JP2002506072A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2002506072A5 JP2002506072A5 JP2000535645A JP2000535645A JP2002506072A5 JP 2002506072 A5 JP2002506072 A5 JP 2002506072A5 JP 2000535645 A JP2000535645 A JP 2000535645A JP 2000535645 A JP2000535645 A JP 2000535645A JP 2002506072 A5 JP2002506072 A5 JP 2002506072A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- alkyloxy
- carboxy
- thieno
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 125000003118 aryl group Chemical group 0.000 description 37
- -1 benzo [b] thiophenyl Chemical group 0.000 description 12
- 125000000217 alkyl group Chemical group 0.000 description 9
- 229910052739 hydrogen Inorganic materials 0.000 description 8
- 239000001257 hydrogen Substances 0.000 description 8
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 8
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 description 4
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 4
- 125000004093 cyano group Chemical group *C#N 0.000 description 3
- 125000004122 cyclic group Chemical group 0.000 description 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 3
- 229920006395 saturated elastomer Polymers 0.000 description 3
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 description 2
- 125000005129 aryl carbonyl group Chemical group 0.000 description 2
- 125000004104 aryloxy group Chemical group 0.000 description 2
- 125000000623 heterocyclic group Chemical group 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 125000004043 oxo group Chemical group O=* 0.000 description 2
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 125000005157 alkyl carboxy group Chemical group 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 description 1
- 125000005605 benzo group Chemical group 0.000 description 1
- 125000005872 benzooxazolyl group Chemical group 0.000 description 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 125000004230 chromenyl group Chemical group O1C(C=CC2=CC=CC=C12)* 0.000 description 1
- 125000001475 halogen functional group Chemical group 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
- 150000003949 imides Chemical class 0.000 description 1
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 description 1
- 125000001041 indolyl group Chemical group 0.000 description 1
- 125000000842 isoxazolyl group Chemical group 0.000 description 1
- 150000003951 lactams Chemical class 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Chemical group 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 description 1
- 229910052717 sulfur Chemical group 0.000 description 1
- 239000011593 sulfur Chemical group 0.000 description 1
- 125000004953 trihalomethyl group Chemical group 0.000 description 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK34498 | 1998-03-12 | ||
| DK0344/98 | 1998-03-12 | ||
| DK48098 | 1998-04-03 | ||
| DK0480/98 | 1998-04-03 | ||
| DK199800938 | 1998-07-15 | ||
| DKPA199800938 | 1998-07-15 | ||
| DKPA199801385 | 1998-10-28 | ||
| DK199801385 | 1998-10-28 | ||
| DKPA199801612 | 1998-12-07 | ||
| DK199801612 | 1998-12-07 | ||
| PCT/DK1999/000121 WO1999046267A1 (en) | 1998-03-12 | 1999-03-11 | Modulators of protein tyrosine phosphatases (ptpases) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002506072A JP2002506072A (ja) | 2002-02-26 |
| JP2002506072A5 true JP2002506072A5 (enExample) | 2006-04-27 |
Family
ID=27512769
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000535645A Withdrawn JP2002506072A (ja) | 1998-03-12 | 1999-03-11 | プロテインチロシンホスファターゼ（ＰＴＰａｓｅ）のモジュレーター |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1080095B1 (enExample) |
| JP (1) | JP2002506072A (enExample) |
| KR (1) | KR20010041814A (enExample) |
| CN (1) | CN1300291A (enExample) |
| AT (1) | ATE308546T1 (enExample) |
| AU (1) | AU2713599A (enExample) |
| BR (1) | BR9908726A (enExample) |
| CA (1) | CA2323493A1 (enExample) |
| DE (1) | DE69928100D1 (enExample) |
| HU (1) | HUP0104984A3 (enExample) |
| IL (1) | IL138319A0 (enExample) |
| NO (1) | NO20004527L (enExample) |
| PL (1) | PL342816A1 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100370975C (zh) | 2000-12-18 | 2008-02-27 | 株式会社医药分子设计研究所 | 炎症性细胞因子产生游离抑制剂 |
| CA2488342A1 (en) * | 2002-06-05 | 2003-12-18 | Institute Of Medicinal Molecular Design, Inc. | Therapeutic drug for diabetes |
| CN1658849A (zh) * | 2002-06-05 | 2005-08-24 | 株式会社医药分子设计研究所 | Ap－1和nfat活化抑制剂 |
| WO2003103665A1 (ja) | 2002-06-06 | 2003-12-18 | 株式会社医薬分子設計研究所 | 抗アレルギー薬 |
| US7626042B2 (en) | 2002-06-06 | 2009-12-01 | Institute Of Medicinal Molecular Design, Inc. | O-substituted hydroxyaryl derivatives |
| SI1753512T1 (sl) * | 2004-05-28 | 2008-12-31 | 4Sc Ag | Tetrahidropiridotiofeni |
| WO2005118592A1 (en) * | 2004-06-04 | 2005-12-15 | Altana Pharma Ag | Tetrahydropyridothiophenes for use in the treatment of cancer |
| AU2005251485A1 (en) * | 2004-06-11 | 2005-12-22 | 4Sc Ag | Tetrahydropyridothiophenes for treating hyperproliferative disorders |
| HUE032540T2 (en) * | 2004-06-24 | 2017-09-28 | Vertex Pharma | Modulators of ATP-binding cassette transporters |
| WO2006084869A1 (en) * | 2005-02-09 | 2006-08-17 | Nycomed Gmbh | Tetrahydropyridothiophenes for the treatment of proliferative diseases such as cancer |
| US7741488B2 (en) * | 2005-02-11 | 2010-06-22 | 4Sc Ag | Tetrahydropyridothiophenes as antiproliferative agents for the treatment of cancer |
| BRPI0616239A2 (pt) * | 2005-09-15 | 2011-06-14 | Hoffmann La Roche | derivados de Ácido 4-amino-tieno[3,2-c]piridina-7-carboxÍlico, formulaÇço farmacÊutica contendo os mesmos bem como seus usos |
| CN1939922B (zh) * | 2005-09-27 | 2010-10-13 | 天津和美生物技术有限公司 | 可抑制细胞释放肿瘤坏死因子的5H-噻吩[3，4-c]吡咯-4，6-二酮衍生物 |
| NZ767139A (en) * | 2009-12-04 | 2022-08-26 | Sunovion Pharmaceuticals Inc | Multicyclic compounds and methods of use thereof |
| CN102382076B (zh) * | 2010-09-03 | 2016-08-17 | 中国医学科学院药物研究所 | 芳酮和芳酰胺类化合物及其制法和药物用途 |
| CN102838625B (zh) * | 2011-06-22 | 2015-04-15 | 中国科学院上海药物研究所 | 四氢吡啶并噻唑类化合物、其制备方法、包含该化合物的药物组合物及其用途 |
| CN104955456B (zh) * | 2013-01-28 | 2018-07-03 | H.隆德贝克有限公司 | 作为分拣蛋白抑制剂的n-取代的-5-取代的邻氨甲酰苯甲酸 |
| CN104788425A (zh) * | 2015-03-12 | 2015-07-22 | 佛山市赛维斯医药科技有限公司 | 一类含烟酸酰胺和哌啶结构ptp1b抑制剂、制备方法及其用途 |
| CN106866523A (zh) * | 2015-03-12 | 2017-06-20 | 佛山市赛维斯医药科技有限公司 | 含烟酸酰胺结构的ptp1b抑制剂、制备方法及其用途 |
| CN104788424A (zh) * | 2015-03-12 | 2015-07-22 | 佛山市赛维斯医药科技有限公司 | 含烟酸酰胺和哌啶结构的ptp1b抑制剂、制备方法及其用途 |
| CN106748999A (zh) * | 2015-03-12 | 2017-05-31 | 佛山市赛维斯医药科技有限公司 | 一类含烟酸酰胺结构的ptp1b抑制剂、制备方法及其用途 |
| CN104829629B (zh) * | 2015-03-26 | 2017-03-15 | 天津药物研究院有限公司 | 含磺酰胺基的四氢噻吩并[2,3‑c]吡啶衍生物、其制备方法和用途 |
| US10196403B2 (en) | 2016-07-29 | 2019-02-05 | Sunovion Pharmaceuticals Inc. | Compounds and compositions and uses thereof |
| KR20190065246A (ko) | 2016-07-29 | 2019-06-11 | 선오비온 파마슈티컬스 인코포레이티드 | 화합물 및 조성물 및 이들의 용도 |
| WO2018151861A1 (en) | 2017-02-16 | 2018-08-23 | Sunovion Pharamaceuticials Inc. | Methods of treating schizophrenia |
| JP7191085B2 (ja) | 2017-08-02 | 2022-12-16 | サノビオン ファーマシューティカルズ インク | イソクロマン化合物およびその使用 |
| EP3752508A1 (en) | 2018-02-16 | 2020-12-23 | Sunovion Pharmaceuticals Inc. | Salts, crystal forms, and production methods thereof |
| MX2021010880A (es) | 2019-03-14 | 2022-01-18 | Sunovion Pharmaceuticals Inc | Sales de un compuesto de isocromanilo y formas cristalinas, procesos de preparacion, usos terapeuticos y composiciones farmaceuticas de las mismas. |
| US12410191B2 (en) | 2019-05-21 | 2025-09-09 | Zhejiang Hisun Pharmaceutical Co., Ltd. | Macrolide derivatives, preparation method and application thereof |
| CN115461056B (zh) * | 2020-04-14 | 2024-04-16 | 普渡研究基金会 | 淋巴特异性酪氨酸磷酸酶(lyp)抑制剂 |
| WO2021211489A1 (en) | 2020-04-14 | 2021-10-21 | Sunovion Pharmaceuticals Inc. | (s)-(4,5-dihydro-7h-thieno[2,3-c]pyran-7-yl)-n-methylmethanamine for treating neurological and psychiatric disorders |
-
1999
- 1999-03-11 CN CN99806016A patent/CN1300291A/zh active Pending
- 1999-03-11 IL IL13831999A patent/IL138319A0/xx unknown
- 1999-03-11 PL PL99342816A patent/PL342816A1/xx not_active Application Discontinuation
- 1999-03-11 HU HU0104984A patent/HUP0104984A3/hu unknown
- 1999-03-11 KR KR1020007010093A patent/KR20010041814A/ko not_active Withdrawn
- 1999-03-11 BR BR9908726-0A patent/BR9908726A/pt not_active IP Right Cessation
- 1999-03-11 AT AT99907332T patent/ATE308546T1/de not_active IP Right Cessation
- 1999-03-11 JP JP2000535645A patent/JP2002506072A/ja not_active Withdrawn
- 1999-03-11 CA CA002323493A patent/CA2323493A1/en not_active Abandoned
- 1999-03-11 DE DE69928100T patent/DE69928100D1/de not_active Expired - Lifetime
- 1999-03-11 EP EP99907332A patent/EP1080095B1/en not_active Expired - Lifetime
- 1999-03-11 AU AU27135/99A patent/AU2713599A/en not_active Abandoned
-
2000
- 2000-09-11 NO NO20004527A patent/NO20004527L/no unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2002506072A5 (enExample) | ||
| ES2645859T3 (es) | Derivados de tienopiridina como inhibidores de MEK | |
| ES2250167T3 (es) | Derivados condensados de indol y su uso como ligandos del receptor 5ht, en particular 5ht2c. | |
| ES2587013T3 (es) | Derivados de ciclohexano espirocíclicos | |
| AU726639B2 (en) | Thienopyrimidines having PDE V-inhibiting action | |
| ES2759510T3 (es) | Compuestos tetracíclicos | |
| WO2005023818A3 (en) | Heterobicyclic compounds as pharmaceutically active agents | |
| BRPI0714041A2 (pt) | derivados de heteroaril substituìdos | |
| HRP20110498T1 (hr) | Azetidini kao inhibitori mek za liječenje proliferativnih bolesti | |
| ES2430663T3 (es) | Compuestos heterocíclicos para el tratamiento de afecciones relacionadas con el estrés | |
| CA2521732A1 (en) | Substituted 3-cyanothiophene acetamides as glucagon receptor antagonists | |
| AR030306A1 (es) | Derivados de piperazina, un procedimiento para su preparacion, composiciones farmaceuticas, un metodo para su fabricacion y el uso de dichos derivados para la fabricacion de un medicamento | |
| JP2013539789A5 (enExample) | ||
| GB0100621D0 (en) | Chemical compounds VI | |
| US6420368B1 (en) | Thienopyrimidines | |
| ES2323301T3 (es) | Derivados de triazolo 4,5-d pirimidina y su uso como antagonistas del receptor purinergico. | |
| JP2005526058A (ja) | グリコゲンホスホリラーゼの阻害剤としての複素環式アミド誘導体 | |
| AU2003209445A1 (en) | Heterocyclic amide derivatives having glycogen phosphorylase inhibitory activity | |
| SI9200105B (en) | Imidazo(2,1-b)(3)benzazepine derivatives, compositions and method of use | |
| ES2535490T3 (es) | Preparación de moduladores de receptores 5-HT | |
| EP1657242A4 (en) | imidazopyridine | |
| AU743230B2 (en) | Condensed thienopyrimidines with phosphodiesterase-V inhibiting action | |
| RU96111027A (ru) | Трициклические 5,6-дигидро-9h-пиразоло [3,4-c]-1,2,4-триазоло [4,3-a]пиридины | |
| KR20020010719A (ko) | 포스포디에스테라제 저해제로서의 티에노피리미딘 | |
| JP2004508330A5 (enExample) |