JP2002512509A - ブロメラインの成分 - Google Patents
ブロメラインの成分Info
- Publication number
- JP2002512509A JP2002512509A JP53742398A JP53742398A JP2002512509A JP 2002512509 A JP2002512509 A JP 2002512509A JP 53742398 A JP53742398 A JP 53742398A JP 53742398 A JP53742398 A JP 53742398A JP 2002512509 A JP2002512509 A JP 2002512509A
- Authority
- JP
- Japan
- Prior art keywords
- bromelain
- ccs
- cells
- activation
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6472—Cysteine endopeptidases (3.4.22)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/63—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from plants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4873—Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Pulmonology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. SDS−PAGEで測定したとき約15.07kDa、25.85kDa 及び27.45kDaの分子量を持つタンパク質を含み、10.4及び10.4 5の等電点を持ちそして下記の方法、すなわち i. pH5.0の酢酸バッファー中にブロメラインを溶解し、 ii. S−セファロース上300mlを越える酢酸バッファー中の0〜0. 8M塩化ナトリウムの直線勾配で溶出するファスト・フロー高速液体 クロマト グラフィーによりブロメラインの成分を分離し、 iii. カラムから溶出する最後の二重ピークに対応する画分を集め、そして iv. (iii)で集めた画分からタンパク質を単離する方法、 により得ることができるブロメラインの成分。 2. 医薬、特に、 i. T細胞の活性化、 ii. MAPキナーゼ経路の活性化、又は iii. 成長因子又はサイトカインの生産、 により媒介される疾病又は状態の治療又は予防に、又は癌の治療又は予防に使用 するための、請求項1記載のブロメラインの成分。 3. 細胞の成長及び増殖を制御している経路を調節するための、請求項1記載 のブロメラインの成分。 4. 細胞による成長因子又はサイトカインの生産を阻害するための、請求項1 記載のブロメラインの成分。 5. MAPキナーゼ経路の活性化を阻害するための、請求項1記載のブロメラ インの成分。 6. T細胞の活性化を阻害するための、請求項1記載のブロメラインの成分。 7. 免疫抑制剤として使用するための、請求項1記載のブロメラインの成分。 8. 成長因子及びサイトカインの生産を阻止するため、又は自己免疫疾患、宿 主による移植拒否、アレルギー反応、毒物ショック、アポプトシス、寄生体又は 病原体の感染又は癌の治療又は予防するための、請求項1記載のブロメラインの 成分。 9. 細胞の成長及び増殖を制御する細胞内シグナル発信経路を調節するための 薬剤の調製における、アナナイン、コモサイン、アナナイン及びコモサインの混 合物又は請求項1記載のブロメラインの成分の使用。 10. 細胞による成長因子及びサイトカインの生産を阻害するための薬剤の調 製における、アナナイン、コモサイン、アナナイン及びコモサインの混合物又は 請求項1記載のブロメラインの成分の使用。 11. MAPキナーゼ経路の活性化を減少又は防止するための薬剤の調製にお ける、アナナイン、コモサイン、アナナイン及びコモサインの混合物又は請求項 1記載のブロメラインの成分の使用。 12. T細胞の活性化を減少又は防止するための薬剤の調製における、アナナ イン、コモサイン、アナナイン及びコモサインの混合物又は請求項1記載のブロ メラインの成分の使用。 13. 該薬剤が免疫抑制剤である、アナナイン、コモサイン、アナナイン及び コモサインの混合物又は請求項1記載のブロメラインの成分の使用。 14. i. T細胞の活性化、 ii. MAPキナーゼ経路の活性化、又は iii.成長因子又はサイトカインの生産、 により媒介される疾患又は状態の治療又は予防のため、又は癌の治療又は予防の ための薬剤の調製におけるアナナイン、コモサイン、アナナイン及びコモサイン の混合物又はブロメラインのCCS画分の使用。 15. 成長因子及び他のサイトカインの生産を阻止するための又は自己免疫疾 患、宿主による移植拒否、アレルギー反応、毒物ショック、アポプトシス、寄生 体又は病原体の感染又は癌の治療又は予防のための薬剤の調製におけるアナナイ ン、コモサイン、アナナイン及びコモサインの混合物又は請求項1記載のブロメ ラインの成分の使用。 16. 薬学的に又は獣医学的に許容され得る賦形剤と共にブロメラインのCC S画分を含んで成る薬学用又は獣医用の組成物。 17. 経腸投与、例えば、経口投与、経鼻投与、バッカル投与、局所投与又は 肛門投与に適する、請求項16記載の薬学用又は獣医用の組成物。 18. 非経口投与、例えば、静脈内、皮下、筋肉内又は腹腔内ルートによる投 与に適する、請求項16記載の薬学用又は獣医用の組成物。 19. 経口投与に適しかつ腸溶被覆製剤である、請求項16記載の薬学用又は 獣医用の組成物。
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9703827.7 | 1997-02-25 | ||
GBGB9703827.7A GB9703827D0 (en) | 1997-02-25 | 1997-02-25 | Novel protein |
GB9703850.9 | 1997-02-25 | ||
GBGB9703850.9A GB9703850D0 (en) | 1997-02-25 | 1997-02-25 | Novel protein |
GB9704252.7 | 1997-02-28 | ||
GBGB9704252.7A GB9704252D0 (en) | 1997-02-28 | 1997-02-28 | Novel protein |
GB9706119.6 | 1997-03-25 | ||
GBGB9706119.6A GB9706119D0 (en) | 1997-03-25 | 1997-03-25 | Novel protein |
PCT/GB1998/000590 WO1998038291A1 (en) | 1997-02-25 | 1998-02-25 | Component of bromelain |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010037537A Division JP2010143945A (ja) | 1997-02-25 | 2010-02-23 | ブロメライン成分を含む製薬組成物及び同ブロメライン成分を薬剤の調製に使用する方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2002512509A true JP2002512509A (ja) | 2002-04-23 |
JP4673454B2 JP4673454B2 (ja) | 2011-04-20 |
Family
ID=27451608
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53742498A Expired - Fee Related JP4651756B2 (ja) | 1997-02-25 | 1998-02-25 | ブロメラインの成分である単離されたタンパク質、同タンパク質を含む治療剤及び製薬組成物 |
JP53742398A Expired - Fee Related JP4673454B2 (ja) | 1997-02-25 | 1998-02-25 | ブロメラインの成分 |
JP2010037537A Pending JP2010143945A (ja) | 1997-02-25 | 2010-02-23 | ブロメライン成分を含む製薬組成物及び同ブロメライン成分を薬剤の調製に使用する方法 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53742498A Expired - Fee Related JP4651756B2 (ja) | 1997-02-25 | 1998-02-25 | ブロメラインの成分である単離されたタンパク質、同タンパク質を含む治療剤及び製薬組成物 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010037537A Pending JP2010143945A (ja) | 1997-02-25 | 2010-02-23 | ブロメライン成分を含む製薬組成物及び同ブロメライン成分を薬剤の調製に使用する方法 |
Country Status (8)
Country | Link |
---|---|
EP (4) | EP1908823B1 (ja) |
JP (3) | JP4651756B2 (ja) |
CN (2) | CN1204258C (ja) |
AT (3) | ATE382084T1 (ja) |
AU (2) | AU6303698A (ja) |
DE (2) | DE69838909T2 (ja) |
ES (4) | ES2288762T3 (ja) |
WO (2) | WO1998038291A1 (ja) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998038320A1 (en) | 1997-02-25 | 1998-09-03 | Cortecs (Uk) Limited | Component of bromelain |
US20020102253A1 (en) | 1997-02-25 | 2002-08-01 | Mynott Tracey Lehanne | Component of bromelain |
ATE222121T1 (de) * | 1998-07-15 | 2002-08-15 | Ursapharm Arzneimittel Gmbh | Verwendung von bromelainproteasen zur hemmung der blutgerinnung |
WO2000038708A1 (en) * | 1998-12-24 | 2000-07-06 | Phairson Medical Inc. | Treatment and prevention of immune rejection reactions |
US6977245B2 (en) * | 1999-04-12 | 2005-12-20 | The United States Of America As Represented By The Department Of Health And Human Services | Oligodeoxynucleotide and its use to induce an immune response |
AU2002252378B2 (en) * | 2001-03-19 | 2007-10-18 | Intercell Usa, Inc. | Transcutaneous immunostimulation |
CA2995985A1 (en) | 2015-08-20 | 2017-02-23 | Anatara Lifesciences Limited | Enzymatic fractions with anti-inflammatory activity |
EP4121022A4 (en) * | 2020-03-20 | 2024-06-19 | Novel Concepts Medical Ltd | COMPOSITIONS AND METHODS FOR THE TREATMENT AND PREVENTION OF CORONAVIRUS INFECTION |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0216977A (ja) * | 1987-10-22 | 1990-01-19 | Genzyme Corp | システインプロテイナーゼ |
WO1996000082A1 (en) * | 1994-06-24 | 1996-01-04 | Cortecs Limited | Medical use of bromelain |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL105699A0 (en) * | 1992-06-26 | 1993-09-22 | Genzyme Corp | Hydrophilic creams for delivery of therapeutic agents |
ES2138625T3 (es) * | 1992-06-30 | 2000-01-16 | Cortecs Uk Ltd | Uso de enzimas especialmente bromelaina, en el tratamiento de diarrea no infecciosa. |
US5387517A (en) * | 1994-03-23 | 1995-02-07 | Ethicon, Inc. | Thiol activated protease from stem bromelain for treating devitalized tissue |
-
1998
- 1998-02-25 EP EP07024577A patent/EP1908823B1/en not_active Expired - Lifetime
- 1998-02-25 AT AT98907053T patent/ATE382084T1/de not_active IP Right Cessation
- 1998-02-25 EP EP07011287A patent/EP1865055B1/en not_active Expired - Lifetime
- 1998-02-25 JP JP53742498A patent/JP4651756B2/ja not_active Expired - Fee Related
- 1998-02-25 EP EP98907053A patent/EP0996710B1/en not_active Expired - Lifetime
- 1998-02-25 AU AU63036/98A patent/AU6303698A/en not_active Abandoned
- 1998-02-25 WO PCT/GB1998/000590 patent/WO1998038291A1/en active IP Right Grant
- 1998-02-25 DE DE69838909T patent/DE69838909T2/de not_active Expired - Lifetime
- 1998-02-25 JP JP53742398A patent/JP4673454B2/ja not_active Expired - Fee Related
- 1998-02-25 ES ES98907054T patent/ES2288762T3/es not_active Expired - Lifetime
- 1998-02-25 ES ES98907053T patent/ES2297878T3/es not_active Expired - Lifetime
- 1998-02-25 AU AU63037/98A patent/AU6303798A/en not_active Abandoned
- 1998-02-25 ES ES07024577T patent/ES2377539T3/es not_active Expired - Lifetime
- 1998-02-25 AT AT98907054T patent/ATE364700T1/de not_active IP Right Cessation
- 1998-02-25 DE DE69837923T patent/DE69837923T2/de not_active Expired - Lifetime
- 1998-02-25 CN CNB988028255A patent/CN1204258C/zh not_active Expired - Fee Related
- 1998-02-25 AT AT07024577T patent/ATE533842T1/de active
- 1998-02-25 ES ES07011287T patent/ES2403433T3/es not_active Expired - Lifetime
- 1998-02-25 WO PCT/GB1998/000591 patent/WO1998038319A1/en active IP Right Grant
- 1998-02-25 EP EP98907054A patent/EP1012304B1/en not_active Expired - Lifetime
- 1998-02-25 CN CNB98803901XA patent/CN100400659C/zh not_active Expired - Fee Related
-
2010
- 2010-02-23 JP JP2010037537A patent/JP2010143945A/ja active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0216977A (ja) * | 1987-10-22 | 1990-01-19 | Genzyme Corp | システインプロテイナーゼ |
WO1996000082A1 (en) * | 1994-06-24 | 1996-01-04 | Cortecs Limited | Medical use of bromelain |
Also Published As
Publication number | Publication date |
---|---|
EP1865055B1 (en) | 2012-12-05 |
JP2001513635A (ja) | 2001-09-04 |
WO1998038319A1 (en) | 1998-09-03 |
EP1012304A1 (en) | 2000-06-28 |
ES2297878T3 (es) | 2008-05-01 |
CN1252096A (zh) | 2000-05-03 |
EP0996710B1 (en) | 2007-12-26 |
DE69838909D1 (de) | 2008-02-07 |
EP1012304B1 (en) | 2007-06-13 |
ES2403433T3 (es) | 2013-05-17 |
WO1998038291A1 (en) | 1998-09-03 |
JP4651756B2 (ja) | 2011-03-16 |
DE69837923D1 (de) | 2007-07-26 |
ATE364700T1 (de) | 2007-07-15 |
CN1249002A (zh) | 2000-03-29 |
EP1908823B1 (en) | 2011-11-16 |
ATE533842T1 (de) | 2011-12-15 |
JP4673454B2 (ja) | 2011-04-20 |
AU6303798A (en) | 1998-09-18 |
DE69838909T2 (de) | 2009-01-08 |
EP1908823A1 (en) | 2008-04-09 |
EP0996710A1 (en) | 2000-05-03 |
ES2377539T3 (es) | 2012-03-28 |
AU6303698A (en) | 1998-09-18 |
CN100400659C (zh) | 2008-07-09 |
DE69837923T2 (de) | 2008-02-14 |
ES2288762T3 (es) | 2008-01-16 |
CN1204258C (zh) | 2005-06-01 |
EP1865055A1 (en) | 2007-12-12 |
JP2010143945A (ja) | 2010-07-01 |
ATE382084T1 (de) | 2008-01-15 |
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