JP2002515511A - 放射線及び成長因子レセプター・チロシン・キナーゼのインヒビターを使用するヒト腫瘍の治療 - Google Patents

放射線及び成長因子レセプター・チロシン・キナーゼのインヒビターを使用するヒト腫瘍の治療

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Publication number
JP2002515511A
JP2002515511A JP2000549641A JP2000549641A JP2002515511A JP 2002515511 A JP2002515511 A JP 2002515511A JP 2000549641 A JP2000549641 A JP 2000549641A JP 2000549641 A JP2000549641 A JP 2000549641A JP 2002515511 A JP2002515511 A JP 2002515511A
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JP
Japan
Prior art keywords
antibody
egfr
family
tyrosine kinase
receptor tyrosine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000549641A
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English (en)
Japanese (ja)
Inventor
ダブリュ． ワクサル，ハーラン
エヌ． サレー，マンスーア
ロバート，フランシスコ
ジェイ ブックスバウム，ドナルド
Original Assignee
イムクローン システムズ インコーポレイティド
ユーエービー リサーチ ファウンデイション
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Application filed by イムクローン システムズ インコーポレイティド, ユーエービー リサーチ ファウンデイション filed Critical イムクローン システムズ インコーポレイティド
Publication of JP2002515511A publication Critical patent/JP2002515511A/ja
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2000549641A 1998-05-15 1999-05-14 放射線及び成長因子レセプター・チロシン・キナーゼのインヒビターを使用するヒト腫瘍の治療 Pending JP2002515511A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US8561398P 1998-05-15 1998-05-15
US7961298A 1998-05-15 1998-05-15
US60/085,613 1998-05-15
US09/079,612 1998-05-15
US20613898A 1998-12-07 1998-12-07
US09/206,138 1998-12-07
PCT/US1999/010741 WO1999060023A1 (fr) 1998-05-15 1999-05-14 Traitement de tumeurs humaines a l'aide d'un rayonnement et d'inhibiteurs de tyrosine kinases de recepteurs du facteur de croissance

Publications (1)

Publication Number Publication Date
JP2002515511A true JP2002515511A (ja) 2002-05-28

Family

ID=27373511

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000549641A Pending JP2002515511A (ja) 1998-05-15 1999-05-14 放射線及び成長因子レセプター・チロシン・キナーゼのインヒビターを使用するヒト腫瘍の治療

Country Status (14)

Country Link
EP (1) EP1080113A4 (fr)
JP (1) JP2002515511A (fr)
KR (1) KR20010071271A (fr)
CN (1) CN1314917A (fr)
AU (1) AU4079999A (fr)
BR (1) BR9910511A (fr)
CA (1) CA2332331A1 (fr)
CZ (1) CZ20004224A3 (fr)
HK (1) HK1040720A1 (fr)
IL (1) IL139707A0 (fr)
MX (1) MXPA00011248A (fr)
PL (1) PL348634A1 (fr)
SK (1) SK17282000A3 (fr)
WO (1) WO1999060023A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008500815A (ja) * 2004-03-19 2008-01-17 イムクローン システムズ インコーポレイティド ヒト抗上皮成長因子受容体抗体
JP2015509944A (ja) * 2012-02-23 2015-04-02 ユー３・ファーマ・ゲーエムベーハー 放射線感受性を調節するためのｈｅｒ３阻害剤

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US6800738B1 (en) 1991-06-14 2004-10-05 Genentech, Inc. Method for making humanized antibodies
US6417168B1 (en) 1998-03-04 2002-07-09 The Trustees Of The University Of Pennsylvania Compositions and methods of treating tumors
EP1745799B1 (fr) 1998-03-04 2015-09-02 The Trustees of The University of Pennsylvania Compositions et méthodes pour le traitement de tumeurs
US6706721B1 (en) 1998-04-29 2004-03-16 Osi Pharmaceuticals, Inc. N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate
AU780454B2 (en) 1999-06-03 2005-03-24 Jessie L.S. Au Methods and compositions for modulating cell proliferation and cell death
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UA74803C2 (uk) 1999-11-11 2006-02-15 Осі Фармасьютікалз, Інк. Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
US7087613B2 (en) 1999-11-11 2006-08-08 Osi Pharmaceuticals, Inc. Treating abnormal cell growth with a stable polymorph of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride
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CU22979A1 (es) * 2000-12-08 2004-09-09 Centro Inmunologia Molecular Combinación inmunoterapéutica para el tratamiento de tumores que sobre-expresan receptores con actividad quinasa en residuos de tirosina
US7081454B2 (en) 2001-03-28 2006-07-25 Bristol-Myers Squibb Co. Tyrosine kinase inhibitors
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CA2524305C (fr) 2003-05-01 2015-12-08 Imclone Systems Incorporated Anticorps entierement humains diriges contre le recepteur du facteur de croissance 1 de type insuline
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UA85058C2 (ru) 2003-08-13 2008-12-25 Пфайзер Продактс Инк. Модифицированное моноклональное антитело человека, которое специфически связывается с рецептором подобного к инсулину фактора роста i человека (igf-ir)
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008500815A (ja) * 2004-03-19 2008-01-17 イムクローン システムズ インコーポレイティド ヒト抗上皮成長因子受容体抗体
JP4734319B2 (ja) * 2004-03-19 2011-07-27 イムクローン・リミテッド・ライアビリティ・カンパニー ヒト抗上皮成長因子受容体抗体
JP2015509944A (ja) * 2012-02-23 2015-04-02 ユー３・ファーマ・ゲーエムベーハー 放射線感受性を調節するためのｈｅｒ３阻害剤
JP2017165711A (ja) * 2012-02-23 2017-09-21 ダイイチサンキョウヨーロッパ ゲーエムベーハー 放射線感受性を調節するためのｈｅｒ３阻害剤
US10357566B2 (en) 2012-02-23 2019-07-23 Daiichi Sankyo Europe Gmbh HER3 inhibitor for modulating radiosensitivity
US11351259B2 (en) 2012-02-23 2022-06-07 Daiichi Sankyo Europe Gmbh HER3 inhibitor for modulating radiosensitivity

Also Published As

Publication number Publication date
CZ20004224A3 (cs) 2002-02-13
AU4079999A (en) 1999-12-06
MXPA00011248A (es) 2004-09-06
EP1080113A4 (fr) 2002-04-17
SK17282000A3 (sk) 2002-04-04
CN1314917A (zh) 2001-09-26
EP1080113A1 (fr) 2001-03-07
WO1999060023A1 (fr) 1999-11-25
IL139707A0 (en) 2002-02-10
PL348634A1 (en) 2002-06-03
HK1040720A1 (zh) 2002-06-21
CA2332331A1 (fr) 1999-11-25
KR20010071271A (ko) 2001-07-28
BR9910511A (pt) 2001-11-20

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