JP2002510622A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2002510622A5 JP2002510622A5 JP2000541995A JP2000541995A JP2002510622A5 JP 2002510622 A5 JP2002510622 A5 JP 2002510622A5 JP 2000541995 A JP2000541995 A JP 2000541995A JP 2000541995 A JP2000541995 A JP 2000541995A JP 2002510622 A5 JP2002510622 A5 JP 2002510622A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- groups
- polysubstituted
- trifluoromethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 4
- -1 t-butoxycarbonyl group Chemical group 0.000 description 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 3
- 229910052736 halogen Inorganic materials 0.000 description 2
- 150000002367 halogens Chemical class 0.000 description 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 description 1
- 125000006624 (C1-C6) alkoxycarbonylamino group Chemical group 0.000 description 1
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 description 1
- 150000001204 N-oxides Chemical class 0.000 description 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 description 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 description 1
- 125000004093 cyano group Chemical group *C#N 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19814838A DE19814838C2 (de) | 1998-04-02 | 1998-04-02 | Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung |
| DE19814838.0 | 1998-04-02 | ||
| PCT/EP1999/001918 WO1999051224A1 (de) | 1998-04-02 | 1999-03-22 | Indolyl-3-glyoxylsäure-derivate mit antitumorwirkung |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011053448A Division JP2011148809A (ja) | 1998-04-02 | 2011-03-10 | 抗腫瘍作用を有するインドリル−３−グリオキシル酸誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002510622A JP2002510622A (ja) | 2002-04-09 |
| JP2002510622A5 true JP2002510622A5 (enExample) | 2011-05-19 |
| JP5253696B2 JP5253696B2 (ja) | 2013-07-31 |
Family
ID=7863398
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000541995A Expired - Fee Related JP5253696B2 (ja) | 1998-04-02 | 1999-03-22 | 抗腫瘍作用を有するインドリル−３−グリオキシル酸誘導体 |
| JP2011053448A Pending JP2011148809A (ja) | 1998-04-02 | 2011-03-10 | 抗腫瘍作用を有するインドリル−３−グリオキシル酸誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011053448A Pending JP2011148809A (ja) | 1998-04-02 | 2011-03-10 | 抗腫瘍作用を有するインドリル−３−グリオキシル酸誘導体 |
Country Status (32)
| Country | Link |
|---|---|
| US (4) | US6232327B1 (enExample) |
| EP (1) | EP1071420B1 (enExample) |
| JP (2) | JP5253696B2 (enExample) |
| KR (1) | KR100583545B1 (enExample) |
| CN (1) | CN1148183C (enExample) |
| AR (1) | AR018175A1 (enExample) |
| AT (1) | ATE304352T1 (enExample) |
| AU (1) | AU768510B2 (enExample) |
| BG (1) | BG64838B1 (enExample) |
| BR (1) | BR9909902A (enExample) |
| CA (1) | CA2326833C (enExample) |
| DE (2) | DE19814838C2 (enExample) |
| DK (1) | DK1071420T3 (enExample) |
| EE (1) | EE04354B1 (enExample) |
| ES (1) | ES2249884T3 (enExample) |
| GE (1) | GEP20032967B (enExample) |
| HR (1) | HRP20000643A2 (enExample) |
| HU (1) | HUP0101530A3 (enExample) |
| ID (1) | ID26504A (enExample) |
| IL (2) | IL138737A0 (enExample) |
| IS (1) | IS2307B (enExample) |
| NO (1) | NO327721B1 (enExample) |
| NZ (1) | NZ507084A (enExample) |
| PL (1) | PL192779B1 (enExample) |
| RS (1) | RS49866B (enExample) |
| RU (1) | RU2262339C2 (enExample) |
| SK (1) | SK286393B6 (enExample) |
| TR (1) | TR200002853T2 (enExample) |
| TW (1) | TWI230608B (enExample) |
| UA (1) | UA70942C2 (enExample) |
| WO (1) | WO1999051224A1 (enExample) |
| ZA (1) | ZA200006150B (enExample) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19814838C2 (de) * | 1998-04-02 | 2001-01-18 | Asta Medica Ag | Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung |
| DE19946301A1 (de) | 1998-04-02 | 2001-04-19 | Asta Medica Ag | Indolyl-3-glyoxylsäure-Derivate mit therapeutisch wertvollen Eigenschaften |
| AU4834200A (en) * | 1999-05-10 | 2000-11-21 | Protarga, Inc. | Fatty acid-n-substituted indol-3-glyoxyl-amide compositions and uses thereof |
| AU777725B2 (en) * | 1999-09-17 | 2004-10-28 | Baylor University | Indole-containing and combretastatin-related anti-mitotic and anti-tubulin polymerization agents |
| US6849656B1 (en) | 1999-09-17 | 2005-02-01 | Baylor University | Indole-containing and combretastatin-related anti-mitotic and anti-tubulin polymerization agents |
| TWI269654B (en) * | 1999-09-28 | 2007-01-01 | Baxter Healthcare Sa | N-substituted indole-3-glyoxylamide compounds having anti-tumor action |
| KR20070053362A (ko) * | 1999-11-23 | 2007-05-23 | 메틸진, 인크. | 히스톤 디아세틸라제의 억제제 |
| GB9928696D0 (en) | 1999-12-03 | 2000-02-02 | Swan Thomas & Co Ltd | Optical devices and methods of manufacture thereof |
| IT1315267B1 (it) | 1999-12-23 | 2003-02-03 | Novuspharma Spa | Derivati di 2-(1h-indol-3-il)-2-oxo-acetammidi ad attivita'antitumorale |
| DE19962300A1 (de) * | 1999-12-23 | 2001-06-28 | Asta Medica Ag | Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung |
| IT1318641B1 (it) * | 2000-07-25 | 2003-08-27 | Novuspharma Spa | Ammidi di acidi 2-(1h-indol-3-il)-2-oxo-acetici ad attivita'antitumorale. |
| DE10037310A1 (de) | 2000-07-28 | 2002-02-07 | Asta Medica Ag | Neue Indolderivate und deren Verwendung als Arzneimittel |
| JP2005504790A (ja) | 2001-09-13 | 2005-02-17 | シンタ ファーマスーティカルズ コーポレイション | 癌を治療するための３−グリオキシリルアミドインドール |
| TWI323658B (en) | 2001-12-06 | 2010-04-21 | Nat Health Research Institutes | Novel compounds of indol-3-yl-2-oxyacetylamide derivatives, pharmaceutical composition thereof, and method for manufacturing the same |
| US7109227B2 (en) | 2002-08-26 | 2006-09-19 | National Health Research Institutes | Imidazolamino compounds |
| CA2509222A1 (en) * | 2002-12-10 | 2004-06-24 | Wyeth | Substituted indole oxo-acetyl amino acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
| DE10318609A1 (de) * | 2003-04-24 | 2004-11-11 | Elbion Ag | 5-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika |
| DE10318611A1 (de) * | 2003-04-24 | 2004-11-11 | Elbion Ag | 4-, 6- oder 7-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika |
| WO2004108702A1 (de) * | 2003-06-05 | 2004-12-16 | Zentaris Gmbh | Indolderivate mit apoptose induzierender wirkung |
| US7205299B2 (en) * | 2003-06-05 | 2007-04-17 | Zentaris Gmbh | Indole derivatives having an apoptosis-inducing effect |
| EP1484329A1 (de) * | 2003-06-06 | 2004-12-08 | Zentaris GmbH | Indolderivate mit Apoptose induzierender Wirkung |
| US20050075364A1 (en) * | 2003-07-01 | 2005-04-07 | Kap-Sun Yeung | Indole, azaindole and related heterocyclic N-substituted piperazine derivatives |
| US7211588B2 (en) * | 2003-07-25 | 2007-05-01 | Zentaris Gmbh | N-substituted indolyl-3-glyoxylamides, their use as medicaments and process for their preparation |
| EP1670787B1 (en) | 2003-09-11 | 2012-05-30 | iTherX Pharma, Inc. | Cytokine inhibitors |
| US20050124623A1 (en) | 2003-11-26 | 2005-06-09 | Bender John A. | Diazaindole-dicarbonyl-piperazinyl antiviral agents |
| DE102004031538A1 (de) * | 2004-06-29 | 2006-02-09 | Baxter International Inc., Deerfield | Pharmazeutische Darreichungsform zur oralen Verabreichung eines schwerlöslichen Wirkstoffs, Verfahren zu deren Herstellung und Kit |
| WO2006002887A1 (en) * | 2004-06-29 | 2006-01-12 | Baxter International Inc. | Aqueous drink solution of indibulin (d-24851) and an organic acid |
| AU2005304952B2 (en) * | 2004-11-08 | 2013-04-04 | Baxter Healthcare S.A. | Nanoparticulate compositions of tubulin inhibitors |
| US20060100209A1 (en) * | 2004-11-09 | 2006-05-11 | Chong-Hui Gu | Formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione |
| US20060100432A1 (en) * | 2004-11-09 | 2006-05-11 | Matiskella John D | Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione |
| ES2644450T3 (es) | 2004-12-31 | 2017-11-29 | Dr. Reddy's Laboratories Ltd. | Nuevos derivados de bencilamina como inhibidores de CETP |
| US8604055B2 (en) | 2004-12-31 | 2013-12-10 | Dr. Reddy's Laboratories Ltd. | Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors |
| WO2006099256A2 (en) * | 2005-03-11 | 2006-09-21 | Vertex Pharmaceuticals Incorporated | Modulators of atp-binding cassette transporters |
| US20060280787A1 (en) * | 2005-06-14 | 2006-12-14 | Baxter International Inc. | Pharmaceutical formulation of the tubulin inhibitor indibulin for oral administration with improved pharmacokinetic properties, and process for the manufacture thereof |
| US7598380B2 (en) * | 2005-08-03 | 2009-10-06 | Bristol-Myers Squibb Company | Method of preparation of azaindole derivatives |
| WO2007044560A2 (en) * | 2005-10-06 | 2007-04-19 | Vertex Pharmaceuticals Incorporated | Modulators of atp-binding cassette transporters |
| US7851476B2 (en) * | 2005-12-14 | 2010-12-14 | Bristol-Myers Squibb Company | Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine |
| US7807671B2 (en) | 2006-04-25 | 2010-10-05 | Bristol-Myers Squibb Company | Diketo-piperazine and piperidine derivatives as antiviral agents |
| MX2009001327A (es) * | 2006-08-07 | 2009-06-05 | Ironwood Pharmaceuticals Inc | Compuestos de indol. |
| WO2008066807A1 (en) * | 2006-11-28 | 2008-06-05 | Ziopharm Oncology, Inc. | Use of indolyl-3-glyoxylic acid derivatives including indibulin, alone or in combination with further agents for treating cancer |
| EP1964835A1 (en) * | 2007-02-28 | 2008-09-03 | Centre National de la Recherche Scientifique | Derivatives of psammaplin A, a method for their synthesis and their use for the prevention or treatment of cancer |
| CN101085779A (zh) * | 2007-07-11 | 2007-12-12 | 中国人民武装警察部队医学院 | 取代吲哚－3－基草酰表鬼臼毒素衍生物及其盐及其用途 |
| GB0715103D0 (en) * | 2007-08-03 | 2007-09-12 | Lectus Therapeutics Ltd | Calcium ion channel modulators and uses thereof |
| GB0909441D0 (en) * | 2009-06-02 | 2009-07-15 | Univ Sheffield | Novel indole derivatives |
| US9585810B2 (en) | 2010-10-14 | 2017-03-07 | Fresenius Medical Care Holdings, Inc. | Systems and methods for delivery of peritoneal dialysis (PD) solutions with integrated inter-chamber diffuser |
| AR084433A1 (es) | 2010-12-22 | 2013-05-15 | Ironwood Pharmaceuticals Inc | Inhibidores de la faah y composiciones farmaceuticas que los contienen |
| WO2012154967A1 (en) | 2011-05-12 | 2012-11-15 | Proteostasis Therapeutics, Inc. | Proteostasis regulators |
| US9199967B2 (en) | 2011-08-18 | 2015-12-01 | Dr. Reddy's Laboratories Ltd. | Substituted heterocyclic amine compounds as cholestryl ester-transfer protein (CETP) inhibitors |
| EP2760864B1 (en) | 2011-09-27 | 2018-01-24 | Dr. Reddy's Laboratories Ltd. | 5-BENZYLAMINOMETHYL-6-AMINOPYRAZOLO[3,4-b]PYRIDINE DERIVATIVES AS CHOLESTERYL ESTER-TRANSFER PROTEIN (CETP) INHIBITORS USEFUL FOR THE TREATMENT OF ATHEROSCLEROSIS |
| CN102942516B (zh) * | 2012-11-05 | 2015-02-25 | 宁波大学 | 一种生物碱类化合物及其制备方法和应用 |
| WO2014089177A2 (en) | 2012-12-04 | 2014-06-12 | Massachusetts Institute Of Technology | Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines |
| CA2905509A1 (en) | 2013-03-15 | 2014-09-18 | Memorial Sloan-Kettering Cancer Center | Hsp90-targeted cardiac imaging and therapy |
| IL225540A (en) * | 2013-04-02 | 2015-09-24 | Igal Nir | A method, system, and software for automatically generating a speech database for speech recognition |
| WO2015073528A1 (en) | 2013-11-12 | 2015-05-21 | Proteostasis Therapeutics, Inc. | Proteasome activity enhancing compounds |
| CN105198788A (zh) * | 2015-09-30 | 2015-12-30 | 蒋军荣 | 一种吲哚氧代乙酰(n-二芳甲基)哌嗪衍生物及其制备方法和应用 |
| US10918627B2 (en) | 2016-05-11 | 2021-02-16 | Massachusetts Institute Of Technology | Convergent and enantioselective total synthesis of Communesin analogs |
| WO2018209239A1 (en) | 2017-05-11 | 2018-11-15 | Massachusetts Institute Of Technology | Potent agelastatin derivatives as modulators for cancer invasion and metastasis |
| US10640508B2 (en) | 2017-10-13 | 2020-05-05 | Massachusetts Institute Of Technology | Diazene directed modular synthesis of compounds with quaternary carbon centers |
| US11535634B2 (en) | 2019-06-05 | 2022-12-27 | Massachusetts Institute Of Technology | Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof |
| US12030888B2 (en) | 2021-02-24 | 2024-07-09 | Massachusetts Institute Of Technology | Himastatin derivatives, and processes of preparation thereof, and uses thereof |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1028812A (en) * | 1962-08-28 | 1966-05-11 | Ici Ltd | Indole derivatives |
| GB1089071A (en) * | 1964-02-28 | 1967-11-01 | Merck & Co Inc | Indole derivatives |
| FR2182915A1 (en) * | 1972-03-30 | 1973-12-14 | Nelson Res & Dev | Substd indoles, benzimidazoles - as anti-immune agents , antitumour agents, serotonin inhibitors, hypnotics |
| AU671865B2 (en) * | 1992-10-20 | 1996-09-12 | Toray Industries, Inc. | Eosinophil infiltration inhibitor |
| US5405864A (en) * | 1993-10-15 | 1995-04-11 | Syntex (U.S.A.) Inc. | Chemotherapeutic maleimides |
| IL113210A (en) * | 1994-04-01 | 2001-01-28 | Lilly Co Eli | 1H-indole-3- glyoxylamide spla2 inhibitors and pharmaceutical compositions containing them |
| EP0747380B1 (en) * | 1995-06-07 | 1998-09-30 | Eli Lilly And Company | Compounds and compositions with nitrogen-containing non-basic side chains |
| DE19636150A1 (de) * | 1996-09-06 | 1998-03-12 | Asta Medica Ag | N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung |
| US6262044B1 (en) * | 1998-03-12 | 2001-07-17 | Novo Nordisk A/S | Modulators of protein tyrosine phosphatases (PTPASES) |
| US6225329B1 (en) * | 1998-03-12 | 2001-05-01 | Novo Nordisk A/S | Modulators of protein tyrosine phosphatases (PTPases) |
| HUP0102612A2 (hu) | 1998-03-12 | 2001-11-28 | Novo Nordisk A/S | Fehérje-tirozinfoszfatázokat moduláló vegyületek és ezeket tartalmazó gyógyászati készítmények |
| DE19814838C2 (de) * | 1998-04-02 | 2001-01-18 | Asta Medica Ag | Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung |
| DE19946301A1 (de) * | 1998-04-02 | 2001-04-19 | Asta Medica Ag | Indolyl-3-glyoxylsäure-Derivate mit therapeutisch wertvollen Eigenschaften |
| ES2262072T3 (es) | 1998-04-28 | 2006-11-16 | Elbion Ag | Derivados de indol y su utilizacion como inhibidores de la fosfodiesterasa 4. |
| JP2000239252A (ja) | 1999-02-16 | 2000-09-05 | Mitsubishi Chemicals Corp | インドール誘導体 |
| AU4834200A (en) | 1999-05-10 | 2000-11-21 | Protarga, Inc. | Fatty acid-n-substituted indol-3-glyoxyl-amide compositions and uses thereof |
| DE19962300A1 (de) * | 1999-12-23 | 2001-06-28 | Asta Medica Ag | Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung |
| US7205299B2 (en) | 2003-06-05 | 2007-04-17 | Zentaris Gmbh | Indole derivatives having an apoptosis-inducing effect |
| DE102004031538A1 (de) | 2004-06-29 | 2006-02-09 | Baxter International Inc., Deerfield | Pharmazeutische Darreichungsform zur oralen Verabreichung eines schwerlöslichen Wirkstoffs, Verfahren zu deren Herstellung und Kit |
| US20060280787A1 (en) | 2005-06-14 | 2006-12-14 | Baxter International Inc. | Pharmaceutical formulation of the tubulin inhibitor indibulin for oral administration with improved pharmacokinetic properties, and process for the manufacture thereof |
-
1998
- 1998-04-02 DE DE19814838A patent/DE19814838C2/de not_active Expired - Fee Related
-
1999
- 1999-03-22 AT AT99910372T patent/ATE304352T1/de active
- 1999-03-22 HR HR20000643A patent/HRP20000643A2/hr not_active Application Discontinuation
- 1999-03-22 IL IL13873799A patent/IL138737A0/xx active IP Right Grant
- 1999-03-22 SK SK1430-2000A patent/SK286393B6/sk not_active IP Right Cessation
- 1999-03-22 AU AU29349/99A patent/AU768510B2/en not_active Ceased
- 1999-03-22 CN CNB998059234A patent/CN1148183C/zh not_active Expired - Fee Related
- 1999-03-22 EP EP99910372A patent/EP1071420B1/de not_active Expired - Lifetime
- 1999-03-22 DE DE59912562T patent/DE59912562D1/de not_active Expired - Lifetime
- 1999-03-22 ES ES99910372T patent/ES2249884T3/es not_active Expired - Lifetime
- 1999-03-22 EE EEP200000581A patent/EE04354B1/xx not_active IP Right Cessation
- 1999-03-22 KR KR1020007010934A patent/KR100583545B1/ko not_active Expired - Fee Related
- 1999-03-22 BR BR9909902-0A patent/BR9909902A/pt not_active IP Right Cessation
- 1999-03-22 TR TR2000/02853T patent/TR200002853T2/xx unknown
- 1999-03-22 JP JP2000541995A patent/JP5253696B2/ja not_active Expired - Fee Related
- 1999-03-22 CA CA002326833A patent/CA2326833C/en not_active Expired - Fee Related
- 1999-03-22 NZ NZ507084A patent/NZ507084A/en not_active IP Right Cessation
- 1999-03-22 GE GEAP19995611A patent/GEP20032967B/en unknown
- 1999-03-22 RU RU2000128035/15A patent/RU2262339C2/ru not_active IP Right Cessation
- 1999-03-22 HU HU0101530A patent/HUP0101530A3/hu unknown
- 1999-03-22 UA UA2000116192A patent/UA70942C2/uk unknown
- 1999-03-22 WO PCT/EP1999/001918 patent/WO1999051224A1/de not_active Ceased
- 1999-03-22 DK DK99910372T patent/DK1071420T3/da active
- 1999-03-22 ID IDW20001988A patent/ID26504A/id unknown
- 1999-03-22 RS YUP-593/00A patent/RS49866B/sr unknown
- 1999-03-22 PL PL343525A patent/PL192779B1/pl unknown
- 1999-03-23 TW TW088104599A patent/TWI230608B/zh not_active IP Right Cessation
- 1999-03-31 AR ARP990101501A patent/AR018175A1/es unknown
- 1999-04-02 US US09/285,058 patent/US6232327B1/en not_active Expired - Lifetime
-
2000
- 2000-09-22 IS IS5635A patent/IS2307B/is unknown
- 2000-09-27 IL IL138737A patent/IL138737A/en not_active IP Right Cessation
- 2000-09-29 NO NO20004916A patent/NO327721B1/no not_active IP Right Cessation
- 2000-10-12 BG BG104849A patent/BG64838B1/bg unknown
- 2000-10-31 ZA ZA200006150A patent/ZA200006150B/en unknown
-
2001
- 2001-03-19 US US09/810,604 patent/US20030023093A1/en not_active Abandoned
-
2002
- 2002-12-04 US US10/309,204 patent/US7579365B2/en not_active Expired - Fee Related
-
2007
- 2007-08-20 US US11/894,591 patent/US20080027110A1/en not_active Abandoned
-
2011
- 2011-03-10 JP JP2011053448A patent/JP2011148809A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2002510622A5 (enExample) | ||
| NO996316L (no) | Faktor Xa-inhibitorer med en noeytral P1-spesifisitetsgruppe | |
| WO2001062705A3 (en) | Aminoalcohol derivatives | |
| AU4327600A (en) | Aryl sulfonyls as factor xa inhibitors | |
| WO2003055441A3 (en) | Medicaments | |
| CA2408602A1 (en) | Phenylglycine derivatives | |
| WO2003035668A3 (en) | Novel anti-inflammatory androstane derivatives -17-carboxy-lactone substituted steroids with an aryl-carboxylic ester in position 17.alpha | |
| DK1526132T3 (da) | Substituerede oxazolidinoner og deres anvendelse som faktor Xa-hæmmer | |
| TR200100432T2 (tr) | Hepatit C inhibitörü tri-peptidler | |
| DE50015330D1 (de) | Herstellung von n-substituierten 2,7-dialkyl-4-hydroxy-5-amino-8-aryl-octanoylamiden | |
| ATE269312T1 (de) | N-(amidinophenyl)-n'-(subst.)-3h-2,4- benzodiazepin-3-on derivative als faktor xa inhibitoren | |
| AP9901442A0 (en) | 4-(2-Keto-1-benzimidazolinyl) piperidine compounds as orl1-receptor agonists. | |
| CO4770975A1 (es) | Derivados de quinazolina sustituidos | |
| HUP0401729A2 (hu) | IV típusú foszfodiészteráz inhibitor hatású alkin-aril-naftiridin-4(1H)-on-származékok és ezeket tartalmazó gyógyszerkészítmények | |
| CA2206754A1 (en) | Benzimidazole derivatives with antihistaminic activity | |
| DE60039238D1 (de) | C-2-modifizierte erythromycinderivate | |
| EP1741428A3 (en) | Cell adhesion inhibitors | |
| SE0004245D0 (sv) | Novel compounds and their use | |
| CA2203237A1 (en) | Aminotetrazole derivatives useful as nitric oxide synthase inhibitors | |
| TR200100700T2 (tr) | EtO2C--CH2-(R)Cgl-Aze-Pab-OH'nin kristalin formları | |
| AU2001286768A1 (en) | Novel macrocycles and uses thereof | |
| NO20026095L (no) | Kumarinderivater med COMT inhiberende aktivitet | |
| SE9904765D0 (sv) | Pharmaceutically-useful compounds | |
| CA2412596A1 (en) | Cyclic gmp-specific phosphodiesterase inhibitors | |
| NO981393D0 (no) | Guanidinoproteasehemmere |