ATE533842T1 - Bromelainbestandteil - Google Patents

Bromelainbestandteil

Info

Publication number
ATE533842T1
ATE533842T1 AT07024577T AT07024577T ATE533842T1 AT E533842 T1 ATE533842 T1 AT E533842T1 AT 07024577 T AT07024577 T AT 07024577T AT 07024577 T AT07024577 T AT 07024577T AT E533842 T1 ATE533842 T1 AT E533842T1
Authority
AT
Austria
Prior art keywords
bromelain
component
map kinase
activation
bromelain component
Prior art date
Application number
AT07024577T
Other languages
English (en)
Inventor
Tracey Lehanne Mynott
Christian Engwerda
Keith Peek
Original Assignee
Sarantis Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9703850.9A external-priority patent/GB9703850D0/en
Priority claimed from GBGB9703827.7A external-priority patent/GB9703827D0/en
Priority claimed from GBGB9704252.7A external-priority patent/GB9704252D0/en
Priority claimed from GBGB9706119.6A external-priority patent/GB9706119D0/en
Application filed by Sarantis Pty Ltd filed Critical Sarantis Pty Ltd
Application granted granted Critical
Publication of ATE533842T1 publication Critical patent/ATE533842T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/63—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4873—Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT07024577T 1997-02-25 1998-02-25 Bromelainbestandteil ATE533842T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9703850.9A GB9703850D0 (en) 1997-02-25 1997-02-25 Novel protein
GBGB9703827.7A GB9703827D0 (en) 1997-02-25 1997-02-25 Novel protein
GBGB9704252.7A GB9704252D0 (en) 1997-02-28 1997-02-28 Novel protein
GBGB9706119.6A GB9706119D0 (en) 1997-03-25 1997-03-25 Novel protein

Publications (1)

Publication Number Publication Date
ATE533842T1 true ATE533842T1 (de) 2011-12-15

Family

ID=27451608

Family Applications (3)

Application Number Title Priority Date Filing Date
AT07024577T ATE533842T1 (de) 1997-02-25 1998-02-25 Bromelainbestandteil
AT98907054T ATE364700T1 (de) 1997-02-25 1998-02-25 Bestandteil von bromelain
AT98907053T ATE382084T1 (de) 1997-02-25 1998-02-25 Bromelinbestandteil

Family Applications After (2)

Application Number Title Priority Date Filing Date
AT98907054T ATE364700T1 (de) 1997-02-25 1998-02-25 Bestandteil von bromelain
AT98907053T ATE382084T1 (de) 1997-02-25 1998-02-25 Bromelinbestandteil

Country Status (8)

Country Link
EP (4) EP1012304B1 (de)
JP (3) JP4673454B2 (de)
CN (2) CN1204258C (de)
AT (3) ATE533842T1 (de)
AU (2) AU6303698A (de)
DE (2) DE69838909T2 (de)
ES (4) ES2297878T3 (de)
WO (2) WO1998038319A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1252101A (zh) 1997-02-25 2000-05-03 科特克斯(英国)有限公司 菠萝蛋白酶成分
US20020102253A1 (en) 1997-02-25 2002-08-01 Mynott Tracey Lehanne Component of bromelain
DE59805215D1 (de) * 1998-07-15 2002-09-19 Ursapharm Arzneimittel Gmbh Verwendung von bromelainproteasen zur hemmung der blutgerinnung
WO2000038708A1 (en) * 1998-12-24 2000-07-06 Phairson Medical Inc. Treatment and prevention of immune rejection reactions
US6977245B2 (en) * 1999-04-12 2005-12-20 The United States Of America As Represented By The Department Of Health And Human Services Oligodeoxynucleotide and its use to induce an immune response
EP2316482A1 (de) * 2001-03-19 2011-05-04 Intercell USA, Inc. Transkutane Immunostimulierung
AU2016308267A1 (en) 2015-08-20 2018-03-29 Anatara Lifesciences Limited Enzymatic fractions with anti-inflammatory activity
WO2021186454A1 (en) * 2020-03-20 2021-09-23 Alkalay Rachel Compositions and methods for treating and preventing non-malignant respiratory disease

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8724728D0 (en) * 1987-10-22 1987-11-25 Genzyme Corp Cysteine proteinase
IL105699A0 (en) * 1992-06-26 1993-09-22 Genzyme Corp Hydrophilic creams for delivery of therapeutic agents
AU672986B2 (en) * 1992-06-30 1996-10-24 Cortecs Limited Use of enzymes, especially bromelain, in the treatment of diarrhoea
US5387517A (en) * 1994-03-23 1995-02-07 Ethicon, Inc. Thiol activated protease from stem bromelain for treating devitalized tissue
GB9412711D0 (en) * 1994-06-24 1994-08-17 Cortecs Ltd Medical use of bromelain

Also Published As

Publication number Publication date
DE69837923D1 (de) 2007-07-26
ATE382084T1 (de) 2008-01-15
CN1249002A (zh) 2000-03-29
DE69838909T2 (de) 2009-01-08
JP4651756B2 (ja) 2011-03-16
EP0996710A1 (de) 2000-05-03
AU6303698A (en) 1998-09-18
CN1204258C (zh) 2005-06-01
JP4673454B2 (ja) 2011-04-20
EP0996710B1 (de) 2007-12-26
JP2001513635A (ja) 2001-09-04
ES2377539T3 (es) 2012-03-28
EP1012304B1 (de) 2007-06-13
EP1865055A1 (de) 2007-12-12
AU6303798A (en) 1998-09-18
CN100400659C (zh) 2008-07-09
DE69837923T2 (de) 2008-02-14
ES2297878T3 (es) 2008-05-01
ATE364700T1 (de) 2007-07-15
EP1908823B1 (de) 2011-11-16
ES2403433T3 (es) 2013-05-17
EP1012304A1 (de) 2000-06-28
EP1865055B1 (de) 2012-12-05
WO1998038291A1 (en) 1998-09-03
WO1998038319A1 (en) 1998-09-03
CN1252096A (zh) 2000-05-03
JP2010143945A (ja) 2010-07-01
ES2288762T3 (es) 2008-01-16
EP1908823A1 (de) 2008-04-09
JP2002512509A (ja) 2002-04-23
DE69838909D1 (de) 2008-02-07

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