JP2002513785A5 - - Google Patents
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- Publication number
- JP2002513785A5 JP2002513785A5 JP2000547072A JP2000547072A JP2002513785A5 JP 2002513785 A5 JP2002513785 A5 JP 2002513785A5 JP 2000547072 A JP2000547072 A JP 2000547072A JP 2000547072 A JP2000547072 A JP 2000547072A JP 2002513785 A5 JP2002513785 A5 JP 2002513785A5
- Authority
- JP
- Japan
- Prior art keywords
- carbon atoms
- alkyl
- phenyl
- hydrogen
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004432 carbon atoms Chemical group C* 0.000 description 205
- 125000000217 alkyl group Chemical group 0.000 description 108
- 229910052739 hydrogen Inorganic materials 0.000 description 108
- 239000001257 hydrogen Substances 0.000 description 108
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 107
- 229910052731 fluorine Inorganic materials 0.000 description 95
- 229910052801 chlorine Inorganic materials 0.000 description 92
- 239000000460 chlorine Substances 0.000 description 92
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 82
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 59
- 150000002431 hydrogen Chemical class 0.000 description 56
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 52
- 229910052794 bromium Inorganic materials 0.000 description 35
- 229910052740 iodine Inorganic materials 0.000 description 35
- 125000005466 alkylenyl group Chemical group 0.000 description 26
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 26
- 125000000753 cycloalkyl group Chemical group 0.000 description 25
- 125000001072 heteroaryl group Chemical group 0.000 description 22
- -1 methoxy, hydroxy Chemical group 0.000 description 13
- 150000003839 salts Chemical class 0.000 description 11
- 239000011780 sodium chloride Substances 0.000 description 11
- 125000003342 alkenyl group Chemical group 0.000 description 10
- 150000001875 compounds Chemical class 0.000 description 9
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 description 8
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 description 8
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 6
- 230000000302 ischemic Effects 0.000 description 6
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 description 4
- 125000005027 hydroxyaryl group Chemical group 0.000 description 4
- 210000000056 organs Anatomy 0.000 description 4
- 125000001424 substituent group Chemical group 0.000 description 4
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 4
- 239000000825 pharmaceutical preparation Substances 0.000 description 3
- 206010002383 Angina pectoris Diseases 0.000 description 2
- 210000003169 Central Nervous System Anatomy 0.000 description 2
- 210000003414 Extremities Anatomy 0.000 description 2
- 206010061255 Ischaemia Diseases 0.000 description 2
- 208000010125 Myocardial Infarction Diseases 0.000 description 2
- 229910052780 Nobelium Inorganic materials 0.000 description 2
- 210000001428 Peripheral Nervous System Anatomy 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 230000004663 cell proliferation Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000002093 peripheral Effects 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000000241 respiratory Effects 0.000 description 2
- 230000035939 shock Effects 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 238000002054 transplantation Methods 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- 102100010106 SLC4A10 Human genes 0.000 description 1
- 101710024985 SLC4A10 Proteins 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 125000004429 atoms Chemical group 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 230000000271 cardiovascular Effects 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
- 230000001419 dependent Effects 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19820064A DE19820064A1 (de) | 1998-05-06 | 1998-05-06 | Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
| DE19820064.1 | 1998-05-06 | ||
| PCT/EP1999/002940 WO1999057102A1 (de) | 1998-05-06 | 1999-04-30 | Substituierte sulfonylcyanamide, verfahren zu ihrer herstellung und ihre verwendung als medikament |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002513785A JP2002513785A (ja) | 2002-05-14 |
| JP2002513785A5 true JP2002513785A5 (xx) | 2006-06-22 |
| JP4546644B2 JP4546644B2 (ja) | 2010-09-15 |
Family
ID=7866747
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000547072A Expired - Fee Related JP4546644B2 (ja) | 1998-05-06 | 1999-04-30 | 置換スルホニルシアナミド、その調製方法および医薬としての使用 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6573288B1 (xx) |
| EP (1) | EP1076651B1 (xx) |
| JP (1) | JP4546644B2 (xx) |
| KR (1) | KR20010043304A (xx) |
| CN (1) | CN1177829C (xx) |
| AR (1) | AR016255A1 (xx) |
| AT (1) | ATE293606T1 (xx) |
| AU (1) | AU756844B2 (xx) |
| BR (1) | BR9911009A (xx) |
| CA (1) | CA2331863A1 (xx) |
| DE (3) | DE19820064A1 (xx) |
| DK (1) | DK1076651T3 (xx) |
| ES (1) | ES2241326T3 (xx) |
| HK (1) | HK1038008A1 (xx) |
| HR (1) | HRP20000746A2 (xx) |
| HU (1) | HU225377B1 (xx) |
| ID (1) | ID28020A (xx) |
| IL (1) | IL139264A (xx) |
| NO (1) | NO317886B1 (xx) |
| NZ (1) | NZ507964A (xx) |
| PL (1) | PL344041A1 (xx) |
| PT (1) | PT1076651E (xx) |
| RU (1) | RU2221789C2 (xx) |
| SK (1) | SK16582000A3 (xx) |
| TR (1) | TR200003248T2 (xx) |
| WO (1) | WO1999057102A1 (xx) |
| ZA (1) | ZA200006166B (xx) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030220383A1 (en) * | 2002-02-14 | 2003-11-27 | Aventis Pharma Deutschland Gmbh | Use of inhibitors of the sodium-dependent chloride/bicarbonate exchanger for the treatment of thrombotic and inflammatory disorders |
| DE10206354A1 (de) * | 2002-02-14 | 2003-08-28 | Aventis Pharma Gmbh | Verwendung von Inhibitoren des Natrium-abhängigen Chlorid-Bicarbonat-Austauschers zur Behandlung von thrombotischen und inflammatorischer Erkrankungen |
| ITTO20060575A1 (it) * | 2006-08-02 | 2008-02-03 | Univ Pisa | Inibitori di zinco proteinasi tioaril sostituiti e loro usi |
| WO2018002673A1 (en) | 2016-07-01 | 2018-01-04 | N4 Pharma Uk Limited | Novel formulations of angiotensin ii receptor antagonists |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1334092C (en) * | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
| IL98319A (en) * | 1990-07-05 | 1997-04-15 | Roussel Uclaf | Sulphurous derivatives of imidazole, their preparation process, and pharmaceutical compositions containing them |
| US5126342A (en) * | 1990-10-01 | 1992-06-30 | Merck & Co., Inc. | Imidazole angiotensin ii antagonists incorporating acidic functional groups |
| CA2058198A1 (en) * | 1991-01-04 | 1992-07-05 | Adalbert Wagner | Azole derivatives, process for their preparation, and their use |
| TW215434B (xx) * | 1992-03-07 | 1993-11-01 | Hoechst Ag | |
| US5310929A (en) * | 1992-08-06 | 1994-05-10 | E. I. Du Pont De Nemours And Company | Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists |
| FR2711368B1 (fr) * | 1993-09-16 | 1996-01-05 | Roussel Uclaf | Nouveau procédé de préparation de dérivés soufrés de l'imidazole et les nouveaux intermédiaires obtenus. |
| FR2716883B1 (fr) * | 1994-03-04 | 1996-04-26 | Roussel Uclaf | Nouveaux dérivés tétrasubstitués de l'imidazole, leur préparation, nouveaux intermédiaires obtenus, leur application à titre de médicaments, compositions pharmaceutiques les renfermant. |
| DE19540995A1 (de) * | 1995-11-03 | 1997-05-07 | Hoechst Ag | Substituierte Sulfonimidamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| EP0855392A3 (de) * | 1997-01-22 | 2000-01-05 | Hoechst Aktiengesellschaft | Fünfgliedrige Heterocyclen mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19741635A1 (de) * | 1997-09-22 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Biphenylsulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
| DE19804251A1 (de) | 1998-02-04 | 1999-08-05 | Hoechst Marion Roussel De Gmbh | Biphenylsulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
-
1998
- 1998-05-06 DE DE19820064A patent/DE19820064A1/de not_active Withdrawn
-
1999
- 1999-04-30 CN CNB998073148A patent/CN1177829C/zh not_active Expired - Fee Related
- 1999-04-30 PT PT99948554T patent/PT1076651E/pt unknown
- 1999-04-30 EP EP99948554A patent/EP1076651B1/de not_active Expired - Lifetime
- 1999-04-30 DK DK99948554T patent/DK1076651T3/da active
- 1999-04-30 US US09/674,606 patent/US6573288B1/en not_active Expired - Lifetime
- 1999-04-30 DE DE19980787T patent/DE19980787D2/de not_active Expired - Lifetime
- 1999-04-30 DE DE59911949T patent/DE59911949D1/de not_active Expired - Lifetime
- 1999-04-30 NZ NZ507964A patent/NZ507964A/xx unknown
- 1999-04-30 RU RU2000130719/04A patent/RU2221789C2/ru not_active IP Right Cessation
- 1999-04-30 JP JP2000547072A patent/JP4546644B2/ja not_active Expired - Fee Related
- 1999-04-30 AT AT99948554T patent/ATE293606T1/de not_active IP Right Cessation
- 1999-04-30 ES ES99948554T patent/ES2241326T3/es not_active Expired - Lifetime
- 1999-04-30 TR TR2000/03248T patent/TR200003248T2/xx unknown
- 1999-04-30 AU AU59479/99A patent/AU756844B2/en not_active Ceased
- 1999-04-30 PL PL99344041A patent/PL344041A1/xx unknown
- 1999-04-30 KR KR1020007012268A patent/KR20010043304A/ko not_active Application Discontinuation
- 1999-04-30 BR BR9911009-1A patent/BR9911009A/pt not_active IP Right Cessation
- 1999-04-30 CA CA002331863A patent/CA2331863A1/en not_active Abandoned
- 1999-04-30 IL IL13926499A patent/IL139264A/en not_active IP Right Cessation
- 1999-04-30 WO PCT/EP1999/002940 patent/WO1999057102A1/de not_active Application Discontinuation
- 1999-04-30 HU HU0102459A patent/HU225377B1/hu not_active IP Right Cessation
- 1999-04-30 ID IDW20002257A patent/ID28020A/id unknown
- 1999-04-30 SK SK1658-2000A patent/SK16582000A3/sk unknown
- 1999-05-04 AR ARP990102087A patent/AR016255A1/es unknown
-
2000
- 2000-10-31 ZA ZA200006166A patent/ZA200006166B/xx unknown
- 2000-11-03 NO NO20005549A patent/NO317886B1/no unknown
- 2000-11-03 HR HR20000746A patent/HRP20000746A2/hr not_active Application Discontinuation
-
2001
- 2001-11-12 HK HK01107942A patent/HK1038008A1/xx unknown
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