JP2002521425A5 - - Google Patents
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- Publication number
- JP2002521425A5 JP2002521425A5 JP2000561979A JP2000561979A JP2002521425A5 JP 2002521425 A5 JP2002521425 A5 JP 2002521425A5 JP 2000561979 A JP2000561979 A JP 2000561979A JP 2000561979 A JP2000561979 A JP 2000561979A JP 2002521425 A5 JP2002521425 A5 JP 2002521425A5
- Authority
- JP
- Japan
- Prior art keywords
- microparticle
- microparticles
- particles
- surfactant
- polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000011859 microparticle Substances 0.000 description 78
- 238000000034 method Methods 0.000 description 41
- 239000002245 particle Substances 0.000 description 25
- 229920000642 polymer Polymers 0.000 description 23
- 239000000427 antigen Substances 0.000 description 17
- 102000036639 antigens Human genes 0.000 description 17
- 108091007433 antigens Proteins 0.000 description 17
- 229920002521 macromolecule Polymers 0.000 description 17
- 239000000203 mixture Substances 0.000 description 17
- 239000004094 surface-active agent Substances 0.000 description 16
- 239000002671 adjuvant Substances 0.000 description 11
- 108091033319 polynucleotide Proteins 0.000 description 9
- 102000040430 polynucleotide Human genes 0.000 description 9
- 239000002157 polynucleotide Substances 0.000 description 9
- 239000010419 fine particle Substances 0.000 description 8
- 238000001179 sorption measurement Methods 0.000 description 7
- 239000004372 Polyvinyl alcohol Substances 0.000 description 6
- 229920002451 polyvinyl alcohol Polymers 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- 230000003053 immunization Effects 0.000 description 5
- 238000002649 immunization Methods 0.000 description 5
- 229920001184 polypeptide Polymers 0.000 description 5
- 102000004196 processed proteins & peptides Human genes 0.000 description 5
- 108090000765 processed proteins & peptides Proteins 0.000 description 5
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 4
- 229940061720 alpha hydroxy acid Drugs 0.000 description 4
- 150000001280 alpha hydroxy acids Chemical class 0.000 description 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 241000711549 Hepacivirus C Species 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 3
- 229920001710 Polyorthoester Polymers 0.000 description 3
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 3
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical group O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- 229940088597 hormone Drugs 0.000 description 3
- 239000005556 hormone Substances 0.000 description 3
- 230000028993 immune response Effects 0.000 description 3
- 239000002955 immunomodulating agent Substances 0.000 description 3
- 229940121354 immunomodulator Drugs 0.000 description 3
- 230000006698 induction Effects 0.000 description 3
- 239000000543 intermediate Substances 0.000 description 3
- 239000002745 poly(ortho ester) Substances 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 238000013518 transcription Methods 0.000 description 3
- 230000035897 transcription Effects 0.000 description 3
- 101710154606 Hemagglutinin Proteins 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 101710093908 Outer capsid protein VP4 Proteins 0.000 description 2
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 2
- 229920001244 Poly(D,L-lactide) Polymers 0.000 description 2
- 101710176177 Protein A56 Proteins 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000003945 anionic surfactant Substances 0.000 description 2
- 239000003093 cationic surfactant Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229940088598 enzyme Drugs 0.000 description 2
- 150000002191 fatty alcohols Chemical class 0.000 description 2
- 239000000185 hemagglutinin Substances 0.000 description 2
- 230000005847 immunogenicity Effects 0.000 description 2
- 208000037797 influenza A Diseases 0.000 description 2
- 239000002563 ionic surfactant Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000002503 metabolic effect Effects 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 229920001432 poly(L-lactide) Polymers 0.000 description 2
- 229920001610 polycaprolactone Polymers 0.000 description 2
- 239000004632 polycaprolactone Substances 0.000 description 2
- 229920002721 polycyanoacrylate Polymers 0.000 description 2
- 241000700198 Cavia Species 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 101710125507 Integrase/recombinase Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 229920002732 Polyanhydride Polymers 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 239000004473 Threonine Substances 0.000 description 1
- 229940037003 alum Drugs 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- 230000030741 antigen processing and presentation Effects 0.000 description 1
- 229920002988 biodegradable polymer Polymers 0.000 description 1
- 239000004621 biodegradable polymer Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000000779 depleting effect Effects 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 230000028996 humoral immune response Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 230000002584 immunomodulator Effects 0.000 description 1
- 230000021633 leukocyte mediated immunity Effects 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000037353 metabolic pathway Effects 0.000 description 1
- -1 polynucleoside Proteins 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12453398A | 1998-07-29 | 1998-07-29 | |
| US09/124,533 | 1998-07-29 | ||
| US28585599A | 1999-04-02 | 1999-04-02 | |
| US09/285,855 | 1999-04-02 | ||
| PCT/US1999/017308 WO2000006123A1 (en) | 1998-07-29 | 1999-07-29 | Microparticles with adsorbent surfaces, methods of making same, and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010058491A Division JP2010168392A (ja) | 1998-07-29 | 2010-03-15 | 吸着表面を有する微小粒子、それを作製する方法、およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002521425A JP2002521425A (ja) | 2002-07-16 |
| JP2002521425A5 true JP2002521425A5 (https=) | 2010-05-06 |
| JP4601168B2 JP4601168B2 (ja) | 2010-12-22 |
Family
ID=26822700
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000561979A Expired - Fee Related JP4601168B2 (ja) | 1998-07-29 | 1999-07-29 | 吸着表面を有する微小粒子、それを作製する方法、およびその使用 |
| JP2010058491A Withdrawn JP2010168392A (ja) | 1998-07-29 | 2010-03-15 | 吸着表面を有する微小粒子、それを作製する方法、およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010058491A Withdrawn JP2010168392A (ja) | 1998-07-29 | 2010-03-15 | 吸着表面を有する微小粒子、それを作製する方法、およびその使用 |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1100468B1 (https=) |
| JP (2) | JP4601168B2 (https=) |
| AT (1) | ATE321535T1 (https=) |
| AU (1) | AU763975B2 (https=) |
| CA (1) | CA2338646C (https=) |
| CY (1) | CY1107326T1 (https=) |
| DE (1) | DE69930642T2 (https=) |
| DK (1) | DK1100468T3 (https=) |
| ES (1) | ES2260923T3 (https=) |
| NZ (1) | NZ509853A (https=) |
| PT (1) | PT1100468E (https=) |
| WO (1) | WO2000006123A1 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8206749B1 (en) | 1999-02-26 | 2012-06-26 | Novartis Vaccines And Diagnostics, Inc. | Microemulsions with adsorbed macromolecules and microparticles |
| US7713739B1 (en) | 2000-11-17 | 2010-05-11 | Novartis Vaccines And Diagnostics, Inc. | Microparticle-based transfection and activation of dendritic cells |
| AU7627601A (en) * | 2000-06-29 | 2002-01-08 | Rudiger Marcus Flaig | Drug-delivery systems |
| ATE350015T1 (de) * | 2000-09-28 | 2007-01-15 | Novartis Vaccines & Diagnostic | Mikropartikelzusammensetzungen und verfahren zu ihrer herstellung |
| AR045702A1 (es) * | 2001-10-03 | 2005-11-09 | Chiron Corp | Composiciones de adyuvantes. |
| US7838015B2 (en) * | 2001-10-03 | 2010-11-23 | Novartis Vaccines And Diagnostics, Inc. | Adjuvanted meningococcus compositions |
| CN100354297C (zh) * | 2001-10-03 | 2007-12-12 | 希龙公司 | 辅助的脑膜炎球菌组合物 |
| EP2572707A3 (en) | 2002-02-20 | 2013-11-06 | Novartis Vaccines and Diagnostics, Inc. | Microparticles with adsorbed polypeptide-containing molecules |
| JP2006502228A (ja) | 2002-10-07 | 2006-01-19 | カイロン コーポレイション | Ｈｉｖワクチン処方物 |
| AU2003299994A1 (en) | 2002-12-27 | 2004-07-29 | Chiron Corporation | Immunogenic compositions containing phospholpid |
| US7731967B2 (en) | 2003-04-30 | 2010-06-08 | Novartis Vaccines And Diagnostics, Inc. | Compositions for inducing immune responses |
| EP1631264B8 (en) | 2003-06-02 | 2017-05-24 | GlaxoSmithKline Biologicals SA | Immunogenic compositions based on microparticles comprising adsorbed toxoid and a polysaccharide-containing antigen |
| FR2859909B1 (fr) | 2003-09-22 | 2007-09-07 | Biomerieux Sa | Procede de preparation de microparticules bioresorbables, microparticules obtenues et utilisation |
| US7899527B2 (en) * | 2004-05-13 | 2011-03-01 | Palo Alto Investors | Treatment of conditions through modulation of the autonomic nervous system during at least one predetermined menstrual cycle phase |
| WO2006050394A2 (en) | 2004-11-01 | 2006-05-11 | Novartis Vaccines And Diagnostics Inc. | Combination approaches for generating immune responses |
| ES2434029T3 (es) | 2004-11-15 | 2013-12-13 | Novartis Vaccines And Diagnostics, Inc. | Composiciones inmunogénicas que contiene antígeno de antrax, micropartículas de polímero biodegradable, y adyuvante inmunológico que contiene polinucleótido |
| WO2008051245A2 (en) | 2005-12-02 | 2008-05-02 | Novartis Ag | Nanoparticles for use in immunogenic compositions |
| WO2007100699A2 (en) | 2006-02-24 | 2007-09-07 | Novartis Ag | Microparticles containing biodegradable polymer and cationic polysaccharide for use in immunogenic compositions |
| EP3067048B1 (en) | 2007-12-07 | 2018-02-14 | GlaxoSmithKline Biologicals SA | Compositions for inducing immune responses |
| CA2722765C (en) | 2008-04-28 | 2016-10-04 | Novartis Ag | Nanoparticles for use in pharmaceutical compositions |
| CA2762653A1 (en) | 2009-05-27 | 2010-12-02 | Selecta Biosciences, Inc. | Immunomodulatory agent-polymeric compounds |
| CA2765112A1 (en) | 2009-06-10 | 2010-12-16 | Novartis Ag | Benzonaphthyridine-containing vaccines |
| ES2536429T3 (es) * | 2010-01-24 | 2015-05-25 | Novartis Ag | Micropartículas de polímero biodegradables irradiadas |
| AU2011258165B2 (en) | 2010-05-26 | 2016-11-17 | Selecta Biosciences, Inc. | Dose selection of adjuvanted synthetic nanocarriers |
| KR20130121699A (ko) | 2010-05-28 | 2013-11-06 | 테트리스 온라인, 인코포레이티드 | 상호작용 혼성 비동기 컴퓨터 게임 기반구조 |
| US9192661B2 (en) | 2010-07-06 | 2015-11-24 | Novartis Ag | Delivery of self-replicating RNA using biodegradable polymer particles |
| WO2012061717A1 (en) | 2010-11-05 | 2012-05-10 | Selecta Biosciences, Inc. | Modified nicotinic compounds and related methods |
| CA2840965C (en) | 2011-07-06 | 2021-03-02 | Novartis Ag | Cationic oil-in-water emulsions |
| SG10201605512WA (en) | 2011-07-06 | 2016-09-29 | Novartis Ag | Oil-in-water emulsions that contain nucleic acids |
| JP2014521687A (ja) | 2011-07-29 | 2014-08-28 | セレクタ バイオサイエンシーズ インコーポレーテッド | 体液性および細胞傷害性ｔリンパ球（ｃｔｌ）免疫応答を生成する合成ナノキャリア |
| BR112015021970A2 (pt) | 2013-03-14 | 2017-07-18 | Massachusetts Inst Technology | composições à base de nanopartículas |
| CA3246538A1 (en) | 2022-03-30 | 2023-10-05 | Evonik Operations Gmbh | Formulations composed of cationic lipids and poly(lactic-co-glycolic acid) for the administration of polynucleotides into cells |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0805678B1 (en) * | 1995-01-05 | 2003-10-29 | THE BOARD OF REGENTS acting for and on behalf of THE UNIVERSITY OF MICHIGAN | Surface-modified nanoparticles and method of making and using same |
| GB9514285D0 (en) * | 1995-07-13 | 1995-09-13 | Univ Nottingham | Polymeric lamellar substrate particles for drug delivery |
| US5759583A (en) * | 1995-08-30 | 1998-06-02 | Syntex (U.S.A.) Inc. | Sustained release poly (lactic/glycolic) matrices |
| PT991403E (pt) * | 1997-01-30 | 2003-08-29 | Chiron Corp | Uso de microparticulas com antigenio adsorvido para estimular respostas imunes |
-
1999
- 1999-07-29 AU AU52452/99A patent/AU763975B2/en not_active Ceased
- 1999-07-29 DK DK99937664T patent/DK1100468T3/da active
- 1999-07-29 JP JP2000561979A patent/JP4601168B2/ja not_active Expired - Fee Related
- 1999-07-29 CA CA002338646A patent/CA2338646C/en not_active Expired - Fee Related
- 1999-07-29 ES ES99937664T patent/ES2260923T3/es not_active Expired - Lifetime
- 1999-07-29 NZ NZ509853A patent/NZ509853A/en not_active IP Right Cessation
- 1999-07-29 PT PT99937664T patent/PT1100468E/pt unknown
- 1999-07-29 WO PCT/US1999/017308 patent/WO2000006123A1/en not_active Ceased
- 1999-07-29 EP EP99937664A patent/EP1100468B1/en not_active Expired - Lifetime
- 1999-07-29 DE DE69930642T patent/DE69930642T2/de not_active Expired - Lifetime
- 1999-07-29 AT AT99937664T patent/ATE321535T1/de active
-
2006
- 2006-06-05 CY CY20061100736T patent/CY1107326T1/el unknown
-
2010
- 2010-03-15 JP JP2010058491A patent/JP2010168392A/ja not_active Withdrawn
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