JP2002513418A - 治療活性組成物 - Google Patents
治療活性組成物Info
- Publication number
- JP2002513418A JP2002513418A JP50108699A JP50108699A JP2002513418A JP 2002513418 A JP2002513418 A JP 2002513418A JP 50108699 A JP50108699 A JP 50108699A JP 50108699 A JP50108699 A JP 50108699A JP 2002513418 A JP2002513418 A JP 2002513418A
- Authority
- JP
- Japan
- Prior art keywords
- component
- composition
- pharmaceutically acceptable
- stomach
- vanilloid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 150000004682 monohydrates Chemical class 0.000 description 1
- 235000010460 mustard Nutrition 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- RGOVYLWUIBMPGK-UHFFFAOYSA-N nonivamide Chemical compound CCCCCCCCC(=O)NCC1=CC=C(O)C(OC)=C1 RGOVYLWUIBMPGK-UHFFFAOYSA-N 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 239000000050 smooth muscle relaxant Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid group Chemical class S(O)(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229940100611 topical cream Drugs 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 235000013976 turmeric Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9711962.2A GB9711962D0 (en) | 1997-06-10 | 1997-06-10 | Therapeutically active compositions |
| GB9711962.2 | 1997-06-10 | ||
| PCT/GB1998/001673 WO1998056356A1 (en) | 1997-06-10 | 1998-06-08 | Therapeutically active compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002513418A true JP2002513418A (ja) | 2002-05-08 |
| JP2002513418A5 JP2002513418A5 (https=) | 2005-12-08 |
Family
ID=10813845
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50108699A Ceased JP2002513418A (ja) | 1997-06-10 | 1998-06-08 | 治療活性組成物 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6201014B1 (https=) |
| EP (1) | EP0988028B1 (https=) |
| JP (1) | JP2002513418A (https=) |
| KR (1) | KR20010013618A (https=) |
| CN (1) | CN1198594C (https=) |
| AR (1) | AR012960A1 (https=) |
| AT (1) | ATE262892T1 (https=) |
| AU (1) | AU737606B2 (https=) |
| BR (1) | BR9809994A (https=) |
| CA (1) | CA2291796C (https=) |
| DE (1) | DE69822822T2 (https=) |
| GB (3) | GB9711962D0 (https=) |
| HU (1) | HUP0004245A2 (https=) |
| ID (1) | ID22878A (https=) |
| PL (1) | PL337337A1 (https=) |
| WO (1) | WO1998056356A1 (https=) |
| ZA (1) | ZA984920B (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005521674A (ja) * | 2002-02-01 | 2005-07-21 | ディポメド，インコーポレイティド | 即効性及び徐放性薬物をデリバリーする経口剤形の製造 |
| JP2022546914A (ja) * | 2019-07-18 | 2022-11-10 | ディグニファイ セラピューティクス エルエルシー | 排便を誘導するための組成物および方法 |
| JP2024505139A (ja) * | 2021-01-15 | 2024-02-05 | ディグニファイ セラピューティクス エルエルシー | 排便を誘発するための組成物及び方法 |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6790207B2 (en) * | 1998-06-04 | 2004-09-14 | Curon Medical, Inc. | Systems and methods for applying a selected treatment agent into contact with tissue to treat disorders of the gastrointestinal tract |
| US6802841B2 (en) * | 1998-06-04 | 2004-10-12 | Curon Medical, Inc. | Systems and methods for applying a selected treatment agent into contact with tissue to treat sphincter dysfunction |
| US20110071468A1 (en) * | 1998-06-04 | 2011-03-24 | Mederi Therapeutics, Inc. | Systems and methods for applying a selected treatment agent into contact with tissue to treat sphincter dysfunction |
| GB9812426D0 (en) * | 1998-06-10 | 1998-08-05 | Reckitt & Colmann Prod Ltd | Improvements in or relating to organic compositions |
| GB9925127D0 (en) * | 1999-10-22 | 1999-12-22 | Pharmacia & Upjohn Spa | Oral formulations for anti-tumor compounds |
| WO2001064202A2 (en) * | 2000-03-01 | 2001-09-07 | Euro-Celtique S.A. | Tramadol for the treatment of functional gastrointestinal disorders |
| US7192612B2 (en) * | 2001-02-22 | 2007-03-20 | Purdue Research Foundation | Compositions and methods based on synergies between capsicum extracts and tea catechins for prevention and treatment of cancer |
| AU2002254007B2 (en) | 2001-02-22 | 2006-09-21 | Purdue Research Foundation | Compositions based on vanilloid-catechin synergies for prevention and treatment of cancer |
| US6428822B1 (en) | 2001-04-03 | 2002-08-06 | Chengzhi Life Science Company, Ltd. | Extracts of mixed arctium lappa L., carrot and whole radish for treating hypertension, constipation and detoxification |
| US7198804B2 (en) * | 2002-04-12 | 2007-04-03 | Helixir Co., Ltd. | Crude drug composition for preventing and treating gastrointestinal dyskinetic diseases |
| PT1605956E (pt) * | 2002-12-18 | 2016-03-09 | Centrexion Therapeutics Corp | Administração de capsaicinóides para o tratamento da osteoartrite |
| US20040156931A1 (en) * | 2002-12-18 | 2004-08-12 | Algorx | Administration of capsaicinoids |
| EP1615880A4 (en) * | 2003-04-08 | 2007-03-07 | Algorx Pharmaceuticals Inc | PREPARATION AND CLEANING OF SYNTHETIC TRANS CAPSAICIN |
| US20100159000A1 (en) * | 2003-11-10 | 2010-06-24 | Lundeen Sr James E | Medicine for treating gastrointestinal disorder including fecal incontinence |
| AT413646B (de) * | 2004-04-02 | 2006-04-15 | Hammer Johann Dr | Verwendung von capsaicin und/oder capsaicinoiden |
| US20050277657A1 (en) * | 2004-06-15 | 2005-12-15 | Dusan Ninkov | Method of protection of biologically active essential oils and pharmaceutical composition for weight control and enhance fat burning in adults, adolescents and children |
| EA200701131A1 (ru) * | 2004-11-24 | 2007-12-28 | Алгоркс Фармасьютикалз, Инк. | Гелеобразная препаративная форма капсаициноида и способы её применения |
| ES2533256T3 (es) | 2004-12-28 | 2015-04-08 | Mestex Ag | Uso de resiniferatoxina (RTX) para la fabricación de un medicamento para el tratamiento del dolor |
| US20080103102A1 (en) | 2006-10-27 | 2008-05-01 | Bmb Patent Holding Corporation | Therapeutic compositions and methods of treatment with capsianoside-type compounds |
| CN101835500B (zh) * | 2007-08-29 | 2014-05-28 | 吸附剂治疗学公司 | 具有可变抗衡离子含量的吸收性聚合物组合物及其制备方法和用途 |
| KR20090047637A (ko) * | 2007-11-08 | 2009-05-13 | 재단법인서울대학교산학협력재단 | 커큐민 또는 이의 약학적으로 허용가능한 염을유효성분으로 함유하는 통증 예방 및 치료용 조성물 |
| HUP0700755A2 (en) * | 2007-11-26 | 2009-08-28 | Pannonpharma Gyogyszergyar | Pharmaceutical compositions containing capsaicionoid and non-steroidal anti-inflammatory drug |
| US8697155B2 (en) * | 2008-07-22 | 2014-04-15 | Mayo Foundation For Medical Education And Research | Treatment of obesity and related disorders |
| US20110200669A1 (en) * | 2010-02-15 | 2011-08-18 | Winston Laboratories, Inc. | Method and compositions of civamide to treat disease of the intestines |
| KR101378973B1 (ko) * | 2012-04-13 | 2014-03-28 | 한미약품 주식회사 | 구형에 가까운 형태의 다중 투여 단위 정제를 포함하는 경질 캡슐 복합 제형 및 이의 제조방법 |
| CN103027901B (zh) * | 2012-12-11 | 2014-11-12 | 广东药学院 | 一种载辣椒素壳聚糖微球肠溶片及其制备方法 |
| US10092528B2 (en) | 2013-03-13 | 2018-10-09 | Altria Client Services Llc | Application of encapsulated capsaicin and analogues thereof for controlling calorie intake |
| CA2903493C (en) | 2013-03-15 | 2022-05-31 | Cedars-Sinai Medical Center | Methods of diagnosis, selection, and treatment of diseases and conditions caused by or associated with methanogens |
| US9289418B2 (en) | 2013-03-15 | 2016-03-22 | Cedars-Sinai Medical Center | Methods of diagnosis, selection, and treatment of diseases and conditions caused by or associated with methanogens |
| AU2014380905A1 (en) * | 2014-01-30 | 2016-09-08 | Omniactive Health Technologies Limited | Composition of oily, pungent and odoriferous substances and a process of preparation thereof |
| RU2697851C2 (ru) | 2014-08-13 | 2019-08-21 | Седарс-Синаи Медикал Сентер | Антиметаногенные композиции и их применение |
| EP3277274B1 (en) * | 2015-04-01 | 2024-06-12 | Cedars-Sinai Medical Center | Anti-methanogenic lovastatin analogs or derivatives and uses thereof |
| PL4135652T3 (pl) * | 2020-04-15 | 2025-03-10 | Grünenthal GmbH | Kompozycje rezyniferatoksyny |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2207705A1 (en) * | 1972-11-24 | 1974-06-21 | Marconnet Rene | Deodorisation of body odours - by liberation of odoriferous substances in the intestines |
| EP0015334B1 (en) * | 1977-08-04 | 1982-05-19 | J.B. Tillott Limited | Carminative preparations containing peppermint oil or its active components |
| US4681897A (en) * | 1984-01-16 | 1987-07-21 | The Procter & Gamble Company | Pharmaceutical products providing enhanced analgesia |
| US5403868A (en) | 1988-12-23 | 1995-04-04 | Sandoz Ltd. | Capsaicin derivatives |
| HU206082B (en) * | 1988-12-23 | 1992-08-28 | Sandoz Ag | Process for producing capsaicin derivatives and pharmaceutical compositions comprising such compounds |
| US5063060A (en) | 1989-12-19 | 1991-11-05 | Cisco Limited Partnership | Compositions and method for treating painful, inflammatory or allergic disorders |
| DE4137540A1 (de) * | 1991-11-14 | 1993-05-19 | Steigerwald Arzneimittelwerk | Verwendung von praeparaten der curcuma-pflanzen |
| US5431914A (en) | 1992-04-17 | 1995-07-11 | Adekunle; Michael | Method of treating an internal condition by external application of capsaicin without the need for systemic absorption |
| AU4382693A (en) | 1992-05-21 | 1993-12-13 | Jeff J. Staggs | Therapeutic uses of pungent botanicals and their related compounds |
| US5762963A (en) | 1995-06-07 | 1998-06-09 | Emory University | Method and compositions for controlling oral and pharyngeal pain using capsaicinoids |
| EP0839037B1 (en) * | 1995-07-14 | 2002-11-13 | Sabinsa Corporation | Bioprotectant composition, method of use and extraction process of curcuminoids |
-
1997
- 1997-06-10 GB GBGB9711962.2A patent/GB9711962D0/en active Pending
-
1998
- 1998-06-03 GB GBGB9811819.3A patent/GB9811819D0/en active Pending
- 1998-06-08 WO PCT/GB1998/001673 patent/WO1998056356A1/en not_active Ceased
- 1998-06-08 AU AU77829/98A patent/AU737606B2/en not_active Ceased
- 1998-06-08 ID IDW991447A patent/ID22878A/id unknown
- 1998-06-08 KR KR19997011628A patent/KR20010013618A/ko not_active Withdrawn
- 1998-06-08 DE DE1998622822 patent/DE69822822T2/de not_active Expired - Fee Related
- 1998-06-08 GB GB9827192A patent/GB2332147B/en not_active Expired - Fee Related
- 1998-06-08 HU HU0004245A patent/HUP0004245A2/hu unknown
- 1998-06-08 BR BR9809994-9A patent/BR9809994A/pt not_active Application Discontinuation
- 1998-06-08 CA CA002291796A patent/CA2291796C/en not_active Expired - Fee Related
- 1998-06-08 PL PL98337337A patent/PL337337A1/xx not_active IP Right Cessation
- 1998-06-08 CN CNB988060469A patent/CN1198594C/zh not_active Expired - Fee Related
- 1998-06-08 AT AT98925862T patent/ATE262892T1/de not_active IP Right Cessation
- 1998-06-08 US US09/445,514 patent/US6201014B1/en not_active Expired - Fee Related
- 1998-06-08 JP JP50108699A patent/JP2002513418A/ja not_active Ceased
- 1998-06-08 EP EP98925862A patent/EP0988028B1/en not_active Expired - Lifetime
- 1998-06-10 AR ARP980102742A patent/AR012960A1/es not_active Application Discontinuation
- 1998-06-18 ZA ZA984920A patent/ZA984920B/xx unknown
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005521674A (ja) * | 2002-02-01 | 2005-07-21 | ディポメド，インコーポレイティド | 即効性及び徐放性薬物をデリバリーする経口剤形の製造 |
| JP2022546914A (ja) * | 2019-07-18 | 2022-11-10 | ディグニファイ セラピューティクス エルエルシー | 排便を誘導するための組成物および方法 |
| JP7436622B2 (ja) | 2019-07-18 | 2024-02-21 | ディグニファイ セラピューティクス エルエルシー | 排便を誘導するための組成物および方法 |
| JP2024505139A (ja) * | 2021-01-15 | 2024-02-05 | ディグニファイ セラピューティクス エルエルシー | 排便を誘発するための組成物及び方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0988028B1 (en) | 2004-03-31 |
| ATE262892T1 (de) | 2004-04-15 |
| GB9827192D0 (en) | 1999-02-03 |
| CA2291796A1 (en) | 1998-12-17 |
| GB9711962D0 (en) | 1997-08-06 |
| EP0988028A1 (en) | 2000-03-29 |
| GB2332147A (en) | 1999-06-16 |
| HUP0004245A2 (hu) | 2001-08-28 |
| CN1198594C (zh) | 2005-04-27 |
| KR20010013618A (ko) | 2001-02-26 |
| AR012960A1 (es) | 2000-11-22 |
| BR9809994A (pt) | 2000-08-01 |
| DE69822822D1 (de) | 2004-05-06 |
| CN1259863A (zh) | 2000-07-12 |
| PL337337A1 (en) | 2000-08-14 |
| ZA984920B (en) | 1999-07-01 |
| AU737606B2 (en) | 2001-08-23 |
| GB9811819D0 (en) | 1998-07-29 |
| WO1998056356A1 (en) | 1998-12-17 |
| ID22878A (id) | 1999-12-16 |
| CA2291796C (en) | 2008-03-25 |
| AU7782998A (en) | 1998-12-30 |
| US6201014B1 (en) | 2001-03-13 |
| DE69822822T2 (de) | 2005-01-13 |
| GB2332147B (en) | 1999-10-27 |
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