JP2002509888A - 腫瘍および他の過増殖性疾患の治療におけるビタミンdおよびその類似体 - Google Patents
腫瘍および他の過増殖性疾患の治療におけるビタミンdおよびその類似体Info
- Publication number
- JP2002509888A JP2002509888A JP2000540833A JP2000540833A JP2002509888A JP 2002509888 A JP2002509888 A JP 2002509888A JP 2000540833 A JP2000540833 A JP 2000540833A JP 2000540833 A JP2000540833 A JP 2000540833A JP 2002509888 A JP2002509888 A JP 2002509888A
- Authority
- JP
- Japan
- Prior art keywords
- vitamin
- drug
- calcitriol
- dose
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7969698P | 1998-03-27 | 1998-03-27 | |
| US60/079,696 | 1998-03-27 | ||
| PCT/US1999/006442 WO1999049870A1 (en) | 1998-03-27 | 1999-03-25 | Vitamin d and its analogs in the treatment of tumors and other hyperproliferative disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002509888A true JP2002509888A (ja) | 2002-04-02 |
| JP2002509888A5 JP2002509888A5 (enExample) | 2006-05-18 |
Family
ID=22152202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000540833A Ceased JP2002509888A (ja) | 1998-03-27 | 1999-03-25 | 腫瘍および他の過増殖性疾患の治療におけるビタミンdおよびその類似体 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6521608B1 (enExample) |
| EP (2) | EP2340840B1 (enExample) |
| JP (1) | JP2002509888A (enExample) |
| AT (1) | ATE515265T1 (enExample) |
| AU (1) | AU762481C (enExample) |
| CA (1) | CA2326117A1 (enExample) |
| ES (1) | ES2368824T3 (enExample) |
| WO (1) | WO1999049870A1 (enExample) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004535429A (ja) * | 2001-06-26 | 2004-11-25 | ボーン ケア インターナショナル インコーポレイテッド | 活性なビタミンd類縁体を使用する異常増殖性疾患の治療方法 |
| JP2005510536A (ja) * | 2001-11-28 | 2005-04-21 | ボーン ケア インターナショナル インコーポレイテッド | 活性ビタミンd類縁物質を使用した過剰増殖性疾病の治療 |
| JP2007501865A (ja) * | 2003-06-11 | 2007-02-01 | ノバセア インコーポレイティッド | 放射線治療薬および放射線治療と併用した、活性ビタミンd化合物による癌の治療法 |
| JP2008538114A (ja) * | 2005-03-23 | 2008-10-09 | ビオクセル エッセ ピ ア | 20−アルキル、ジェミニビタミンd3化合物及びその使用方法 |
| JP2016006084A (ja) * | 2004-06-07 | 2016-01-14 | クー バイオロジックス インク.Qu Biologics Inc. | 癌を治療するための細菌組成物 |
| US9775896B2 (en) | 2004-06-07 | 2017-10-03 | Qu Biologics Inc. | Tissue targeted antigenic activation of the immune response to treat cancers |
| US10130692B2 (en) | 2010-07-26 | 2018-11-20 | Qu Biologics Inc. | Immunogenic anti-inflammatory compositions |
| US10251946B2 (en) | 2014-05-02 | 2019-04-09 | Qu Biologics Inc. | Anti-microbial immunomodulation |
Families Citing this family (72)
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| US20040009958A1 (en) * | 1991-01-08 | 2004-01-15 | Bone Care International, Inc. | Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2 |
| US6538037B2 (en) | 1991-01-08 | 2003-03-25 | Bone Care International, Inc. | Methods for preparation and use of 1α,24(S)-dihydroxyvitamin D2 |
| US20040167106A1 (en) * | 1993-06-04 | 2004-08-26 | Rodriguez Gustavo C. | Prevention of ovarian cancer by administration of a Vitamin D compound |
| US5763429A (en) * | 1993-09-10 | 1998-06-09 | Bone Care International, Inc. | Method of treating prostatic diseases using active vitamin D analogues |
| US20020183288A1 (en) * | 1995-04-03 | 2002-12-05 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
| US6242434B1 (en) * | 1997-08-08 | 2001-06-05 | Bone Care International, Inc. | 24-hydroxyvitamin D, analogs and uses thereof |
| US20040043971A1 (en) * | 1995-04-03 | 2004-03-04 | Bone Care International, Inc. | Method of treating and preventing hyperparathyroidism with active vitamin D analogs |
| US6566353B2 (en) | 1996-12-30 | 2003-05-20 | Bone Care International, Inc. | Method of treating malignancy associated hypercalcemia using active vitamin D analogues |
| US6573256B2 (en) | 1996-12-30 | 2003-06-03 | Bone Care International, Inc. | Method of inhibiting angiogenesis using active vitamin D analogues |
| US20030129194A1 (en) * | 1997-02-13 | 2003-07-10 | Bone Care International, Inc. | Targeted therapeutic delivery of vitamin D compounds |
| PL336231A1 (en) | 1997-02-13 | 2000-06-19 | Bone Care International | System for aimed therapeutic delivery of vitamin d compounds |
| US6087350A (en) * | 1997-08-29 | 2000-07-11 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Use of pretreatment chemicals to enhance efficacy of cytotoxic agents |
| EP2340840B1 (en) * | 1998-03-27 | 2012-08-29 | Oregon Health Sciences University | Pulse dose Vitamin D drug for the treatment of hyperproliferative skin diseases |
| DK1276482T3 (da) * | 2000-03-02 | 2008-05-26 | Univ Pittsburgh | Kombinationskemoterapi |
| US7074777B2 (en) * | 2000-04-19 | 2006-07-11 | Chugai Seiyaku Kabushiki Kaisha | Vitamin D derivatives |
| AU6137801A (en) * | 2000-05-09 | 2001-11-20 | Childrens Medical Center | Method and composition for the treatment of angiogenesis |
| IL153378A0 (en) | 2000-07-18 | 2003-07-06 | Bone Care Internat Inc | STABILIZED 1alpha-HYDROXY VITAMIN D |
| US20040087559A1 (en) * | 2000-09-22 | 2004-05-06 | Schwartz Gary G. | Methods for prevention and treatment of cancer |
| EP1270026A1 (en) * | 2001-06-22 | 2003-01-02 | Erik Andersen | Stents comprising vitamin D analogues for restenosis inhibition |
| JP2005515996A (ja) * | 2001-12-03 | 2005-06-02 | ノバセア インコーポレイティッド | 活性型ビタミンd化合物を含む薬学的組成物 |
| EP1552837A1 (en) * | 2002-08-01 | 2005-07-13 | Chugai Seiyaku Kabushiki Kaisha | Antipsoriatic agent |
| US20040138162A1 (en) * | 2002-08-30 | 2004-07-15 | Roodman G. David | Method of resisting osteoclast formation |
| US20040170621A1 (en) * | 2002-08-30 | 2004-09-02 | Roodman G. David | Method of resisting osteoclast formation |
| US20040058895A1 (en) * | 2002-09-18 | 2004-03-25 | Bone Care International, Inc. | Multi-use vessels for vitamin D formulations |
| US20040053895A1 (en) * | 2002-09-18 | 2004-03-18 | Bone Care International, Inc. | Multi-use vessels for vitamin D formulations |
| US7148211B2 (en) | 2002-09-18 | 2006-12-12 | Genzyme Corporation | Formulation for lipophilic agents |
| CN100386083C (zh) * | 2002-11-06 | 2008-05-07 | 诺瓦西股份有限公司 | 用维生素d类化合物制备治疗骨髓发育不良综合症药物的方法 |
| US20050101576A1 (en) * | 2003-11-06 | 2005-05-12 | Novacea, Inc. | Methods of using vitamin D compounds in the treatment of myelodysplastic syndromes |
| WO2004047673A2 (en) * | 2002-11-21 | 2004-06-10 | Novacea, Inc. | Treatment of liver disease with active vitamin d compounds |
| US20050026877A1 (en) * | 2002-12-03 | 2005-02-03 | Novacea, Inc. | Pharmaceutical compositions comprising active vitamin D compounds |
| CA2521221A1 (en) * | 2003-04-02 | 2004-10-14 | Genix Therapeutics, Inc. | Method for the treatment of prostate cancer |
| AU2004247108A1 (en) * | 2003-06-11 | 2004-12-23 | Novacea, Inc | Treatment of immune-mediated disorders with active vitamin D compounds alone or in combination with other therapeutic agents |
| US20050020546A1 (en) * | 2003-06-11 | 2005-01-27 | Novacea, Inc. | Pharmaceutical compositions comprising active vitamin D compounds |
| US20050222190A1 (en) * | 2004-03-30 | 2005-10-06 | Curd John G | 1,4-bis-N-oxide azaanthracenediones and the use thereof |
| US20070275934A1 (en) * | 2004-05-10 | 2007-11-29 | Curd John G | Treatment of pancreatic cancer with active vitamin d compounds in combination with other treatments |
| CA2566346A1 (en) * | 2004-05-10 | 2005-11-24 | Novacea, Inc. | Prevention of arterial restenosis with active vitamin d compounds |
| WO2005110464A2 (en) * | 2004-05-14 | 2005-11-24 | Oregon Health & Science University | Irx5 inhibition as treatment for hyperproliferative disorders |
| US20060003950A1 (en) * | 2004-06-30 | 2006-01-05 | Bone Care International, Inc. | Method of treating prostatic diseases using a combination of vitamin D analogues and other agents |
| US7094775B2 (en) | 2004-06-30 | 2006-08-22 | Bone Care International, Llc | Method of treating breast cancer using a combination of vitamin D analogues and other agents |
| AU2005309806B2 (en) * | 2004-11-22 | 2012-03-08 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-1alpha-hydroxy-17-ene-homopregnacalciferol and its uses |
| US20080069814A1 (en) * | 2005-01-05 | 2008-03-20 | Novacea, Inc. | Prevention of Thrombotic Disorders with Active Vitamin D Compounds or Mimics Thereof |
| WO2006074226A2 (en) * | 2005-01-05 | 2006-07-13 | Novacea, Inc. | Prevention of thrombotic disorders with active vitamin d compounds or mimics thereof |
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| CA2602464A1 (en) * | 2005-03-23 | 2006-11-09 | Bioxell S.P.A. | Methods of treating osteoporosis and secondary hyperparathyroidism using 20-methyl, gemini vitamin d3 compounds |
| MX2007013029A (es) * | 2005-04-22 | 2008-01-11 | Novacea Inc | Tratamiento, prevencion y mejora de trastornos pulmonares asociados con la quimioterapia o radioterapia con compuestos activos de vitamina d o substancias mimeticas de los mismos. |
| GB0513984D0 (en) * | 2005-07-07 | 2005-08-17 | Teva Pharma | Dosage form |
| EP1993559B1 (en) | 2006-02-03 | 2016-06-22 | OPKO Renal, LLC | Treating vitamin d insufficiency and deficiency with 25-hydroxyvitamin d2 and 25-hydroxyvitamin d3 |
| US8193169B2 (en) * | 2006-04-06 | 2012-06-05 | Wisconsin Alumni Research Foundation | (20R)-2α-methyl-19,26,2-trinor-vitamin D analogs |
| ES2670029T3 (es) * | 2006-06-21 | 2018-05-29 | Opko Ireland Global Holdings, Ltd. | Terapia usando agente de repleción de la vitamina D y agente de reemplazo de la hormona de la vitamina D |
| AU2007287099A1 (en) | 2006-08-25 | 2008-02-28 | Cougar Biotechnology, Inc. | Methods for treating cancer comprising the administration of a vitamin D compound and an additional therapeutic agent, and compositions containing the same |
| US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
| US20080051375A1 (en) * | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods for treating cancer comprising the administration of a vitamin d compound and an additional therapeutic agent, and compositions containing the same |
| TW200833345A (en) * | 2006-11-01 | 2008-08-16 | Novacea Inc | Use of vitamin D compounds and mimics thereof to enhance delivery of therapeutics and oxygen to tumors and other tissues |
| HRP20231142T3 (hr) | 2007-04-25 | 2024-01-05 | Eirgen Pharma Ltd. | Kontrolirano oslobađanje 25-hidroksivitamina d |
| JP2010525080A (ja) | 2007-04-25 | 2010-07-22 | プロヴェンティヴ セラピュティックス リミテッド ライアビリティ カンパニー | 慢性腎臓病における続発性副甲状腺機能亢進症の安全かつ効果的な治療および予防方法 |
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| EP2240440A2 (en) * | 2007-12-28 | 2010-10-20 | Wisconsin Alumni Research Foundation | 2-methylene-(20s,25s)-19,26-dinor-vitamin d analogs |
| WO2009097614A1 (en) * | 2008-02-01 | 2009-08-06 | Wisconsin Alumni Research Foundation | Methods of treating multiple sclerosis by administering pulse dose calcitrol |
| ES2954932T3 (es) | 2008-04-02 | 2023-11-27 | Eirgen Pharma Ltd | Métodos, composiciones, usos y kits útiles para la deficiencia de vitamina D y trastornos relacionados |
| CA2750659C (en) | 2009-01-27 | 2017-11-21 | Berg Biosystems, Llc | Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy |
| US8470304B2 (en) | 2009-08-04 | 2013-06-25 | Avidas Pharmaceuticals Llc | Therapeutic vitamin D sun-protecting formulations and methods for their use |
| EA201270226A1 (ru) | 2009-08-14 | 2012-09-28 | БЕРГ БАЙОСИСТЕМЗ, ЭлЭлСи | Витамин d3 и его аналогии для лечения алопеции |
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| US9008389B2 (en) * | 2012-09-28 | 2015-04-14 | Robert D. Williams | System and method for determining the amount of vitamin D generated by a user |
| KR101847947B1 (ko) | 2013-03-15 | 2018-05-28 | 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 | 안정화되고 변형된 비타민 d 방출 제형 |
| HK1222819A1 (zh) | 2013-05-29 | 2017-07-14 | 博格有限责任公司 | 使用维生素d预防或减轻化疗诱发的脱发 |
| ES2536256B2 (es) | 2013-11-20 | 2016-02-01 | Universidade De Santiago De Compostela | Análogos de vitamina d con interés farmacéutico |
| MX2016007786A (es) | 2013-12-16 | 2017-03-03 | Massachusetts Inst Technology | Formulaciones de sal de micronutrientes fortificadas. |
| US10098897B2 (en) * | 2014-07-17 | 2018-10-16 | Mayo Foundation For Medical Education And Research | Methods and materials for reducing development of stenosis of arteriovenous fistulas |
| US10220047B2 (en) | 2014-08-07 | 2019-03-05 | Opko Ireland Global Holdings, Ltd. | Adjunctive therapy with 25-hydroxyvitamin D and articles therefor |
| CN108883120A (zh) | 2016-03-28 | 2018-11-23 | 欧普科爱尔兰环球控股有限公司 | 维生素d治疗方法 |
| RS66574B1 (sr) | 2016-07-29 | 2025-03-31 | Janssen Pharmaceutica Nv | Niraparib za upotrebu u postupku lečenja raka prostate |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004535429A (ja) * | 2001-06-26 | 2004-11-25 | ボーン ケア インターナショナル インコーポレイテッド | 活性なビタミンd類縁体を使用する異常増殖性疾患の治療方法 |
| JP2005510536A (ja) * | 2001-11-28 | 2005-04-21 | ボーン ケア インターナショナル インコーポレイテッド | 活性ビタミンd類縁物質を使用した過剰増殖性疾病の治療 |
| JP2007501865A (ja) * | 2003-06-11 | 2007-02-01 | ノバセア インコーポレイティッド | 放射線治療薬および放射線治療と併用した、活性ビタミンd化合物による癌の治療法 |
| JP2016006084A (ja) * | 2004-06-07 | 2016-01-14 | クー バイオロジックス インク.Qu Biologics Inc. | 癌を治療するための細菌組成物 |
| US9775896B2 (en) | 2004-06-07 | 2017-10-03 | Qu Biologics Inc. | Tissue targeted antigenic activation of the immune response to treat cancers |
| US10086066B2 (en) | 2004-06-07 | 2018-10-02 | Qu Biologics Inc. | Tissue targeted antigenic activation of the immune response to treat cancers |
| JP2008538114A (ja) * | 2005-03-23 | 2008-10-09 | ビオクセル エッセ ピ ア | 20−アルキル、ジェミニビタミンd3化合物及びその使用方法 |
| US10130692B2 (en) | 2010-07-26 | 2018-11-20 | Qu Biologics Inc. | Immunogenic anti-inflammatory compositions |
| US10251946B2 (en) | 2014-05-02 | 2019-04-09 | Qu Biologics Inc. | Anti-microbial immunomodulation |
| US10946083B2 (en) | 2014-05-02 | 2021-03-16 | Qu Biologies Inc. | Anti-microbial immunomodulation |
| US11819543B2 (en) | 2014-05-02 | 2023-11-21 | Qu Biologics Inc. | Anti-microbial immunomodulation |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1064000A4 (en) | 2002-01-02 |
| CA2326117A1 (en) | 1999-10-07 |
| WO1999049870A1 (en) | 1999-10-07 |
| EP1064000B1 (en) | 2011-07-06 |
| EP2340840B1 (en) | 2012-08-29 |
| US20030119795A1 (en) | 2003-06-26 |
| ES2368824T3 (es) | 2011-11-22 |
| AU762481B2 (en) | 2003-06-26 |
| AU3202299A (en) | 1999-10-18 |
| AU762481C (en) | 2004-08-19 |
| EP1064000A1 (en) | 2001-01-03 |
| EP2340840A1 (en) | 2011-07-06 |
| ATE515265T1 (de) | 2011-07-15 |
| US6521608B1 (en) | 2003-02-18 |
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