2-hidroxi- o 2-acetiloxi-4-trifluorometilbenzoico como agente para el tratamiento y prevencion del deterioro cognitivo ligero. |
| CA2497977A1 (en) | 2002-09-20 | 2004-04-01 | Alcon, Inc. | Use of cytokine synthesis inhibitors for the treatment of dry eye disorders |
| JP5780521B2 (ja) | 2008-05-28 | 2015-09-16 | リベラジェン・バイオファーマ・インコーポレイテッドＲｅｖｅｒａＧｅｎ ＢｉｏＰｈａｒｍａ，Ｉｎｃ． | 疾患を治療するための、ＮＦ−κＢの非ホルモン性ステロイド調節因子 |
| NZ755378A (en) | 2009-03-18 | 2022-07-29 | Resverlogix Corp | Novel quinazolinones and related compounds for use as anti-inflammatory agents |
| WO2011127048A2 (en) | 2010-04-05 | 2011-10-13 | Validus Biopharma | NON-HORMONAL STEROID MODULATORS OF NF-ĸB FOR TREATMENT OF DISEASE |
| CN103665012B (zh) * | 2013-12-06 | 2016-06-22 | 辽宁师范大学 | 新型三氟柳无机药物化合物及合成方法 |
| WO2017004205A1 (en) | 2015-06-29 | 2017-01-05 | Reveragen Biopharma, Inc. | NON-HORMONAL STEROID MODULATORS OF NF-κB FOR TREATMENT OF DISEASE |
| US20180016314A1 (en) * | 2016-07-12 | 2018-01-18 | Children's Hospital Medical Center | Treatment of disease via transcription factor modulation |
| JP6923659B2 (ja) * | 2016-10-14 | 2021-08-25 | アンスティテュ パスツール デ モンテビデオＩｎｓｔｉｔｕｔ Ｐａｓｔｅｕｒ Ｄｅ Ｍｏｎｔｅｖｉｄｅｏ | 多能性抗炎症及び代謝調節剤を用いた炎症関連症状の治療方法 |
| KR101975603B1 (ko) | 2018-09-14 | 2019-08-28 | 이영문 | 조력 발전장치 |
| US11382922B2 (en) | 2019-03-07 | 2022-07-12 | Reveragen Biopharma, Inc. | Aqueous oral pharmaceutical suspension compositions |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4096252A (en) * | 1976-06-10 | 1978-06-20 | J. Uriach & Cia S.A. | 4-Trifluoromethylbenzoic acid derivatives as thromboembolic agents |
| IT1276071B1 (it) * | 1995-10-31 | 1997-10-24 | Nicox Ltd | Compositi ad attivita' anti-infiammatoria |
-
1998
- 1998-05-27 ES ES009801154A patent/ES2136581B1/es not_active Expired - Fee Related
-
1999
- 1999-05-26 EP EP99920872A patent/EP1082962B1/en not_active Expired - Lifetime
- 1999-05-26 JP JP2000550490A patent/JP2002516283A/ja active Pending
- 1999-05-26 BR BR9911598-0A patent/BR9911598A/pt not_active Application Discontinuation
- 1999-05-26 AU AU38286/99A patent/AU3828699A/en not_active Abandoned
- 1999-05-26 KR KR1020067026281A patent/KR100762156B1/ko not_active Expired - Fee Related
- 1999-05-26 AT AT99920872T patent/ATE245987T1/de not_active IP Right Cessation
- 1999-05-26 ES ES99920872T patent/ES2204129T3/es not_active Expired - Lifetime
- 1999-05-26 US US09/701,270 patent/US6414025B1/en not_active Expired - Fee Related
- 1999-05-26 DK DK99920872T patent/DK1082962T3/da active
- 1999-05-26 DE DE69910019T patent/DE69910019T2/de not_active Expired - Fee Related
- 1999-05-26 PT PT99920872T patent/PT1082962E/pt unknown
- 1999-05-26 KR KR1020007013316A patent/KR100713601B1/ko not_active Expired - Fee Related
- 1999-05-26 EP EP03012255A patent/EP1362592A1/en not_active Withdrawn
- 1999-05-26 CA CA002332863A patent/CA2332863A1/en not_active Abandoned
- 1999-05-26 WO PCT/ES1999/000154 patent/WO1999061030A1/es not_active Ceased
-
2000
- 2000-11-27 NO NO20005981A patent/NO20005981L/no not_active Application Discontinuation
-
2002
- 2002-04-04 US US10/115,140 patent/US6610745B2/en not_active Expired - Fee Related
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