JP2002502977A - マイクロアレイとその使用 - Google Patents
マイクロアレイとその使用Info
- Publication number
- JP2002502977A JP2002502977A JP2000530797A JP2000530797A JP2002502977A JP 2002502977 A JP2002502977 A JP 2002502977A JP 2000530797 A JP2000530797 A JP 2000530797A JP 2000530797 A JP2000530797 A JP 2000530797A JP 2002502977 A JP2002502977 A JP 2002502977A
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- JP
- Japan
- Prior art keywords
- antibody
- antigen
- antibodies
- protein
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006503310A (ja) * | 2002-10-15 | 2006-01-26 | アブメトリックス， インコーポレイテッド | 短いエピトープに対して向けられる複数組のディジタル抗体、およびその使用 |
| JP2014066729A (ja) * | 2009-03-02 | 2014-04-17 | Dignity Health | 治療デバイスおよび使用方法 |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999039210A1 (en) * | 1998-01-29 | 1999-08-05 | Miller, Samuel | High density arrays for proteome analysis and methods and compositions therefor |
| EP1060395B1 (en) * | 1998-02-04 | 2008-04-30 | Invitrogen Corporation | Microarrays and uses therefor |
| US6682942B1 (en) | 1998-07-14 | 2004-01-27 | Zyomyx, Inc. | Microdevices for screening biomolecules |
| US6576478B1 (en) | 1998-07-14 | 2003-06-10 | Zyomyx, Inc. | Microdevices for high-throughput screening of biomolecules |
| US6406921B1 (en) | 1998-07-14 | 2002-06-18 | Zyomyx, Incorporated | Protein arrays for high-throughput screening |
| US6897073B2 (en) | 1998-07-14 | 2005-05-24 | Zyomyx, Inc. | Non-specific binding resistant protein arrays and methods for making the same |
| US6780582B1 (en) | 1998-07-14 | 2004-08-24 | Zyomyx, Inc. | Arrays of protein-capture agents and methods of use thereof |
| AU1818600A (en) | 1998-11-16 | 2000-06-05 | Genway Biotech, Inc. | Generation of antibodies using polynucleotide vaccination in avian species |
| DE69942314D1 (de) | 1998-12-23 | 2010-06-10 | Medsaic Pty Ltd | Versuchsanordnung zum nachweis von bindungspartnern |
| WO2001016600A1 (fr) * | 1999-08-31 | 2001-03-08 | Mitsubishi Chemical Corporation | Methode d'analyse d'une interaction mutuelle entre une proteine et une molecule |
| WO2001027611A2 (en) * | 1999-10-13 | 2001-04-19 | Incyte Genomics, Inc. | Multiplex cytokine analysis |
| HK1045944A1 (zh) | 1999-11-28 | 2002-12-20 | La Jolla Pharmaceutical Company | 基於抗体亲和力的狼疮治疗方法和筛选方法及用於其的组合物 |
| GB9928789D0 (en) * | 1999-12-03 | 2000-02-02 | Medical Res Council | Naive screening method |
| SG121902A1 (en) * | 2000-01-11 | 2006-05-26 | Maxygen Inc | Integrated systems for diversity generation and screening |
| AU2001233276A1 (en) * | 2000-02-03 | 2001-08-14 | Immunomatrix Inc. | Method and apparatus for signal transduction pathway profiling |
| WO2001062377A2 (en) * | 2000-02-22 | 2001-08-30 | Genospectra, Inc. | Microarray fabrication techniques and apparatus |
| KR20030003686A (ko) * | 2000-02-22 | 2003-01-10 | 제노스펙트라 인코포레이티드 | 마이크로어레이 제작 기술 및 장치 |
| AU5951201A (en) | 2000-05-04 | 2001-11-12 | Univ Yale | High density protein arrays for screening of protein activity |
| DE10023130B4 (de) | 2000-05-11 | 2007-10-18 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Hyphenspezifische Faktoren aus Candida albicans |
| AU2001277172A1 (en) * | 2000-07-26 | 2002-02-05 | Applied Genomics, Inc. | Bstp-trans protein and related reagents and methods of use thereof |
| AU2001284899A1 (en) * | 2000-08-11 | 2002-02-25 | Qianjin Hu | Methods and universal monoclonal antibody array |
| AUPR005600A0 (en) * | 2000-09-12 | 2000-10-05 | University Of Sydney, The | Diagnostic assay |
| US7354721B2 (en) | 2000-09-22 | 2008-04-08 | Clontech Laboratories, Inc. | Highly sensitive proteomic analysis methods, and kits and systems for practicing the same |
| US20020137104A1 (en) * | 2000-11-27 | 2002-09-26 | Antonio Cosma | High throughput determination of antigen expression |
| EP1270740A1 (en) * | 2001-06-29 | 2003-01-02 | SIRS-Lab GmbH | Biochip and its use for determining inflammation |
| US7297553B2 (en) | 2002-05-28 | 2007-11-20 | Nanosphere, Inc. | Method for attachment of silylated molecules to glass surfaces |
| AU2002322458A1 (en) | 2001-07-13 | 2003-01-29 | Nanosphere, Inc. | Method for immobilizing molecules onto surfaces |
| KR20030011982A (ko) * | 2001-07-25 | 2003-02-12 | 주식회사 인투젠 | ｃＤＮＡ 마이크로어레이 분석법을 이용한 위암의 진단과항암제 개발에 사용되는 표적유전자 및 이것이 배열된마이크로어레이용 고형 지지체 |
| US20030228709A1 (en) * | 2002-03-25 | 2003-12-11 | Kozlowski Roland Zbignieiw | Arrays |
| AU2003284166A1 (en) * | 2002-10-23 | 2004-05-13 | University Of Hawaii | Methods for diagnosing and treating pre-term labor |
| JP2006512583A (ja) * | 2003-01-02 | 2006-04-13 | バイオフォース ナノサイエンシズ インコーポレイテッド | 小サンプル体積における分子分析の方法及び装置 |
| DE10315031B4 (de) * | 2003-04-02 | 2014-02-13 | Analytik Jena Ag | Verfahren zur Erkennung von Sepsis und/oder sepsisähnlichen Zuständen |
| WO2004087949A2 (de) * | 2003-04-02 | 2004-10-14 | Sirs-Lab Gmbh | Verfahren zur erkennung akuter generalisierter entzündlicher zustände (sirs), sepsis, sepsisähnlichen zuständen und systemischen infektionen |
| US20040248323A1 (en) | 2003-06-09 | 2004-12-09 | Protometrix, Inc. | Methods for conducting assays for enzyme activity on protein microarrays |
| DE102004015605B4 (de) * | 2004-03-30 | 2012-04-26 | Sirs-Lab Gmbh | Verfahren zur Vorhersage des individuellen Krankheitsverlaufs bei Sepsis |
| DE102004049897B4 (de) | 2004-10-13 | 2007-11-22 | Sirs-Lab Gmbh | Verfahren zur Unterscheidung zwischen nichtinfektiösen und infektiösen Ursachen eines Multiorganversagens |
| US20060292559A1 (en) * | 2005-06-23 | 2006-12-28 | Beckman Coulter, Inc. | Cell-based microarrays, and methods for their preparation and use |
| WO2007024877A2 (en) | 2005-08-22 | 2007-03-01 | Cornell Research Foundation, Inc. | Compositions and methods for analyzing protein interactions |
| DK3255146T3 (da) | 2009-03-16 | 2019-08-19 | Pangu Biopharma Ltd | Præparater og fremgangsmåder omfattende histidyl-tRNA-synthetasesplejsningsvarianter med ikke-kanoniske biologiske aktiviteter |
| JP5848236B2 (ja) | 2009-03-31 | 2016-01-27 | エータイアー ファーマ， インコーポレイテッド | 非標準的な生物活性を有するアスパルチルｔＲＮＡ合成酵素を含む組成物および方法 |
| CA2797093C (en) | 2010-04-26 | 2019-10-29 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-trna synthetase |
| EP2563381B1 (en) | 2010-04-27 | 2017-08-09 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of isoleucyl trna synthetases |
| CN103097524B (zh) | 2010-04-28 | 2016-08-03 | Atyr医药公司 | 与丙氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| US9068177B2 (en) | 2010-04-29 | 2015-06-30 | Atyr Pharma, Inc | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-tRNA synthetases |
| CN103097523B (zh) | 2010-04-29 | 2016-09-28 | Atyr医药公司 | 与天冬酰胺酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| JP5991963B2 (ja) | 2010-04-29 | 2016-09-14 | エータイアー ファーマ， インコーポレイテッド | バリルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| WO2011135459A2 (en) | 2010-04-29 | 2011-11-03 | Medical Prognosis Institute A/S | Methods and devices for predicting treatment efficacy |
| JP6008840B2 (ja) | 2010-05-03 | 2016-10-19 | エータイアー ファーマ， インコーポレイテッド | フェニルアラニルαｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| JP6008841B2 (ja) | 2010-05-03 | 2016-10-19 | エータイアー ファーマ， インコーポレイテッド | メチオニルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| US8961961B2 (en) | 2010-05-03 | 2015-02-24 | a Tyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of arginyl-tRNA synthetases |
| JP6008844B2 (ja) | 2010-05-04 | 2016-10-19 | エータイアー ファーマ， インコーポレイテッド | ｐ３８ＭＵＬＴＩ−ｔＲＮＡ合成酵素複合体のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| JP6396656B2 (ja) | 2010-05-14 | 2018-09-26 | エータイアー ファーマ， インコーポレイテッド | フェニルアラニルβｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| US9034598B2 (en) | 2010-05-17 | 2015-05-19 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-tRNA synthetases |
| US8962560B2 (en) | 2010-06-01 | 2015-02-24 | Atyr Pharma Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Lysyl-tRNA synthetases |
| AU2011289831C1 (en) | 2010-07-12 | 2017-06-15 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases |
| US9188593B2 (en) | 2010-07-16 | 2015-11-17 | The University Of British Columbia | Methods for assaying cellular binding interactions |
| AU2011293294B2 (en) | 2010-08-25 | 2016-03-24 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Tyrosyl-tRNA synthetases |
| JP6039656B2 (ja) | 2011-06-01 | 2016-12-07 | メディカル プログノシス インスティテュート エー／エス | 癌再発の予後予測のための方法および装置 |
| ES1076494Y (es) * | 2012-02-15 | 2012-06-12 | Duart Andoni Monforte | Dispositivo para la elaboracion de bebida |
| AU2013221317B2 (en) | 2012-02-16 | 2017-07-06 | Pangu Biopharma Limited | Histidyl-tRNA synthetases for treating autoimmune and inflammatory diseases |
| DE102012020496A1 (de) | 2012-10-18 | 2014-04-24 | Charité - Universitätsmedizin Berlin | Biomarker zur Diagnostik und Behandlung von Neurofibromatose Typ 1 |
| NZ709167A (en) | 2012-11-27 | 2020-03-27 | Univ Pontificia Catolica Chile | Compositions and methods for diagnosing thyroid tumors |
| WO2014195032A1 (en) | 2013-06-07 | 2014-12-11 | Medical Prognosis Institute A/S | Methods and devices for predicting treatment efficacy of fulvestrant in cancer patients |
| WO2016008048A1 (en) | 2014-07-15 | 2016-01-21 | Ontario Institute For Cancer Research | Methods and devices for predicting anthracycline treatment efficacy |
| CN108398554B (zh) * | 2018-03-07 | 2020-08-07 | 深圳市伯劳特生物制品有限公司 | 一种抗torch-IgM型抗体谱芯片及其制备方法与TORCH检测的试剂盒 |
| CN108398550B (zh) * | 2018-03-07 | 2022-07-26 | 深圳市伯劳特生物制品有限公司 | 一种组合物、芯片及其制备方法和包含有该芯片的检测装置 |
| CN108398564B (zh) * | 2018-03-07 | 2020-08-07 | 深圳市伯劳特生物制品有限公司 | 一种抗torch-IgG型抗体谱芯片及其制备方法与TORCH检测的试剂盒 |
| EP4423664A4 (en) | 2021-10-25 | 2025-08-27 | Singular Genomics Systems Inc | HANDLING AND DETECTION OF BIOLOGICAL SAMPLES |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03500928A (ja) * | 1987-11-09 | 1991-02-28 | リガンド・ファーマシューティカルズ・インコーポレーテッド | ポリペプチド誘発モノクローナル受容体を用いる蛋白リガンド検出 |
| JPH056800Y2 (enExample) * | 1987-04-27 | 1993-02-22 | ||
| JPH09510539A (ja) * | 1993-12-24 | 1997-10-21 | マルティライト リミティド | 結合アッセイ |
| JPH11512293A (ja) * | 1995-09-15 | 1999-10-26 | アフィメトリックス，インコーポレイティド | 高密度オリゴヌクレオチドアレーに対するハイブリダイゼーションによる発現モニター |
| JP4029921B2 (ja) * | 1996-01-26 | 2008-01-09 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 光ファイバーバイオセンサ用高密度アレイの製造法と読出法 |
Family Cites Families (194)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4071409A (en) | 1976-05-20 | 1978-01-31 | Corning Glass Works | Immobilization of proteins on inorganic support materials |
| US4281061A (en) * | 1979-07-27 | 1981-07-28 | Syva Company | Double antibody for enhanced sensitivity in immunoassay |
| US4722896A (en) | 1981-01-26 | 1988-02-02 | The Beth Israel Hospital Association | Method for affinity purification of hybridoma antibodies |
| US4444879A (en) * | 1981-01-29 | 1984-04-24 | Science Research Center, Inc. | Immunoassay with article having support film and immunological counterpart of analyte |
| NZ199722A (en) | 1981-02-25 | 1985-12-13 | Genentech Inc | Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain |
| EP0063810B1 (en) | 1981-04-29 | 1986-03-05 | Ciba-Geigy Ag | New devices and kits for immunological analysis |
| US4483929A (en) * | 1982-05-03 | 1984-11-20 | Liposome Technology Incorporated | Liposomes with glycolipid-linked antibodies |
| US4690715A (en) | 1982-06-18 | 1987-09-01 | American Telephone And Telegraph Company, At&T Bell Laboratories | Modification of the properties of metals |
| US4514508A (en) * | 1982-07-06 | 1985-04-30 | Biond Inc. | Assaying for a multiplicity of antigens or antibodies with a detection compound |
| US4973493A (en) | 1982-09-29 | 1990-11-27 | Bio-Metric Systems, Inc. | Method of improving the biocompatibility of solid surfaces |
| US4994373A (en) | 1983-01-27 | 1991-02-19 | Enzo Biochem, Inc. | Method and structures employing chemically-labelled polynucleotide probes |
| US4591570A (en) * | 1983-02-02 | 1986-05-27 | Centocor, Inc. | Matrix of antibody-coated spots for determination of antigens |
| US4865998A (en) * | 1983-03-11 | 1989-09-12 | Sloan-Kettering Institute For Cancer Research | Monoclonal antibodies to human lung cancers and method |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| GB8314523D0 (en) | 1983-05-25 | 1983-06-29 | Lowe C R | Diagnostic device |
| US5096807A (en) | 1985-03-06 | 1992-03-17 | Murex Corporation | Imaging immunoassay detection system with background compensation and its use |
| EP0218680A1 (en) * | 1985-04-10 | 1987-04-22 | Immunicon Corporation | Direct homogeneous assay |
| US5866363A (en) | 1985-08-28 | 1999-02-02 | Pieczenik; George | Method and means for sorting and identifying biological information |
| US4894146A (en) | 1986-01-27 | 1990-01-16 | University Of Utah | Thin channel split flow process and apparatus for particle fractionation |
| US4728591A (en) | 1986-03-07 | 1988-03-01 | Trustees Of Boston University | Self-assembled nanometer lithographic masks and templates and method for parallel fabrication of nanometer scale multi-device structures |
| US4802951A (en) | 1986-03-07 | 1989-02-07 | Trustees Of Boston University | Method for parallel fabrication of nanometer scale multi-device structures |
| US5643948A (en) | 1986-06-11 | 1997-07-01 | Procyon Pharmaceuticals, Inc. | Protein kinase C modulators. K. |
| US4859538A (en) | 1986-11-20 | 1989-08-22 | Ribi Hans O | Novel lipid-protein compositions and articles and methods for their preparation |
| US5079600A (en) | 1987-03-06 | 1992-01-07 | Schnur Joel M | High resolution patterning on solid substrates |
| US4987032A (en) | 1987-06-26 | 1991-01-22 | Fuji Photo Film Co., Ltd. | Functional organic thin film and method of manufacture thereof |
| US5154808A (en) | 1987-06-26 | 1992-10-13 | Fuji Photo Film Co., Ltd. | Functional organic thin film and process for producing the same |
| US4880750A (en) | 1987-07-09 | 1989-11-14 | Miragen, Inc. | Individual-specific antibody identification methods |
| GB8803000D0 (en) | 1988-02-10 | 1988-03-09 | Ekins Roger Philip | Determination of ambient concentrations of several analytes |
| US5807755A (en) | 1987-08-06 | 1998-09-15 | Multilyte Limited | Determination of ambient concentrations of several analytes |
| US5217869A (en) | 1987-10-13 | 1993-06-08 | Terrapin Technologies, Inc. | Method to produce immunodiagnostic reagents |
| US5300425A (en) | 1987-10-13 | 1994-04-05 | Terrapin Technologies, Inc. | Method to produce immunodiagnostic reagents |
| US6692751B1 (en) | 1988-05-06 | 2004-02-17 | New York Blood Center | Methods and systems for producing recombinant viral antigens |
| US4908112A (en) | 1988-06-16 | 1990-03-13 | E. I. Du Pont De Nemours & Co. | Silicon semiconductor wafer for analyzing micronic biological samples |
| US5281540A (en) | 1988-08-02 | 1994-01-25 | Abbott Laboratories | Test array for performing assays |
| US5075077A (en) | 1988-08-02 | 1991-12-24 | Abbott Laboratories | Test card for performing assays |
| SE462454B (sv) | 1988-11-10 | 1990-06-25 | Pharmacia Ab | Maetyta foer anvaendning i biosensorer |
| WO1990005144A1 (en) | 1988-11-11 | 1990-05-17 | Medical Research Council | Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors |
| IT1229691B (it) | 1989-04-21 | 1991-09-06 | Eniricerche Spa | Sensore con antigene legato chimicamente a un dispositivo semiconduttore. |
| US6919211B1 (en) | 1989-06-07 | 2005-07-19 | Affymetrix, Inc. | Polypeptide arrays |
| US5800992A (en) | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
| US6416952B1 (en) | 1989-06-07 | 2002-07-09 | Affymetrix, Inc. | Photolithographic and other means for manufacturing arrays |
| US5424186A (en) | 1989-06-07 | 1995-06-13 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US6346413B1 (en) | 1989-06-07 | 2002-02-12 | Affymetrix, Inc. | Polymer arrays |
| US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
| US5491097A (en) * | 1989-06-15 | 1996-02-13 | Biocircuits Corporation | Analyte detection with multilayered bioelectronic conductivity sensors |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US5252743A (en) | 1989-11-13 | 1993-10-12 | Affymax Technologies N.V. | Spatially-addressable immobilization of anti-ligands on surfaces |
| DE3939973A1 (de) | 1989-12-02 | 1991-06-06 | Basf Ag | Zweidimensional kristallisierte makromolekuelschichten |
| US5283173A (en) | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
| US5858188A (en) | 1990-02-28 | 1999-01-12 | Aclara Biosciences, Inc. | Acrylic microchannels and their use in electrophoretic applications |
| SE470347B (sv) | 1990-05-10 | 1994-01-31 | Pharmacia Lkb Biotech | Mikrostruktur för vätskeflödessystem och förfarande för tillverkning av ett sådant system |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| ES2139598T3 (es) | 1990-07-10 | 2000-02-16 | Medical Res Council | Procedimientos para la produccion de miembros de parejas de union especifica. |
| US5665582A (en) | 1990-10-29 | 1997-09-09 | Dekalb Genetics Corp. | Isolation of biological materials |
| US5639620A (en) | 1990-10-31 | 1997-06-17 | Coulter Corporation | Polymeric particles having a biodegradable gelatin or aminodextran coating and process for making same |
| WO1992008788A1 (en) | 1990-11-19 | 1992-05-29 | The Board Of Trustees Of The University Of Illinois | Mutant orientable proteins and coated substrates |
| US5294369A (en) | 1990-12-05 | 1994-03-15 | Akzo N.V. | Ligand gold bonding |
| DK0834575T3 (da) | 1990-12-06 | 2002-04-02 | Affymetrix Inc A Delaware Corp | Identifikation af nucleinsyrer i prøver |
| WO1992013629A1 (en) * | 1991-01-31 | 1992-08-20 | Wayne State University | A method for analyzing an organic sample |
| US5763170A (en) | 1991-04-16 | 1998-06-09 | Amersham International Plc | Method for forming an array of biological particles |
| US5283283A (en) | 1991-08-02 | 1994-02-01 | The Goodyear Tire & Rubber Company | High modulus blend of poly(α-amino acid) in rubbery elastomer |
| ATE161964T1 (de) | 1991-10-15 | 1998-01-15 | Multilyte Ltd | Bindungstest unter benutzung eines markierten reagens |
| US5605662A (en) * | 1993-11-01 | 1997-02-25 | Nanogen, Inc. | Active programmable electronic devices for molecular biological analysis and diagnostics |
| US6051380A (en) | 1993-11-01 | 2000-04-18 | Nanogen, Inc. | Methods and procedures for molecular biological analysis and diagnostics |
| IL103674A0 (en) | 1991-11-19 | 1993-04-04 | Houston Advanced Res Center | Method and apparatus for molecule detection |
| US5846708A (en) | 1991-11-19 | 1998-12-08 | Massachusetts Institiute Of Technology | Optical and electrical methods and apparatus for molecule detection |
| US5384261A (en) | 1991-11-22 | 1995-01-24 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis using mechanically directed flow paths |
| US5412087A (en) | 1992-04-24 | 1995-05-02 | Affymax Technologies N.V. | Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces |
| ATE262374T1 (de) | 1991-11-22 | 2004-04-15 | Affymetrix Inc | Kombinatorische strategien für polymersynthese |
| US6943034B1 (en) | 1991-11-22 | 2005-09-13 | Affymetrix, Inc. | Combinatorial strategies for polymer synthesis |
| EP1136556B1 (en) | 1991-11-25 | 2005-06-08 | Enzon, Inc. | Method of producing multivalent antigen-binding proteins |
| ES2227512T3 (es) | 1991-12-02 | 2005-04-01 | Medical Research Council | Produccion de anticuerpos contra auto-antigenos a partir de repertorios de segmentos de anticuerpos fijados en un fago. |
| EP0544969B1 (de) | 1991-12-06 | 1997-03-05 | Ciba-Geigy Ag | Elektrophoretische Trennvorrichtung und elektrophoretisches Trennverfahren |
| DE69333823T2 (de) | 1992-03-24 | 2006-05-04 | Cambridge Antibody Technology Ltd., Melbourn | Verfahren zur herstellung von gliedern von spezifischen bindungspaaren |
| CA2064683A1 (en) | 1992-03-26 | 1993-09-27 | Krishna Mohan Rao Kallury | Formation of thermostable enzymes with extra-ordinary heat tolerance by immobilization on phospholipid matrices |
| US6100099A (en) | 1994-09-06 | 2000-08-08 | Abbott Laboratories | Test strip having a diagonal array of capture spots |
| WO1993021528A1 (en) | 1992-04-22 | 1993-10-28 | Ecole Polytechnique Federale De Lausanne (Epfl) | Lipid membrane sensors |
| US6107059A (en) | 1992-04-29 | 2000-08-22 | Affymax Technologies N.V. | Peptide library and screening method |
| US5726026A (en) | 1992-05-01 | 1998-03-10 | Trustees Of The University Of Pennsylvania | Mesoscale sample preparation device and systems for determination and processing of analytes |
| US5637469A (en) | 1992-05-01 | 1997-06-10 | Trustees Of The University Of Pennsylvania | Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems |
| US5304487A (en) | 1992-05-01 | 1994-04-19 | Trustees Of The University Of Pennsylvania | Fluid handling in mesoscale analytical devices |
| US5348886A (en) | 1992-09-04 | 1994-09-20 | Monsanto Company | Method of producing recombinant eukaryotic viruses in bacteria |
| DE4237113B4 (de) | 1992-11-03 | 2006-10-12 | "Iba Gmbh" | Peptide und deren Fusionsproteine, Expressionsvektor und Verfahren zur Herstellung eines Fusionsproteins |
| US5472881A (en) | 1992-11-12 | 1995-12-05 | University Of Utah Research Foundation | Thiol labeling of DNA for attachment to gold surfaces |
| US5532142A (en) | 1993-02-12 | 1996-07-02 | Board Of Regents, The University Of Texas System | Method of isolation and purification of fusion polypeptides |
| IT1270866B (it) | 1993-03-10 | 1997-05-13 | Eniricerche Spa | Vettore ricombinante e suo impiego per la preparazione esocellulare di anticorpi in forma di singola molecola da bacillus subtilis |
| US5436134A (en) | 1993-04-13 | 1995-07-25 | Molecular Probes, Inc. | Cyclic-substituted unsymmetrical cyanine dyes |
| US5677196A (en) | 1993-05-18 | 1997-10-14 | University Of Utah Research Foundation | Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays |
| US5512492A (en) | 1993-05-18 | 1996-04-30 | University Of Utah Research Foundation | Waveguide immunosensor with coating chemistry providing enhanced sensitivity |
| ATE242485T1 (de) | 1993-05-28 | 2003-06-15 | Baylor College Medicine | Verfahren und massenspektrometer zur desorption und ionisierung von analyten |
| US5861242A (en) | 1993-06-25 | 1999-01-19 | Affymetrix, Inc. | Array of nucleic acid probes on biological chips for diagnosis of HIV and methods of using the same |
| US5837832A (en) | 1993-06-25 | 1998-11-17 | Affymetrix, Inc. | Arrays of nucleic acid probes on biological chips |
| US5441876A (en) | 1993-07-30 | 1995-08-15 | The United States Of America As Represented By The Secretary Of The Navy | Process for the preparation of headgroup-modified phospholipids using phosphatidylhydroxyalkanols as intermediates |
| RU2041262C1 (ru) | 1993-08-11 | 1995-08-09 | Институт молекулярной биологии им.В.А.Энгельгардта РАН | Способ иммобилизации водорастворимых биоорганических соединений на капиллярно-пористый носитель |
| US5512131A (en) | 1993-10-04 | 1996-04-30 | President And Fellows Of Harvard College | Formation of microstamped patterns on surfaces and derivative articles |
| US5776748A (en) | 1993-10-04 | 1998-07-07 | President And Fellows Of Harvard College | Method of formation of microstamped patterns on plates for adhesion of cells and other biological materials, devices and uses therefor |
| ATE214633T1 (de) | 1993-10-28 | 2002-04-15 | Houston Advanced Res Ct | Mikrofabriziertes poröses durchflussgerät |
| US5429807A (en) | 1993-10-28 | 1995-07-04 | Beckman Instruments, Inc. | Method and apparatus for creating biopolymer arrays on a solid support surface |
| US5429708A (en) | 1993-12-22 | 1995-07-04 | The Board Of Trustees Of The Leland Stanford Junior University | Molecular layers covalently bonded to silicon surfaces |
| GB9326451D0 (en) | 1993-12-24 | 1994-02-23 | Multilyte Ltd | Binding assay |
| ATE221660T1 (de) | 1994-01-19 | 2002-08-15 | Roche Diagnostics Gmbh | Biotinsilan-verbindungen und diese verbindungen enthaltende bindematrix |
| DE4435728A1 (de) | 1994-01-19 | 1995-07-20 | Boehringer Mannheim Gmbh | Biotinsilan-Verbindungen und diese Verbindungen enthaltende Bindematrix |
| US5623055A (en) | 1994-01-28 | 1997-04-22 | Prolinx, Inc. | Phenylboronic acid complexes derived from aminosalicylic acid for bioconjugate preparation |
| US5594151A (en) | 1994-01-28 | 1997-01-14 | Prolinx, Inc. | Phenylboronic acid complexing reagents derived from aminosalicylic acid |
| US5594111A (en) | 1994-01-28 | 1997-01-14 | Prolinx, Inc. | Phenylboronic acid complexes for bioconjugate preparation |
| WO1995022051A1 (en) | 1994-02-09 | 1995-08-17 | Abbott Laboratories | Diagnostic flow cell device |
| US6335160B1 (en) | 1995-02-17 | 2002-01-01 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
| GB9404709D0 (en) | 1994-03-11 | 1994-04-27 | Multilyte Ltd | Binding assay |
| US6017693A (en) | 1994-03-14 | 2000-01-25 | University Of Washington | Identification of nucleotides, amino acids, or carbohydrates by mass spectrometry |
| US5514501A (en) | 1994-06-07 | 1996-05-07 | The United States Of America As Represented By The Secretary Of Commerce | Process for UV-photopatterning of thiolate monolayers self-assembled on gold, silver and other substrates |
| US6287850B1 (en) | 1995-06-07 | 2001-09-11 | Affymetrix, Inc. | Bioarray chip reaction apparatus and its manufacture |
| DE69527585T2 (de) | 1994-06-08 | 2003-04-03 | Affymetrix, Inc. | Verfahren und Vorrichtung zum Verpacken von Chips |
| US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
| US5498545A (en) * | 1994-07-21 | 1996-03-12 | Vestal; Marvin L. | Mass spectrometer system and method for matrix-assisted laser desorption measurements |
| US5620850A (en) | 1994-09-26 | 1997-04-15 | President And Fellows Of Harvard College | Molecular recognition at surfaces derivatized with self-assembled monolayers |
| SE9403245D0 (sv) | 1994-09-26 | 1994-09-26 | Pharmacia Biosensor Ab | Improvements relating to bilayer lipid membranes |
| US6121048A (en) | 1994-10-18 | 2000-09-19 | Zaffaroni; Alejandro C. | Method of conducting a plurality of reactions |
| US5571410A (en) | 1994-10-19 | 1996-11-05 | Hewlett Packard Company | Fully integrated miniaturized planar liquid sample handling and analysis device |
| US5603351A (en) | 1995-06-07 | 1997-02-18 | David Sarnoff Research Center, Inc. | Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device |
| US5585069A (en) | 1994-11-10 | 1996-12-17 | David Sarnoff Research Center, Inc. | Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis |
| US5688642A (en) | 1994-12-01 | 1997-11-18 | The United States Of America As Represented By The Secretary Of The Navy | Selective attachment of nucleic acid molecules to patterned self-assembled surfaces |
| US5622826A (en) | 1994-12-22 | 1997-04-22 | Houston Advanced Research Center | Method for immobilization of molecules on platinum solid support surfaces |
| US5814565A (en) | 1995-02-23 | 1998-09-29 | University Of Utah Research Foundation | Integrated optic waveguide immunosensor |
| DE19507166C1 (de) | 1995-03-01 | 1996-04-18 | Deutsches Krebsforsch | Antikörper gegen ein Histidin-Fusionspolypeptid, das einen Histidin-Anteil aufweist |
| US5629213A (en) | 1995-03-03 | 1997-05-13 | Kornguth; Steven E. | Analytical biosensor |
| EP0880544A4 (en) | 1995-03-08 | 2003-01-15 | Mat Adsorption Technologies Gm | AFFINITY SEPARATION MEMBRANE WITH MODIFIED SURFACE |
| US6140045A (en) | 1995-03-10 | 2000-10-31 | Meso Scale Technologies | Multi-array, multi-specific electrochemiluminescence testing |
| EP0821726B1 (en) | 1995-03-10 | 2014-05-07 | Meso Scale Technologies, LLC. | Multi-array, multi-specific electrochemiluminescence testing |
| US6309820B1 (en) | 1995-04-07 | 2001-10-30 | University Of North Carolina At Chapel Hill | Polypeptides having a functional domain of interest and methods of identifying and using same |
| AU707444B2 (en) * | 1995-04-25 | 1999-07-08 | Irori | Remotely programmable matrices with memories and uses thereof |
| US5624711A (en) | 1995-04-27 | 1997-04-29 | Affymax Technologies, N.V. | Derivatization of solid supports and methods for oligomer synthesis |
| US5827659A (en) * | 1995-05-19 | 1998-10-27 | Perseptive Biosystems, Inc. | Methods and apparatus for sequencing polymers using mass spectrometry |
| US5625184A (en) * | 1995-05-19 | 1997-04-29 | Perseptive Biosystems, Inc. | Time-of-flight mass spectrometry analysis of biomolecules |
| US5700642A (en) | 1995-05-22 | 1997-12-23 | Sri International | Oligonucleotide sizing using immobilized cleavable primers |
| US5776674A (en) | 1995-06-05 | 1998-07-07 | Seq, Ltd | Chemical biochemical and biological processing in thin films |
| US5545531A (en) | 1995-06-07 | 1996-08-13 | Affymax Technologies N.V. | Methods for making a device for concurrently processing multiple biological chip assays |
| US5840300A (en) | 1995-09-11 | 1998-11-24 | Trustees Of The University Of Pennsylvania | Methods and compositions comprising single chain recombinant antibodies |
| DE19543232A1 (de) | 1995-11-07 | 1997-05-15 | Knoell Hans Forschung Ev | Herstellung einer Matrix-gebundenen miniaturisierten kombinatorischen Poly- und Oligomerbibliothek |
| US5763263A (en) | 1995-11-27 | 1998-06-09 | Dehlinger; Peter J. | Method and apparatus for producing position addressable combinatorial libraries |
| WO1997021094A1 (en) | 1995-12-01 | 1997-06-12 | Innogenetics N.V. | Impedimetric detection system and method of production thereof |
| DE19548152A1 (de) | 1995-12-22 | 1997-06-26 | Boehringer Mannheim Gmbh | Verfahren zur Bedeckung einer Oberfläche mit einem Film eines Oligoethylenglykolderivates |
| US5942443A (en) | 1996-06-28 | 1999-08-24 | Caliper Technologies Corporation | High throughput screening assay systems in microscale fluidic devices |
| US5925552A (en) | 1996-04-25 | 1999-07-20 | Medtronic, Inc. | Method for attachment of biomolecules to medical devices surfaces |
| US5731152A (en) | 1996-05-13 | 1998-03-24 | Motorola, Inc. | Methods and systems for biological reagent placement |
| US6103479A (en) | 1996-05-30 | 2000-08-15 | Cellomics, Inc. | Miniaturized cell array methods and apparatus for cell-based screening |
| JPH1025299A (ja) | 1996-07-12 | 1998-01-27 | Nec Corp | 整列ペプチド、及びそれを用いたタンパク質の結合・相互作用部位検出方法 |
| US5827658A (en) | 1996-08-09 | 1998-10-27 | The United States Of America As Reprsented By The Department Of Health And Human Services | Isolation of amplified genes via cDNA subtractive hybridization |
| US20030017149A1 (en) | 1996-10-10 | 2003-01-23 | Hoeffler James P. | Single chain monoclonal antibody fusion reagents that regulate transcription in vivo |
| GB9624927D0 (en) | 1996-11-29 | 1997-01-15 | Oxford Glycosciences Uk Ltd | Gels and their use |
| US5905024A (en) | 1996-12-17 | 1999-05-18 | University Of Chicago | Method for performing site-specific affinity fractionation for use in DNA sequencing |
| EP1249705A3 (en) | 1996-12-31 | 2003-11-05 | Genometrix Genomics Incorporated | Multiplexed molecular analysis apparatus and its fabrication method |
| NZ516848A (en) | 1997-06-20 | 2004-03-26 | Ciphergen Biosystems Inc | Retentate chromatography apparatus with applications in biology and medicine |
| US5981734A (en) | 1997-07-17 | 1999-11-09 | University Of Chicago | Methods for immobilizing nucleic acids on a gel substrate |
| JP4313861B2 (ja) | 1997-08-01 | 2009-08-12 | キヤノン株式会社 | プローブアレイの製造方法 |
| US6960457B1 (en) | 1997-09-04 | 2005-11-01 | Stanford University | Reversible immobilization of arginine-tagged moieties on a silicate surface |
| US5922617A (en) | 1997-11-12 | 1999-07-13 | Functional Genetics, Inc. | Rapid screening assay methods and devices |
| US6232066B1 (en) | 1997-12-19 | 2001-05-15 | Neogen, Inc. | High throughput assay system |
| US6087102A (en) | 1998-01-07 | 2000-07-11 | Clontech Laboratories, Inc. | Polymeric arrays and methods for their use in binding assays |
| WO1999039210A1 (en) | 1998-01-29 | 1999-08-05 | Miller, Samuel | High density arrays for proteome analysis and methods and compositions therefor |
| EP1060395B1 (en) | 1998-02-04 | 2008-04-30 | Invitrogen Corporation | Microarrays and uses therefor |
| US6087103A (en) | 1998-03-04 | 2000-07-11 | Lifespan Biosciences, Inc. | Tagged ligand arrays for identifying target-ligand interactions |
| US6001607A (en) | 1998-04-13 | 1999-12-14 | Incyte Pharmaceuticals, Inc. | Human growth-associated methyltransfeases |
| JP4163383B2 (ja) | 1998-04-14 | 2008-10-08 | カリフォルニア・インスティテュート・オブ・テクノロジー | 検体活性を判定するための方法とシステム |
| JP4540846B2 (ja) | 1998-04-30 | 2010-09-08 | マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ | 所望の生物学的特性を与えるクローンを発現ライブラリーから同定する新規方法 |
| US6406921B1 (en) | 1998-07-14 | 2002-06-18 | Zyomyx, Incorporated | Protein arrays for high-throughput screening |
| US6682942B1 (en) | 1998-07-14 | 2004-01-27 | Zyomyx, Inc. | Microdevices for screening biomolecules |
| US6780582B1 (en) | 1998-07-14 | 2004-08-24 | Zyomyx, Inc. | Arrays of protein-capture agents and methods of use thereof |
| US6576478B1 (en) | 1998-07-14 | 2003-06-10 | Zyomyx, Inc. | Microdevices for high-throughput screening of biomolecules |
| US20020119579A1 (en) | 1998-07-14 | 2002-08-29 | Peter Wagner | Arrays devices and methods of use thereof |
| US6897073B2 (en) | 1998-07-14 | 2005-05-24 | Zyomyx, Inc. | Non-specific binding resistant protein arrays and methods for making the same |
| US6197599B1 (en) | 1998-07-30 | 2001-03-06 | Guorong Chin | Method to detect proteins |
| US6190908B1 (en) | 1998-08-12 | 2001-02-20 | The Scripps Research Institute | Modulation of polypeptide display on modified filamentous phage |
| US6635311B1 (en) | 1999-01-07 | 2003-10-21 | Northwestern University | Methods utilizing scanning probe microscope tips and products therefor or products thereby |
| FR2792285B1 (fr) | 1999-04-16 | 2001-06-08 | Onera (Off Nat Aerospatiale) | Surface aerodynamique d'aeronef a deflecteur de bord de fuite |
| US7107329B1 (en) | 1999-05-21 | 2006-09-12 | Lucent Technologies Inc. | In networks of interconnected router nodes for routing data traffic, a method of and system for imperceptibly upgrading router node software and the like without traffic interruption |
| US6899137B2 (en) | 1999-06-28 | 2005-05-31 | California Institute Of Technology | Microfabricated elastomeric valve and pump systems |
| KR100379411B1 (ko) | 1999-06-28 | 2003-04-10 | 엘지전자 주식회사 | 바이오칩 및 그의 생체 물질 패터닝 및 측정 방법 |
| NZ519217A (en) | 1999-12-10 | 2004-03-26 | Invitrogen Corp | Use of multiple recombination sites with unique specificity in recombinational cloning |
| US6406840B1 (en) | 1999-12-17 | 2002-06-18 | Biomosaic Systems, Inc. | Cell arrays and the uses thereof |
| AU3986501A (en) | 2000-02-23 | 2001-09-03 | Zyomyx Inc | Chips having elevated sample surfaces |
| US7132251B1 (en) | 2000-05-04 | 2006-11-07 | Procognia Ltd | Method and composition for analyzing a carbohydrate polymer |
| AU5951201A (en) | 2000-05-04 | 2001-11-12 | Univ Yale | High density protein arrays for screening of protein activity |
| US6531283B1 (en) | 2000-06-20 | 2003-03-11 | Molecular Staging, Inc. | Protein expression profiling |
| DE10039643A1 (de) | 2000-08-14 | 2002-02-28 | Max Planck Gesellschaft | Funktionalisierte Perylentetracarbonsäurediimide |
| US7094568B2 (en) | 2000-08-17 | 2006-08-22 | Sense Proteomic Ltd. | Method for producing proteins tagged at the N- or C-terminus |
| US7354721B2 (en) | 2000-09-22 | 2008-04-08 | Clontech Laboratories, Inc. | Highly sensitive proteomic analysis methods, and kits and systems for practicing the same |
| US6699665B1 (en) | 2000-11-08 | 2004-03-02 | Surface Logix, Inc. | Multiple array system for integrating bioarrays |
| CN1527720A (zh) | 2001-05-11 | 2004-09-08 | Ү³��ѧ | 利用蛋白组芯片全面分析蛋白活性 |
| EP1451579A4 (en) | 2001-11-19 | 2005-12-28 | Protometrix Inc | METHOD OF USING NON-ANTIBODY PROTEIN FOR DETECTING AND MEASURING AN ANALYTE |
| US20050233473A1 (en) | 2002-08-16 | 2005-10-20 | Zyomyx, Inc. | Methods and reagents for surface functionalization |
| GB0300150D0 (en) | 2003-01-04 | 2003-02-05 | Banks J & Co Ltd | Lockable releasable safety catch |
| US20040248323A1 (en) | 2003-06-09 | 2004-12-09 | Protometrix, Inc. | Methods for conducting assays for enzyme activity on protein microarrays |
| US20050026215A1 (en) | 2003-07-17 | 2005-02-03 | Predki Paul F. | Method for the prediction of an epitope |
-
1999
- 1999-02-04 EP EP99905748A patent/EP1060395B1/en not_active Expired - Lifetime
- 1999-02-04 DE DE69938623T patent/DE69938623T2/de not_active Expired - Lifetime
- 1999-02-04 EP EP09180044A patent/EP2189791A3/en not_active Withdrawn
- 1999-02-04 US US09/245,615 patent/US7794946B1/en not_active Expired - Fee Related
- 1999-02-04 AU AU25838/99A patent/AU2583899A/en not_active Abandoned
- 1999-02-04 CA CA002318175A patent/CA2318175A1/en not_active Abandoned
- 1999-02-04 AT AT99905748T patent/ATE393912T1/de not_active IP Right Cessation
- 1999-02-04 WO PCT/US1999/002442 patent/WO1999040434A1/en not_active Ceased
- 1999-02-04 EP EP08155312A patent/EP1965213A3/en not_active Withdrawn
- 1999-02-04 JP JP2000530797A patent/JP2002502977A/ja active Pending
-
2001
- 2001-10-26 US US10/035,368 patent/US20020164656A1/en not_active Abandoned
-
2009
- 2009-06-23 US US12/490,069 patent/US8012703B2/en not_active Expired - Fee Related
-
2011
- 2011-06-30 US US13/173,637 patent/US8637264B2/en not_active Expired - Fee Related
-
2012
- 2012-10-09 US US13/648,169 patent/US20130123127A1/en not_active Abandoned
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH056800Y2 (enExample) * | 1987-04-27 | 1993-02-22 | ||
| JPH03500928A (ja) * | 1987-11-09 | 1991-02-28 | リガンド・ファーマシューティカルズ・インコーポレーテッド | ポリペプチド誘発モノクローナル受容体を用いる蛋白リガンド検出 |
| JPH09510539A (ja) * | 1993-12-24 | 1997-10-21 | マルティライト リミティド | 結合アッセイ |
| JPH11512293A (ja) * | 1995-09-15 | 1999-10-26 | アフィメトリックス，インコーポレイティド | 高密度オリゴヌクレオチドアレーに対するハイブリダイゼーションによる発現モニター |
| JP4029921B2 (ja) * | 1996-01-26 | 2008-01-09 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 光ファイバーバイオセンサ用高密度アレイの製造法と読出法 |
Non-Patent Citations (6)
| Title |
|---|
| JPN6008059699, Ｊ Ｉｍｍｕｎｏｌ Ｍｅｔｈｏｄｓ, 1992, Ｖｏｌ．１５２ Ｎｏ．１, Ｐａｇｅ．５９−６７ * |
| JPN6009053629, Ａｎａｌ Ｃｈｉｍ Ａｃｔａ, 1989, Ｖｏｌ．２２７， Ｎｏ．１, Ｐａｇｅ．７３−９６ * |
| JPN6010030570, ＡＣＳ Ｓｙｍｐ Ｓｅｒ （Ａｍ Ｃｈｅｍ Ｓｏｃ）, 1997, Ｎｏ．６５７， Ｐａｇｅ．１７０−１８４ * |
| JPN6010030575, Ｍｉｃｒｏｂｉｏｌｏｇｙ, 1997, Ｖｏｌ．１４３， Ｎｏ．２， Ｐａｇｅ．６６３−６７３ * |
| JPN6010030578, Ｅｌｅｃｔｒｏｐｈｏｒｅｓｉｓ, 1997, Ｖｏｌ．１８， Ｎｏ．８， Ｐａｇｅ．１４９１−１４９７ * |
| JPN6010030581, Ｉｎｔ Ｊ Ｃａｎｃｅｒ, 1990, Ｖｏｌ．４５， Ｎｏ．６， Ｐａｇｅ．１０４０−１０４４ * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006503310A (ja) * | 2002-10-15 | 2006-01-26 | アブメトリックス， インコーポレイテッド | 短いエピトープに対して向けられる複数組のディジタル抗体、およびその使用 |
| JP2014066729A (ja) * | 2009-03-02 | 2014-04-17 | Dignity Health | 治療デバイスおよび使用方法 |
| US9463458B2 (en) | 2009-03-02 | 2016-10-11 | Dignity Health | Diagnostic devices and methods of use |
Also Published As
| Publication number | Publication date |
|---|---|
| ATE393912T1 (de) | 2008-05-15 |
| EP2189791A3 (en) | 2011-03-09 |
| DE69938623D1 (de) | 2008-06-12 |
| US8012703B2 (en) | 2011-09-06 |
| US20100022407A1 (en) | 2010-01-28 |
| US20020164656A1 (en) | 2002-11-07 |
| EP2189791A2 (en) | 2010-05-26 |
| EP1060395A1 (en) | 2000-12-20 |
| EP1965213A2 (en) | 2008-09-03 |
| EP1060395B1 (en) | 2008-04-30 |
| CA2318175A1 (en) | 1999-08-12 |
| US7794946B1 (en) | 2010-09-14 |
| US20130123127A1 (en) | 2013-05-16 |
| DE69938623T2 (de) | 2009-05-28 |
| WO1999040434A1 (en) | 1999-08-12 |
| US20120004131A1 (en) | 2012-01-05 |
| EP1060395A4 (en) | 2005-02-09 |
| EP1965213A3 (en) | 2009-07-15 |
| AU2583899A (en) | 1999-08-23 |
| US8637264B2 (en) | 2014-01-28 |
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