CN1300291A - 蛋白质酪氨酸磷酸酶(ptp酶)的调节物 - Google Patents

蛋白质酪氨酸磷酸酶(ptp酶)的调节物 Download PDF

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Publication number
CN1300291A
CN1300291A CN99806016A CN99806016A CN1300291A CN 1300291 A CN1300291 A CN 1300291A CN 99806016 A CN99806016 A CN 99806016A CN 99806016 A CN99806016 A CN 99806016A CN 1300291 A CN1300291 A CN 1300291A
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CN
China
Prior art keywords
amino
dihydro
thieno
oxalyl
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN99806016A
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English (en)
Chinese (zh)
Inventor
尼尔斯·P·H·莫勒
亨里克·S·安德森
拉斯·F·艾弗森
奥利·H·奥尔森
斯文·布兰纳
丹尼尔·D·霍尔斯沃思
法里德·巴克尔
卢克·M·贾奇
弗兰克·U·阿克斯
托德·K·琼斯
威廉·C·里普卡
纪雨
罗伊·T·乌耶达
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ang Cytogen Co
Novo Nordisk AS
Original Assignee
Ang Cytogen Co
Novo Nordisk AS
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Filing date
Publication date
Application filed by Ang Cytogen Co, Novo Nordisk AS filed Critical Ang Cytogen Co
Publication of CN1300291A publication Critical patent/CN1300291A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/66—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/18—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Electrodes Of Semiconductors (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Bipolar Transistors (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Control Of El Displays (AREA)
  • Indole Compounds (AREA)
CN99806016A 1998-03-12 1999-03-11 蛋白质酪氨酸磷酸酶(ptp酶)的调节物 Pending CN1300291A (zh)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
DK0344/1998 1998-03-12
DK34498 1998-03-12
DK0480/1998 1998-04-03
DK48098 1998-04-03
DKPA199800938 1998-07-15
DKPA199800938 1998-07-15
DKPA199801385 1998-10-28
DKPA199801385 1998-10-28
DKPA199801612 1998-12-07
DKPA199801612 1998-12-07

Publications (1)

Publication Number Publication Date
CN1300291A true CN1300291A (zh) 2001-06-20

Family

ID=27512769

Family Applications (1)

Application Number Title Priority Date Filing Date
CN99806016A Pending CN1300291A (zh) 1998-03-12 1999-03-11 蛋白质酪氨酸磷酸酶(ptp酶)的调节物

Country Status (13)

Country Link
EP (1) EP1080095B1 (enExample)
JP (1) JP2002506072A (enExample)
KR (1) KR20010041814A (enExample)
CN (1) CN1300291A (enExample)
AT (1) ATE308546T1 (enExample)
AU (1) AU2713599A (enExample)
BR (1) BR9908726A (enExample)
CA (1) CA2323493A1 (enExample)
DE (1) DE69928100D1 (enExample)
HU (1) HUP0104984A3 (enExample)
IL (1) IL138319A0 (enExample)
NO (1) NO20004527L (enExample)
PL (1) PL342816A1 (enExample)

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007036138A1 (en) * 2005-09-27 2007-04-05 Tianjin Hemay Bio-Tech Co. Ltd 5H-THIENO [3,4-c] PYRROLE-4, 6-DIONE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR
CN102382076A (zh) * 2010-09-03 2012-03-21 中国医学科学院药物研究所 芳酮和芳酰胺类化合物及其制法和药物用途
CN102838625A (zh) * 2011-06-22 2012-12-26 中国科学院上海药物研究所 四氢吡啶并噻唑类化合物、其制备方法、包含该化合物的药物组合物及其用途
CN104193761A (zh) * 2009-12-04 2014-12-10 桑诺维恩药品公司 多环化合物及其使用方法
CN104277051A (zh) * 2005-09-15 2015-01-14 霍夫曼-拉罗奇有限公司 4-氨基-噻吩并[3,2-c]吡啶-7-羧酸衍生物
CN104788425A (zh) * 2015-03-12 2015-07-22 佛山市赛维斯医药科技有限公司 一类含烟酸酰胺和哌啶结构ptp1b抑制剂、制备方法及其用途
CN104788424A (zh) * 2015-03-12 2015-07-22 佛山市赛维斯医药科技有限公司 含烟酸酰胺和哌啶结构的ptp1b抑制剂、制备方法及其用途
CN104829629A (zh) * 2015-03-26 2015-08-12 天津药物研究院有限公司 含磺酰胺基的四氢噻吩并[2,3-c]吡啶衍生物、其制备方法和用途
CN103641765B (zh) * 2004-06-24 2016-08-17 沃泰克斯药物股份有限公司 Atp-结合弹夹转运蛋白的调控剂
CN106748999A (zh) * 2015-03-12 2017-05-31 佛山市赛维斯医药科技有限公司 一类含烟酸酰胺结构的ptp1b抑制剂、制备方法及其用途
CN106866523A (zh) * 2015-03-12 2017-06-20 佛山市赛维斯医药科技有限公司 含烟酸酰胺结构的ptp1b抑制剂、制备方法及其用途
US10196403B2 (en) 2016-07-29 2019-02-05 Sunovion Pharmaceuticals Inc. Compounds and compositions and uses thereof
US10780074B2 (en) 2017-08-02 2020-09-22 Sunovion Pharmaceuticals Inc. Compounds and uses thereof
US10815249B2 (en) 2018-02-16 2020-10-27 Sunovion Pharmaceuticals Inc. Salts, crystal forms, and production methods thereof
US11077090B2 (en) 2016-07-29 2021-08-03 Sunovion Pharmaceuticals Inc. Compounds and compositions and uses thereof
US11129807B2 (en) 2017-02-16 2021-09-28 Sunovion Pharmaceuticals Inc. Methods of treating schizophrenia
US11136304B2 (en) 2019-03-14 2021-10-05 Sunovion Pharmaceuticals Inc. Salts of a heterocyclic compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof
US11738002B2 (en) 2020-04-14 2023-08-29 Sunovion Pharmaceuticals Inc. Methods of treating neurological and psychiatric disorders

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* Cited by examiner, † Cited by third party
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UA82827C2 (en) 2000-12-18 2008-05-26 Inhibitors against the production and release of inflammatory cytokines
CA2487891A1 (en) * 2002-06-05 2003-12-18 Institute Of Medicinal Molecular Design, Inc. Inhibitors against the activation of ap-1 and nfat
TWI280876B (en) * 2002-06-05 2007-05-11 Inst Med Molecular Design Inc Therapeutic drug for diabetes
CN1658872B (zh) 2002-06-06 2010-09-22 株式会社医药分子设计研究所 抗过敏药
KR20110028554A (ko) 2002-06-06 2011-03-18 가부시키가이샤 이야쿠 분지 셋케이 겐쿠쇼 Ｏ-치환 히드록시아릴 유도체
KR20070037578A (ko) * 2004-05-28 2007-04-05 알타나 파마 아게 테트라히드로피리도티오펜
ATE397000T1 (de) * 2004-06-04 2008-06-15 Nycomed Gmbh Tetrahydropyridothiophenen zur verwendung in der behandlung von krebs
JP2008501768A (ja) * 2004-06-11 2008-01-24 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規の化合物及びテトラヒドロピリドチオフェンの使用
EP1851229A1 (en) * 2005-02-09 2007-11-07 Nycomed GmbH Tetrahydropyridothiophenes for the treatment of proliferative diseases such as cancer
JP2008530053A (ja) * 2005-02-11 2008-08-07 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 癌の治療のための抗増殖性剤としてのテトラヒドロピリドチオフェン
EP2948147B1 (en) * 2013-01-28 2019-03-13 H. Lundbeck A/S N-substituted-5-substituted phthalamic acids as sortilin inhibitors
US12410191B2 (en) 2019-05-21 2025-09-09 Zhejiang Hisun Pharmaceutical Co., Ltd. Macrolide derivatives, preparation method and application thereof
WO2021211191A1 (en) * 2020-04-14 2021-10-21 Purdue Research Foundation Novel lymphoid-specific tyrosine phosphatase (lyp) inhibitors

Cited By (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103641765B (zh) * 2004-06-24 2016-08-17 沃泰克斯药物股份有限公司 Atp-结合弹夹转运蛋白的调控剂
CN104788328B (zh) * 2004-06-24 2017-09-12 沃泰克斯药物股份有限公司 Atp‑结合弹夹转运蛋白的调控剂
CN104277051B (zh) * 2005-09-15 2017-06-09 霍夫曼-拉罗奇有限公司 4‑氨基‑噻吩并[3,2‑c]吡啶‑7‑羧酸衍生物
CN104277051A (zh) * 2005-09-15 2015-01-14 霍夫曼-拉罗奇有限公司 4-氨基-噻吩并[3,2-c]吡啶-7-羧酸衍生物
WO2007036138A1 (en) * 2005-09-27 2007-04-05 Tianjin Hemay Bio-Tech Co. Ltd 5H-THIENO [3,4-c] PYRROLE-4, 6-DIONE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR
US10894033B2 (en) 2009-12-04 2021-01-19 Sunovion Pharmaceuticals Inc. Multicyclic compounds and methods of use thereof
CN106883246B (zh) * 2009-12-04 2020-05-29 桑诺维恩药品公司 多环化合物及其使用方法
US10085968B2 (en) 2009-12-04 2018-10-02 Sunovion Pharmaceuticals Inc. Multicyclic compounds and methods of use thereof
CN104193761A (zh) * 2009-12-04 2014-12-10 桑诺维恩药品公司 多环化合物及其使用方法
CN104193761B (zh) * 2009-12-04 2017-10-17 桑诺维恩药品公司 多环化合物及其使用方法
CN106883246A (zh) * 2009-12-04 2017-06-23 桑诺维恩药品公司 多环化合物及其使用方法
CN102382076A (zh) * 2010-09-03 2012-03-21 中国医学科学院药物研究所 芳酮和芳酰胺类化合物及其制法和药物用途
CN102382076B (zh) * 2010-09-03 2016-08-17 中国医学科学院药物研究所 芳酮和芳酰胺类化合物及其制法和药物用途
CN102838625A (zh) * 2011-06-22 2012-12-26 中国科学院上海药物研究所 四氢吡啶并噻唑类化合物、其制备方法、包含该化合物的药物组合物及其用途
CN106866523A (zh) * 2015-03-12 2017-06-20 佛山市赛维斯医药科技有限公司 含烟酸酰胺结构的ptp1b抑制剂、制备方法及其用途
CN106748999A (zh) * 2015-03-12 2017-05-31 佛山市赛维斯医药科技有限公司 一类含烟酸酰胺结构的ptp1b抑制剂、制备方法及其用途
CN104788425A (zh) * 2015-03-12 2015-07-22 佛山市赛维斯医药科技有限公司 一类含烟酸酰胺和哌啶结构ptp1b抑制剂、制备方法及其用途
CN104788424A (zh) * 2015-03-12 2015-07-22 佛山市赛维斯医药科技有限公司 含烟酸酰胺和哌啶结构的ptp1b抑制剂、制备方法及其用途
CN104829629A (zh) * 2015-03-26 2015-08-12 天津药物研究院有限公司 含磺酰胺基的四氢噻吩并[2,3-c]吡啶衍生物、其制备方法和用途
US10196403B2 (en) 2016-07-29 2019-02-05 Sunovion Pharmaceuticals Inc. Compounds and compositions and uses thereof
US11958862B2 (en) 2016-07-29 2024-04-16 Sumitomo Pharma America, Inc. Compounds and compositions and uses thereof
US10927124B2 (en) 2016-07-29 2021-02-23 Sunovion Pharmaceuticals Inc. Compounds and compositions and uses thereof
US11077090B2 (en) 2016-07-29 2021-08-03 Sunovion Pharmaceuticals Inc. Compounds and compositions and uses thereof
US11129807B2 (en) 2017-02-16 2021-09-28 Sunovion Pharmaceuticals Inc. Methods of treating schizophrenia
US10780074B2 (en) 2017-08-02 2020-09-22 Sunovion Pharmaceuticals Inc. Compounds and uses thereof
US11491133B2 (en) 2017-08-02 2022-11-08 Sunovion Pharmaceuticals Inc. Heteroaryl-isochroman compounds and uses thereof
US11440921B2 (en) 2018-02-16 2022-09-13 Sunovion Pharmaceuticals Inc. Salts, crystal forms, and production methods thereof
US10815249B2 (en) 2018-02-16 2020-10-27 Sunovion Pharmaceuticals Inc. Salts, crystal forms, and production methods thereof
US11987591B2 (en) 2018-02-16 2024-05-21 Sumitomo Pharma America, Inc. Salts, crystal forms, and production methods thereof
US11136304B2 (en) 2019-03-14 2021-10-05 Sunovion Pharmaceuticals Inc. Salts of a heterocyclic compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof
US11738002B2 (en) 2020-04-14 2023-08-29 Sunovion Pharmaceuticals Inc. Methods of treating neurological and psychiatric disorders

Also Published As

Publication number Publication date
IL138319A0 (en) 2001-10-31
EP1080095A1 (en) 2001-03-07
HUP0104984A2 (hu) 2002-04-29
EP1080095B1 (en) 2005-11-02
KR20010041814A (ko) 2001-05-25
AU2713599A (en) 1999-09-27
HUP0104984A3 (en) 2003-07-28
ATE308546T1 (de) 2005-11-15
CA2323493A1 (en) 1999-09-16
NO20004527D0 (no) 2000-09-11
DE69928100D1 (de) 2005-12-08
PL342816A1 (en) 2001-07-02
NO20004527L (no) 2000-11-07
JP2002506072A (ja) 2002-02-26
BR9908726A (pt) 2000-11-21

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