JP2003511420A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2003511420A5 JP2003511420A5 JP2001529742A JP2001529742A JP2003511420A5 JP 2003511420 A5 JP2003511420 A5 JP 2003511420A5 JP 2001529742 A JP2001529742 A JP 2001529742A JP 2001529742 A JP2001529742 A JP 2001529742A JP 2003511420 A5 JP2003511420 A5 JP 2003511420A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- immunogenic composition
- antigen
- composition
- particles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 description 51
- 102000004169 proteins and genes Human genes 0.000 description 37
- 108090000623 proteins and genes Proteins 0.000 description 37
- 230000002163 immunogen Effects 0.000 description 32
- 239000002245 particle Substances 0.000 description 25
- 239000000427 antigen Substances 0.000 description 22
- 102000036639 antigens Human genes 0.000 description 22
- 108091007433 antigens Proteins 0.000 description 22
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 8
- 239000002671 adjuvant Substances 0.000 description 7
- 241000711549 Hepacivirus C Species 0.000 description 6
- 241000725303 Human immunodeficiency virus Species 0.000 description 6
- 229920000642 polymer Polymers 0.000 description 6
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 5
- 230000004044 response Effects 0.000 description 5
- 230000024932 T cell mediated immunity Effects 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 230000000087 stabilizing effect Effects 0.000 description 3
- 108010056594 Avian Proteins Proteins 0.000 description 2
- 108010077805 Bacterial Proteins Proteins 0.000 description 2
- 108010058643 Fungal Proteins Proteins 0.000 description 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
- 108700039791 Hepatitis C virus nucleocapsid Proteins 0.000 description 2
- 101900228187 Human herpesvirus 2 Envelope glycoprotein B Proteins 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 229920002732 Polyanhydride Polymers 0.000 description 2
- 229920000954 Polyglycolide Polymers 0.000 description 2
- 229920001710 Polyorthoester Polymers 0.000 description 2
- 101800001690 Transmembrane protein gp41 Proteins 0.000 description 2
- 108010067390 Viral Proteins Proteins 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 229940061720 alpha hydroxy acid Drugs 0.000 description 2
- 150000001280 alpha hydroxy acids Chemical class 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 230000003053 immunization Effects 0.000 description 2
- 238000002649 immunization Methods 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 229920000747 poly(lactic acid) Polymers 0.000 description 2
- 239000002745 poly(ortho ester) Substances 0.000 description 2
- 229920001610 polycaprolactone Polymers 0.000 description 2
- 239000004632 polycaprolactone Substances 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- SJZRECIVHVDYJC-UHFFFAOYSA-N 4-hydroxybutyric acid Chemical compound OCCCC(O)=O SJZRECIVHVDYJC-UHFFFAOYSA-N 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 238000010382 chemical cross-linking Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000005354 coacervation Methods 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15929899P | 1999-10-13 | 1999-10-13 | |
| US60/159,298 | 1999-10-13 | ||
| PCT/US2000/028040 WO2001026681A2 (en) | 1999-10-13 | 2000-10-10 | Method of obtaining cellular immune responses from proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011063393A Division JP2011116796A (ja) | 1999-10-13 | 2011-03-22 | タンパク質から細胞性免疫応答を得る方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003511420A JP2003511420A (ja) | 2003-03-25 |
| JP2003511420A5 true JP2003511420A5 (https=) | 2007-11-29 |
Family
ID=22571953
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001529742A Withdrawn JP2003511420A (ja) | 1999-10-13 | 2000-10-10 | タンパク質から細胞性免疫応答を得る方法 |
| JP2011063393A Withdrawn JP2011116796A (ja) | 1999-10-13 | 2011-03-22 | タンパク質から細胞性免疫応答を得る方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011063393A Withdrawn JP2011116796A (ja) | 1999-10-13 | 2011-03-22 | タンパク質から細胞性免疫応答を得る方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6534064B1 (https=) |
| EP (1) | EP1221968B1 (https=) |
| JP (2) | JP2003511420A (https=) |
| AT (1) | ATE454901T1 (https=) |
| AU (1) | AU7877900A (https=) |
| CA (1) | CA2388676A1 (https=) |
| DE (1) | DE60043708D1 (https=) |
| ES (1) | ES2337017T3 (https=) |
| PT (1) | PT1221968E (https=) |
| WO (1) | WO2001026681A2 (https=) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7141244B1 (en) * | 1992-03-02 | 2006-11-28 | Chiron Srl | Helicobacter pylori proteins useful for vaccines and diagnostics |
| WO1997025429A1 (en) * | 1996-01-04 | 1997-07-17 | Rican Limited | Helicobacter pylori bacterioferritin |
| US20040006034A1 (en) * | 1998-06-05 | 2004-01-08 | Eyal Raz | Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof |
| GB9807721D0 (en) * | 1998-04-08 | 1998-06-10 | Chiron Spa | Antigen |
| AU2487300A (en) | 1998-12-31 | 2000-07-31 | Chiron Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
| WO2000039302A2 (en) | 1998-12-31 | 2000-07-06 | Chiron Corporation | Improved expression of hiv polypeptides and production of virus-like particles |
| DE60043708D1 (de) * | 1999-10-13 | 2010-03-04 | Novartis Vaccines & Diagnostic | Verfahren zur erhaltung zellimmuneantworten gegen proteinen |
| EP1333858B8 (en) | 2000-11-07 | 2006-06-14 | Immunovaccine Technologies Inc. | Vaccines with enhanced immune response and methods for their preparation |
| WO2002080982A2 (en) * | 2001-01-12 | 2002-10-17 | Chiron Corporation | Nucleic acid mucosal immunization |
| GB0110431D0 (en) * | 2001-04-27 | 2001-06-20 | Glaxosmithkline Biolog Sa | Novel compounds |
| ITRM20010336A1 (it) * | 2001-06-13 | 2002-12-13 | Biostrands S R L | Anticorpo umano ricombinante diretto contro la proteina non strutturale ns3 del virus dell'epatite c (hcv), acido nucleico codificante e usi |
| CA2489019A1 (en) * | 2001-06-15 | 2002-12-27 | Nordic Vaccine Technology A/S | Therapeutical vaccination |
| CZ20033515A3 (cs) * | 2001-06-29 | 2005-01-12 | Chiron Corporation | Kompozice vakcíny HCV E1E2 |
| AU2002320314A1 (en) | 2001-07-05 | 2003-01-21 | Chiron, Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
| US20030170614A1 (en) | 2001-08-31 | 2003-09-11 | Megede Jan Zur | Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof |
| JP2005506322A (ja) * | 2001-08-31 | 2005-03-03 | カイロン ソチエタ ア レスポンサビリタ リミタータ | Ｈｅｌｉｃｏｂａｃｔｅｒｐｙｌｏｒｉワクチン接種 |
| AU2002339224B2 (en) | 2001-09-14 | 2008-10-09 | Kuros Us Llc | Packaging of immunostimulatory substances into virus-like particles: method of preparation and use |
| KR20040111402A (ko) * | 2002-03-13 | 2004-12-31 | 기린 비루 가부시키가이샤 | 인플루엔자 м2 단백질에 대한 인간 모노클로날 항체 및그의 제조 및 사용 방법 |
| CA2479920A1 (en) * | 2002-03-29 | 2003-10-09 | The Regents Of The University Of California | Microgel particles for the delivery of bioactive materials |
| JP2004099584A (ja) | 2002-05-02 | 2004-04-02 | Keio Gijuku | Ｈｓｖを用いた抗腫瘍剤 |
| AU2003299994A1 (en) * | 2002-12-27 | 2004-07-29 | Chiron Corporation | Immunogenic compositions containing phospholpid |
| US20040203084A1 (en) * | 2003-04-10 | 2004-10-14 | Doug Levinson | Profiling conformational variants, antibody compositions and methods of using the same |
| US7731967B2 (en) | 2003-04-30 | 2010-06-08 | Novartis Vaccines And Diagnostics, Inc. | Compositions for inducing immune responses |
| FR2859909B1 (fr) * | 2003-09-22 | 2007-09-07 | Biomerieux Sa | Procede de preparation de microparticules bioresorbables, microparticules obtenues et utilisation |
| AU2006252406B2 (en) * | 2005-06-01 | 2012-05-17 | California Institute Of Technology | Method of targeted gene delivery using viral vectors |
| CA2523032A1 (en) | 2005-10-07 | 2007-04-07 | Immunovaccine Technologies Inc. | Vaccines for cancer therapy |
| AU2006304725B2 (en) * | 2005-10-17 | 2012-03-15 | Novartis Ag | Multiclade HIV vaccines |
| EP1973608A1 (en) | 2005-12-14 | 2008-10-01 | Cytos Biotechnology AG | Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity |
| MX2008015529A (es) | 2006-06-12 | 2009-01-13 | Cytos Biotechnology Ag | Procesos para empacar oligonucleotidos en particulas similares a virus de bacteriofagos de arn. |
| BRPI0714495B8 (pt) | 2006-07-21 | 2021-05-25 | California Inst Of Techn | lentivírus deficiente para replicação recombinante pseudotipado |
| CA2671873C (en) | 2006-12-12 | 2018-10-09 | Brian Stephen Sproat | Oligonucleotides containing high concentrations of guanine monomers |
| CA2700808C (en) | 2007-09-27 | 2017-11-14 | Immunovaccine Technologies Inc. | Use of liposomes in a carrier comprising a continuous hydrophobic phase for delivery of polynucleotides in vivo |
| US20100209452A1 (en) * | 2007-10-03 | 2010-08-19 | Immunovaccine Technologies, Inc | Compositions comprising an antigen, an amphipathic compound and a hydrophobic carrier, and uses thereof |
| EP3067048B1 (en) | 2007-12-07 | 2018-02-14 | GlaxoSmithKline Biologicals SA | Compositions for inducing immune responses |
| ES2524699T3 (es) * | 2008-06-05 | 2014-12-11 | Immunovaccine Technologies Inc. | Composiciones que comprenden liposomas, un antígeno, un polinucleótido y un vehículo que comprende una fase continua de una sustancia hidrófoba |
| CA2730760A1 (en) * | 2008-07-16 | 2010-01-21 | Surmodics Pharmaceuticals, Inc. | Process for preparing microparticles containing bioactive peptides |
| ES2455544T5 (es) | 2009-07-24 | 2017-08-16 | Immune Design Corp | Vectores de lentivirus pseudotipificados con una glucoproteína de envoltura de virus sindbis |
| EP2550362B1 (en) | 2010-03-25 | 2017-01-04 | Oregon Health&Science University | Cmv glycoproteins and recombinant vectors |
| CA2832109C (en) | 2011-06-10 | 2021-07-06 | Oregon Health & Science University | Cmv glycoproteins and recombinant vectors |
| EP2568289A3 (en) | 2011-09-12 | 2013-04-03 | International AIDS Vaccine Initiative | Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies |
| JP6240077B2 (ja) | 2011-10-06 | 2017-11-29 | イムノバクシーン・テクノロジーズ・インコーポレイテッドＩｍｍｕｎｏｖａｃｃｉｎｅ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃ． | Ｔｌｒ２を活性化するか、またはその活性を増加させるアジュバントを含むリポソーム組成物およびその使用 |
| US9402894B2 (en) | 2011-10-27 | 2016-08-02 | International Aids Vaccine Initiative | Viral particles derived from an enveloped virus |
| US9713635B2 (en) | 2012-03-30 | 2017-07-25 | Immune Design Corp. | Materials and methods for producing improved lentiviral vector particles |
| US8323662B1 (en) | 2012-03-30 | 2012-12-04 | Immune Design Corp. | Methods useful for generating highly mannosylated pseudotyped lentiviral vector particles comprising a Vpx protein |
| PT2831095T (pt) | 2012-03-30 | 2019-01-30 | Immune Design Corp | Partículas de vectores lentivirais com melhor eficácia de transdução de células que expressam dc-sign |
| US20130302366A1 (en) | 2012-05-09 | 2013-11-14 | Christopher Marshall | Conformationally Specific Viral Immunogens |
| EP2679596B1 (en) | 2012-06-27 | 2017-04-12 | International Aids Vaccine Initiative | HIV-1 env glycoprotein variant |
| EP2848937A1 (en) | 2013-09-05 | 2015-03-18 | International Aids Vaccine Initiative | Methods of identifying novel HIV-1 immunogens |
| US10058604B2 (en) | 2013-10-07 | 2018-08-28 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
| EP3069730A3 (en) | 2015-03-20 | 2017-03-15 | International Aids Vaccine Initiative | Soluble hiv-1 envelope glycoprotein trimers |
| EP3072901A1 (en) | 2015-03-23 | 2016-09-28 | International Aids Vaccine Initiative | Soluble hiv-1 envelope glycoprotein trimers |
| BR112019004935A2 (pt) | 2016-09-13 | 2019-06-04 | Allergan, Inc. | composições de toxina clostridial não proteíca estabilizada |
| EP3515483A4 (en) | 2016-09-21 | 2020-12-16 | The Governors of the University of Alberta | HEPATITIS C VIRUS IMMUNOGENIC COMPOSITIONS AND THEIR USE PROCEDURES |
| BR112020025764A2 (pt) | 2018-06-19 | 2021-05-11 | Biontech Us Inc. | neoantígenos e usos dos mesmos |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2750045A1 (de) * | 1977-11-09 | 1979-05-10 | Behringwerke Ag | Verfahren zur entfernung von detergentien aus virusantigensuspensionen |
| US4722840A (en) * | 1984-09-12 | 1988-02-02 | Chiron Corporation | Hybrid particle immunogens |
| JPS62138500A (ja) * | 1985-12-11 | 1987-06-22 | Sumitomo Pharmaceut Co Ltd | ポリペプチドの製法 |
| JPH01500999A (ja) * | 1986-10-20 | 1989-04-06 | チロン コーポレイション | Ｈｓｖの治療的処置に用いるワクチン |
| JPH0751513B2 (ja) * | 1988-04-28 | 1995-06-05 | 国立予防衛生研究所長 | Ａ型肝炎ワクチン |
| CA2037151A1 (en) * | 1990-03-23 | 1991-09-24 | F. Hoffmann-La Roche Ag | Plasmodium sporozoite antigen |
| EP0565794A1 (en) * | 1992-04-14 | 1993-10-20 | British Biotech Pharmaceuticals Limited | Induction of CTL responses |
| EP0678034B1 (en) * | 1993-01-11 | 1999-05-26 | Dana Farber Cancer Institute | Inducing cytotoxic t lymphocyte responses |
| US5916596A (en) * | 1993-02-22 | 1999-06-29 | Vivorx Pharmaceuticals, Inc. | Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof |
| US5709995A (en) * | 1994-03-17 | 1998-01-20 | The Scripps Research Institute | Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses |
| US5955342A (en) * | 1994-08-15 | 1999-09-21 | Connaught Laboratories Limited | Non-infectious, replication-defective, self-assembling HIV-1 viral particles containing antigenic markers in the gag coding region |
| US5851826A (en) * | 1995-07-26 | 1998-12-22 | Children's Medical Center Corporation | Helper virus-free herpesvirus vector packaging system |
| ZA982763B (en) * | 1997-04-09 | 1998-10-05 | Akzo Nobel Nv | Vaccines |
| EP0980257A1 (en) | 1997-05-01 | 2000-02-23 | Chiron Corporation | Use of virus-like particles as adjuvants |
| EP0913479A3 (en) * | 1997-10-27 | 2000-10-25 | Smithkline Beecham Corporation | Adenine glycosylase |
| ES2175668T3 (es) * | 1997-12-16 | 2002-11-16 | Chiron Corp | Uso de microparticulas combinadas con emulsiones de aceite en agua submicronicas. |
| PT1090033E (pt) * | 1998-06-24 | 2005-05-31 | Innogenetics Nv | Particulas de proteinas de envelope do hcv: utilizacao para vacinacao |
| DE60043708D1 (de) * | 1999-10-13 | 2010-03-04 | Novartis Vaccines & Diagnostic | Verfahren zur erhaltung zellimmuneantworten gegen proteinen |
-
2000
- 2000-10-10 DE DE60043708T patent/DE60043708D1/de not_active Expired - Lifetime
- 2000-10-10 AU AU78779/00A patent/AU7877900A/en not_active Abandoned
- 2000-10-10 PT PT00968937T patent/PT1221968E/pt unknown
- 2000-10-10 JP JP2001529742A patent/JP2003511420A/ja not_active Withdrawn
- 2000-10-10 EP EP00968937A patent/EP1221968B1/en not_active Expired - Lifetime
- 2000-10-10 US US09/686,345 patent/US6534064B1/en not_active Expired - Lifetime
- 2000-10-10 WO PCT/US2000/028040 patent/WO2001026681A2/en not_active Ceased
- 2000-10-10 AT AT00968937T patent/ATE454901T1/de active
- 2000-10-10 CA CA002388676A patent/CA2388676A1/en not_active Abandoned
- 2000-10-10 ES ES00968937T patent/ES2337017T3/es not_active Expired - Lifetime
-
2003
- 2003-01-08 US US10/340,034 patent/US7604802B2/en not_active Expired - Fee Related
-
2011
- 2011-03-22 JP JP2011063393A patent/JP2011116796A/ja not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2003511420A5 (https=) | ||
| JP4918188B2 (ja) | サブミクロンの水中油型エマルジョンと合わせた微粒子の使用 | |
| US8529906B2 (en) | Compositions for inducing immune responses | |
| CA2279204C (en) | Use of microparticles with adsorbed antigen to stimulate immune responses | |
| US6534064B1 (en) | Stabilized protein particles for inducing cellular immune responses | |
| EP1322292B1 (en) | Microparticle compositions and methods for the manufacture thereof | |
| JP6013400B2 (ja) | 免疫応答を誘導するための組成物 | |
| US20030138453A1 (en) | Microparticles for delivery of heterologous nucleic acids | |
| JP2002508334A5 (https=) | ||
| JP2006526649A5 (https=) | ||
| AU2001294898A1 (en) | Microparticle compositions and methods for the manufacture thereof | |
| JP2004518631A5 (https=) | ||
| JP2002521425A5 (https=) | ||
| RU95120086A (ru) | Вакцинная композиция, способ ее получения, 3-0-дезацилированный монофосфориллипид а, способ получения его раствора, применение, способ лечения | |
| EP1275380A1 (en) | Use of microparticles with adsorbed antigen to stimulate immune responses |