|
US6506798B1
(en)
|
1997-07-01 |
2003-01-14 |
Warner-Lambert Company |
4-Arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective MEK inhibitors
|
|
US7354894B2
(en)
|
1998-08-18 |
2008-04-08 |
The Regents Of The University Of California |
Preventing airway mucus production by administration of EGF-R antagonists
|
|
US6846799B1
(en)
|
1998-08-18 |
2005-01-25 |
The Regents Of The University Of California |
Preventing airway mucus production by administration of EGF-R antagonists
|
|
WO2000035435A1
(en)
*
|
1998-12-15 |
2000-06-22 |
Warner-Lambert Company |
Use of a mek inhibitor for preventing transplant rejection
|
|
IL144103A0
(en)
*
|
1999-01-07 |
2002-05-23 |
Warner Lambert Co |
Antiviral method using mek inhibitors
|
|
AU2201500A
(en)
|
1999-01-13 |
2000-08-01 |
Warner-Lambert Company |
Benzenesulfonamide derivatives and their use as mek inhibitors
|
|
CA2348236A1
(en)
*
|
1999-01-13 |
2000-07-20 |
Stephen Douglas Barrett |
4-arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective mek inhibitors
|
|
AU2482700A
(en)
|
1999-01-13 |
2000-08-01 |
Warner-Lambert Company |
1-heterocycle substituted diarylamines
|
|
HRP20010524A2
(en)
|
1999-01-13 |
2002-08-31 |
Warner Lambert Co |
Benzoheterocycles and their use as mek inhibitors
|
|
JP2002534497A
(ja)
|
1999-01-13 |
2002-10-15 |
ワーナー−ランバート・カンパニー |
スルホヒドロキサム酸およびスルホヒドロキサメートおよびmek阻害剤としてのその使用
|
|
OA11861A
(en)
*
|
1999-04-21 |
2006-03-02 |
Warner Lambert Co |
Method for making 2-(N-phenylamino) benzoic acids.
|
|
US6686499B1
(en)
|
1999-04-21 |
2004-02-03 |
Warner-Lambert Company |
Method for making 2-(N-phenylamino)benzoic acids
|
|
GB9910580D0
(en)
|
1999-05-08 |
1999-07-07 |
Zeneca Ltd |
Chemical compounds
|
|
GB9910579D0
(en)
*
|
1999-05-08 |
1999-07-07 |
Zeneca Ltd |
Chemical compounds
|
|
GB9910577D0
(en)
*
|
1999-05-08 |
1999-07-07 |
Zeneca Ltd |
Chemical compounds
|
|
CN1373660A
(zh)
*
|
1999-07-16 |
2002-10-09 |
沃尼尔·朗伯公司 |
使用mek抑制剂治疗慢性疼痛的方法
|
|
CA2403017A1
(en)
*
|
2000-03-15 |
2001-09-20 |
Warner-Lambert Company |
5-amide substituted diarylamines as mex inhibitors
|
|
US7001905B2
(en)
|
2000-03-15 |
2006-02-21 |
Warner-Lambert Company |
Substituted diarylamines as MEK inhibitors
|
|
DE10017480A1
(de)
*
|
2000-04-07 |
2001-10-11 |
Transmit Technologietransfer |
Verwendung von Substanzen, die als MEK Inhibitor wirken, zur Herstellung eines Arneimittels gegen DNA- und RNA-Viren
|
|
CA2416685C
(en)
*
|
2000-07-19 |
2008-10-07 |
Warner-Lambert Company |
Oxygenated esters of 4-iodo phenylamino benzhydroxamic acids
|
|
JP2004507518A
(ja)
*
|
2000-08-25 |
2004-03-11 |
ワーナー−ランバート・カンパニー・エルエルシー |
N−アリール−アントラニル酸及びその誘導体の製造法
|
|
CA2419567A1
(en)
|
2000-09-01 |
2002-03-07 |
George Vande Woude |
Inhibition of mitogen-activated protein kinase (mapk) pathway: a selective therapeutic strategy against melanoma
|
|
US7253184B2
(en)
|
2000-11-02 |
2007-08-07 |
Astrazeneca Ab |
4-Substituted quinolines as antitumor agents
|
|
WO2002044166A1
(en)
|
2000-11-02 |
2002-06-06 |
Astrazeneca Ab |
Substituted quinolines as antitumor agents
|
|
WO2002076496A1
(en)
*
|
2001-03-22 |
2002-10-03 |
Van Andel Institute |
Anthrax lethal factor inhibits tumor growth and angiogenesis
|
|
IL149462A0
(en)
*
|
2001-05-09 |
2002-11-10 |
Warner Lambert Co |
Method of treating or inhibiting neutrophil chemotaxis by administering a mek inhibitor
|
|
JP2005515253A
(ja)
|
2002-01-23 |
2005-05-26 |
ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー |
N−(4−置換フェニル)−アントラニル酸ヒドロキサメートエステル
|
|
DOP2003000556A
(es)
|
2002-01-23 |
2003-10-31 |
Warner Lambert Co |
Esteres hidroxamato de acido n-(4-fenil-sustituido)-antranilico.
|
|
US7235537B2
(en)
|
2002-03-13 |
2007-06-26 |
Array Biopharma, Inc. |
N3 alkylated benzimidazole derivatives as MEK inhibitors
|
|
DE60330227D1
(de)
|
2002-03-13 |
2010-01-07 |
Array Biopharma Inc |
N3-alkylierte benzimidazol-derivate als mek-hemmer
|
|
EP1651214B1
(en)
|
2003-07-24 |
2009-09-16 |
Warner-Lambert Company LLC |
Benzimidazole derivatives as mek inhibitors
|
|
US7144907B2
(en)
|
2003-09-03 |
2006-12-05 |
Array Biopharma Inc. |
Heterocyclic inhibitors of MEK and methods of use thereof
|
|
US7538120B2
(en)
|
2003-09-03 |
2009-05-26 |
Array Biopharma Inc. |
Method of treating inflammatory diseases
|
|
WO2005028426A1
(ja)
|
2003-09-19 |
2005-03-31 |
Chugai Seiyaku Kabushiki Kaisha |
新規4−フェニルアミノ−ベンズアルドオキシム誘導体並びにそのmek阻害剤としての使用
|
|
EP1682495A1
(en)
|
2003-10-21 |
2006-07-26 |
Warner-Lambert Company LLC |
Polymorphic form of n- (r)-2,3-dihydroxy-propoxy -3,4-d ifluoro-2-(2-fluoro-4-iodophenylamino)-benzamide
|
|
CN1905873A
(zh)
|
2003-11-19 |
2007-01-31 |
阵列生物制药公司 |
Mek的杂环抑制剂及其使用方法
|
|
US7732616B2
(en)
|
2003-11-19 |
2010-06-08 |
Array Biopharma Inc. |
Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof
|
|
US7517994B2
(en)
|
2003-11-19 |
2009-04-14 |
Array Biopharma Inc. |
Heterocyclic inhibitors of MEK and methods of use thereof
|
|
EP1684694A2
(en)
|
2003-11-21 |
2006-08-02 |
Array Biopharma, Inc. |
Akt protein kinase inhibitors
|
|
UA89035C2
(ru)
|
2003-12-03 |
2009-12-25 |
Лео Фарма А/С |
Эфиры гидроксамовых кислот и их фармацевтическое применение
|
|
WO2005094830A1
(en)
*
|
2004-03-30 |
2005-10-13 |
Pfizer Products Inc. |
Combinations of signal transduction inhibitors
|
|
TWI361066B
(en)
|
2004-07-26 |
2012-04-01 |
Chugai Pharmaceutical Co Ltd |
5-substituted-2-phenylamino benzamides as mek inhibitors
|
|
KR20090006885A
(ko)
|
2004-08-17 |
2009-01-15 |
에프. 호프만-라 로슈 아게 |
치환 히단토인
|
|
TW200621766A
(en)
*
|
2004-09-17 |
2006-07-01 |
Hoffmann La Roche |
Substituted hydantoins
|
|
MX2007004781A
(es)
|
2004-10-20 |
2007-05-11 |
Applied Research Systems |
Derivados de 3-arilamino piridina.
|
|
US8022247B2
(en)
|
2005-04-06 |
2011-09-20 |
Chugai Seiyaku Kabushiki Kaisha |
Process for production of 2,3,4-trifluoro-5-(iodo or bromo)-benzoic acid
|
|
US8299076B2
(en)
|
2005-05-18 |
2012-10-30 |
Array Biopharma Inc. |
Crystalline forms of 2-(2-flouro-4-iodophenylamino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide
|
|
DE602006021205D1
(de)
|
2005-10-07 |
2011-05-19 |
Exelixis Inc |
Azetidine als mek-inhibitoren bei der behandlung proliferativer erkrankungen
|
|
US7612212B2
(en)
|
2006-02-22 |
2009-11-03 |
Hoffmann-La Roche Inc. |
Substituted hydantoins
|
|
WO2007132867A1
(ja)
|
2006-05-15 |
2007-11-22 |
Takeda Pharmaceutical Company Limited |
癌の予防及び治療剤
|
|
DE602007011628D1
(de)
|
2006-07-06 |
2011-02-10 |
Array Biopharma Inc |
Dihydrofuropyrimidine als akt-proteinkinaseinhibitoren
|
|
US8063050B2
(en)
|
2006-07-06 |
2011-11-22 |
Array Biopharma Inc. |
Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
|
|
CA2656618C
(en)
|
2006-07-06 |
2014-08-26 |
Array Biopharma Inc. |
Cyclopenta [d] pyrimidines as akt protein kinase inhibitors
|
|
EP2054418B1
(en)
|
2006-07-06 |
2011-11-09 |
Array Biopharma Inc. |
Dihydrothieno pyrimidines as akt protein kinase inhibitors
|
|
EP1908751A1
(en)
*
|
2006-10-03 |
2008-04-09 |
EOS S.p.A. |
N-hydroxy benzamides with antitumour activity
|
|
KR20090071666A
(ko)
|
2006-10-23 |
2009-07-01 |
다케다 야쿠힌 고교 가부시키가이샤 |
Mapk/erk 키나아제 억제제
|
|
JP5311673B2
(ja)
|
2006-12-14 |
2013-10-09 |
エグゼリクシス, インコーポレイテッド |
Mek阻害剤の使用方法
|
|
WO2008075741A1
(ja)
*
|
2006-12-20 |
2008-06-26 |
Keio University |
糖尿病治療剤及び予防剤
|
|
US8846683B2
(en)
|
2007-07-05 |
2014-09-30 |
Array Biopharma, Inc. |
Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
|
|
US9409886B2
(en)
|
2007-07-05 |
2016-08-09 |
Array Biopharma Inc. |
Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
|
|
AR067413A1
(es)
|
2007-07-05 |
2009-10-07 |
Genentech Inc |
Compuestos heterociclicos que contienen ciclopenta[d]pirimidina inhibidores de proteinquinasas akt, composiciones farmaceuticas que los contienen, metodo de preparacion y uso de las mismas para el tratamiento de enfermedades hiperproliferativas, tales como cancer
|
|
ES2533557T3
(es)
|
2007-07-05 |
2015-04-13 |
Array Biopharma, Inc. |
Pirimidil ciclopentanos como inhibidores de proteína cinasa AKT
|
|
US7557221B2
(en)
|
2007-08-16 |
2009-07-07 |
Hoffman-La Roche Inc. |
Substituted hydantoins
|
|
MX2010006331A
(es)
|
2007-12-20 |
2010-07-05 |
Hoffmann La Roche |
Hidantoinas sustituidas como inhibidores de cinasa mek.
|
|
WO2009089459A1
(en)
|
2008-01-09 |
2009-07-16 |
Array Biopharma Inc. |
Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors
|
|
MX2010007546A
(es)
|
2008-01-09 |
2010-09-30 |
Array Biopharma Inc |
Pirimidil ciclopentanos hidroxilados en forma de inhibidores de akt proteína quinasa.
|
|
US8530457B2
(en)
|
2008-05-20 |
2013-09-10 |
Fox Chase Cancer Center |
Method for the treatment of lymphangioleiomyomatosis (LAM)
|
|
UA107183C2
(uk)
|
2008-08-04 |
2014-12-10 |
|
Феніламіно-ізонікотинамідні сполуки, їх застосування, фармацевтична композиція, що їх містить, та спосіб лікування гіперпроліферативних захворювань
|
|
JP5553415B2
(ja)
|
2008-08-27 |
2014-07-16 |
レオ ファーマ アクティーゼルスカブ |
Vegfr−2受容体としてのピリジン誘導体、及びタンパク質チロシンキナーゼ阻害剤
|
|
WO2010051933A2
(en)
|
2008-11-10 |
2010-05-14 |
Bayer Schering Pharma Aktiengesellschaft |
Substituted sulphonamido phenoxybenzamides
|
|
US9084781B2
(en)
|
2008-12-10 |
2015-07-21 |
Novartis Ag |
MEK mutations conferring resistance to MEK inhibitors
|
|
JP2013508318A
(ja)
|
2009-10-21 |
2013-03-07 |
バイエル・ファルマ・アクチェンゲゼルシャフト |
置換されたベンゾスルホンアミド誘導体
|
|
US20120263714A1
(en)
|
2009-10-21 |
2012-10-18 |
Bayer Intellectual Property Gmbh |
Substituted halophenoxybenzamide derivatives
|
|
CA2777430A1
(en)
|
2009-10-21 |
2011-04-28 |
Bayer Pharma Aktiengesellschaft |
Substituted benzosulphonamides
|
|
MX340392B
(es)
|
2010-02-25 |
2016-07-06 |
Dana Farber Cancer Inst Inc |
Mutaciones del protooncogen de serina/treonina-proteina cinasa b-raf (braf) que confieren resistencia a los inhibidores del protooncogen de serina/treonina-proteina cinasa b-raf.
|
|
CN103038364A
(zh)
|
2010-03-09 |
2013-04-10 |
达纳-法伯癌症研究所公司 |
诊断和治疗具有或发展对于第一种癌症治疗的抗性的患者中的癌症的方法
|
|
WO2012055953A1
(en)
|
2010-10-29 |
2012-05-03 |
Bayer Pharma Aktiengesellschaft |
Substituted phenoxypyridines
|
|
KR102482184B1
(ko)
|
2010-12-22 |
2022-12-28 |
페이트 세러퓨틱스, 인코포레이티드 |
단세포 분류 및 iPSC의 증강된 재프로그래밍을 위한 세포 배양 플랫폼
|
|
CN103841976A
(zh)
|
2011-04-01 |
2014-06-04 |
基因泰克公司 |
Akt和mek抑制剂化合物的组合及其使用方法
|
|
CN103841975A
(zh)
|
2011-04-01 |
2014-06-04 |
基因泰克公司 |
Akt抑制剂化合物和厄洛替尼的组合以及使用方法
|
|
US9833439B2
(en)
|
2011-05-25 |
2017-12-05 |
Universite Paris Descartes |
ERK inhibitors for use in treating spinal muscular atrophy
|
|
CN103204827B
(zh)
|
2012-01-17 |
2014-12-03 |
上海科州药物研发有限公司 |
作为蛋白激酶抑制剂的苯并噻二唑化合物及其制备方法和用途
|
|
US20150141470A1
(en)
|
2012-05-08 |
2015-05-21 |
The Broad Institute, Inc. |
Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy
|
|
JP6300042B2
(ja)
|
2012-10-12 |
2018-03-28 |
エグゼリクシス, インコーポレイテッド |
癌の処置に使用するための化合物の製造方法
|
|
WO2015038704A1
(en)
|
2013-09-11 |
2015-03-19 |
The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone |
Compositions for preparing cardiomyocytes
|
|
CA2935804A1
(en)
|
2014-01-14 |
2015-07-23 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for identification, assessment, prevention, and treatment of melanoma using pd-l1 isoforms
|
|
US11268069B2
(en)
|
2014-03-04 |
2022-03-08 |
Fate Therapeutics, Inc. |
Reprogramming methods and cell culture platforms
|
|
US10023879B2
(en)
|
2014-06-04 |
2018-07-17 |
Fate Therapeutics, Inc. |
Minimal volume reprogramming of mononuclear cells
|
|
CN105384754B
(zh)
*
|
2014-09-02 |
2018-04-20 |
上海科州药物研发有限公司 |
作为蛋白激酶抑制剂的杂环类化合物及其制备方法和用途
|
|
WO2016057367A1
(en)
|
2014-10-06 |
2016-04-14 |
Dana-Farber Cancer Institute, Inc. |
Angiopoietin-2 biomarkers predictive of anti-immune checkpoint response
|
|
EP3250680A4
(en)
|
2015-01-26 |
2018-12-05 |
Fate Therapeutics, Inc. |
Methods and compositions for inducing hematopoietic cell differentiation
|
|
MA41866A
(fr)
|
2015-03-31 |
2018-02-06 |
Massachusetts Gen Hospital |
Molécules à auto-assemblage pour l'administration ciblée de médicaments
|
|
CN108291237B
(zh)
|
2015-10-16 |
2023-11-21 |
菲特治疗公司 |
用于诱导和维护基态多能性的平台
|
|
AU2016349504B2
(en)
|
2015-11-04 |
2023-02-09 |
Fate Therapeutics, Inc. |
Genomic engineering of pluripotent cells
|
|
SG11201803145RA
(en)
|
2015-11-04 |
2018-05-30 |
Fate Therapeutics Inc |
Methods and compositions for inducing hematopoietic cell differentiation
|
|
US11096964B2
(en)
|
2016-01-20 |
2021-08-24 |
Fate Therapeutics, Inc. |
Compositions and methods for immune cell modulation in adoptive immunotherapies
|
|
WO2017127755A1
(en)
|
2016-01-20 |
2017-07-27 |
Fate Therapeutics, Inc. |
Compositions and methods for immune cell modulation in adoptive immunotherapies
|
|
US10913728B2
(en)
*
|
2016-07-28 |
2021-02-09 |
The Johns Hopkins University |
O-substituted hydroxamic acids
|
|
EP3548049A4
(en)
|
2016-12-05 |
2020-07-22 |
Fate Therapeutics, Inc. |
COMPOSITIONS AND METHODS FOR MODULATION OF IMMUNE CELLS IN ADOPTIVE IMMUNOTHERAPIES
|
|
CN107556201B
(zh)
*
|
2017-09-08 |
2020-10-27 |
山西智创药研科技有限公司 |
一种制备间氨基苯酚的工艺方法
|
|
CA3120351A1
(en)
*
|
2018-11-20 |
2020-05-28 |
Nflection Therapeutics, Inc. |
Aryl-aniline and heteroaryl-aniline compounds for treatment of skin cancers
|
|
JP7546297B2
(ja)
*
|
2018-11-20 |
2024-09-06 |
エヌフレクション セラピューティクス インコーポレイテッド |
皮膚障害の処置のためのチエニル-アニリン化合物
|
|
BR112021018168B1
(pt)
|
2019-03-21 |
2023-11-28 |
Onxeo |
Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer
|
|
CA3159348A1
(en)
|
2019-11-08 |
2021-05-14 |
Inserm (Institut National De La Sante Et De La Recherche Medicale) |
Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
|
|
WO2021148581A1
(en)
|
2020-01-22 |
2021-07-29 |
Onxeo |
Novel dbait molecule and its use
|
|
TW202342018A
(zh)
|
2022-03-04 |
2023-11-01 |
美商奇奈特生物製藥公司 |
Mek激酶抑制劑
|
|
WO2025073765A1
(en)
|
2023-10-03 |
2025-04-10 |
Institut National de la Santé et de la Recherche Médicale |
Methods of prognosis and treatment of patients suffering from melanoma
|