HUP0104984A2 - Fehérje-tirozinfoszfatázokat (PTPázokat) moduláló vegyületek és ezeket tartalmazó gyógyászati készítmények és alkalmazásuk - Google Patents
Fehérje-tirozinfoszfatázokat (PTPázokat) moduláló vegyületek és ezeket tartalmazó gyógyászati készítmények és alkalmazásukInfo
- Publication number
- HUP0104984A2 HUP0104984A2 HU0104984A HUP0104984A HUP0104984A2 HU P0104984 A2 HUP0104984 A2 HU P0104984A2 HU 0104984 A HU0104984 A HU 0104984A HU P0104984 A HUP0104984 A HU P0104984A HU P0104984 A2 HUP0104984 A2 HU P0104984A2
- Authority
- HU
- Hungary
- Prior art keywords
- aryl
- alkyl
- nr7r8
- thieno
- alkyloxy
- Prior art date
Links
- 102000002727 Protein Tyrosine Phosphatase Human genes 0.000 title abstract 2
- 108020000494 protein-tyrosine phosphatase Proteins 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- -1 indolyl- Chemical group 0.000 abstract 14
- 125000003118 aryl group Chemical group 0.000 abstract 7
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 230000002265 prevention Effects 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 229910006069 SO3H Inorganic materials 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004104 aryloxy group Chemical group 0.000 abstract 2
- 125000005605 benzo group Chemical group 0.000 abstract 2
- 125000004122 cyclic group Chemical group 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 2
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000014644 Brain disease Diseases 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 206010022489 Insulin Resistance Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000005098 aryl alkoxy carbonyl group Chemical group 0.000 abstract 1
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 abstract 1
- 125000005110 aryl thio group Chemical group 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000003412 degenerative effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 208000026278 immune system disease Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 125000000842 isoxazolyl group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 125000004953 trihalomethyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/66—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/18—Bridged systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Electrodes Of Semiconductors (AREA)
- Bipolar Transistors (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Control Of El Displays (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
A tal lm ny t rgy t az (1) ltal nos képletű vegyületek, valamintezeket tartalmazó gyógy szati készítmények képezik; a tal lm nyszerinti vegyületek a fehérjetirozinfoszfat zok inhibitoraikéntviselkednek; e vegyületek és gyógy szati készítmények eredményesenalkalmazhatók kül"nb"ző betegségek kezelésére és megelőzésére, ígyt"bbek k"z"tt péld ul az I-es típusú diabetes, a II-es típusúdiabetes, cs"kkent glükóz tolarencia, inzulin rezisztencia vagyelhízotts g kezelésére vagy megelőzésére; ezen kívül a tal lm nyszerinti vegyületek eredményesen adhatók az immunrendszerrendellenességeinek, az osteoporosis, a burj nz sos rendellenességek(ide értve a r kot és a psoriasist) kezelésére, az agy betegségeinek,ide értve az Alzheimer-kórt és skizofréni t, kezelésére vagymegelőzésére. Az (1) ltal nos képletben A jelentése a kettős k"tésselegyütt t"bbek k"z"tt indolil-, benzo[b]tionil-, benzo[b]furil-,indazolil-, benzo[b]izoxazolil-, benzimidazolil-, 9H-tieno[2,3-c]kromenil-, 4,5,6,7-tetrahidrobenzo[b]tiofenil-, 4,5,6,7-tetrahidrotieno[2,3-b]piridil-, 4,7-dihidro-5H-tieno[2,3-c]tiopiranil-, 4,7-dihidro-5H-tieno[2,3-c]-tiopiranil-6-oxid-, 4,7-dihidro-5H-tieno[2,3-c]tiopiranil-6,6-dioxid vagy 4,5,6,7-tetrahidro-4,7-etapon-tieno[2,3-b]piridilcsoport; R1 jelentése hidrogénatom, -COR5, -OR6, -CF3, nitro-, ciano-, -SO3H, -SO2NR7R8, -PO(OH)2, -C(=NH)NH2, -NR7R8 vagy 5tagú heterociklusos gyűrű vagy R1 jelentése(a) ltal nos képletű csoport, amelyben R12, R13 és R14 jelentése egymstól függetlenül péld ul hidrogénatom, 1-6 szénatomos alkil-, aril-,aril-(1-n szénatomos alkil)-csoport; R2 jelentése t"bbek k"z"tt -COR5,-OR6, -CF3, nitro-, ciano-, -SO3H, -SO2NR7R8, -PO(OH)2, -NR7R8 vagyhetoriklusos gyűrű; vagy R3, R16 és R17 jelentése egym stólfüggetlenül t"bbek k"z"tt halogénatom, nitro-, ciano-, trihalogén-metil-, alkil-, aril-, aril-alkil, aril-oxi-karbonil-, aril-alkiloxi-karbonil-, alkiloxi-, ariloxi-, aril-alkiloxi-alkil-tio-, alkil- tio-,aril-tio-, ahol az alkil- és arilcsoportok adott esetben szubsztitulva lehetnek, tov bb R11, jelentése -NR7R8 vagy -alkil-NR7R8; vagy R3jelentése (a) ltal nos képletű csoport, amelyben R12, R13 és R14jelentése egym stól függetlenül péld ul 1-6 szénatomos alkil-, aril-,aril-alkilcsoport; R4 jelentése hidrogénatom, hidroxi-, alkil-, aril-,aril-alkil, -NR7R8; R5 jelentése t"bbek k"z"tt hidroxi-, alkil-,aril-, aril-alkil-, alkil-oxi-, aril-oxi-, =CF3, vagy -NR7R8; R7 és R8együttes jelentése t"bbek k"z"tt péld ul a nitrogénatommal együtt,amelyhez kapcsolódnak, telített részben telített vagy arom s gyűrűs,biciklusos vagy triciklusos gyűrűs rendszert képeznek, amelyben 3-14szénatom és 0-3 heteroatom van nitrogénatom, oxigénatom és/vagykénatom k"zül v lasztva, ahol a gyűrűs rendszer adott esetbenszubsztitu lva lehet. Ó
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK34498 | 1998-03-12 | ||
| DK48098 | 1998-04-03 | ||
| DKPA199800938 | 1998-07-15 | ||
| DKPA199801385 | 1998-10-28 | ||
| DKPA199801612 | 1998-12-07 | ||
| PCT/DK1999/000121 WO1999046267A1 (en) | 1998-03-12 | 1999-03-11 | Modulators of protein tyrosine phosphatases (ptpases) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0104984A2 true HUP0104984A2 (hu) | 2002-04-29 |
| HUP0104984A3 HUP0104984A3 (en) | 2003-07-28 |
Family
ID=27512769
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0104984A HUP0104984A3 (en) | 1998-03-12 | 1999-03-11 | Modulators of protein tyrosine phosphatases (ptpases) pharmaceutical compositions containing them and their use |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1080095B1 (hu) |
| JP (1) | JP2002506072A (hu) |
| KR (1) | KR20010041814A (hu) |
| CN (1) | CN1300291A (hu) |
| AT (1) | ATE308546T1 (hu) |
| AU (1) | AU2713599A (hu) |
| BR (1) | BR9908726A (hu) |
| CA (1) | CA2323493A1 (hu) |
| DE (1) | DE69928100D1 (hu) |
| HU (1) | HUP0104984A3 (hu) |
| IL (1) | IL138319A0 (hu) |
| NO (1) | NO20004527L (hu) |
| PL (1) | PL342816A1 (hu) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8263657B2 (en) | 2000-12-18 | 2012-09-11 | Institute Of Medicinal Molecular Design, Inc. | Inhibitors against the production and release of inflammatory cytokines |
| JPWO2003103647A1 (ja) * | 2002-06-05 | 2005-10-06 | 株式会社医薬分子設計研究所 | Ａｐ−１及びｎｆａｔ活性化阻害剤 |
| EA008769B1 (ru) * | 2002-06-05 | 2007-08-31 | Инститьют Оф Медисинал Молекьюлар Дизайн. Инк. | Лекарственное средство для лечения диабета |
| CN1658855B (zh) | 2002-06-06 | 2010-04-28 | 株式会社医药分子设计研究所 | O-取代羟基芳基衍生物 |
| EP1514544A4 (en) | 2002-06-06 | 2009-01-07 | Inst Med Molecular Design Inc | HYPO-ALLERGENIC |
| EP1753512B1 (en) * | 2004-05-28 | 2008-07-09 | Nycomed GmbH | Tetrahydropyridothiophenes |
| EP1756118B1 (en) * | 2004-06-04 | 2008-05-28 | Nycomed GmbH | Tetrahydropyridothiophenes for use in the treatment of cancer |
| EP1758655A2 (en) * | 2004-06-11 | 2007-03-07 | Altana Pharma AG | Tetrahydropyridothiophenes for treating hyperproliferative disorders |
| PL1773816T3 (pl) * | 2004-06-24 | 2015-06-30 | Vertex Pharma | Modulatory transporterów posiadających kasetę wiążącą ATP |
| JP2008529989A (ja) * | 2005-02-09 | 2008-08-07 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 癌のような増殖性の疾病の治療用のテトラヒドロピリドチオフェン |
| CA2596501A1 (en) * | 2005-02-11 | 2006-08-17 | Altana Pharma Ag | Tetrahydropyridothiophenes as antripoliferative agents for the treatment of cancer |
| AU2006290802B2 (en) * | 2005-09-15 | 2012-06-07 | F. Hoffmann-La Roche Ag | 4-amino-thieno[3,2-c]pyridine-7-carboxylic acid derivatives |
| CN1939922B (zh) * | 2005-09-27 | 2010-10-13 | 天津和美生物技术有限公司 | 可抑制细胞释放肿瘤坏死因子的5H-噻吩[3，4-c]吡咯-4，6-二酮衍生物 |
| RU2707067C2 (ru) | 2009-12-04 | 2019-11-22 | Суновион Фармасьютикалз, Инк. | Полициклические соединения и способы их применения |
| CN102382076B (zh) * | 2010-09-03 | 2016-08-17 | 中国医学科学院药物研究所 | 芳酮和芳酰胺类化合物及其制法和药物用途 |
| CN102838625B (zh) * | 2011-06-22 | 2015-04-15 | 中国科学院上海药物研究所 | 四氢吡啶并噻唑类化合物、其制备方法、包含该化合物的药物组合物及其用途 |
| JP6409004B2 (ja) | 2013-01-28 | 2018-10-17 | ハー・ルンドベック・アクチエゼルスカベット | ソルチリン阻害剤としてのｎ置換された５置換フタルアミド酸 |
| CN104788425A (zh) * | 2015-03-12 | 2015-07-22 | 佛山市赛维斯医药科技有限公司 | 一类含烟酸酰胺和哌啶结构ptp1b抑制剂、制备方法及其用途 |
| CN104788424A (zh) * | 2015-03-12 | 2015-07-22 | 佛山市赛维斯医药科技有限公司 | 含烟酸酰胺和哌啶结构的ptp1b抑制剂、制备方法及其用途 |
| CN106748999A (zh) * | 2015-03-12 | 2017-05-31 | 佛山市赛维斯医药科技有限公司 | 一类含烟酸酰胺结构的ptp1b抑制剂、制备方法及其用途 |
| CN104725308A (zh) * | 2015-03-12 | 2015-06-24 | 佛山市赛维斯医药科技有限公司 | 含烟酸酰胺结构的ptp1b抑制剂、制备方法及其用途 |
| CN104829629B (zh) * | 2015-03-26 | 2017-03-15 | 天津药物研究院有限公司 | 含磺酰胺基的四氢噻吩并[2,3‑c]吡啶衍生物、其制备方法和用途 |
| EP3490607A4 (en) | 2016-07-29 | 2020-04-08 | Sunovion Pharmaceuticals Inc. | COMPOUNDS AND COMPOSITIONS, AND USES THEREOF |
| MA45857A (fr) | 2016-07-29 | 2021-05-19 | Sunovion Pharmaceuticals Inc | Composés et compositions, et utilisations associées |
| CN116808023A (zh) | 2017-02-16 | 2023-09-29 | 桑诺维恩药品公司 | 治疗精神分裂症的方法 |
| JP7191085B2 (ja) | 2017-08-02 | 2022-12-16 | サノビオン ファーマシューティカルズ インク | イソクロマン化合物およびその使用 |
| MX2020008537A (es) | 2018-02-16 | 2021-01-08 | Sunovion Pharmaceuticals Inc | Sales, formas cristalinas y metodos de produccion de las mismas. |
| EP3938045A1 (en) | 2019-03-14 | 2022-01-19 | Sunovion Pharmaceuticals Inc. | Salts of a isochromanyl compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof |
| IL297248A (en) | 2020-04-14 | 2022-12-01 | Sunovion Pharmaceuticals Inc | (s)-(5,4-dihydro-7h-thiano[3,2-c]pyran-7-yl)-n-methylmethanamine for the treatment of neurological and psychiatric disorders |
-
1999
- 1999-03-11 AT AT99907332T patent/ATE308546T1/de not_active IP Right Cessation
- 1999-03-11 EP EP99907332A patent/EP1080095B1/en not_active Expired - Lifetime
- 1999-03-11 IL IL13831999A patent/IL138319A0/xx unknown
- 1999-03-11 BR BR9908726-0A patent/BR9908726A/pt not_active IP Right Cessation
- 1999-03-11 DE DE69928100T patent/DE69928100D1/de not_active Expired - Lifetime
- 1999-03-11 JP JP2000535645A patent/JP2002506072A/ja not_active Withdrawn
- 1999-03-11 AU AU27135/99A patent/AU2713599A/en not_active Abandoned
- 1999-03-11 HU HU0104984A patent/HUP0104984A3/hu unknown
- 1999-03-11 KR KR1020007010093A patent/KR20010041814A/ko not_active Application Discontinuation
- 1999-03-11 CA CA002323493A patent/CA2323493A1/en not_active Abandoned
- 1999-03-11 CN CN99806016A patent/CN1300291A/zh active Pending
- 1999-03-11 PL PL99342816A patent/PL342816A1/xx not_active Application Discontinuation
-
2000
- 2000-09-11 NO NO20004527A patent/NO20004527L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL138319A0 (en) | 2001-10-31 |
| JP2002506072A (ja) | 2002-02-26 |
| EP1080095B1 (en) | 2005-11-02 |
| ATE308546T1 (de) | 2005-11-15 |
| CA2323493A1 (en) | 1999-09-16 |
| AU2713599A (en) | 1999-09-27 |
| BR9908726A (pt) | 2000-11-21 |
| HUP0104984A3 (en) | 2003-07-28 |
| CN1300291A (zh) | 2001-06-20 |
| PL342816A1 (en) | 2001-07-02 |
| KR20010041814A (ko) | 2001-05-25 |
| NO20004527L (no) | 2000-11-07 |
| NO20004527D0 (no) | 2000-09-11 |
| EP1080095A1 (en) | 2001-03-07 |
| DE69928100D1 (de) | 2005-12-08 |
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