JP2002508334A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2002508334A5 JP2002508334A5 JP2000538716A JP2000538716A JP2002508334A5 JP 2002508334 A5 JP2002508334 A5 JP 2002508334A5 JP 2000538716 A JP2000538716 A JP 2000538716A JP 2000538716 A JP2000538716 A JP 2000538716A JP 2002508334 A5 JP2002508334 A5 JP 2002508334A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- microparticles
- poly
- selected antigen
- lactide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 description 34
- 239000000427 antigen Substances 0.000 description 26
- 102000036639 antigens Human genes 0.000 description 26
- 108091007433 antigens Proteins 0.000 description 26
- 239000011859 microparticle Substances 0.000 description 25
- 239000007764 o/w emulsion Substances 0.000 description 12
- 229920000642 polymer Polymers 0.000 description 5
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 3
- 229920001244 Poly(D,L-lactide) Polymers 0.000 description 3
- PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 description 3
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 229920001432 poly(L-lactide) Polymers 0.000 description 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 3
- 229920000053 polysorbate 80 Polymers 0.000 description 3
- 229940031439 squalene Drugs 0.000 description 3
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 3
- JJTUDXZGHPGLLC-IMJSIDKUSA-N 4511-42-6 Chemical compound C[C@@H]1OC(=O)[C@H](C)OC1=O JJTUDXZGHPGLLC-IMJSIDKUSA-N 0.000 description 2
- 241000711549 Hepacivirus C Species 0.000 description 2
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 230000003053 immunization Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 229920000747 poly(lactic acid) Polymers 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 description 1
- 208000034530 PLAA-associated neurodevelopmental disease Diseases 0.000 description 1
- 229920002732 Polyanhydride Polymers 0.000 description 1
- 229920000331 Polyhydroxybutyrate Polymers 0.000 description 1
- 229940061720 alpha hydroxy acid Drugs 0.000 description 1
- 150000001280 alpha hydroxy acids Chemical class 0.000 description 1
- 229920002988 biodegradable polymer Polymers 0.000 description 1
- 239000004621 biodegradable polymer Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 1
- 229920001610 polycaprolactone Polymers 0.000 description 1
- 239000004632 polycaprolactone Substances 0.000 description 1
- PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6972497P | 1997-12-16 | 1997-12-16 | |
| US60/069,724 | 1997-12-16 | ||
| PCT/US1998/001656 WO1999030737A1 (en) | 1997-12-16 | 1998-01-29 | Use of microparticles combined with submicron oil-in-water emulsions |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007292637A Division JP2008050374A (ja) | 1997-12-16 | 2007-11-09 | サブミクロンの水中油型エマルジョンと合わせた微粒子の使用 |
| JP2011250804A Division JP2012036223A (ja) | 1997-12-16 | 2011-11-16 | サブミクロンの水中油型エマルジョンと合わせた微粒子の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002508334A JP2002508334A (ja) | 2002-03-19 |
| JP2002508334A5 true JP2002508334A5 (https=) | 2012-01-26 |
| JP4918188B2 JP4918188B2 (ja) | 2012-04-18 |
Family
ID=22090819
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000538716A Expired - Fee Related JP4918188B2 (ja) | 1997-12-16 | 1998-01-29 | サブミクロンの水中油型エマルジョンと合わせた微粒子の使用 |
| JP2007292637A Withdrawn JP2008050374A (ja) | 1997-12-16 | 2007-11-09 | サブミクロンの水中油型エマルジョンと合わせた微粒子の使用 |
| JP2011250804A Withdrawn JP2012036223A (ja) | 1997-12-16 | 2011-11-16 | サブミクロンの水中油型エマルジョンと合わせた微粒子の使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007292637A Withdrawn JP2008050374A (ja) | 1997-12-16 | 2007-11-09 | サブミクロンの水中油型エマルジョンと合わせた微粒子の使用 |
| JP2011250804A Withdrawn JP2012036223A (ja) | 1997-12-16 | 2011-11-16 | サブミクロンの水中油型エマルジョンと合わせた微粒子の使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US6086901A (https=) |
| EP (1) | EP1042001B1 (https=) |
| JP (3) | JP4918188B2 (https=) |
| AT (1) | ATE215385T1 (https=) |
| AU (1) | AU6253898A (https=) |
| CA (1) | CA2314934C (https=) |
| DE (1) | DE69804671T2 (https=) |
| DK (1) | DK1042001T3 (https=) |
| ES (1) | ES2175668T3 (https=) |
| PT (1) | PT1042001E (https=) |
| WO (1) | WO1999030737A1 (https=) |
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2017507C (en) * | 1989-05-25 | 1996-11-12 | Gary Van Nest | Adjuvant formulation comprising a submicron oil droplet emulsion |
| KR100372375B1 (ko) | 1993-12-23 | 2003-04-21 | 머클한스피터 | 면역반응의강화방법 |
| EP2298900A1 (en) * | 1996-09-17 | 2011-03-23 | Novartis Vaccines and Diagnostics, Inc. | Compositions and methods for treating intracellular diseases |
| ATE235890T1 (de) * | 1997-01-30 | 2003-04-15 | Chiron Corp | Verwendung von mikropartikeln mit adsorbiertem antigen zur stimulierung der immunabwehr |
| US20040202680A1 (en) * | 1997-01-30 | 2004-10-14 | O'hagan Derek | Microparticles with adsorbent surfaces, methods of making same, and uses thereof |
| US6884435B1 (en) | 1997-01-30 | 2005-04-26 | Chiron Corporation | Microparticles with adsorbent surfaces, methods of making same, and uses thereof |
| US7393630B2 (en) * | 1997-12-16 | 2008-07-01 | Novartis Vaccines And Diagnostics, Inc. | Use of microparticles combined with submicron oil-in-water emulsions |
| WO1999030737A1 (en) * | 1997-12-16 | 1999-06-24 | Chiron Corporation | Use of microparticles combined with submicron oil-in-water emulsions |
| EP1156781B1 (en) * | 1999-02-26 | 2005-06-08 | Chiron Corporation | Microemulsions with adsorbed macromolecules and microparticles |
| CA2371994C (en) * | 1999-02-26 | 2010-09-28 | Guido Grandi | Enhancement of bactericidal activity of neisseria antigens with oligonucleotides containing cg motifs |
| PT1221968E (pt) * | 1999-10-13 | 2010-04-16 | Novartis Vaccines & Diagnostic | Processo de obtenção de respostas imunes celulares de proteínas |
| AU783918B2 (en) * | 1999-11-19 | 2005-12-22 | Eisai Inc. | Continuous-flow method for preparing microparticles |
| US7329408B2 (en) * | 1999-12-01 | 2008-02-12 | Novartis Vaccines And Diagnostics, Inc. | Eliciting HCV-specific antibodies |
| US20030129251A1 (en) | 2000-03-10 | 2003-07-10 | Gary Van Nest | Biodegradable immunomodulatory formulations and methods for use thereof |
| US7129222B2 (en) * | 2000-03-10 | 2006-10-31 | Dynavax Technologies Corporation | Immunomodulatory formulations and methods for use thereof |
| US20040022814A1 (en) * | 2000-06-15 | 2004-02-05 | O'hagan Derek | Microparticles with adsorbent surfaces, methods of making same, and uses thereof |
| US20030138769A1 (en) * | 2000-08-16 | 2003-07-24 | Birkett Ashley J. | Immunogenic HBc chimer particles having enhanced stability |
| MXPA03002643A (es) | 2000-09-28 | 2003-06-19 | Chiron Corp | Composiciones de microparticulas y metodos para producirlas. |
| ES2260291T3 (es) * | 2000-09-28 | 2006-11-01 | Chiron Corporation | Microparticulas para la administracion de acidos nucleicos heterologos. |
| CA2439111A1 (en) * | 2001-04-05 | 2002-10-17 | Chiron Corporation | Mucosal boosting following parenteral priming |
| US8481043B2 (en) * | 2001-06-22 | 2013-07-09 | Cpex Pharmaceuticals, Inc. | Nasal immunization |
| SK15762003A3 (sk) * | 2001-06-29 | 2005-01-03 | Chiron Corporation | Kompozícia vakcíny HCV E1E2 |
| US20030175863A1 (en) * | 2001-08-15 | 2003-09-18 | Birkett Ashley J. | Influenza immunogen and vaccine |
| US7361352B2 (en) | 2001-08-15 | 2008-04-22 | Acambis, Inc. | Influenza immunogen and vaccine |
| US20030185858A1 (en) * | 2001-08-15 | 2003-10-02 | Birkett Ashley J. | Immunogenic HBc chimer particles stabilized with an N-terminal cysteine |
| AR045702A1 (es) * | 2001-10-03 | 2005-11-09 | Chiron Corp | Composiciones de adyuvantes. |
| WO2003055323A1 (en) * | 2001-12-27 | 2003-07-10 | Genesis Group Inc. | Seal oil based lipid emulsions and uses thereof |
| WO2003059385A2 (en) * | 2002-01-14 | 2003-07-24 | Chiron Corporation | Hiv vaccine and method of use |
| US7351413B2 (en) * | 2002-02-21 | 2008-04-01 | Lorantis, Limited | Stabilized HBc chimer particles as immunogens for chronic hepatitis |
| US6861410B1 (en) | 2002-03-21 | 2005-03-01 | Chiron Corporation | Immunological adjuvant compositions |
| CA2479920A1 (en) * | 2002-03-29 | 2003-10-09 | The Regents Of The University Of California | Microgel particles for the delivery of bioactive materials |
| RU2214278C1 (ru) * | 2002-05-27 | 2003-10-20 | Закрытое Акционерное Общество "Нита-Фарм" | Адьювант для биопрепаратов |
| CA2531280A1 (en) * | 2002-07-03 | 2004-01-15 | Cambridge Scientific, Inc. | Vaccines to induce mucosal immunity |
| JP4726485B2 (ja) * | 2002-08-02 | 2011-07-20 | 大日本住友製薬株式会社 | 細菌細胞壁骨格成分製剤 |
| CN100471486C (zh) * | 2002-08-12 | 2009-03-25 | 戴纳伐克斯技术股份有限公司 | 免疫调节组合物,其制备方法和使用方法 |
| CA2501476A1 (en) | 2002-10-07 | 2004-04-22 | Chiron Corporation | Hiv vaccine formulations |
| AU2003286512A1 (en) * | 2002-10-18 | 2004-05-04 | Charles N. Ellis | Method for rating severity of psoriasis |
| EP2263687B1 (en) * | 2002-12-27 | 2015-03-25 | Novartis Vaccines and Diagnostics, Inc. | Immunogenic compositions containing phospholipid |
| WO2004065578A2 (en) * | 2003-01-14 | 2004-08-05 | Chiron Corporation | Microparticles comprising polynucleotide adsorbed on the surface of or entrapped within the microparticles |
| AU2004226591B2 (en) * | 2003-04-04 | 2009-06-04 | Zoetis Services Llc | Microfluidized oil-in-water emulsions and vaccine compositions |
| WO2004091491A2 (en) * | 2003-04-10 | 2004-10-28 | Transform Pharmaceuticals, Inc. | Profiling conformational variants, antibody compositions and methods of using the same |
| US20070207211A1 (en) * | 2003-04-10 | 2007-09-06 | Pr Pharmaceuticals, Inc. | Emulsion-based microparticles and methods for the production thereof |
| ES2427092T3 (es) * | 2003-04-10 | 2013-10-28 | Evonik Corporation | Un método para la producción de micropartículas a base de emulsión |
| CA2523266A1 (en) * | 2003-04-25 | 2004-11-11 | Chiron Corporation | Compositions comprising cationic microparticles and hcv e1e2 dna and methods of use thereof |
| JP5557415B2 (ja) | 2003-06-02 | 2014-07-23 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | 吸着させたトキソイドおよび多糖類含有抗原を含む微粒子に基づく免疫原性組成物 |
| US7208395B2 (en) * | 2003-06-26 | 2007-04-24 | Semiconductor Energy Laboratory Co., Ltd. | Laser irradiation apparatus, laser irradiation method, and method for manufacturing semiconductor device |
| US20050053667A1 (en) * | 2003-07-09 | 2005-03-10 | Darrell Irvine | Programmed immune responses using a vaccination node |
| CN1852687B (zh) * | 2003-07-15 | 2014-01-22 | 赢创有限公司 | 控释组合物的制备方法 |
| JP5165240B2 (ja) * | 2003-07-23 | 2013-03-21 | ピーアール ファーマシューティカルズ， インコーポレイテッド | 徐放組成物 |
| JP5041279B2 (ja) * | 2004-04-22 | 2012-10-03 | 株式会社 Ｍｂｒ | 細菌細胞壁骨格成分を含有する製剤 |
| FR2873386B1 (fr) | 2004-07-22 | 2011-01-14 | Agence Francaise De Securite Sanitaire Des Aliments Afssa | Composition vaccinale contre le rhodococcus equi |
| EP1812056B1 (en) * | 2004-11-15 | 2013-08-07 | Novartis Vaccines and Diagnostics, Inc. | Immunogenic compositions containing anthrax antigen, biodegradable polymer microparticles, and polynucleotide-containing immunological adjuvant |
| UA99719C2 (ru) | 2006-11-03 | 2012-09-25 | Шеринг-Плау Лтд. | Вакцина для собак против болезни лайма |
| CL2008001806A1 (es) | 2007-06-20 | 2008-09-05 | Wyeth Corp | Composicion de vacuna en emulsion agua en aceite que comprende un antigeno y un adyuvante en la fase acuosa; y metodo de elaboracion. |
| EA017887B1 (ru) * | 2007-08-02 | 2013-03-29 | Байондвакс Фармасьютикалз Лтд. | Полимерные мультиэпитопные вакцины против гриппа |
| CN106310293A (zh) | 2007-09-27 | 2017-01-11 | 免疫疫苗技术有限公司 | 在包括连续疏水相的载体中的脂质体在体内输送多核苷酸中的应用 |
| US20100209452A1 (en) * | 2007-10-03 | 2010-08-19 | Immunovaccine Technologies, Inc | Compositions comprising an antigen, an amphipathic compound and a hydrophobic carrier, and uses thereof |
| CA2744739A1 (en) | 2007-12-03 | 2009-06-11 | President And Fellows Of Harvard College | Chlamydia antigens |
| EP3067048B1 (en) | 2007-12-07 | 2018-02-14 | GlaxoSmithKline Biologicals SA | Compositions for inducing immune responses |
| EP2262480B1 (en) * | 2008-03-04 | 2018-02-14 | Liquidia Technologies, Inc. | Immunomodulator particles |
| WO2009146523A1 (en) * | 2008-06-05 | 2009-12-10 | Immunovaccine Technologies Inc. | Compositions comprising liposomes, an antigen, a polynucleotide and a carrier comprising a continuous phase of a hydrophobic substance |
| WO2010032138A2 (en) * | 2008-09-18 | 2010-03-25 | Novartis Ag | Vaccine adjuvant combinations |
| BRPI0922132A2 (pt) | 2008-12-03 | 2018-10-23 | Protea Vaccine Tech Ltd | fragmentos glutamil trna sintetase (gts). |
| WO2011067758A2 (en) | 2009-12-02 | 2011-06-09 | Protea Vaccine Technologies Ltd. | Immunogenic fragments and multimers from streptococcus pneumoniae proteins |
| AU2011230619C1 (en) | 2010-03-25 | 2016-06-23 | Oregon Health & Science University | CMV glycoproteins and recombinant vectors |
| US20110293690A1 (en) * | 2010-05-27 | 2011-12-01 | Tyco Healthcare Group Lp | Biodegradable Polymer Encapsulated Microsphere Particulate Film and Method of Making Thereof |
| NZ606591A (en) | 2010-07-06 | 2015-02-27 | Novartis Ag | Cationic oil-in-water emulsions |
| WO2012114323A1 (en) | 2011-02-22 | 2012-08-30 | Biondvax Pharmaceuticals Ltd. | Multimeric multiepitope polypeptides in improved seasonal and pandemic influenza vaccines |
| HUE037408T2 (hu) | 2011-06-10 | 2018-08-28 | Univ Oregon Health & Science | CMV glikoproteinek és rekombináns vektorok |
| US20130004640A1 (en) * | 2011-07-01 | 2013-01-03 | Pepsico, Inc. | Complex coacervates, methods and food products |
| JP6059220B2 (ja) | 2011-07-06 | 2017-01-18 | ノバルティス アーゲー | 核酸を含む水中油型エマルジョン |
| MX350258B (es) | 2011-07-06 | 2017-08-31 | Novartis Ag | Emulsiones cationicas de aceite en agua. |
| CA2789539A1 (en) | 2011-09-12 | 2013-03-12 | International Aids Vaccine Initiative | Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies |
| CN113876945A (zh) | 2011-10-06 | 2022-01-04 | 免疫疫苗技术有限公司 | 包括激活或增加tlr2活性的佐剂的脂质体组合物及其应用 |
| US9402894B2 (en) | 2011-10-27 | 2016-08-02 | International Aids Vaccine Initiative | Viral particles derived from an enveloped virus |
| EP3492095A1 (en) | 2012-04-01 | 2019-06-05 | Technion Research & Development Foundation Limited | Extracellular matrix metalloproteinase inducer (emmprin) peptides and binding antibodies |
| ES2631608T3 (es) | 2012-06-27 | 2017-09-01 | International Aids Vaccine Initiative | Variante de la glicoproteína Env del VIH-1 |
| EP2848937A1 (en) | 2013-09-05 | 2015-03-18 | International Aids Vaccine Initiative | Methods of identifying novel HIV-1 immunogens |
| US10058604B2 (en) | 2013-10-07 | 2018-08-28 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
| JP6550072B2 (ja) | 2014-04-03 | 2019-07-24 | バイオンドバックス ファーマシューティカルズ リミテッド | 多量体マルチエピトープインフルエンザポリペプチドの組成物及びそれらの生成 |
| EP3069730A3 (en) | 2015-03-20 | 2017-03-15 | International Aids Vaccine Initiative | Soluble hiv-1 envelope glycoprotein trimers |
| US9931394B2 (en) | 2015-03-23 | 2018-04-03 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5075109A (en) * | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
| CA2017507C (en) * | 1989-05-25 | 1996-11-12 | Gary Van Nest | Adjuvant formulation comprising a submicron oil droplet emulsion |
| BR9106604A (pt) * | 1990-06-29 | 1993-06-22 | Chiron Corp | Composicao de vacina e processo para estimular uma resposta imunologica em um animal hospedeiro |
| US5928865A (en) * | 1992-03-02 | 1999-07-27 | Chiron S.P.A. | Compositions comprising isolated Helicobacter pylori CagI polynucleotides and method of preparation thereof |
| DE69431404T2 (de) * | 1993-10-22 | 2003-04-30 | Genentech Inc., San Francisco | Verfahren zur mikroverkapselung von antigenen und verwendung der zusammensetzungen als impfstoffe |
| US5961970A (en) * | 1993-10-29 | 1999-10-05 | Pharmos Corporation | Submicron emulsions as vaccine adjuvants |
| US5629167A (en) * | 1994-04-19 | 1997-05-13 | Biocine S.P.A. | Detection of antibodies against Chlamydia trachomatis pgp3 antigen in patient sera by enzyme-linked immunosorbent assay |
| US6355247B1 (en) * | 1994-06-02 | 2002-03-12 | Chiron Corporation | Nucleic acid immunization using a virus-based infection/transfection system |
| GB9412273D0 (en) * | 1994-06-18 | 1994-08-10 | Univ Nottingham | Administration means |
| SK165197A3 (en) * | 1995-06-07 | 1999-01-11 | Astra Ab | Nucleic acid and amino acid sequences relating to helicobacter pylori for diagnostics and therapeutics |
| GB9514285D0 (en) * | 1995-07-13 | 1995-09-13 | Univ Nottingham | Polymeric lamellar substrate particles for drug delivery |
| GB9518864D0 (en) * | 1995-09-14 | 1995-11-15 | Cambridge Res & Innovation | Oligonucleotides and their uses |
| GB9603314D0 (en) * | 1996-02-16 | 1996-04-17 | Biocine Spa | Immunogenic detoxified mutant toxins |
| US5783567A (en) * | 1997-01-22 | 1998-07-21 | Pangaea Pharmaceuticals, Inc. | Microparticles for delivery of nucleic acid |
| WO1999030737A1 (en) * | 1997-12-16 | 1999-06-24 | Chiron Corporation | Use of microparticles combined with submicron oil-in-water emulsions |
-
1998
- 1998-01-29 WO PCT/US1998/001656 patent/WO1999030737A1/en not_active Ceased
- 1998-01-29 EP EP98904739A patent/EP1042001B1/en not_active Expired - Lifetime
- 1998-01-29 CA CA002314934A patent/CA2314934C/en not_active Expired - Fee Related
- 1998-01-29 ES ES98904739T patent/ES2175668T3/es not_active Expired - Lifetime
- 1998-01-29 DK DK98904739T patent/DK1042001T3/da active
- 1998-01-29 US US09/015,736 patent/US6086901A/en not_active Expired - Lifetime
- 1998-01-29 AU AU62538/98A patent/AU6253898A/en not_active Abandoned
- 1998-01-29 PT PT98904739T patent/PT1042001E/pt unknown
- 1998-01-29 JP JP2000538716A patent/JP4918188B2/ja not_active Expired - Fee Related
- 1998-01-29 DE DE69804671T patent/DE69804671T2/de not_active Expired - Lifetime
- 1998-01-29 AT AT98904739T patent/ATE215385T1/de active
-
2000
- 2000-05-02 US US09/564,416 patent/US6306405B1/en not_active Expired - Lifetime
-
2001
- 2001-08-20 US US09/935,466 patent/US6458370B1/en not_active Expired - Lifetime
-
2002
- 2002-08-02 US US10/211,025 patent/US6855492B2/en not_active Expired - Lifetime
-
2007
- 2007-11-09 JP JP2007292637A patent/JP2008050374A/ja not_active Withdrawn
-
2011
- 2011-11-16 JP JP2011250804A patent/JP2012036223A/ja not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2002508334A5 (https=) | ||
| Zhou et al. | Poly-d, l-lactide–co-poly (ethylene glycol) microspheres as potential vaccine delivery systems | |
| Esparza et al. | Parameters affecting the immunogenicity of microencapsulated tetanus toxoid | |
| JP2003511420A5 (https=) | ||
| Singh et al. | Nanoparticles and microparticles as vaccine-delivery systems | |
| CN1043189C (zh) | 缓释药剂的制备方法 | |
| JP4918188B2 (ja) | サブミクロンの水中油型エマルジョンと合わせた微粒子の使用 | |
| US6287604B1 (en) | Biodegradable targetable microparticle delivery system | |
| JP2963540B2 (ja) | 薬剤移送用ポリマーミクロ粒子 | |
| AU2001294898B2 (en) | Microparticle compositions and methods for the manufacture thereof | |
| Singh et al. | Immunogenicity and protection in small-animal models with controlled-release tetanus toxoid microparticles as a single-dose vaccine | |
| Singh et al. | Controlled release microparticles as a single dose hepatitis B vaccine: evaluation of immunogenicity in mice | |
| Lima et al. | Poly-DL-lactide-co-glycolide microspheres as a controlled release antigen delivery system | |
| Lavelle et al. | The stability and immunogenicity of a protein antigen encapsulated in biodegradable microparticles based on blends of lactide polymers and polyethylene glycol | |
| JP2001511148A (ja) | 免疫応答を刺激するための吸着された抗原を有するマイクロパーティクルの使用 | |
| JP2004509914A5 (https=) | ||
| Singh et al. | A comparison of biodegradable microparticles and MF59 as systemic adjuvants for recombinant gD from HSV-2 | |
| JP2006526649A5 (https=) | ||
| JP2002521425A5 (https=) | ||
| AU2001294898A1 (en) | Microparticle compositions and methods for the manufacture thereof | |
| JP2016117774A (ja) | リン脂質を含む免疫原性組成物 | |
| JP2007308500A (ja) | Ｇｍ−ｃｓｆの放出の延長 | |
| Vela Ramirez et al. | Polyanhydride nanovaccines induce germinal center B cell formation and sustained serum antibody responses | |
| JP2006520746A5 (https=) | ||
| Khang et al. | Preparation and characterization of Japanese encephalitis virus vaccine loaded poly (L‐lactide‐co‐glycolide) microspheres for oral immunization |