JP4601168B2 - 吸着表面を有する微小粒子、それを作製する方法、およびその使用 - Google Patents
吸着表面を有する微小粒子、それを作製する方法、およびその使用 Download PDFInfo
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- JP4601168B2 JP4601168B2 JP2000561979A JP2000561979A JP4601168B2 JP 4601168 B2 JP4601168 B2 JP 4601168B2 JP 2000561979 A JP2000561979 A JP 2000561979A JP 2000561979 A JP2000561979 A JP 2000561979A JP 4601168 B2 JP4601168 B2 JP 4601168B2
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- microparticles
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- LCJVIYPJPCBWKS-NXPQJCNCSA-N thymosin Chemical compound SC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CO)C(=O)N[C@H](CO)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@H](CCC(O)=O)C(O)=O LCJVIYPJPCBWKS-NXPQJCNCSA-N 0.000 description 1
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- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 239000003656 tris buffered saline Substances 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
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- BPKIMPVREBSLAJ-QTBYCLKRSA-N ziconotide Chemical compound C([C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]2C(=O)N[C@@H]3C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@H](C(N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CSSC2)C(N)=O)=O)CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CSSC3)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(N1)=O)CCSC)[C@@H](C)O)C1=CC=C(O)C=C1 BPKIMPVREBSLAJ-QTBYCLKRSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Absorbent Articles And Supports Therefor (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12453398A | 1998-07-29 | 1998-07-29 | |
| US09/124,533 | 1998-07-29 | ||
| US28585599A | 1999-04-02 | 1999-04-02 | |
| US09/285,855 | 1999-04-02 | ||
| PCT/US1999/017308 WO2000006123A1 (en) | 1998-07-29 | 1999-07-29 | Microparticles with adsorbent surfaces, methods of making same, and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010058491A Division JP2010168392A (ja) | 1998-07-29 | 2010-03-15 | 吸着表面を有する微小粒子、それを作製する方法、およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002521425A JP2002521425A (ja) | 2002-07-16 |
| JP2002521425A5 JP2002521425A5 (https=) | 2010-05-06 |
| JP4601168B2 true JP4601168B2 (ja) | 2010-12-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000561979A Expired - Fee Related JP4601168B2 (ja) | 1998-07-29 | 1999-07-29 | 吸着表面を有する微小粒子、それを作製する方法、およびその使用 |
| JP2010058491A Withdrawn JP2010168392A (ja) | 1998-07-29 | 2010-03-15 | 吸着表面を有する微小粒子、それを作製する方法、およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010058491A Withdrawn JP2010168392A (ja) | 1998-07-29 | 2010-03-15 | 吸着表面を有する微小粒子、それを作製する方法、およびその使用 |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1100468B1 (https=) |
| JP (2) | JP4601168B2 (https=) |
| AT (1) | ATE321535T1 (https=) |
| AU (1) | AU763975B2 (https=) |
| CA (1) | CA2338646C (https=) |
| CY (1) | CY1107326T1 (https=) |
| DE (1) | DE69930642T2 (https=) |
| DK (1) | DK1100468T3 (https=) |
| ES (1) | ES2260923T3 (https=) |
| NZ (1) | NZ509853A (https=) |
| PT (1) | PT1100468E (https=) |
| WO (1) | WO2000006123A1 (https=) |
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| US8206749B1 (en) | 1999-02-26 | 2012-06-26 | Novartis Vaccines And Diagnostics, Inc. | Microemulsions with adsorbed macromolecules and microparticles |
| US7713739B1 (en) | 2000-11-17 | 2010-05-11 | Novartis Vaccines And Diagnostics, Inc. | Microparticle-based transfection and activation of dendritic cells |
| AU7627601A (en) * | 2000-06-29 | 2002-01-08 | Rudiger Marcus Flaig | Drug-delivery systems |
| ATE350015T1 (de) * | 2000-09-28 | 2007-01-15 | Novartis Vaccines & Diagnostic | Mikropartikelzusammensetzungen und verfahren zu ihrer herstellung |
| AR045702A1 (es) * | 2001-10-03 | 2005-11-09 | Chiron Corp | Composiciones de adyuvantes. |
| US7838015B2 (en) * | 2001-10-03 | 2010-11-23 | Novartis Vaccines And Diagnostics, Inc. | Adjuvanted meningococcus compositions |
| CN100354297C (zh) * | 2001-10-03 | 2007-12-12 | 希龙公司 | 辅助的脑膜炎球菌组合物 |
| EP2572707A3 (en) | 2002-02-20 | 2013-11-06 | Novartis Vaccines and Diagnostics, Inc. | Microparticles with adsorbed polypeptide-containing molecules |
| JP2006502228A (ja) | 2002-10-07 | 2006-01-19 | カイロン コーポレイション | Ｈｉｖワクチン処方物 |
| AU2003299994A1 (en) | 2002-12-27 | 2004-07-29 | Chiron Corporation | Immunogenic compositions containing phospholpid |
| US7731967B2 (en) | 2003-04-30 | 2010-06-08 | Novartis Vaccines And Diagnostics, Inc. | Compositions for inducing immune responses |
| EP1631264B8 (en) | 2003-06-02 | 2017-05-24 | GlaxoSmithKline Biologicals SA | Immunogenic compositions based on microparticles comprising adsorbed toxoid and a polysaccharide-containing antigen |
| FR2859909B1 (fr) | 2003-09-22 | 2007-09-07 | Biomerieux Sa | Procede de preparation de microparticules bioresorbables, microparticules obtenues et utilisation |
| US7899527B2 (en) * | 2004-05-13 | 2011-03-01 | Palo Alto Investors | Treatment of conditions through modulation of the autonomic nervous system during at least one predetermined menstrual cycle phase |
| WO2006050394A2 (en) | 2004-11-01 | 2006-05-11 | Novartis Vaccines And Diagnostics Inc. | Combination approaches for generating immune responses |
| ES2434029T3 (es) | 2004-11-15 | 2013-12-13 | Novartis Vaccines And Diagnostics, Inc. | Composiciones inmunogénicas que contiene antígeno de antrax, micropartículas de polímero biodegradable, y adyuvante inmunológico que contiene polinucleótido |
| WO2008051245A2 (en) | 2005-12-02 | 2008-05-02 | Novartis Ag | Nanoparticles for use in immunogenic compositions |
| WO2007100699A2 (en) | 2006-02-24 | 2007-09-07 | Novartis Ag | Microparticles containing biodegradable polymer and cationic polysaccharide for use in immunogenic compositions |
| EP3067048B1 (en) | 2007-12-07 | 2018-02-14 | GlaxoSmithKline Biologicals SA | Compositions for inducing immune responses |
| CA2722765C (en) | 2008-04-28 | 2016-10-04 | Novartis Ag | Nanoparticles for use in pharmaceutical compositions |
| CA2762653A1 (en) | 2009-05-27 | 2010-12-02 | Selecta Biosciences, Inc. | Immunomodulatory agent-polymeric compounds |
| CA2765112A1 (en) | 2009-06-10 | 2010-12-16 | Novartis Ag | Benzonaphthyridine-containing vaccines |
| ES2536429T3 (es) * | 2010-01-24 | 2015-05-25 | Novartis Ag | Micropartículas de polímero biodegradables irradiadas |
| AU2011258165B2 (en) | 2010-05-26 | 2016-11-17 | Selecta Biosciences, Inc. | Dose selection of adjuvanted synthetic nanocarriers |
| KR20130121699A (ko) | 2010-05-28 | 2013-11-06 | 테트리스 온라인, 인코포레이티드 | 상호작용 혼성 비동기 컴퓨터 게임 기반구조 |
| US9192661B2 (en) | 2010-07-06 | 2015-11-24 | Novartis Ag | Delivery of self-replicating RNA using biodegradable polymer particles |
| WO2012061717A1 (en) | 2010-11-05 | 2012-05-10 | Selecta Biosciences, Inc. | Modified nicotinic compounds and related methods |
| CA2840965C (en) | 2011-07-06 | 2021-03-02 | Novartis Ag | Cationic oil-in-water emulsions |
| SG10201605512WA (en) | 2011-07-06 | 2016-09-29 | Novartis Ag | Oil-in-water emulsions that contain nucleic acids |
| JP2014521687A (ja) | 2011-07-29 | 2014-08-28 | セレクタ バイオサイエンシーズ インコーポレーテッド | 体液性および細胞傷害性ｔリンパ球（ｃｔｌ）免疫応答を生成する合成ナノキャリア |
| BR112015021970A2 (pt) | 2013-03-14 | 2017-07-18 | Massachusetts Inst Technology | composições à base de nanopartículas |
| CA3246538A1 (en) | 2022-03-30 | 2023-10-05 | Evonik Operations Gmbh | Formulations composed of cationic lipids and poly(lactic-co-glycolic acid) for the administration of polynucleotides into cells |
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| EP0805678B1 (en) * | 1995-01-05 | 2003-10-29 | THE BOARD OF REGENTS acting for and on behalf of THE UNIVERSITY OF MICHIGAN | Surface-modified nanoparticles and method of making and using same |
| GB9514285D0 (en) * | 1995-07-13 | 1995-09-13 | Univ Nottingham | Polymeric lamellar substrate particles for drug delivery |
| US5759583A (en) * | 1995-08-30 | 1998-06-02 | Syntex (U.S.A.) Inc. | Sustained release poly (lactic/glycolic) matrices |
| PT991403E (pt) * | 1997-01-30 | 2003-08-29 | Chiron Corp | Uso de microparticulas com antigenio adsorvido para estimular respostas imunes |
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1999
- 1999-07-29 AU AU52452/99A patent/AU763975B2/en not_active Ceased
- 1999-07-29 DK DK99937664T patent/DK1100468T3/da active
- 1999-07-29 JP JP2000561979A patent/JP4601168B2/ja not_active Expired - Fee Related
- 1999-07-29 CA CA002338646A patent/CA2338646C/en not_active Expired - Fee Related
- 1999-07-29 ES ES99937664T patent/ES2260923T3/es not_active Expired - Lifetime
- 1999-07-29 NZ NZ509853A patent/NZ509853A/en not_active IP Right Cessation
- 1999-07-29 PT PT99937664T patent/PT1100468E/pt unknown
- 1999-07-29 WO PCT/US1999/017308 patent/WO2000006123A1/en not_active Ceased
- 1999-07-29 EP EP99937664A patent/EP1100468B1/en not_active Expired - Lifetime
- 1999-07-29 DE DE69930642T patent/DE69930642T2/de not_active Expired - Lifetime
- 1999-07-29 AT AT99937664T patent/ATE321535T1/de active
-
2006
- 2006-06-05 CY CY20061100736T patent/CY1107326T1/el unknown
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2010
- 2010-03-15 JP JP2010058491A patent/JP2010168392A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP1100468A1 (en) | 2001-05-23 |
| EP1100468B1 (en) | 2006-03-29 |
| HK1035862A1 (en) | 2001-12-14 |
| ES2260923T3 (es) | 2006-11-01 |
| ATE321535T1 (de) | 2006-04-15 |
| CA2338646C (en) | 2008-10-07 |
| AU763975B2 (en) | 2003-08-07 |
| JP2002521425A (ja) | 2002-07-16 |
| JP2010168392A (ja) | 2010-08-05 |
| DE69930642T2 (de) | 2006-12-28 |
| PT1100468E (pt) | 2006-07-31 |
| CA2338646A1 (en) | 2000-02-10 |
| DK1100468T3 (da) | 2006-07-31 |
| DE69930642D1 (de) | 2006-05-18 |
| NZ509853A (en) | 2003-08-29 |
| WO2000006123A1 (en) | 2000-02-10 |
| CY1107326T1 (el) | 2012-11-21 |
| AU5245299A (en) | 2000-02-21 |
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