ES2403433T3 - Componente de bromelina - Google Patents

Componente de bromelina Download PDF

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Publication number
ES2403433T3
ES2403433T3 ES07011287T ES07011287T ES2403433T3 ES 2403433 T3 ES2403433 T3 ES 2403433T3 ES 07011287 T ES07011287 T ES 07011287T ES 07011287 T ES07011287 T ES 07011287T ES 2403433 T3 ES2403433 T3 ES 2403433T3
Authority
ES
Spain
Prior art keywords
bromelain
fraction
ccz
composition according
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES07011287T
Other languages
English (en)
Spanish (es)
Inventor
Tracey Lehanne Mynott
Christian Engwerda
Keithcortecs Peek (Uk) Limited
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sarantis Pty Ltd
Original Assignee
Sarantis Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9703827.7A external-priority patent/GB9703827D0/en
Priority claimed from GBGB9703850.9A external-priority patent/GB9703850D0/en
Priority claimed from GBGB9704252.7A external-priority patent/GB9704252D0/en
Priority claimed from GBGB9706119.6A external-priority patent/GB9706119D0/en
Application filed by Sarantis Pty Ltd filed Critical Sarantis Pty Ltd
Application granted granted Critical
Publication of ES2403433T3 publication Critical patent/ES2403433T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/63—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4873—Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Botany (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES07011287T 1997-02-25 1998-02-25 Componente de bromelina Expired - Lifetime ES2403433T3 (es)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
GB9703827 1997-02-25
GB9703850 1997-02-25
GBGB9703827.7A GB9703827D0 (en) 1997-02-25 1997-02-25 Novel protein
GBGB9703850.9A GB9703850D0 (en) 1997-02-25 1997-02-25 Novel protein
GBGB9704252.7A GB9704252D0 (en) 1997-02-28 1997-02-28 Novel protein
GB9704252 1997-02-28
GBGB9706119.6A GB9706119D0 (en) 1997-03-25 1997-03-25 Novel protein
GB9706119 1997-03-25

Publications (1)

Publication Number Publication Date
ES2403433T3 true ES2403433T3 (es) 2013-05-17

Family

ID=27451608

Family Applications (4)

Application Number Title Priority Date Filing Date
ES07011287T Expired - Lifetime ES2403433T3 (es) 1997-02-25 1998-02-25 Componente de bromelina
ES98907054T Expired - Lifetime ES2288762T3 (es) 1997-02-25 1998-02-25 Componente de bromelina.
ES98907053T Expired - Lifetime ES2297878T3 (es) 1997-02-25 1998-02-25 Componente de la bromelaina.
ES07024577T Expired - Lifetime ES2377539T3 (es) 1997-02-25 1998-02-25 Componente de la bromelaína

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES98907054T Expired - Lifetime ES2288762T3 (es) 1997-02-25 1998-02-25 Componente de bromelina.
ES98907053T Expired - Lifetime ES2297878T3 (es) 1997-02-25 1998-02-25 Componente de la bromelaina.
ES07024577T Expired - Lifetime ES2377539T3 (es) 1997-02-25 1998-02-25 Componente de la bromelaína

Country Status (8)

Country Link
EP (4) EP0996710B1 (ja)
JP (3) JP4673454B2 (ja)
CN (2) CN100400659C (ja)
AT (3) ATE533842T1 (ja)
AU (2) AU6303798A (ja)
DE (2) DE69838909T2 (ja)
ES (4) ES2403433T3 (ja)
WO (2) WO1998038319A1 (ja)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1252101A (zh) 1997-02-25 2000-05-03 科特克斯(英国)有限公司 菠萝蛋白酶成分
US20020102253A1 (en) 1997-02-25 2002-08-01 Mynott Tracey Lehanne Component of bromelain
PT1096951E (pt) 1998-07-15 2003-01-31 Ursapharm Arzneimittel Gmbh Utilizacao de proteases de bromelaina para a preparacao de um medicamento para a inibicao de coagulacao do sangue
WO2000038708A1 (en) * 1998-12-24 2000-07-06 Phairson Medical Inc. Treatment and prevention of immune rejection reactions
US6977245B2 (en) * 1999-04-12 2005-12-20 The United States Of America As Represented By The Department Of Health And Human Services Oligodeoxynucleotide and its use to induce an immune response
AU2002252378B2 (en) * 2001-03-19 2007-10-18 Intercell Usa, Inc. Transcutaneous immunostimulation
EP3337499A4 (en) 2015-08-20 2019-02-20 Anatara Lifesciences Limited ENZYMATIC FRACTIONS WITH ANTI-INFLAMMATORY EFFECT
CN116096360A (zh) * 2020-03-20 2023-05-09 新概念医疗有限公司 用于治疗或预防炎症性疾病，包括10 i型和ii型糖尿病以及甲状腺疾病的组合物和方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8724728D0 (en) * 1987-10-22 1987-11-25 Genzyme Corp Cysteine proteinase
IL105699A0 (en) * 1992-06-26 1993-09-22 Genzyme Corp Hydrophilic creams for delivery of therapeutic agents
DE69326351T2 (de) * 1992-06-30 2000-05-18 Cortecs (Uk) Ltd., Isleworth Verwendung von enzymen insbesondere brorelain zur behandlung von nicht-infektiöser diarrhöe
US5387517A (en) * 1994-03-23 1995-02-07 Ethicon, Inc. Thiol activated protease from stem bromelain for treating devitalized tissue
GB9412711D0 (en) * 1994-06-24 1994-08-17 Cortecs Ltd Medical use of bromelain

Also Published As

Publication number Publication date
AU6303798A (en) 1998-09-18
EP1865055A1 (en) 2007-12-12
ES2297878T3 (es) 2008-05-01
JP2001513635A (ja) 2001-09-04
EP1908823B1 (en) 2011-11-16
JP4651756B2 (ja) 2011-03-16
ATE382084T1 (de) 2008-01-15
EP1908823A1 (en) 2008-04-09
JP2002512509A (ja) 2002-04-23
CN1252096A (zh) 2000-05-03
ES2377539T3 (es) 2012-03-28
ATE364700T1 (de) 2007-07-15
DE69838909D1 (de) 2008-02-07
DE69838909T2 (de) 2009-01-08
CN1204258C (zh) 2005-06-01
AU6303698A (en) 1998-09-18
EP1012304A1 (en) 2000-06-28
EP1012304B1 (en) 2007-06-13
ATE533842T1 (de) 2011-12-15
DE69837923D1 (de) 2007-07-26
EP0996710A1 (en) 2000-05-03
WO1998038319A1 (en) 1998-09-03
JP4673454B2 (ja) 2011-04-20
EP1865055B1 (en) 2012-12-05
CN1249002A (zh) 2000-03-29
CN100400659C (zh) 2008-07-09
DE69837923T2 (de) 2008-02-14
EP0996710B1 (en) 2007-12-26
WO1998038291A1 (en) 1998-09-03
ES2288762T3 (es) 2008-01-16
JP2010143945A (ja) 2010-07-01

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