JP2001513635A - ブロメラインの成分 - Google Patents
ブロメラインの成分Info
- Publication number
- JP2001513635A JP2001513635A JP53742498A JP53742498A JP2001513635A JP 2001513635 A JP2001513635 A JP 2001513635A JP 53742498 A JP53742498 A JP 53742498A JP 53742498 A JP53742498 A JP 53742498A JP 2001513635 A JP2001513635 A JP 2001513635A
- Authority
- JP
- Japan
- Prior art keywords
- bromelain
- protein
- fraction
- ccz
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/63—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from plants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6472—Cysteine endopeptidases (3.4.22)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4873—Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Botany (AREA)
- Rheumatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Toxicology (AREA)
- Transplantation (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. SDS−PAGEにより測定するとき約27.45kDaの分子量を持ち かつ下記の方法、すなわち i. pH5.0の酢酸バッファー中にブロメラインを溶解し、 ii. S−セファロース上、300mlを越える酢酸バッファー中 の0〜0.8M塩化ナトリウムの直線勾配で溶出するファスト高速液体 クロマトグラフィーによりブロメラインの諸成分を分離し、 iii. カラムから溶出する第3のピークに対応する画分であって、 ステムブロメラインプロテアーゼピークの最初の主要なピークの立ち上 がり末端上に現れる画分を集め、そして iv. (iii)で集めた画分からタンパク質を単離する方法、 により得ることができるブロメラインの画分。 2. SDS−PAGEで測定するとき約27.45kDaの分子量を持ち、等 電点電気泳動により測定するとき9.7の等電点を持ちそして下記のアミノ末端 配列、 Val Leu Pro Asp Ser Ile Asp Trp Arg Gln Lys Gly Ala Val Thr Glu Val Lys Asn Arg Gly を有する、ブロメラインの成分であるタンパク質。 3. 請求項2に記載のタンパク質をコードする配列又はそれに相補的な配列を を有する核酸。 4. ヒト用又は獣医用医薬品に使用するための、請求項1又は請求項2に記載 のブロメラインの画分又はタンパク質。 5. 免疫刺激剤として使用するための、請求項1又は請求項2に記載のブロメ ラインの画分又はタンパク質。 6. 免疫刺激剤の調製における、請求項1又は請求項2に記載のブロメライン の画分又はタンパク質の使用。 7. 免疫刺激剤が栄養失調、感染(例えば、HIV及びマラリア)、腫瘍(例 えば、リンパ腫、骨髄腫及び他のもの)、外傷(例えば、火傷、創傷及び手術) 、医学的処置(例えば、ステロイド、シクロスポリン及びシクロホスファミドな どの薬物での処置)、タンパク質喪失(下痢及び火傷などにおける)、糖尿病及 び老齢から生ずる一次免疫不全又は二次免疫不全の治療のためのものである、請 求項6記載のブロメラインの画分又はタンパク質又は請求項6に記載の使用。 8. 免疫刺激剤がワクチンのアジュバントである、請求項7記載のタンパク質 又は使用。 9. 抗−微生物剤としての使用のための、請求項1記載のブロメライン画分又 は請求項2記載のタンパク質。 10. 抗−微生物剤の調製における、請求項1又は請求項2記載のブロメライ ン画分又はタンパク質の使用。 11. 抗−ガン剤としての使用のための、請求項1記載のブロメライン画分又 は請求項2記載のタンパク質。 12. 抗ガン剤の調製における、請求項1又は請求項2記載のブロメライン画 分又はタンパク質の使用。 13. 抗ガン剤が卵巣、乳房、結腸、又は肺のガン、黒色腫、白血病及びリン パ腫を治療するために用いられるものである、請求項11記載のタンパク質又は 請求項12記載の使用。 14. 薬学的に又は獣医学的に許容され得る賦形剤と共に請求項1記載のブロ メライン画分又は請求項2記載のタンパク質を含んで成る薬学的又は獣医学的組 成物。 15. ワクチン、請求項1記載のブロメライン画分又は請求項2記載のタンパ ク質を含むアジュバント及び薬学的又は獣医学的に許容され得る賦形剤又は担体 を含んでなるワクチン組成物。 16. 例えば、経口投与、経鼻投与、バッカル投与、又は肛門投与などの経腸 投与用に製剤化される、請求項14又は請求項15記載の組成物。 17. 例えば、静脈内、皮下、筋肉内又は腹腔内ルートによる非経口投与用に 製剤化される、請求項14又は請求項15記載の組成物。
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9703827.7 | 1997-02-25 | ||
GBGB9703827.7A GB9703827D0 (en) | 1997-02-25 | 1997-02-25 | Novel protein |
GBGB9703850.9A GB9703850D0 (en) | 1997-02-25 | 1997-02-25 | Novel protein |
GB9703850.9 | 1997-02-25 | ||
GBGB9704252.7A GB9704252D0 (en) | 1997-02-28 | 1997-02-28 | Novel protein |
GB9704252.7 | 1997-02-28 | ||
GBGB9706119.6A GB9706119D0 (en) | 1997-03-25 | 1997-03-25 | Novel protein |
GB9706119.6 | 1997-03-25 | ||
PCT/GB1998/000591 WO1998038319A1 (en) | 1997-02-25 | 1998-02-25 | Component of bromelain |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2001513635A true JP2001513635A (ja) | 2001-09-04 |
JP4651756B2 JP4651756B2 (ja) | 2011-03-16 |
Family
ID=27451608
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53742398A Expired - Fee Related JP4673454B2 (ja) | 1997-02-25 | 1998-02-25 | ブロメラインの成分 |
JP53742498A Expired - Fee Related JP4651756B2 (ja) | 1997-02-25 | 1998-02-25 | ブロメラインの成分である単離されたタンパク質、同タンパク質を含む治療剤及び製薬組成物 |
JP2010037537A Pending JP2010143945A (ja) | 1997-02-25 | 2010-02-23 | ブロメライン成分を含む製薬組成物及び同ブロメライン成分を薬剤の調製に使用する方法 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53742398A Expired - Fee Related JP4673454B2 (ja) | 1997-02-25 | 1998-02-25 | ブロメラインの成分 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010037537A Pending JP2010143945A (ja) | 1997-02-25 | 2010-02-23 | ブロメライン成分を含む製薬組成物及び同ブロメライン成分を薬剤の調製に使用する方法 |
Country Status (8)
Country | Link |
---|---|
EP (4) | EP0996710B1 (ja) |
JP (3) | JP4673454B2 (ja) |
CN (2) | CN100400659C (ja) |
AT (3) | ATE533842T1 (ja) |
AU (2) | AU6303798A (ja) |
DE (2) | DE69838909T2 (ja) |
ES (4) | ES2403433T3 (ja) |
WO (2) | WO1998038319A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7833963B2 (en) | 1997-02-25 | 2010-11-16 | Sarantis Pty Ltd | Component of bromelain |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1252101A (zh) | 1997-02-25 | 2000-05-03 | 科特克斯(英国)有限公司 | 菠萝蛋白酶成分 |
PT1096951E (pt) | 1998-07-15 | 2003-01-31 | Ursapharm Arzneimittel Gmbh | Utilizacao de proteases de bromelaina para a preparacao de um medicamento para a inibicao de coagulacao do sangue |
WO2000038708A1 (en) * | 1998-12-24 | 2000-07-06 | Phairson Medical Inc. | Treatment and prevention of immune rejection reactions |
US6977245B2 (en) * | 1999-04-12 | 2005-12-20 | The United States Of America As Represented By The Department Of Health And Human Services | Oligodeoxynucleotide and its use to induce an immune response |
AU2002252378B2 (en) * | 2001-03-19 | 2007-10-18 | Intercell Usa, Inc. | Transcutaneous immunostimulation |
EP3337499A4 (en) | 2015-08-20 | 2019-02-20 | Anatara Lifesciences Limited | ENZYMATIC FRACTIONS WITH ANTI-INFLAMMATORY EFFECT |
CN116096360A (zh) * | 2020-03-20 | 2023-05-09 | 新概念医疗有限公司 | 用于治疗或预防炎症性疾病,包括10 i型和ii型糖尿病以及甲状腺疾病的组合物和方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996000082A1 (en) * | 1994-06-24 | 1996-01-04 | Cortecs Limited | Medical use of bromelain |
JPH0838173A (ja) * | 1994-03-23 | 1996-02-13 | Ethicon Inc | 壊死組織を処理するための新規なプロテアーゼ |
JPH08503691A (ja) * | 1992-06-30 | 1996-04-23 | コーテックス リミテッド | 下痢の治療における酵素、特にブロメラインの使用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8724728D0 (en) * | 1987-10-22 | 1987-11-25 | Genzyme Corp | Cysteine proteinase |
IL105699A0 (en) * | 1992-06-26 | 1993-09-22 | Genzyme Corp | Hydrophilic creams for delivery of therapeutic agents |
-
1998
- 1998-02-25 AT AT07024577T patent/ATE533842T1/de active
- 1998-02-25 AT AT98907053T patent/ATE382084T1/de not_active IP Right Cessation
- 1998-02-25 EP EP98907053A patent/EP0996710B1/en not_active Expired - Lifetime
- 1998-02-25 DE DE69838909T patent/DE69838909T2/de not_active Expired - Lifetime
- 1998-02-25 EP EP98907054A patent/EP1012304B1/en not_active Expired - Lifetime
- 1998-02-25 ES ES07011287T patent/ES2403433T3/es not_active Expired - Lifetime
- 1998-02-25 ES ES98907054T patent/ES2288762T3/es not_active Expired - Lifetime
- 1998-02-25 ES ES98907053T patent/ES2297878T3/es not_active Expired - Lifetime
- 1998-02-25 AU AU63037/98A patent/AU6303798A/en not_active Abandoned
- 1998-02-25 DE DE69837923T patent/DE69837923T2/de not_active Expired - Lifetime
- 1998-02-25 JP JP53742398A patent/JP4673454B2/ja not_active Expired - Fee Related
- 1998-02-25 CN CNB98803901XA patent/CN100400659C/zh not_active Expired - Fee Related
- 1998-02-25 AU AU63036/98A patent/AU6303698A/en not_active Abandoned
- 1998-02-25 WO PCT/GB1998/000591 patent/WO1998038319A1/en active IP Right Grant
- 1998-02-25 JP JP53742498A patent/JP4651756B2/ja not_active Expired - Fee Related
- 1998-02-25 EP EP07011287A patent/EP1865055B1/en not_active Expired - Lifetime
- 1998-02-25 AT AT98907054T patent/ATE364700T1/de not_active IP Right Cessation
- 1998-02-25 WO PCT/GB1998/000590 patent/WO1998038291A1/en active IP Right Grant
- 1998-02-25 EP EP07024577A patent/EP1908823B1/en not_active Expired - Lifetime
- 1998-02-25 CN CNB988028255A patent/CN1204258C/zh not_active Expired - Fee Related
- 1998-02-25 ES ES07024577T patent/ES2377539T3/es not_active Expired - Lifetime
-
2010
- 2010-02-23 JP JP2010037537A patent/JP2010143945A/ja active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08503691A (ja) * | 1992-06-30 | 1996-04-23 | コーテックス リミテッド | 下痢の治療における酵素、特にブロメラインの使用 |
JPH0838173A (ja) * | 1994-03-23 | 1996-02-13 | Ethicon Inc | 壊死組織を処理するための新規なプロテアーゼ |
WO1996000082A1 (en) * | 1994-06-24 | 1996-01-04 | Cortecs Limited | Medical use of bromelain |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7833963B2 (en) | 1997-02-25 | 2010-11-16 | Sarantis Pty Ltd | Component of bromelain |
US9663777B2 (en) | 1997-02-25 | 2017-05-30 | Sarantis Pty Ltd | Component of bromelain |
Also Published As
Publication number | Publication date |
---|---|
AU6303798A (en) | 1998-09-18 |
EP1865055A1 (en) | 2007-12-12 |
ES2297878T3 (es) | 2008-05-01 |
ES2403433T3 (es) | 2013-05-17 |
EP1908823B1 (en) | 2011-11-16 |
JP4651756B2 (ja) | 2011-03-16 |
ATE382084T1 (de) | 2008-01-15 |
EP1908823A1 (en) | 2008-04-09 |
JP2002512509A (ja) | 2002-04-23 |
CN1252096A (zh) | 2000-05-03 |
ES2377539T3 (es) | 2012-03-28 |
ATE364700T1 (de) | 2007-07-15 |
DE69838909D1 (de) | 2008-02-07 |
DE69838909T2 (de) | 2009-01-08 |
CN1204258C (zh) | 2005-06-01 |
AU6303698A (en) | 1998-09-18 |
EP1012304A1 (en) | 2000-06-28 |
EP1012304B1 (en) | 2007-06-13 |
ATE533842T1 (de) | 2011-12-15 |
DE69837923D1 (de) | 2007-07-26 |
EP0996710A1 (en) | 2000-05-03 |
WO1998038319A1 (en) | 1998-09-03 |
JP4673454B2 (ja) | 2011-04-20 |
EP1865055B1 (en) | 2012-12-05 |
CN1249002A (zh) | 2000-03-29 |
CN100400659C (zh) | 2008-07-09 |
DE69837923T2 (de) | 2008-02-14 |
EP0996710B1 (en) | 2007-12-26 |
WO1998038291A1 (en) | 1998-09-03 |
ES2288762T3 (es) | 2008-01-16 |
JP2010143945A (ja) | 2010-07-01 |
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