JP2002502882A - インターロイキン−12とともに処方された肺炎球菌および髄膜炎菌のワクチン - Google Patents

インターロイキン−12とともに処方された肺炎球菌および髄膜炎菌のワクチン

Info

Publication number
JP2002502882A
JP2002502882A JP2000531187A JP2000531187A JP2002502882A JP 2002502882 A JP2002502882 A JP 2002502882A JP 2000531187 A JP2000531187 A JP 2000531187A JP 2000531187 A JP2000531187 A JP 2000531187A JP 2002502882 A JP2002502882 A JP 2002502882A
Authority
JP
Japan
Prior art keywords
antigen
suspension
interleukin
vaccine
carrier molecule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000531187A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002502882A5 (enExample
Inventor
ラポスタ,ビンセント・ジエイ
エルドリツジ,ジヨン・エイチ
Original Assignee
アメリカン・サイアナミド・カンパニー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アメリカン・サイアナミド・カンパニー filed Critical アメリカン・サイアナミド・カンパニー
Publication of JP2002502882A publication Critical patent/JP2002502882A/ja
Publication of JP2002502882A5 publication Critical patent/JP2002502882A5/ja
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/245Herpetoviridae, e.g. herpes simplex virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/095Neisseria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/09Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092Streptococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505Inorganic adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55522Cytokines; Lymphokines; Interferons
    • A61K2039/55527Interleukins
    • A61K2039/55538IL-12
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031Proteins
    • A61K2039/6037Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2000531187A 1998-02-12 1999-02-10 インターロイキン−12とともに処方された肺炎球菌および髄膜炎菌のワクチン Pending JP2002502882A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7452898P 1998-02-12 1998-02-12
US60/074,528 1998-02-12
PCT/US1999/002847 WO1999040936A2 (en) 1998-02-12 1999-02-10 Pneumococcal and meningococcal vaccines formulated with interleukin-12

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2009193167A Division JP2010006827A (ja) 1998-02-12 2009-08-24 インターロイキン−12とともに処方された髄膜炎菌のワクチン
JP2010144063A Division JP2010265279A (ja) 1998-02-12 2010-06-24 インターロイキン−12とともに処方された肺炎球菌および髄膜炎菌のワクチン

Publications (2)

Publication Number Publication Date
JP2002502882A true JP2002502882A (ja) 2002-01-29
JP2002502882A5 JP2002502882A5 (enExample) 2006-03-02

Family

ID=22120049

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2000531187A Pending JP2002502882A (ja) 1998-02-12 1999-02-10 インターロイキン−12とともに処方された肺炎球菌および髄膜炎菌のワクチン
JP2009193167A Pending JP2010006827A (ja) 1998-02-12 2009-08-24 インターロイキン−12とともに処方された髄膜炎菌のワクチン
JP2010144063A Pending JP2010265279A (ja) 1998-02-12 2010-06-24 インターロイキン−12とともに処方された肺炎球菌および髄膜炎菌のワクチン

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2009193167A Pending JP2010006827A (ja) 1998-02-12 2009-08-24 インターロイキン−12とともに処方された髄膜炎菌のワクチン
JP2010144063A Pending JP2010265279A (ja) 1998-02-12 2010-06-24 インターロイキン−12とともに処方された肺炎球菌および髄膜炎菌のワクチン

Country Status (9)

Country Link
EP (1) EP1053015A2 (enExample)
JP (3) JP2002502882A (enExample)
KR (1) KR100585408B1 (enExample)
CN (1) CN1200730C (enExample)
AU (1) AU759391B2 (enExample)
BR (1) BR9907884A (enExample)
CA (1) CA2320223A1 (enExample)
IL (2) IL137809A0 (enExample)
WO (1) WO1999040936A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010265279A (ja) * 1998-02-12 2010-11-25 Wyeth Holdings Corp インターロイキン−12とともに処方された肺炎球菌および髄膜炎菌のワクチン

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6908757B1 (en) 1998-03-26 2005-06-21 The Procter & Gamble Company Serine protease variants having amino acid deletions and substitutions
CN1373802A (zh) 1999-07-22 2002-10-09 宝洁公司 在特定表位区域具有氨基酸缺失和取代的枯草杆菌蛋白酶变体
EP1196548A2 (en) 1999-07-22 2002-04-17 The Procter & Gamble Company Protease conjugates having sterically protected clip sites
US6946128B1 (en) 1999-07-22 2005-09-20 The Procter & Gamble Company Protease conjugates having sterically protected epitope regions
EP1210415A2 (en) 1999-07-22 2002-06-05 The Procter & Gamble Company Subtilisin protease variants having amino acid substitutions in defined epitope regions
MXPA05003863A (es) 2002-10-11 2005-09-08 Chiron Srl Vacunas polipeptidicas para amplia proteccion contra lineas hipervirulentas de meningococos.
JP4827726B2 (ja) 2003-01-30 2011-11-30 ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル 複数の髄膜炎菌血清群に対する注射可能ワクチン
ES2397923T3 (es) 2003-10-02 2013-03-12 Novartis Ag Vacunas líquidas para múltiples serogrupos meningocócicos
GB0409745D0 (en) 2004-04-30 2004-06-09 Chiron Srl Compositions including unconjugated carrier proteins
GB0500787D0 (en) 2005-01-14 2005-02-23 Chiron Srl Integration of meningococcal conjugate vaccination
NZ550533A (en) 2004-04-30 2010-02-26 Novartis Vaccines & Diagnostic Meningococcal conjugate vaccination comprising N. meningitidis and diphtheria toxin
GB0410866D0 (en) 2004-05-14 2004-06-16 Chiron Srl Haemophilius influenzae
GB0424092D0 (en) 2004-10-29 2004-12-01 Chiron Srl Immunogenic bacterial vesicles with outer membrane proteins
GB0502095D0 (en) 2005-02-01 2005-03-09 Chiron Srl Conjugation of streptococcal capsular saccharides
EP2298795A1 (en) 2005-02-18 2011-03-23 Novartis Vaccines and Diagnostics, Inc. Immunogens from uropathogenic escherichia coli
NZ561042A (en) 2005-02-18 2011-03-31 Novartis Vaccines & Diagnostic Proteins and nucleic acids from meningitis/sepsis-associated escherichia coli - SEQ ID: 7052
EP2425856A1 (en) * 2005-04-08 2012-03-07 Wyeth LLC Multivalent pneumococcal polysaccharide-protein conjugate composition
US7955605B2 (en) * 2005-04-08 2011-06-07 Wyeth Llc Multivalent pneumococcal polysaccharide-protein conjugate composition
US20090074712A1 (en) * 2005-05-19 2009-03-19 Compton Methods for Treatment and Prevention of Infection
GB0524066D0 (en) 2005-11-25 2006-01-04 Chiron Srl 741 ii
JP2010500399A (ja) 2006-08-16 2010-01-07 ノバルティス アーゲー 尿路病原性大腸菌由来の免疫原
GB0713880D0 (en) 2007-07-17 2007-08-29 Novartis Ag Conjugate purification
GB0714963D0 (en) 2007-08-01 2007-09-12 Novartis Ag Compositions comprising antigens
GB0818453D0 (en) 2008-10-08 2008-11-12 Novartis Ag Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom
NZ587382A (en) 2008-02-21 2012-01-12 Novartis Ag Meningococcal fhbp polypeptides
AU2010220103A1 (en) 2009-03-06 2011-09-22 Novartis Ag Chlamydia antigens
NZ612315A (en) 2009-04-14 2014-10-31 Novartis Ag Compositions for immunising against staphylococcus aureus
MX2012000395A (es) 2009-07-07 2012-02-28 Novartis Ag Inmunogenos conservados de escherichia coli.
US8871214B2 (en) 2009-07-16 2014-10-28 Novartis Ag Detoxified Escherichia coli immunogens
EP3017828A1 (en) 2009-08-27 2016-05-11 GlaxoSmithKline Biologicals SA Hybrid polypeptides including meningococcal fhbp sequences
EP2475385A1 (en) 2009-09-10 2012-07-18 Novartis AG Combination vaccines against respiratory tract diseases
GB0917002D0 (en) 2009-09-28 2009-11-11 Novartis Vaccines Inst For Global Health Srl Improved shigella blebs
GB0917003D0 (en) 2009-09-28 2009-11-11 Novartis Vaccines Inst For Global Health Srl Purification of bacterial vesicles
CA2776004A1 (en) 2009-09-30 2011-04-07 Novartis Ag Expression of meningococcal fhbp polypeptides
MX373250B (es) 2009-09-30 2020-05-04 Glaxosmithkline Biologicals S A Star Conjugación de polisacáridos capsulares de tipo 5 y de tipo 8 de staphylococcus aureus.
GB0918392D0 (en) 2009-10-20 2009-12-02 Novartis Ag Diagnostic and therapeutic methods
WO2011051893A1 (en) 2009-10-27 2011-05-05 Novartis Ag Modified meningococcal fhbp polypeptides
GB0919690D0 (en) 2009-11-10 2009-12-23 Guy S And St Thomas S Nhs Foun compositions for immunising against staphylococcus aureus
US9173954B2 (en) 2009-12-30 2015-11-03 Glaxosmithkline Biologicals Sa Polysaccharide immunogens conjugated to E. coli carrier proteins
GB201003333D0 (en) 2010-02-26 2010-04-14 Novartis Ag Immunogenic proteins and compositions
GB201005625D0 (en) 2010-04-01 2010-05-19 Novartis Ag Immunogenic proteins and compositions
WO2011127316A1 (en) 2010-04-07 2011-10-13 Novartis Ag Method for generating a parvovirus b19 virus-like particle
GB201009861D0 (en) 2010-06-11 2010-07-21 Novartis Ag OMV vaccines
EP2591097A1 (en) 2010-07-06 2013-05-15 Novartis AG Norovirus derived immunogenic compositions and methods
GB201101665D0 (en) 2011-01-31 2011-03-16 Novartis Ag Immunogenic compositions
GB201017519D0 (en) 2010-10-15 2010-12-01 Novartis Vaccines Inst For Global Health S R L Vaccines
WO2012072769A1 (en) 2010-12-01 2012-06-07 Novartis Ag Pneumococcal rrgb epitopes and clade combinations
WO2012085668A2 (en) 2010-12-24 2012-06-28 Novartis Ag Compounds
WO2013016460A1 (en) 2011-07-25 2013-01-31 Novartis Ag Compositions and methods for assessing functional immunogenicity of parvovirus vaccines
GB201114923D0 (en) 2011-08-30 2011-10-12 Novartis Ag Immunogenic proteins and compositions
US9358284B2 (en) 2011-09-14 2016-06-07 Glaxosmithkline Biologicals Sa Methods for making saccharide-protein glycoconjugates
US9511130B2 (en) 2011-09-14 2016-12-06 Glaxosmithkline Biologicals Sa Escherichia coli vaccine combination
CN103974718A (zh) 2011-12-08 2014-08-06 诺华股份有限公司 基于艰难梭菌毒素的疫苗
WO2013108272A2 (en) 2012-01-20 2013-07-25 International Centre For Genetic Engineering And Biotechnology Blood stage malaria vaccine
EP2817320A1 (en) 2012-02-24 2014-12-31 Novartis AG Pilus proteins and compositions
MX374919B (es) 2012-04-26 2025-03-06 Glaxosmithkline Biologicals S A Star ANTÍGENOS Y COMBINACIONES DE ANTÍGENOS PARA USARSE PARA ELEVAR LA RESPUESTA INMUNE CONTRA Haemophilus influenzae.
US10279026B2 (en) 2012-04-26 2019-05-07 Glaxosmithkline Biologicals Sa Antigens and antigen combinations
MX2014014067A (es) 2012-05-22 2015-02-04 Novartis Ag Conjugado de serogrupo x de meningococo.
CA2882382A1 (en) 2012-09-18 2014-03-27 Novartis Ag Outer membrane vesicles
BR112015007126A2 (pt) 2012-10-02 2017-08-08 Glaxosmithkline Biologicals Sa composição, método para induzir uma resposta imune, e, uso de uma composição
EP3482770B1 (en) 2012-10-03 2020-11-25 GlaxoSmithKline Biologicals S.A. Immunogenic compositions
SG10201706671WA (en) 2012-11-30 2017-09-28 Glaxosmithkline Biologicals Sa Pseudomonas antigens and antigen combinations
US9107906B1 (en) 2014-10-28 2015-08-18 Adma Biologics, Inc. Compositions and methods for the treatment of immunodeficiency
US10259865B2 (en) 2017-03-15 2019-04-16 Adma Biologics, Inc. Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection
CN114544913B (zh) * 2022-02-23 2024-04-09 沈阳建筑大学 一种土壤调查加密采样布点优化方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5153312A (en) * 1990-09-28 1992-10-06 American Cyanamid Company Oligosaccharide conjugate vaccines
CA2059692C (en) * 1991-01-28 2004-11-16 Peter J. Kniskern Pneumoccoccal polysaccharide conjugate vaccine
CA2059693C (en) * 1991-01-28 2003-08-19 Peter J. Kniskern Polysaccharide antigens from streptococcus pneumoniae
US5571515A (en) * 1994-04-18 1996-11-05 The Wistar Institute Of Anatomy & Biology Compositions and methods for use of IL-12 as an adjuvant
DE69529219T2 (de) * 1994-07-01 2003-11-06 Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville Helicobacter proteine und impstoffe
EP0784486B1 (en) * 1994-10-05 2006-04-05 Vanderbilt University Interleukin-12 as an adjuvant for paramyxoviridae vaccines
GB9422990D0 (en) * 1994-11-15 1995-01-04 Cortecs Ltd Immunogenic compositions
US5866134A (en) * 1995-03-24 1999-02-02 Schering Corporation Method for enhancing the antibody response to specific antigens with Interleukin-10
AU5507098A (en) * 1995-12-19 1998-03-19 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Enhancement of dna immunization through the use of cytokines
WO1997045139A2 (en) * 1996-05-31 1997-12-04 Genetics Institute, Inc. Il-12 as an adjuvant for bordetella pertussis vaccines
US6438586B1 (en) * 1996-09-30 2002-08-20 Emc Corporation File transfer utility which employs an intermediate data storage system
AU759391B2 (en) * 1998-02-12 2003-04-10 Wyeth Holdings Corporation Pneumococcal and meningococcal vaccines formulated with interleukin-12
US6303114B1 (en) * 1998-03-05 2001-10-16 The Medical College Of Ohio IL-12 enhancement of immune responses to T-independent antigens

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010265279A (ja) * 1998-02-12 2010-11-25 Wyeth Holdings Corp インターロイキン−12とともに処方された肺炎球菌および髄膜炎菌のワクチン

Also Published As

Publication number Publication date
IL137809A0 (en) 2001-10-31
CN1292706A (zh) 2001-04-25
KR100585408B1 (ko) 2006-06-01
AU2596599A (en) 1999-08-30
BR9907884A (pt) 2000-10-24
EP1053015A2 (en) 2000-11-22
CA2320223A1 (en) 1999-08-19
WO1999040936A2 (en) 1999-08-19
CN1200730C (zh) 2005-05-11
JP2010265279A (ja) 2010-11-25
IL137809A (en) 2007-12-03
JP2010006827A (ja) 2010-01-14
KR20010040898A (ko) 2001-05-15
WO1999040936A3 (en) 1999-10-28
AU759391B2 (en) 2003-04-10

Similar Documents

Publication Publication Date Title
JP2002502882A (ja) インターロイキン−12とともに処方された肺炎球菌および髄膜炎菌のワクチン
Westerink et al. ProJuvant™(Pluronic F127®/chitosan) enhances the immune response to intranasally administered tetanus toxoid
JP3485184B2 (ja) インターロイキン含有安定ワクチン組成物
US8642042B2 (en) Protein matrix vaccines and methods of making and administering such vaccines
US4455142A (en) Method of coadministering an antigen and an immunopotentiator
JP2022000449A (ja) 多価肺炎球菌多糖体−タンパク質複合体組成物
EP0482068A1 (en) Cytokine and hormone carriers for conjugate vaccines
JP2003514868A (ja) 血清型BおよびC由来のNeisseriameningitidis抗原、ならびにさらなる抗原を含む組成物
JP2001527050A (ja) ワクチン
US6413520B1 (en) Methods of immunizing adults using anti-meningococcal vaccine compositions
PL174130B1 (pl) Złożona szczepionka pediatryczna przeciwko błonicy, tężcowi, ksztuścowi oraz Haemophilus influenzae typu b
US6890540B1 (en) Vaccine formulation
JP2002526420A (ja) 脊椎動物における実質的に無毒で生物学的に活性な粘膜アジュバント
US6841160B2 (en) Meningococcal vaccines formulated with interleukin-12
US20240366744A1 (en) Haemophilus influenzae saccharide-carrier conjugate compositions and uses thereof
Brey Development of vaccines based on formulations containing nonionic block copolymers
JP2002502883A (ja) インターロイキン−12および呼吸合法体ウイルス抗原を含んで成るワクチン
MXPA00007879A (en) Pneumococcal and meningococcal vaccines formulated with interleukin-12
HK1249403A1 (en) Protein matrix vaccines and methods of making and administering such vac-cines
MXPA00007881A (en) Vaccines comprising interleukin-12 and respiratory syncytial viral antigens

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20060112

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20060112

RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7422

Effective date: 20080509

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20090224

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20090521

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20090528

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090824

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20100223