JP2002509888A5 - - Google Patents
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- Publication number
- JP2002509888A5 JP2002509888A5 JP2000540833A JP2000540833A JP2002509888A5 JP 2002509888 A5 JP2002509888 A5 JP 2002509888A5 JP 2000540833 A JP2000540833 A JP 2000540833A JP 2000540833 A JP2000540833 A JP 2000540833A JP 2002509888 A5 JP2002509888 A5 JP 2002509888A5
- Authority
- JP
- Japan
- Prior art keywords
- vitamin
- calcitriol
- cancer
- drug
- stated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000003814 drug Substances 0.000 description 17
- 239000011710 vitamin D Substances 0.000 description 16
- 229930003316 Vitamin D Natural products 0.000 description 14
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 14
- 229940079593 drug Drugs 0.000 description 14
- 235000019166 vitamin D Nutrition 0.000 description 14
- 150000003710 vitamin D derivatives Chemical class 0.000 description 14
- 229940046008 vitamin d Drugs 0.000 description 14
- 239000011612 calcitriol Substances 0.000 description 12
- 229960005084 calcitriol Drugs 0.000 description 10
- 235000020964 calcitriol Nutrition 0.000 description 10
- GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 description 10
- 238000000034 method Methods 0.000 description 8
- 239000002552 dosage form Substances 0.000 description 6
- 208000037147 Hypercalcaemia Diseases 0.000 description 3
- 230000000148 hypercalcaemia Effects 0.000 description 3
- 208000030915 hypercalcemia disease Diseases 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 230000001028 anti-proliverative effect Effects 0.000 description 2
- 210000000481 breast Anatomy 0.000 description 2
- 230000035563 calcemia Effects 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 239000006186 oral dosage form Substances 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 229940122361 Bisphosphonate Drugs 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 208000028018 Lymphocytic leukaemia Diseases 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 208000037196 Medullary thyroid carcinoma Diseases 0.000 description 1
- 208000034578 Multiple myelomas Diseases 0.000 description 1
- 229940121682 Osteoclast inhibitor Drugs 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 208000006265 Renal cell carcinoma Diseases 0.000 description 1
- 201000000582 Retinoblastoma Diseases 0.000 description 1
- 208000021712 Soft tissue sarcoma Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 150000004663 bisphosphonates Chemical class 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 206010006007 bone sarcoma Diseases 0.000 description 1
- 229960002882 calcipotriol Drugs 0.000 description 1
- LWQQLNNNIPYSNX-UROSTWAQSA-N calcipotriol Chemical compound C1([C@H](O)/C=C/[C@@H](C)[C@@H]2[C@]3(CCCC(/[C@@H]3CC2)=C\C=C\2C([C@@H](O)C[C@H](O)C/2)=C)C)CC1 LWQQLNNNIPYSNX-UROSTWAQSA-N 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 210000003679 cervix uteri Anatomy 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000004696 endometrium Anatomy 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 208000003747 lymphoid leukemia Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 208000023356 medullary thyroid gland carcinoma Diseases 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000003739 neck Anatomy 0.000 description 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 206010041823 squamous cell carcinoma Diseases 0.000 description 1
- 208000013818 thyroid gland medullary carcinoma Diseases 0.000 description 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 102000009310 vitamin D receptors Human genes 0.000 description 1
- 108050000156 vitamin D receptors Proteins 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7969698P | 1998-03-27 | 1998-03-27 | |
| US60/079,696 | 1998-03-27 | ||
| PCT/US1999/006442 WO1999049870A1 (en) | 1998-03-27 | 1999-03-25 | Vitamin d and its analogs in the treatment of tumors and other hyperproliferative disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002509888A JP2002509888A (ja) | 2002-04-02 |
| JP2002509888A5 true JP2002509888A5 (enExample) | 2006-05-18 |
Family
ID=22152202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000540833A Ceased JP2002509888A (ja) | 1998-03-27 | 1999-03-25 | 腫瘍および他の過増殖性疾患の治療におけるビタミンｄおよびその類似体 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6521608B1 (enExample) |
| EP (2) | EP1064000B1 (enExample) |
| JP (1) | JP2002509888A (enExample) |
| AT (1) | ATE515265T1 (enExample) |
| AU (1) | AU762481C (enExample) |
| CA (1) | CA2326117A1 (enExample) |
| ES (1) | ES2368824T3 (enExample) |
| WO (1) | WO1999049870A1 (enExample) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040009958A1 (en) * | 1991-01-08 | 2004-01-15 | Bone Care International, Inc. | Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2 |
| US6538037B2 (en) | 1991-01-08 | 2003-03-25 | Bone Care International, Inc. | Methods for preparation and use of 1α,24(S)-dihydroxyvitamin D2 |
| US20040167106A1 (en) * | 1993-06-04 | 2004-08-26 | Rodriguez Gustavo C. | Prevention of ovarian cancer by administration of a Vitamin D compound |
| US5763429A (en) * | 1993-09-10 | 1998-06-09 | Bone Care International, Inc. | Method of treating prostatic diseases using active vitamin D analogues |
| US20020183288A1 (en) * | 1995-04-03 | 2002-12-05 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
| US6242434B1 (en) * | 1997-08-08 | 2001-06-05 | Bone Care International, Inc. | 24-hydroxyvitamin D, analogs and uses thereof |
| US20040043971A1 (en) * | 1995-04-03 | 2004-03-04 | Bone Care International, Inc. | Method of treating and preventing hyperparathyroidism with active vitamin D analogs |
| US6566353B2 (en) | 1996-12-30 | 2003-05-20 | Bone Care International, Inc. | Method of treating malignancy associated hypercalcemia using active vitamin D analogues |
| US6503893B2 (en) | 1996-12-30 | 2003-01-07 | Bone Care International, Inc. | Method of treating hyperproliferative diseases using active vitamin D analogues |
| US20020128240A1 (en) * | 1996-12-30 | 2002-09-12 | Bone Care International, Inc. | Treatment of hyperproliferative diseases using active vitamin D analogues |
| US6573256B2 (en) | 1996-12-30 | 2003-06-03 | Bone Care International, Inc. | Method of inhibiting angiogenesis using active vitamin D analogues |
| US20030129194A1 (en) * | 1997-02-13 | 2003-07-10 | Bone Care International, Inc. | Targeted therapeutic delivery of vitamin D compounds |
| CA2279590A1 (en) * | 1997-02-13 | 1998-08-20 | Bone Care International, Inc. | Targeted therapeutic delivery of vitamin d compounds |
| US6087350A (en) * | 1997-08-29 | 2000-07-11 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Use of pretreatment chemicals to enhance efficacy of cytotoxic agents |
| ES2368824T3 (es) * | 1998-03-27 | 2011-11-22 | Oregon Health & Science University | Vitamina d y sus análogos en el tratamiento de tumores y otros desórdenes hiperproliferativos. |
| JP2003525254A (ja) * | 2000-03-02 | 2003-08-26 | ユニヴァーシティ オヴ ピッツバーグ オヴ ザ コモンウェルス システム オヴ ハイアー エデュケーション | 併用化学療法 |
| JP4803939B2 (ja) * | 2000-04-19 | 2011-10-26 | 中外製薬株式会社 | ビタミンｄ誘導体 |
| CA2409759A1 (en) * | 2000-05-09 | 2001-11-15 | Children's Medical Center Corporation | Method and composition for the treatment of angiogenesis |
| EP2070911A2 (en) | 2000-07-18 | 2009-06-17 | Bone Care International, Inc. | Stabilized 1Alpha-Hydroxy vitamin D |
| US20040087559A1 (en) * | 2000-09-22 | 2004-05-06 | Schwartz Gary G. | Methods for prevention and treatment of cancer |
| EP1270026A1 (en) * | 2001-06-22 | 2003-01-02 | Erik Andersen | Stents comprising vitamin D analogues for restenosis inhibition |
| KR20050044655A (ko) * | 2001-12-03 | 2005-05-12 | 노바세아, 인크. | 활성 비타민 ｄ 화합물을 함유하는 약제학적 조성물 |
| EP1552837A1 (en) * | 2002-08-01 | 2005-07-13 | Chugai Seiyaku Kabushiki Kaisha | Antipsoriatic agent |
| US20040170621A1 (en) * | 2002-08-30 | 2004-09-02 | Roodman G. David | Method of resisting osteoclast formation |
| US20040138162A1 (en) * | 2002-08-30 | 2004-07-15 | Roodman G. David | Method of resisting osteoclast formation |
| US20040058895A1 (en) * | 2002-09-18 | 2004-03-25 | Bone Care International, Inc. | Multi-use vessels for vitamin D formulations |
| US7148211B2 (en) * | 2002-09-18 | 2006-12-12 | Genzyme Corporation | Formulation for lipophilic agents |
| US20040053895A1 (en) * | 2002-09-18 | 2004-03-18 | Bone Care International, Inc. | Multi-use vessels for vitamin D formulations |
| EP1562606A4 (en) * | 2002-11-06 | 2006-05-24 | Novacea Inc | METHODS OF USING VITAMIN D COMPOUNDS TO TREAT MYELODYSPLASIC SYNDROMES |
| US20050101576A1 (en) * | 2003-11-06 | 2005-05-12 | Novacea, Inc. | Methods of using vitamin D compounds in the treatment of myelodysplastic syndromes |
| AU2003295773A1 (en) * | 2002-11-21 | 2004-06-18 | Novacea, Inc. | Treatment of liver disease with active vitamin d compounds |
| US20050026877A1 (en) * | 2002-12-03 | 2005-02-03 | Novacea, Inc. | Pharmaceutical compositions comprising active vitamin D compounds |
| CA2521221A1 (en) * | 2003-04-02 | 2004-10-14 | Genix Therapeutics, Inc. | Method for the treatment of prostate cancer |
| US20050020546A1 (en) * | 2003-06-11 | 2005-01-27 | Novacea, Inc. | Pharmaceutical compositions comprising active vitamin D compounds |
| AU2004247109A1 (en) * | 2003-06-11 | 2004-12-23 | Novacea, Inc | Treatment of cancer with active vitamin D compounds in combination with radiotherapeutic agents and treatments |
| CA2528378A1 (en) * | 2003-06-11 | 2004-12-23 | Novacea, Inc. | Treatment of immune-mediated disorders with active vitamin d compounds alone or in combination with other therapeutic agents |
| WO2005097128A1 (en) * | 2004-03-30 | 2005-10-20 | Novacea, Inc. | 1,4-bis-n-oxide azaanthracenediones and the use thereof |
| AU2005244061A1 (en) * | 2004-05-10 | 2005-11-24 | Novacea, Inc. | Prevention of arterial restenosis with active vitamin D compounds |
| WO2005117542A2 (en) * | 2004-05-10 | 2005-12-15 | Novacea, Inc. | Treatment of pancreatic cancer with active vitamin d compounds in combination with other treatments |
| WO2005110464A2 (en) * | 2004-05-14 | 2005-11-24 | Oregon Health & Science University | Irx5 inhibition as treatment for hyperproliferative disorders |
| PL1765391T3 (pl) * | 2004-06-07 | 2013-08-30 | Qu Biologics Inc | Kompozycje bakteryjne do leczenia nowotworów |
| US9107864B2 (en) | 2004-06-07 | 2015-08-18 | Qu Biologics Inc. | Tissue targeted antigenic activation of the immune response to treat cancers |
| US20060003950A1 (en) * | 2004-06-30 | 2006-01-05 | Bone Care International, Inc. | Method of treating prostatic diseases using a combination of vitamin D analogues and other agents |
| US7094775B2 (en) * | 2004-06-30 | 2006-08-22 | Bone Care International, Llc | Method of treating breast cancer using a combination of vitamin D analogues and other agents |
| MX2007006546A (es) * | 2004-11-22 | 2007-08-17 | Wisconsin Alumni Res Found | Analogos de 17,20(e)-deshidro vitamina d y sus usos. |
| JP2008526856A (ja) * | 2005-01-05 | 2008-07-24 | ノバセア インコーポレイティッド | 活性ビタミンｄ化合物またはその模倣体による血栓性疾患の予防 |
| US20080069814A1 (en) * | 2005-01-05 | 2008-03-20 | Novacea, Inc. | Prevention of Thrombotic Disorders with Active Vitamin D Compounds or Mimics Thereof |
| US20100144671A1 (en) | 2005-03-04 | 2010-06-10 | Women And Infants Hospital Of Ri, Inc. | Compositions and Methods for Cancer Treatment |
| CN101198336A (zh) * | 2005-03-23 | 2008-06-11 | 拜奥艾克塞尔股份公司 | 20－烷基双生维生素d3化合物及其使用方法 |
| EP1879596A4 (en) * | 2005-03-23 | 2009-01-21 | Bioxell Spa | 20 ALKYL, GEMINI VITAMIN D3 COMPOUNDS AND METHOD OF USE THEREOF |
| BRPI0610077A2 (pt) * | 2005-04-22 | 2010-05-25 | Novacea Inc | tratamento, prevenção e atenuação de distúrbios pulmonares associados à quimioterapia ou radioterapia com compostos de vitamina d ativos ou miméticos destes |
| GB0513984D0 (en) * | 2005-07-07 | 2005-08-17 | Teva Pharma | Dosage form |
| CA2882048C (en) | 2006-02-03 | 2020-03-24 | Proventiv Therapeutics, Llc | Treating vitamin d insufficiency and deficiency with 25-hydroxyvitamin d2 and 25-hydroxyvitamin d3 |
| US8193169B2 (en) * | 2006-04-06 | 2012-06-05 | Wisconsin Alumni Research Foundation | (20R)-2α-methyl-19,26,2-trinor-vitamin D analogs |
| EP2679228B1 (en) * | 2006-06-21 | 2018-03-21 | Opko Ireland Global Holdings, Ltd. | Therapy using vitamin D repletion agent and vitamin D hormone replacement agent |
| US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
| US20080051375A1 (en) * | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods for treating cancer comprising the administration of a vitamin d compound and an additional therapeutic agent, and compositions containing the same |
| CN101528309A (zh) | 2006-08-25 | 2009-09-09 | 库伽尔生物科技公司 | 包括给予维生素d化合物和另外的治疗剂的治疗癌症的方法 |
| TW200833345A (en) * | 2006-11-01 | 2008-08-16 | Novacea Inc | Use of vitamin D compounds and mimics thereof to enhance delivery of therapeutics and oxygen to tumors and other tissues |
| WO2009047644A2 (en) | 2007-04-25 | 2009-04-16 | Cytochroma Inc. | Method of treating vitamin d insufficiency and deficiency |
| KR101759244B1 (ko) | 2007-04-25 | 2017-07-18 | 사이토크로마 인코포레이티드 | 비타민 ｄ 화합물과 밀랍성 담체를 포함하는 경구 조절성 방출 조성물 |
| EP3225243B1 (en) | 2007-04-25 | 2025-09-03 | Opko Renal, LLC | Method of safely and effectively treating and preventing secondary hyperparathyroidism in chronic kidney disease |
| MX2010007263A (es) * | 2007-12-28 | 2011-03-15 | Wisconsin Alumni Res Foundation Star | Análogos de vitamina d-2-metilen-(20s, 25s)-19, 26-dinor. |
| US20090221538A1 (en) * | 2008-02-01 | 2009-09-03 | Hayes Colleen E | Methods of treating multiple sclerosis by administering pulse dose calcitriol |
| CN106853250A (zh) | 2008-04-02 | 2017-06-16 | 赛特克罗公司 | 用于维生素d缺乏症和相关障碍的方法、组合物、用途和试剂盒 |
| KR20170096238A (ko) * | 2009-01-27 | 2017-08-23 | 베르그 엘엘씨 | 화학요법과 연관된 부작용을 경감시키기 위한 비타민 ｄ３ 및 이의 유사물 |
| US8470304B2 (en) * | 2009-08-04 | 2013-06-25 | Avidas Pharmaceuticals Llc | Therapeutic vitamin D sun-protecting formulations and methods for their use |
| MX338746B (es) | 2009-08-14 | 2016-04-29 | Berg Llc | Vitamina d3 y analogos de la misma para tratar alopecia. |
| SI2552484T1 (sl) | 2010-03-29 | 2020-07-31 | Opko Ireland Global Holdings, Ltd. | Postopki in sestavki za znižanje ravni paratiroidnega hormona |
| SG10201604175XA (en) | 2010-07-26 | 2016-07-28 | Qu Biolog Inc | Immunogenic anti-inflammatory compositions |
| US9008389B2 (en) * | 2012-09-28 | 2015-04-14 | Robert D. Williams | System and method for determining the amount of vitamin D generated by a user |
| KR101847947B1 (ko) | 2013-03-15 | 2018-05-28 | 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 | 안정화되고 변형된 비타민 ｄ 방출 제형 |
| CA2913543C (en) | 2013-05-29 | 2024-01-09 | Berg Llc | Preventing or mitigating chemotherapy induced alopecia using vitamin d |
| ES2536256B2 (es) | 2013-11-20 | 2016-02-01 | Universidade De Santiago De Compostela | Análogos de vitamina d con interés farmacéutico |
| SG10201808645TA (en) | 2013-12-16 | 2018-11-29 | Massachusetts Inst Technology | Fortified Micronutrient Salt Formulations |
| CA3254723A1 (en) | 2014-05-02 | 2025-04-15 | Qu Biologics Inc. | ANTIMICROBIAL IMMUNOMODULATION |
| WO2016011397A1 (en) * | 2014-07-17 | 2016-01-21 | Mayo Foundation For Medical Education And Research | Methods and materials for reducing development of stenosis of arteriovenous fistulas |
| US10220047B2 (en) | 2014-08-07 | 2019-03-05 | Opko Ireland Global Holdings, Ltd. | Adjunctive therapy with 25-hydroxyvitamin D and articles therefor |
| CA3018019A1 (en) | 2016-03-28 | 2017-10-26 | Opko Ireland Global Holdings, Limited | Methods of vitamin d treatment |
| ES3014630T3 (en) | 2016-07-29 | 2025-04-23 | Janssen Pharmaceutica Nv | Niraparib for use in a method of treating prostate cancer |
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-
1999
- 1999-03-25 ES ES99914109T patent/ES2368824T3/es not_active Expired - Lifetime
- 1999-03-25 EP EP99914109A patent/EP1064000B1/en not_active Expired - Lifetime
- 1999-03-25 AT AT99914109T patent/ATE515265T1/de not_active IP Right Cessation
- 1999-03-25 CA CA002326117A patent/CA2326117A1/en not_active Abandoned
- 1999-03-25 WO PCT/US1999/006442 patent/WO1999049870A1/en not_active Ceased
- 1999-03-25 JP JP2000540833A patent/JP2002509888A/ja not_active Ceased
- 1999-03-25 US US09/647,075 patent/US6521608B1/en not_active Expired - Lifetime
- 1999-03-25 EP EP10184333A patent/EP2340840B1/en not_active Expired - Lifetime
- 1999-03-25 AU AU32022/99A patent/AU762481C/en not_active Ceased
-
2002
- 2002-11-21 US US10/302,654 patent/US20030119795A1/en not_active Abandoned
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