ES8407051A1 - Procedimiento para la preparacion de derivados de imidazo-i,2-c,3,4-e pirimidina. - Google Patents

Procedimiento para la preparacion de derivados de imidazo-i,2-c,3,4-e pirimidina.

Info

Publication number
ES8407051A1
ES8407051A1 ES522617A ES522617A ES8407051A1 ES 8407051 A1 ES8407051 A1 ES 8407051A1 ES 522617 A ES522617 A ES 522617A ES 522617 A ES522617 A ES 522617A ES 8407051 A1 ES8407051 A1 ES 8407051A1
Authority
ES
Spain
Prior art keywords
pyrazolo
pyrimidines
imidazo
production
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES522617A
Other languages
English (en)
Other versions
ES522617A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of ES522617A0 publication Critical patent/ES522617A0/es
Publication of ES8407051A1 publication Critical patent/ES8407051A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C07D231/40—Acylated on said nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE IMIDAZO 1,2-CPIRAZOLO 3,4-EPIRIMIDINA.CONSIS TE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON ANION COMO YODURO O AZIDA, PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES FARMACEUTICAMENTE ACEPTABLES, DONDE R1, R2, R3, R4, R5 SON H, ALCOHILO DE C 1 A 6 O ALCOHILO FLUORADO DE C 1 A 3; X ES UN GRUPO DE FORMULA (II) O NHCHR5CHR4OH. LA REACCION SE EFECTUA EN UN DISOLVENTE NO REACTIVO COMO CETONA, SULFOXIDO DE DIMETILO N,N-DIASCOHILACETAMIDA Y OTROS Y A TEMPERATURA ELEVADA.SE UTILIZAN PARA TRATAR SICOSIS EN MAMIFEROS.
ES522617A 1982-05-24 1983-05-23 Procedimiento para la preparacion de derivados de imidazo-i,2-c,3,4-e pirimidina. Expired ES8407051A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/381,484 US4469868A (en) 1982-05-24 1982-05-24 Alkylimidazo[1,2-c]pyrazolo[3,4-e]pyrimidines

Publications (2)

Publication Number Publication Date
ES522617A0 ES522617A0 (es) 1984-09-01
ES8407051A1 true ES8407051A1 (es) 1984-09-01

Family

ID=23505215

Family Applications (4)

Application Number Title Priority Date Filing Date
ES522617A Expired ES8407051A1 (es) 1982-05-24 1983-05-23 Procedimiento para la preparacion de derivados de imidazo-i,2-c,3,4-e pirimidina.
ES529372A Expired ES8506019A1 (es) 1982-05-24 1984-02-01 Procedimiento para la preparacion de derivados de imidazo (1, 2-c) pirazolo (3, 4-e) pirimidina
ES529373A Granted ES529373A0 (es) 1982-05-24 1984-02-01 Procedimiento para la preparacion de derivados de imidazo (1, 2-c) pirazolo (3, 4-e) pirimidina
ES529371A Expired ES8506315A1 (es) 1982-05-24 1984-02-01 Procedimiento para la preparacion de derivados de imidazo (1, 2-c) pirazolo (3, 4-e) pirimidina

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES529372A Expired ES8506019A1 (es) 1982-05-24 1984-02-01 Procedimiento para la preparacion de derivados de imidazo (1, 2-c) pirazolo (3, 4-e) pirimidina
ES529373A Granted ES529373A0 (es) 1982-05-24 1984-02-01 Procedimiento para la preparacion de derivados de imidazo (1, 2-c) pirazolo (3, 4-e) pirimidina
ES529371A Expired ES8506315A1 (es) 1982-05-24 1984-02-01 Procedimiento para la preparacion de derivados de imidazo (1, 2-c) pirazolo (3, 4-e) pirimidina

Country Status (22)

Country Link
US (1) US4469868A (es)
EP (1) EP0095289B1 (es)
JP (1) JPS58210087A (es)
KR (1) KR870000931B1 (es)
AR (1) AR240941A1 (es)
AT (1) ATE24510T1 (es)
AU (1) AU553708B2 (es)
CA (1) CA1210393A (es)
DE (1) DE3368635D1 (es)
DK (1) DK161968C (es)
ES (4) ES8407051A1 (es)
FI (1) FI74012C (es)
GR (1) GR79262B (es)
HK (1) HK102989A (es)
HU (1) HU187913B (es)
IE (1) IE55111B1 (es)
IL (1) IL68360A (es)
NO (1) NO160444C (es)
NZ (1) NZ204321A (es)
PH (1) PH18454A (es)
PT (1) PT76745B (es)
ZA (1) ZA832637B (es)

Families Citing this family (20)

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Publication number Priority date Publication date Assignee Title
WO1988000192A1 (en) * 1986-06-26 1988-01-14 Warner-Lambert Company 5-SUBSTITUTED PYRAZOLO[4,3-d]PYRIMIDIN-7-ONES
KR20070118068A (ko) * 2004-11-23 2007-12-13 레디 유에스 테라퓨틱스 인코포레이티드 신규의 이원 헤테로고리 화합물, 그 제조방법 및 이들을포함하는 조성물
ES2645371T3 (es) 2005-06-06 2017-12-05 Intra-Cellular Therapies, Inc. Compuestos orgánicos
US9006258B2 (en) 2006-12-05 2015-04-14 Intra-Cellular Therapies, Inc. Method of treating female sexual dysfunction with a PDE1 inhibitor
SG171774A1 (en) 2008-12-06 2011-07-28 Intra Cellular Therapies Inc Organic compounds
EP2434895A4 (en) 2009-05-13 2013-08-07 Intra Cellular Therapies Inc ORGANIC CONNECTIONS
JP5911854B2 (ja) 2010-05-31 2016-04-27 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 有機化合物
TW201206937A (en) 2010-05-31 2012-02-16 Intra Cellular Therapies Inc Organic compounds
MX363696B (es) * 2011-04-21 2019-03-28 Origenis Gmbh Pirazolo[4,3-d]pirimidinas utiles como inhibidores de cinasas.
WO2014060112A1 (en) 2012-10-19 2014-04-24 Origenis Gmbh Pyrazolo[4,3-d]pyrimidines as kinase inhibitors
US9801882B2 (en) 2013-02-17 2017-10-31 Intra-Cellular Therapies, Inc. Phosphodiesterase-1 inhibitors and their use in treatment of cardiovascular diseases
ES2871327T3 (es) 2013-03-15 2021-10-28 Intra Cellular Therapies Inc Inhibidores de la PDE1 para uso en el tratamiento y/o prevención de enfermedades o trastornos de SNC o SNP
CA2906640C (en) 2013-03-15 2021-07-20 Intra-Cellular Therapies, Inc. Substituted imidazo-[1,2-a]pyrazolo[4.3-e]pyrimidin-4[5h]-one compounds and pharmaceutical compositions and use therof as pde1 inhibitors
EP3157926B1 (en) 2014-06-20 2019-05-15 Intra-Cellular Therapies, Inc. Organic compounds
EP3177627B1 (en) 2014-08-07 2019-07-24 Intra-Cellular Therapies, Inc. Imidazo[1,2-a]-pyrazolo[4,3-e]-pyrimidin-4-one derivatives with pde1 inhibiting activity
US10285992B2 (en) 2014-08-07 2019-05-14 Intra-Cellular Therapies, Inc. Combinations of PDE1 inhibitors and NEP inhibitors and associated methods
EP3725789B1 (en) 2014-09-17 2022-03-09 Intra-Cellular Therapies, Inc. 7,8-dihydro-[2h]-imidazo-[1,2-a]pyrazolo[4,3-e]pyrimidin-4(5h)-one derivatives as phosphodiesterase 1 (pde1) inhibitors for treating diseases, disorders or injuries of the central nervous system (cns)
US10682354B2 (en) 2016-03-28 2020-06-16 Intra-Cellular Therapies, Inc. Compositions and methods
EP3970719A1 (en) 2016-09-12 2022-03-23 Intra-Cellular Therapies, Inc. Pde1 inhibitor for use in a method of treatment or prophylaxis of inflammation and/or an inflammatory disease or disorder
EP3746081A4 (en) 2018-01-31 2021-10-27 Intra-Cellular Therapies, Inc. INNOVATIVE USES

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CH422807A (de) * 1963-08-16 1966-10-31 Wander Ag Dr A Verfahren zur Herstellung von Imidazo- und Pyrimidochinazolinen
US3313815A (en) * 1964-05-04 1967-04-11 Sterling Drug Inc 8-chloropyrazolo-[1, 5-c]quinazoline derivatives and methods of preparing same
US3309369A (en) * 1966-04-11 1967-03-14 Wander Ag Dr A Imidazo- and pyrimido-quinazolines
US3594379A (en) * 1968-09-16 1971-07-20 Sandoz Ag 2,3-dihydroimidazo(1,2-c)quinazolines
DE2058501A1 (de) * 1970-11-27 1972-05-31 Bayer Ag Verfahren zur Herstellung von neuen N-verbrueckten bicyclischen Heteroaromaten
GB1347493A (en) * 1971-02-11 1974-02-27 Aspro Nicholas Ltd Benzazine derivatives
US3984556A (en) * 1973-01-19 1976-10-05 Sandoz, Inc. Alkyl-substituted-tricyclic quinazolinones for lowering blood pressure
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JPS5398997A (en) * 1977-02-09 1978-08-29 Sumitomo Chem Co Ltd Fused pyridine derivertives and process for their preparation
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US4396770A (en) * 1982-04-09 1983-08-02 Hoechst-Roussel Pharmaceuticals Inc. 1-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-4-hydroxy-4-phenylpiperidines
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US4409230A (en) * 1982-04-09 1983-10-11 Hoechst-Roussel Pharmaceuticals Inc. Pharmaceutical compositions and methods employing 8-[3-(6-fluoro-1,2-benzisoxazol-3-yl)propyl]-1-phenyl-1,3,8-triazaspiro-[4.]decan-4-one and derivatives thereof
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US4374245A (en) * 1982-04-09 1983-02-15 Hoechst-Roussel Pharmaceuticals Inc. 8-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
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Also Published As

Publication number Publication date
FI74012C (fi) 1987-12-10
DK227183D0 (da) 1983-05-20
DK161968B (da) 1991-09-02
ZA832637B (en) 1984-01-25
PH18454A (en) 1985-07-18
ATE24510T1 (de) 1987-01-15
HK102989A (en) 1990-01-05
FI831742A0 (fi) 1983-05-18
ES522617A0 (es) 1984-09-01
EP0095289B1 (en) 1986-12-30
US4469868A (en) 1984-09-04
NZ204321A (en) 1986-06-11
NO831792L (no) 1983-11-25
ES529372A0 (es) 1985-06-16
KR870000931B1 (ko) 1987-05-11
ES8506004A1 (es) 1985-06-16
AU1342783A (en) 1983-12-01
KR840004756A (ko) 1984-10-24
ES8506019A1 (es) 1985-06-16
AR240941A2 (es) 1991-03-27
IE55111B1 (en) 1990-06-06
DE3368635D1 (en) 1987-02-05
JPS58210087A (ja) 1983-12-07
EP0095289A3 (en) 1984-09-05
NO160444C (no) 1989-04-19
NO160444B (no) 1989-01-09
ES529371A0 (es) 1985-07-01
FI74012B (fi) 1987-08-31
GR79262B (es) 1984-10-22
PT76745A (en) 1983-06-01
CA1210393A (en) 1986-08-26
ES8506315A1 (es) 1985-07-01
AR240941A1 (es) 1991-03-27
AU553708B2 (en) 1986-07-24
JPH0320395B2 (es) 1991-03-19
HU187913B (en) 1986-03-28
IL68360A0 (en) 1986-10-31
ES529373A0 (es) 1985-06-16
FI831742L (fi) 1983-11-25
DK161968C (da) 1992-02-03
PT76745B (en) 1986-04-21
EP0095289A2 (en) 1983-11-30
IL68360A (en) 1986-10-31
DK227183A (da) 1983-11-25
IE830822L (en) 1983-11-24

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MM4A Patent lapsed

Effective date: 19960506