JP2002509888A5 - - Google Patents
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- Publication number
- JP2002509888A5 JP2002509888A5 JP2000540833A JP2000540833A JP2002509888A5 JP 2002509888 A5 JP2002509888 A5 JP 2002509888A5 JP 2000540833 A JP2000540833 A JP 2000540833A JP 2000540833 A JP2000540833 A JP 2000540833A JP 2002509888 A5 JP2002509888 A5 JP 2002509888A5
- Authority
- JP
- Japan
- Prior art keywords
- vitamin
- calcitriol
- cancer
- drug
- stated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000003814 drug Substances 0.000 description 17
- 239000011710 vitamin D Substances 0.000 description 16
- 229930003316 Vitamin D Natural products 0.000 description 14
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 14
- 229940079593 drug Drugs 0.000 description 14
- 235000019166 vitamin D Nutrition 0.000 description 14
- 150000003710 vitamin D derivatives Chemical class 0.000 description 14
- 229940046008 vitamin d Drugs 0.000 description 14
- 239000011612 calcitriol Substances 0.000 description 12
- 229960005084 calcitriol Drugs 0.000 description 10
- 235000020964 calcitriol Nutrition 0.000 description 10
- GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 description 10
- 238000000034 method Methods 0.000 description 8
- 239000002552 dosage form Substances 0.000 description 6
- 208000037147 Hypercalcaemia Diseases 0.000 description 3
- 230000000148 hypercalcaemia Effects 0.000 description 3
- 208000030915 hypercalcemia disease Diseases 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 230000001028 anti-proliverative effect Effects 0.000 description 2
- 210000000481 breast Anatomy 0.000 description 2
- 230000035563 calcemia Effects 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 239000006186 oral dosage form Substances 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 229940122361 Bisphosphonate Drugs 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 208000028018 Lymphocytic leukaemia Diseases 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 208000037196 Medullary thyroid carcinoma Diseases 0.000 description 1
- 208000034578 Multiple myelomas Diseases 0.000 description 1
- 229940121682 Osteoclast inhibitor Drugs 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 208000006265 Renal cell carcinoma Diseases 0.000 description 1
- 201000000582 Retinoblastoma Diseases 0.000 description 1
- 208000021712 Soft tissue sarcoma Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 150000004663 bisphosphonates Chemical class 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 206010006007 bone sarcoma Diseases 0.000 description 1
- 229960002882 calcipotriol Drugs 0.000 description 1
- LWQQLNNNIPYSNX-UROSTWAQSA-N calcipotriol Chemical compound C1([C@H](O)/C=C/[C@@H](C)[C@@H]2[C@]3(CCCC(/[C@@H]3CC2)=C\C=C\2C([C@@H](O)C[C@H](O)C/2)=C)C)CC1 LWQQLNNNIPYSNX-UROSTWAQSA-N 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 210000003679 cervix uteri Anatomy 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000004696 endometrium Anatomy 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 208000003747 lymphoid leukemia Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 208000023356 medullary thyroid gland carcinoma Diseases 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000003739 neck Anatomy 0.000 description 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 206010041823 squamous cell carcinoma Diseases 0.000 description 1
- 208000013818 thyroid gland medullary carcinoma Diseases 0.000 description 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 102000009310 vitamin D receptors Human genes 0.000 description 1
- 108050000156 vitamin D receptors Proteins 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7969698P | 1998-03-27 | 1998-03-27 | |
| US60/079,696 | 1998-03-27 | ||
| PCT/US1999/006442 WO1999049870A1 (en) | 1998-03-27 | 1999-03-25 | Vitamin d and its analogs in the treatment of tumors and other hyperproliferative disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002509888A JP2002509888A (ja) | 2002-04-02 |
| JP2002509888A5 true JP2002509888A5 (enExample) | 2006-05-18 |
Family
ID=22152202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000540833A Ceased JP2002509888A (ja) | 1998-03-27 | 1999-03-25 | 腫瘍および他の過増殖性疾患の治療におけるビタミンｄおよびその類似体 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6521608B1 (enExample) |
| EP (2) | EP1064000B1 (enExample) |
| JP (1) | JP2002509888A (enExample) |
| AT (1) | ATE515265T1 (enExample) |
| AU (1) | AU762481C (enExample) |
| CA (1) | CA2326117A1 (enExample) |
| ES (1) | ES2368824T3 (enExample) |
| WO (1) | WO1999049870A1 (enExample) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040009958A1 (en) * | 1991-01-08 | 2004-01-15 | Bone Care International, Inc. | Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2 |
| US6538037B2 (en) | 1991-01-08 | 2003-03-25 | Bone Care International, Inc. | Methods for preparation and use of 1α,24(S)-dihydroxyvitamin D2 |
| US20040167106A1 (en) * | 1993-06-04 | 2004-08-26 | Rodriguez Gustavo C. | Prevention of ovarian cancer by administration of a Vitamin D compound |
| US5763429A (en) * | 1993-09-10 | 1998-06-09 | Bone Care International, Inc. | Method of treating prostatic diseases using active vitamin D analogues |
| US6242434B1 (en) * | 1997-08-08 | 2001-06-05 | Bone Care International, Inc. | 24-hydroxyvitamin D, analogs and uses thereof |
| US20020183288A1 (en) * | 1995-04-03 | 2002-12-05 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
| US20040043971A1 (en) * | 1995-04-03 | 2004-03-04 | Bone Care International, Inc. | Method of treating and preventing hyperparathyroidism with active vitamin D analogs |
| US20020128240A1 (en) * | 1996-12-30 | 2002-09-12 | Bone Care International, Inc. | Treatment of hyperproliferative diseases using active vitamin D analogues |
| US6573256B2 (en) | 1996-12-30 | 2003-06-03 | Bone Care International, Inc. | Method of inhibiting angiogenesis using active vitamin D analogues |
| US6566353B2 (en) * | 1996-12-30 | 2003-05-20 | Bone Care International, Inc. | Method of treating malignancy associated hypercalcemia using active vitamin D analogues |
| US6503893B2 (en) * | 1996-12-30 | 2003-01-07 | Bone Care International, Inc. | Method of treating hyperproliferative diseases using active vitamin D analogues |
| US20030129194A1 (en) * | 1997-02-13 | 2003-07-10 | Bone Care International, Inc. | Targeted therapeutic delivery of vitamin D compounds |
| CA2279590A1 (en) * | 1997-02-13 | 1998-08-20 | Bone Care International, Inc. | Targeted therapeutic delivery of vitamin d compounds |
| US6087350A (en) | 1997-08-29 | 2000-07-11 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Use of pretreatment chemicals to enhance efficacy of cytotoxic agents |
| EP1064000B1 (en) * | 1998-03-27 | 2011-07-06 | Oregon Health & Science University | Vitamin d and its analogs in the treatment of tumors and other hyperproliferative disorders |
| EP1276482B1 (en) * | 2000-03-02 | 2008-01-16 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Combination chemotherapy |
| JP4803939B2 (ja) * | 2000-04-19 | 2011-10-26 | 中外製薬株式会社 | ビタミンｄ誘導体 |
| US20040224877A1 (en) * | 2000-05-09 | 2004-11-11 | Steven Pirie-Shepherd | Method and Composition for the Treatment of Angiogenesis |
| WO2002006218A2 (en) | 2000-07-18 | 2002-01-24 | Bone Care International, Inc. | STABILIZED 1α-HYDROXY VITAMIN D |
| US20040087559A1 (en) * | 2000-09-22 | 2004-05-06 | Schwartz Gary G. | Methods for prevention and treatment of cancer |
| EP1270026A1 (en) * | 2001-06-22 | 2003-01-02 | Erik Andersen | Stents comprising vitamin D analogues for restenosis inhibition |
| MXPA04005260A (es) * | 2001-12-03 | 2005-03-23 | Novacea Inc | Composiciones farmaceuticas que comprenden compuestos activos de vitamina d. |
| JPWO2004012743A1 (ja) * | 2002-08-01 | 2006-09-21 | 中外製薬株式会社 | 乾癬治療剤 |
| US20040170621A1 (en) * | 2002-08-30 | 2004-09-02 | Roodman G. David | Method of resisting osteoclast formation |
| US20040138162A1 (en) * | 2002-08-30 | 2004-07-15 | Roodman G. David | Method of resisting osteoclast formation |
| US7148211B2 (en) * | 2002-09-18 | 2006-12-12 | Genzyme Corporation | Formulation for lipophilic agents |
| US20040053895A1 (en) * | 2002-09-18 | 2004-03-18 | Bone Care International, Inc. | Multi-use vessels for vitamin D formulations |
| US20040058895A1 (en) * | 2002-09-18 | 2004-03-25 | Bone Care International, Inc. | Multi-use vessels for vitamin D formulations |
| MXPA05004985A (es) * | 2002-11-06 | 2005-08-02 | Novacea Inc | Metodos de uso de compuestos de vitamina d en el tratamiento de sindromes mielodisplasticos. |
| US20050101576A1 (en) * | 2003-11-06 | 2005-05-12 | Novacea, Inc. | Methods of using vitamin D compounds in the treatment of myelodysplastic syndromes |
| AU2003295773A1 (en) * | 2002-11-21 | 2004-06-18 | Novacea, Inc. | Treatment of liver disease with active vitamin d compounds |
| US20050026877A1 (en) * | 2002-12-03 | 2005-02-03 | Novacea, Inc. | Pharmaceutical compositions comprising active vitamin D compounds |
| US20060217316A1 (en) * | 2003-04-02 | 2006-09-28 | Ragab El-Rashidy | Method for the treatment of prostate cancer |
| US20050020546A1 (en) * | 2003-06-11 | 2005-01-27 | Novacea, Inc. | Pharmaceutical compositions comprising active vitamin D compounds |
| AU2004247108A1 (en) * | 2003-06-11 | 2004-12-23 | Novacea, Inc | Treatment of immune-mediated disorders with active vitamin D compounds alone or in combination with other therapeutic agents |
| JP2007501865A (ja) * | 2003-06-11 | 2007-02-01 | ノバセア インコーポレイティッド | 放射線治療薬および放射線治療と併用した、活性ビタミンｄ化合物による癌の治療法 |
| WO2005097128A1 (en) * | 2004-03-30 | 2005-10-20 | Novacea, Inc. | 1,4-bis-n-oxide azaanthracenediones and the use thereof |
| US20070142339A1 (en) * | 2004-05-10 | 2007-06-21 | Novacea, Inc. | Prevention of arterial restenosis with active vitamin d compounds |
| WO2005117542A2 (en) * | 2004-05-10 | 2005-12-15 | Novacea, Inc. | Treatment of pancreatic cancer with active vitamin d compounds in combination with other treatments |
| WO2005110464A2 (en) * | 2004-05-14 | 2005-11-24 | Oregon Health & Science University | Irx5 inhibition as treatment for hyperproliferative disorders |
| NZ581806A (en) * | 2004-06-07 | 2011-10-28 | Qu Biolog Inc | Bacterial compositions for the treatment of cancer |
| US9107864B2 (en) | 2004-06-07 | 2015-08-18 | Qu Biologics Inc. | Tissue targeted antigenic activation of the immune response to treat cancers |
| US20060003950A1 (en) * | 2004-06-30 | 2006-01-05 | Bone Care International, Inc. | Method of treating prostatic diseases using a combination of vitamin D analogues and other agents |
| US7094775B2 (en) * | 2004-06-30 | 2006-08-22 | Bone Care International, Llc | Method of treating breast cancer using a combination of vitamin D analogues and other agents |
| ATE469883T1 (de) * | 2004-11-22 | 2010-06-15 | Wisconsin Alumni Res Found | 2-methylen-19-nor-1alpha-hydroxy-17- enhormopregnacalziferol und anwendungen davon |
| US20080069814A1 (en) * | 2005-01-05 | 2008-03-20 | Novacea, Inc. | Prevention of Thrombotic Disorders with Active Vitamin D Compounds or Mimics Thereof |
| EP1833485A2 (en) * | 2005-01-05 | 2007-09-19 | Novacea, Inc. | Prevention of thrombotic disorders with active vitamin d compounds or mimics thereof |
| WO2006096555A1 (en) * | 2005-03-04 | 2006-09-14 | Women And Infants Hospital Of Ri, Inc. | Compositions and methods for cancer treatment |
| US20090099140A1 (en) * | 2005-03-23 | 2009-04-16 | Bioxell S.P.A. | 20-Alkyl, Gemini Vitamin D3 Compounds and Methods of Use Thereof |
| WO2006117684A1 (en) * | 2005-03-23 | 2006-11-09 | Bioxell S.P.A. | Methods of treating osteoporosis and secondary hyperparathyroidism using 20-methyl, gemini vitamin d3 compounds |
| JP2008538580A (ja) * | 2005-04-22 | 2008-10-30 | ノバセア インコーポレイティッド | 活性ビタミンｄ化合物またはその模倣体による、化学療法または放射線療法と関連する肺疾患の治療、予防、および改善 |
| GB0513984D0 (en) * | 2005-07-07 | 2005-08-17 | Teva Pharma | Dosage form |
| SI1993559T1 (sl) | 2006-02-03 | 2017-01-31 | Opko Renal, Llc | Zdravljenje nezadostnosti in pomanjkanja vitamina D s 25-hidroksivitaminon D2 in 25-hidroksivitaminom D3 |
| US8193169B2 (en) * | 2006-04-06 | 2012-06-05 | Wisconsin Alumni Research Foundation | (20R)-2α-methyl-19,26,2-trinor-vitamin D analogs |
| PT3357496T (pt) * | 2006-06-21 | 2020-05-12 | Opko Ireland Global Holdings Ltd | Terapia utilizando um agente de repleção de vitamina d e um agente de substituição hormonal de vitamina d |
| US20080051375A1 (en) * | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods for treating cancer comprising the administration of a vitamin d compound and an additional therapeutic agent, and compositions containing the same |
| CA2838089A1 (en) | 2006-08-25 | 2008-02-28 | Cougar Biotechnology, Inc. | Methods for treating cancer comprising the administration of a vitamin d compound and an additional therapeutic agent, and compositions containing the same |
| US20080051380A1 (en) * | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
| TW200833345A (en) * | 2006-11-01 | 2008-08-16 | Novacea Inc | Use of vitamin D compounds and mimics thereof to enhance delivery of therapeutics and oxygen to tumors and other tissues |
| KR20190141269A (ko) | 2007-04-25 | 2019-12-23 | 사이토크로마 인코포레이티드 | 비타민 ｄ 화합물과 밀랍성 담체를 포함하는 경구 조절성 방출 조성물 |
| CN101668532B (zh) | 2007-04-25 | 2014-08-20 | 赛特克罗公司 | 治疗维生素d不足和缺乏、继发性甲状旁腺功能亢进症和维生素d-响应疾病的组合物及其相应的制药用途 |
| PL3225243T3 (pl) | 2007-04-25 | 2025-12-22 | Opko Renal, Llc | Sposób bezpiecznego i skutecznego leczenia i zapobiegania wtórnej nadczynności przytarczyc w przewlekłej chorobie nerek |
| AU2008345085A1 (en) * | 2007-12-28 | 2009-07-09 | Wisconsin Alumni Research Foundation | 2-methylene-(20S,25S)-19,26-dinor-vitamin D analogs |
| WO2009097614A1 (en) * | 2008-02-01 | 2009-08-06 | Wisconsin Alumni Research Foundation | Methods of treating multiple sclerosis by administering pulse dose calcitrol |
| CN102046812A (zh) | 2008-04-02 | 2011-05-04 | 赛特克罗公司 | 用于维生素d缺乏症和相关障碍的方法、组合物、用途和试剂盒 |
| SG2014006324A (en) * | 2009-01-27 | 2014-03-28 | Berg Llc | Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy |
| US8470304B2 (en) * | 2009-08-04 | 2013-06-25 | Avidas Pharmaceuticals Llc | Therapeutic vitamin D sun-protecting formulations and methods for their use |
| CN102655869B (zh) | 2009-08-14 | 2016-08-10 | 博格有限责任公司 | 用于治疗脱发的维生素d3及其类似物 |
| CA2797537C (en) | 2010-03-29 | 2021-11-23 | Cytochroma Inc. | Use of 25-hydroxyvitamin d compound for reducing parathyroid levels |
| EP4324526A3 (en) | 2010-07-26 | 2024-05-22 | Qu Biologics Inc. | Immunogenic anti-inflammatory compositions |
| US9008389B2 (en) * | 2012-09-28 | 2015-04-14 | Robert D. Williams | System and method for determining the amount of vitamin D generated by a user |
| KR101847947B1 (ko) | 2013-03-15 | 2018-05-28 | 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 | 안정화되고 변형된 비타민 ｄ 방출 제형 |
| HK1222819A1 (zh) | 2013-05-29 | 2017-07-14 | 博格有限责任公司 | 使用维生素d预防或减轻化疗诱发的脱发 |
| ES2536256B2 (es) * | 2013-11-20 | 2016-02-01 | Universidade De Santiago De Compostela | Análogos de vitamina d con interés farmacéutico |
| SG11201604805XA (en) | 2013-12-16 | 2016-07-28 | Massachusetts Inst Technology | Fortified micronutrient salt formulations |
| CA2947631A1 (en) | 2014-05-02 | 2015-11-05 | Qu Biologics Inc. | Anti-microbial immunomodulation |
| WO2016011397A1 (en) * | 2014-07-17 | 2016-01-21 | Mayo Foundation For Medical Education And Research | Methods and materials for reducing development of stenosis of arteriovenous fistulas |
| US10220047B2 (en) | 2014-08-07 | 2019-03-05 | Opko Ireland Global Holdings, Ltd. | Adjunctive therapy with 25-hydroxyvitamin D and articles therefor |
| EP4596045A3 (en) | 2016-03-28 | 2025-10-15 | EirGen Pharma Ltd. | Methods of vitamin d treatment |
| MX2019001224A (es) | 2016-07-29 | 2019-06-03 | Janssen Pharmaceutica Nv | Metodos para tratar el cancer de prostata. |
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-
1999
- 1999-03-25 EP EP99914109A patent/EP1064000B1/en not_active Expired - Lifetime
- 1999-03-25 AT AT99914109T patent/ATE515265T1/de not_active IP Right Cessation
- 1999-03-25 CA CA002326117A patent/CA2326117A1/en not_active Abandoned
- 1999-03-25 EP EP10184333A patent/EP2340840B1/en not_active Expired - Lifetime
- 1999-03-25 JP JP2000540833A patent/JP2002509888A/ja not_active Ceased
- 1999-03-25 AU AU32022/99A patent/AU762481C/en not_active Ceased
- 1999-03-25 US US09/647,075 patent/US6521608B1/en not_active Expired - Lifetime
- 1999-03-25 WO PCT/US1999/006442 patent/WO1999049870A1/en not_active Ceased
- 1999-03-25 ES ES99914109T patent/ES2368824T3/es not_active Expired - Lifetime
-
2002
- 2002-11-21 US US10/302,654 patent/US20030119795A1/en not_active Abandoned
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