ES8308327A1 - Un procedimiento para la preparacion de nuevos derivados biciclicos de piridin-5-ona. - Google Patents

Un procedimiento para la preparacion de nuevos derivados biciclicos de piridin-5-ona.

Info

Publication number
ES8308327A1
ES8308327A1 ES513976A ES513976A ES8308327A1 ES 8308327 A1 ES8308327 A1 ES 8308327A1 ES 513976 A ES513976 A ES 513976A ES 513976 A ES513976 A ES 513976A ES 8308327 A1 ES8308327 A1 ES 8308327A1
Authority
ES
Spain
Prior art keywords
derivatives
pyrimidin
novel bicyclic
pharmaceutical compositions
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES513976A
Other languages
English (en)
Other versions
ES513976A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of ES513976A0 publication Critical patent/ES513976A0/es
Publication of ES8308327A1 publication Critical patent/ES8308327A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

UN PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS DERIVADOS BICICLICOS DE PIRIMIDIN-5-ONA. SE HACE REACCIONAR UN ESTER REACTIVO DE FORMULA (II), CON UNA PIPERIDINA (III) EN UN DISOLVENTE INERTE. SI SE DESEA SE TRANSFORMA EL RADICAL Q DEL COMPUESTO OBTENIDO (I) EN UNA SAL POR ADICION DE ACIDO NO TOXICA TERAPEUTICAMENTE ACTIVA POR TRATAMIENTO CON UN ACIDO O POR EL CONTRARIO, SE TRANSFORMA LA SAL EN LA BASE LIBRE CORRESPONDIENTE. R<1 Y R<2 SON HIDROGENO, ALQUILO INFERIOR O AR; R<3 ES HIDROGENO O ALQUILO INFERIOR; ALQ ES UN RADICAL ALCANODIILO INFERIOR; A ES UN RADICAL BIVALENTE TAL COMO -CH<2-CH<2-CH<2- O -R<4C=CR<5- O -R<6C=N; Q ES SELECCIONADO DE ENTRE EL GRUPO -X-AR.
ES513976A 1981-07-15 1982-07-14 Un procedimiento para la preparacion de nuevos derivados biciclicos de piridin-5-ona. Expired ES8308327A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28359081A 1981-07-15 1981-07-15
US06/370,653 US4443451A (en) 1981-07-15 1982-04-21 Bicyclic pyrimidin-5-one derivatives

Publications (2)

Publication Number Publication Date
ES513976A0 ES513976A0 (es) 1983-08-16
ES8308327A1 true ES8308327A1 (es) 1983-08-16

Family

ID=26962133

Family Applications (1)

Application Number Title Priority Date Filing Date
ES513976A Expired ES8308327A1 (es) 1981-07-15 1982-07-14 Un procedimiento para la preparacion de nuevos derivados biciclicos de piridin-5-ona.

Country Status (22)

Country Link
US (1) US4443451A (es)
EP (1) EP0070053B1 (es)
KR (1) KR870000868B1 (es)
AU (1) AU547967B2 (es)
CA (1) CA1207765A (es)
CS (1) CS227690B2 (es)
DD (1) DD215553A5 (es)
DE (1) DE3270589D1 (es)
DK (1) DK160314C (es)
ES (1) ES8308327A1 (es)
FI (1) FI75828C (es)
GR (1) GR76006B (es)
HU (1) HU186952B (es)
IE (1) IE53400B1 (es)
MA (1) MA19536A1 (es)
NO (1) NO166327C (es)
NZ (1) NZ201266A (es)
PH (1) PH18120A (es)
PL (1) PL136680B1 (es)
PT (1) PT75247B (es)
SU (1) SU1138032A3 (es)
YU (1) YU154682A (es)

Families Citing this family (39)

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US4535081A (en) * 1979-11-23 1985-08-13 Pfizer Inc. Antiallergic and antiulcer 1-oxo-1H-thiazolo[3,2-a]pyrimidine-2-carboxamides and intermediates therefor
US4548938A (en) * 1981-07-15 1985-10-22 Janssen Pharmaceutica N.V. 5-H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one compounds
US4485107A (en) * 1982-11-01 1984-11-27 Janssen Pharmaceutica N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones
GB8300728D0 (en) * 1983-01-12 1983-02-16 Erba Farmitalia Substituted carboxy-thiazolo / 3 2 - a / pyrimidine derivatives
US4533665A (en) * 1983-07-27 1985-08-06 Janssen Pharmaceutica [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones
US4581171A (en) * 1983-07-27 1986-04-08 Janssen Pharmaceutica, N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
US4548939A (en) * 1984-10-01 1985-10-22 Janssen Pharmaceutica N. V. 1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
FR2581993B1 (fr) * 1985-05-14 1988-03-18 Synthelabo Derives de (benzoyl-4 piperidino)-2 phenyl-1 alcanols, leur preparation et leur application en therapeutique
ATE146077T1 (de) * 1986-09-22 1996-12-15 Janssen Pharmaceutica Nv Serotonin-antagonisten zur behandlung von wunden
DE3634532A1 (de) * 1986-10-10 1988-04-14 Basf Ag Verfahren zur herstellung von thiazolo-(2,3-b)chinazolonen
US4921854A (en) * 1986-12-30 1990-05-01 Egis Gyogyszergyar Condensed thiazolopyrimidine, pyrimido-thiazine or thiazepine pyrimidine compounds
IL90879A0 (en) * 1988-09-02 1990-02-09 Janssen Pharmaceutica Nv 3-piperidinyl-indazole derivatives,their preparation and antihypertensive compositions containing them
GB8900382D0 (en) * 1989-01-09 1989-03-08 Janssen Pharmaceutica Nv 2-aminopyrimidinone derivatives
US5140029A (en) * 1989-01-09 1992-08-18 Janssen Pharmaceutica N.V. 2-aminopyrimidinone derivatives
US5256659A (en) * 1989-01-09 1993-10-26 Janssen Pharmaceutica N.V. 2-aminopyrimidinone derivatives
FR2644786B1 (fr) * 1989-03-21 1993-12-31 Adir Cie Nouveaux derives fluoro-4 benzoiques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
AU8506791A (en) * 1990-10-01 1992-04-28 Janssen Pharmaceutica N.V. Novel 4-piperidinylcarbonyl derivatives
DE4243287A1 (de) * 1992-06-19 1993-12-23 Basf Ag N-Substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung
JPH07508741A (ja) * 1992-07-13 1995-09-28 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 新規４−（３−ベンゾフラニル）ピペリジニル及び４−（３−ベンゾチエニル）ピペリジニル誘導体，ならびにそれらを含む製薬学的組成物
DE4338396A1 (de) * 1993-11-10 1995-05-11 Basf Ag N-Substituierte Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
SK282231B6 (sk) * 1993-11-19 2001-12-03 Janssen Pharmaceutica N. V. Farmaceutický prostriedok na liečenie psychotických porúch
TW421649B (en) * 1995-01-31 2001-02-11 Janssen Pharmaceutica Nv 4-(1H-indol-1yl)-1-piperidinyl derivatives
ES2097093B1 (es) * 1995-05-26 1998-01-16 Ferrer Int Nuevos compuestos derivados de 5h-tiazolo (3,2-a) pirimidin-5-ona.
US5962473A (en) * 1996-08-16 1999-10-05 Eli Lilly And Company Methods of treating or ameliorating the symptoms of common cold or allergic rhinitis with serotonin 5-HT1F
US6380201B1 (en) 1997-08-05 2002-04-30 Eli Lilly And Company Methods of treating or ameliorating the symptoms of common cold or allergic rhinitis with serotonin 5-HT1F agonists
EP1248770A1 (en) * 1999-12-16 2002-10-16 Biostream Therapeutics 1,3,4-substituted piperidine analogs and uses thereof in treating addictions
US20030129186A1 (en) 2001-07-25 2003-07-10 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
EP1615923A1 (en) * 2003-04-22 2006-01-18 Synthon B.V. Risperidone monohydrochloride
PT1889198E (pt) 2005-04-28 2015-03-06 Proteus Digital Health Inc Sistema fármaco-informático
US7572249B2 (en) * 2006-12-01 2009-08-11 The Procter & Gamble Company Merchandise display systems for baby care articles
US7582075B2 (en) * 2006-08-24 2009-09-01 The Procter & Gamble Company Disposable absorbent article products with improved stages of development identification
WO2008036682A2 (en) 2006-09-18 2008-03-27 Raptor Pharmaceutical Inc. Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
EP2102157B1 (en) * 2006-12-19 2011-06-22 F. Hoffmann-La Roche AG Heteroaryl pyrrolidinyl and piperidinyl ketone derivatives
AU2009259492A1 (en) * 2008-06-18 2009-12-23 F. Hoffmann-La Roche Ag Aryl ketone as MRI
PT2398500T (pt) 2009-02-20 2019-06-14 2 Bbb Medicines B V Sistema de entrega de medicamentos à base de glutationas
ES2942923T3 (es) 2009-05-06 2023-06-07 Laboratory Skin Care Inc Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

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GB1306558A (en) * 1970-08-14 1973-02-14 Seperic Derivatives of thiazolino-pyrimidin-5-ones their preparation and applications
GB1374281A (en) * 1971-08-24 1974-11-20 Seperic Thiazolino-pyrimidin-5-one derivatives process for their pre paration and applications thereof
JPS51146497A (en) * 1975-06-12 1976-12-16 Sankyo Co Ltd Process for preparing pyrido (1,2-a)pyrimidinone derivatives
US4041163A (en) * 1976-03-29 1977-08-09 Pfizer Inc. N-(5-Tetrazolyl)-4-oxo-4H-pyrimido(2,1-b)benzothiazole-3-carboxamide antiallergy agents
GB1582744A (en) * 1976-06-04 1981-01-14 Gruenenthal Gmbh 7h-thiazolo (and 1,3,4-thiadiazolo-)(3,2-a) pyrimidin-7-one-5-carboxylic acids derivatives and medicaments therof
US4471117A (en) * 1979-06-21 1984-09-11 Janssen Pharmaceutica N.V. 3,4-Dihydro-2H-pyrimido(2,1-b)benzothiazoles
US4342870A (en) * 1980-03-28 1982-08-03 Janssen Pharmaceutica N.V. Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives

Also Published As

Publication number Publication date
KR870000868B1 (ko) 1987-04-30
CA1207765A (en) 1986-07-15
FI822511L (fi) 1983-01-16
PH18120A (en) 1985-03-22
PL237492A1 (en) 1984-02-27
IE821689L (en) 1983-01-15
EP0070053A3 (en) 1984-03-21
DK160314B (da) 1991-02-25
PT75247A (en) 1982-08-01
DK160314C (da) 1991-07-29
AU8575982A (en) 1983-01-20
IE53400B1 (en) 1988-11-09
DD215553A5 (de) 1984-11-14
HU186952B (en) 1985-10-28
EP0070053B1 (en) 1986-04-16
MA19536A1 (fr) 1983-04-01
FI75828C (fi) 1988-08-08
NO822439L (no) 1983-01-17
CS227690B2 (en) 1984-05-14
NO166327C (no) 1991-07-10
PL136680B1 (en) 1986-03-31
DE3270589D1 (de) 1986-05-22
FI822511A0 (fi) 1982-07-14
NZ201266A (en) 1985-01-31
AU547967B2 (en) 1985-11-14
US4443451A (en) 1984-04-17
DK316582A (da) 1983-01-16
NO166327B (no) 1991-03-25
GR76006B (es) 1984-08-03
SU1138032A3 (ru) 1985-01-30
KR840000568A (ko) 1984-02-25
EP0070053A2 (en) 1983-01-19
ES513976A0 (es) 1983-08-16
YU154682A (en) 1985-03-20
FI75828B (fi) 1988-04-29
PT75247B (en) 1985-01-07

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FD1A Patent lapsed

Effective date: 19970519