JP2002501041A5 - - Google Patents
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- Publication number
- JP2002501041A5 JP2002501041A5 JP2000528531A JP2000528531A JP2002501041A5 JP 2002501041 A5 JP2002501041 A5 JP 2002501041A5 JP 2000528531 A JP2000528531 A JP 2000528531A JP 2000528531 A JP2000528531 A JP 2000528531A JP 2002501041 A5 JP2002501041 A5 JP 2002501041A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- alkylene
- heterocyclyl
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 description 87
- 125000000623 heterocyclic group Chemical group 0.000 description 61
- 125000001072 heteroaryl group Chemical group 0.000 description 51
- 125000003107 substituted aryl group Chemical group 0.000 description 45
- 150000003839 salts Chemical class 0.000 description 33
- 150000001875 compounds Chemical class 0.000 description 30
- 125000004475 heteroaralkyl group Chemical group 0.000 description 30
- 238000000034 method Methods 0.000 description 28
- 102000004257 Potassium Channel Human genes 0.000 description 25
- 125000003710 aryl alkyl group Chemical group 0.000 description 25
- 108020001213 potassium channel Proteins 0.000 description 25
- 150000001408 amides Chemical class 0.000 description 23
- 150000002148 esters Chemical class 0.000 description 23
- 239000002207 metabolite Substances 0.000 description 23
- 239000002243 precursor Substances 0.000 description 23
- 239000000651 prodrug Substances 0.000 description 23
- 229940002612 prodrug Drugs 0.000 description 23
- 239000013522 chelant Substances 0.000 description 22
- 230000002503 metabolic effect Effects 0.000 description 19
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 description 15
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 description 15
- 125000002947 alkylene group Chemical group 0.000 description 12
- 229910052799 carbon Inorganic materials 0.000 description 12
- 229910052760 oxygen Inorganic materials 0.000 description 12
- 239000003085 diluting agent Substances 0.000 description 10
- 125000004005 formimidoyl group Chemical group [H]\N=C(/[H])* 0.000 description 10
- 239000008194 pharmaceutical composition Substances 0.000 description 10
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 10
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 9
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 8
- 229910052700 potassium Inorganic materials 0.000 description 8
- 239000011591 potassium Substances 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- -1 and R16Is H Chemical group 0.000 description 7
- 229910052739 hydrogen Inorganic materials 0.000 description 6
- 102000003734 Voltage-Gated Potassium Channels Human genes 0.000 description 5
- 108090000013 Voltage-Gated Potassium Channels Proteins 0.000 description 5
- 125000003342 alkenyl group Chemical group 0.000 description 5
- 125000003118 aryl group Chemical group 0.000 description 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 5
- 230000000747 cardiac effect Effects 0.000 description 5
- 210000000170 cell membrane Anatomy 0.000 description 5
- 125000000753 cycloalkyl group Chemical group 0.000 description 5
- 230000002401 inhibitory effect Effects 0.000 description 5
- 229910052757 nitrogen Inorganic materials 0.000 description 5
- 230000004060 metabolic process Effects 0.000 description 4
- 229910052698 phosphorus Inorganic materials 0.000 description 4
- 206010003119 arrhythmia Diseases 0.000 description 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 3
- 125000001424 substituent group Chemical group 0.000 description 3
- 125000001624 naphthyl group Chemical group 0.000 description 2
- 206010003130 Arrhythmia supraventricular Diseases 0.000 description 1
- 102000016924 KATP Channels Human genes 0.000 description 1
- 108010053914 KATP Channels Proteins 0.000 description 1
- 229940100389 Sulfonylurea Drugs 0.000 description 1
- 230000003288 anthiarrhythmic effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000001746 atrial effect Effects 0.000 description 1
- GHDLZGOOOLEJKI-UHFFFAOYSA-N benzenesulfonylurea Chemical class NC(=O)NS(=O)(=O)C1=CC=CC=C1 GHDLZGOOOLEJKI-UHFFFAOYSA-N 0.000 description 1
- 235000013877 carbamide Nutrition 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 210000002837 heart atrium Anatomy 0.000 description 1
- 230000002363 herbicidal effect Effects 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000002336 repolarization Effects 0.000 description 1
- 125000000547 substituted alkyl group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7271998P | 1998-01-27 | 1998-01-27 | |
| US60/072,719 | 1998-01-27 | ||
| PCT/US1999/001663 WO1999037607A1 (en) | 1998-01-27 | 1999-01-27 | Potassium channel inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002501041A JP2002501041A (ja) | 2002-01-15 |
| JP2002501041A5 true JP2002501041A5 (https=) | 2006-01-26 |
Family
ID=22109343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000528531A Pending JP2002501041A (ja) | 1998-01-27 | 1999-01-27 | カリウムチャネル阻害剤 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6333337B1 (https=) |
| EP (1) | EP1051394B1 (https=) |
| JP (1) | JP2002501041A (https=) |
| KR (1) | KR20010034377A (https=) |
| CN (1) | CN1294577A (https=) |
| AT (1) | ATE265426T1 (https=) |
| AU (1) | AU745845B2 (https=) |
| BR (1) | BR9907236A (https=) |
| CA (1) | CA2317457A1 (https=) |
| DE (1) | DE69916792D1 (https=) |
| HU (1) | HUP0101269A3 (https=) |
| ID (1) | ID25853A (https=) |
| IL (1) | IL137219A0 (https=) |
| NO (1) | NO20003600L (https=) |
| NZ (1) | NZ505666A (https=) |
| PL (1) | PL341859A1 (https=) |
| RU (1) | RU2218330C2 (https=) |
| TR (1) | TR200002191T2 (https=) |
| TW (1) | TW542823B (https=) |
| WO (1) | WO1999037607A1 (https=) |
| ZA (1) | ZA99550B (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6333349B1 (en) * | 1997-02-26 | 2001-12-25 | Aventis Pharma Deutschland Gmbh | Sulfonamide-substituted fused 7-membered ring compounds, their use as a medicament, and pharmaceutical preparations comprising them |
| WO2000012077A1 (en) | 1998-09-01 | 2000-03-09 | Bristol-Myers Squibb Company | Potassium channel inhibitors and method |
| JP2003510257A (ja) * | 1999-09-22 | 2003-03-18 | コグネティックス・インコーポレイテッド | カッパ−コノトキシンｐｖｉｉａの使用 |
| AU781365B2 (en) * | 1999-12-21 | 2005-05-19 | Icagen, Inc. | Potassium channel inhibitors |
| US6566380B2 (en) * | 2000-07-25 | 2003-05-20 | Icagen, Inc. | Potassium channel inhibitors |
| US6620849B2 (en) * | 2000-07-26 | 2003-09-16 | Icafen, Inc. | Potassium channel inhibitors |
| DE10059418A1 (de) | 2000-11-30 | 2002-06-20 | Aventis Pharma Gmbh | Ortho, meta-substituierte Bisarylverbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| DE10060807A1 (de) * | 2000-12-07 | 2002-06-20 | Aventis Pharma Gmbh | Ortho, ortho-substituierte stickstoffhaltige Bisarylverbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| DE10061876A1 (de) | 2000-12-12 | 2002-06-20 | Aventis Pharma Gmbh | Arylierte Furan- und Thiophencarbonsäureamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| US6849634B2 (en) | 2000-12-21 | 2005-02-01 | Icagen | Potassium channel inhibitors |
| DE10121003A1 (de) | 2001-04-28 | 2002-12-19 | Aventis Pharma Gmbh | Anthranilsäureamide, Verfahren zur Herstellung, ihrer Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| AU2003205132A1 (en) | 2002-02-12 | 2003-09-04 | Celectricon AB | Systems and methods for rapidly changing the solution environment around sensors |
| US7470518B2 (en) | 2002-02-12 | 2008-12-30 | Cellectricon Ab | Systems and method for rapidly changing the solution environment around sensors |
| US20030199578A1 (en) * | 2002-04-19 | 2003-10-23 | Turner Sean C. | Naphthalene amides as potassium channel openers |
| JP4335131B2 (ja) * | 2002-05-08 | 2009-09-30 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | ヒドロキシテトラヒドロ−ナフタレニル尿素誘導体 |
| DK1569896T3 (da) * | 2002-12-06 | 2007-12-10 | Xention Ltd | Tetrahydronaphthalenderivater |
| AU2003288200A1 (en) * | 2002-12-09 | 2004-06-30 | Bayer Healthcare Ag | Tetrahydro-naphthalene derivatives as vanilloid receptor antagonists |
| GB0315950D0 (en) | 2003-06-11 | 2003-08-13 | Xention Discovery Ltd | Compounds |
| US7662821B2 (en) | 2003-10-08 | 2010-02-16 | Bayer Schering Pharma Ag | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
| US7638515B2 (en) | 2003-10-08 | 2009-12-29 | Bayer Schering Pharma Aktiengesellschaft | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
| PT1670458E (pt) | 2003-10-08 | 2007-03-30 | Schering Ag | Derivados de tetra-hidronaftaleno, processo para a sua preparação e utilização como inibidor de inflamação |
| US20080153859A1 (en) | 2004-04-05 | 2008-06-26 | Hartmut Rehwinkel | Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
| GB0412986D0 (en) | 2004-06-10 | 2004-07-14 | Xention Discovery Ltd | Compounds |
| US7576212B2 (en) | 2004-12-09 | 2009-08-18 | Xention Limited | Thieno[2,3-B] pyridines as potassium channel inhibitors |
| DE102005017316A1 (de) * | 2005-04-14 | 2006-10-19 | Schering Ag | Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer |
| GB0525164D0 (en) | 2005-12-09 | 2006-01-18 | Xention Discovery Ltd | Compounds |
| EP1834948A1 (de) | 2006-03-15 | 2007-09-19 | Bayer Schering Pharma Aktiengesellschaft | Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer |
| BRPI0710723A2 (pt) * | 2006-04-14 | 2012-01-31 | Novartis Ag | uso de biarilcarboxamidas no tratamento de distúrbio relacionados à série de reação hedgehog |
| DE102006019589A1 (de) * | 2006-04-27 | 2007-10-31 | Sanofi-Aventis Deutschland Gmbh | Inhibitoren des TASK-1 und Task-3 Ionenkanals |
| SG174095A1 (en) * | 2006-08-23 | 2011-09-29 | Valeant Pharmaceuticals Int | Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators |
| CN101578259A (zh) * | 2006-11-28 | 2009-11-11 | 威朗国际制药公司 | 作为钾通道调节剂的1,4-二氨基双环瑞替加滨类似物 |
| GB0815784D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| GB0815782D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| GB0815781D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| GB201105659D0 (en) | 2011-04-01 | 2011-05-18 | Xention Ltd | Compounds |
| NO3175985T3 (https=) | 2011-07-01 | 2018-04-28 | ||
| HK1201455A1 (en) | 2012-01-27 | 2015-09-04 | Gilead Sciences Inc | Combination therapies using late sodium ion channel blockers and potassium ion channel blockers |
| CA3151863C (en) | 2021-10-27 | 2024-01-02 | Shanghai Zhimeng Biopharma, Inc. | Compound as potassium channel regulator and preparation and use thereof |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3953506A (en) | 1974-02-07 | 1976-04-27 | American Cyanamid Company | Ureidotetralin compounds |
| GB1479544A (en) | 1974-02-07 | 1977-07-13 | American Cyanamid Co | 1,2,3,4-tetrahydro-1-naphthylurea derivatives their preparation and their use |
| US4005140A (en) | 1974-02-07 | 1977-01-25 | American Cyanamid Company | Ureidotetralin compounds |
| GB8707123D0 (en) | 1987-03-25 | 1987-04-29 | Pfizer Ltd | Antiarrhythmic agents |
| US5006512A (en) | 1987-10-02 | 1991-04-09 | Tsuyoshi Ohnishi | Therapeutic usages of inhibitors for a potassium efflux channel |
| IL88314A (en) | 1987-11-18 | 1994-05-30 | Tanabe Seiyaku Co | Sulphonylamino indane derivatives, their preparation and pharmaceutical compositions containing them |
| DK691488A (da) | 1987-12-14 | 1989-06-15 | Beecham Group Plc | Hidtil ukendte forbindelser |
| US5242947A (en) | 1988-02-10 | 1993-09-07 | New York University | Use of polyamines as ionic-channel regulating agents |
| DE3818245A1 (de) | 1988-05-28 | 1989-12-07 | Hoechst Ag | Kombination von angiotensin-converting-enzyme-hemmern mit kaliumkanal-modulatoren sowie deren verwendung in arzneimitteln |
| KR100195656B1 (ko) * | 1989-05-31 | 1999-06-15 | 로버트 에이.아미테이지 | 치료학적으로 유용한 2-아미노테트랄린 유도체 |
| US5215985A (en) | 1990-07-20 | 1993-06-01 | E. R. Squibb & Sons, Inc. | Method for treating ischemic insult to neurons employing an ATP-sensitive potassium channel blocker |
| DE69129611T2 (de) | 1990-08-20 | 1998-12-17 | Eisai Co., Ltd., Tokio/Tokyo | Sulfonamid-Derivate |
| US5401848A (en) | 1990-11-26 | 1995-03-28 | E. R. Squibb & Sons, Inc. | Indane and quinoline derivatives |
| US5310932A (en) | 1991-04-15 | 1994-05-10 | E. R. Squibb & Sons, Inc. | Chromanyl substituted indole potassium channel openers |
| US5234947A (en) | 1991-11-07 | 1993-08-10 | New York University | Potassium channel activating compounds and methods of use thereof |
| US5356775A (en) | 1992-07-29 | 1994-10-18 | Brigham & Women's Hospital | Primary structure for functional expression from complementary DNA of a mammalian ATP-sensitive potassium channel |
| US5328830A (en) | 1992-09-08 | 1994-07-12 | Miles Inc. | Potassium channel modulators |
| US5374643A (en) | 1992-09-11 | 1994-12-20 | E. R. Squibb & Sons, Inc. | Aryl urea (thiourea) and cyanoguanidine derivatives |
| US5453421A (en) | 1992-09-11 | 1995-09-26 | E. R. Squibb & Sons, Inc. | Aryl and heterocyclic substituted propenamide derivatives |
| DE4302051A1 (de) | 1993-01-26 | 1994-07-28 | Thomae Gmbh Dr K | 5-gliedrige Heterocyclen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| GB9309716D0 (en) | 1993-05-12 | 1993-06-23 | Zeneca Ltd | Heterocyclic derivatives |
| US5401758A (en) | 1993-10-07 | 1995-03-28 | Bristol-Myers Squibb Company | Pyridinyl cyanoguanidine compounds |
| US5631275A (en) | 1993-12-30 | 1997-05-20 | Hoechst Aktiengesellschaft | Substituted benzenesulfonylureas and -thioureas, preparation processes and possible uses of pharmaceutical preparations based on these compounds |
| FR2717805B1 (fr) | 1994-03-28 | 1996-05-10 | Rhone Poulenc Rorer Sa | Dérivés de 5H-indeno[1,2-b]pyrazine-2,3-dione, leur préparation et les médicaments les contenant . |
| US5615460A (en) | 1994-06-06 | 1997-04-01 | The Procter & Gamble Company | Female component for refastenable fastening device having regions of differential extensibility |
| ZA96211B (en) | 1995-01-12 | 1996-07-26 | Teva Pharma | Compositions containing and methods of using 1- aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives |
| AU5772396A (en) | 1995-05-19 | 1996-11-29 | Chiroscience Limited | 3,4-disubstituted-phenylsulphonamides and their therapeutic use |
| EP0874625B1 (en) | 1996-01-22 | 2005-03-16 | Eli Lilly And Company | Indane derivatives for antipsychotic compositions |
| US6083986A (en) | 1996-07-26 | 2000-07-04 | Icagen, Inc. | Potassium channel inhibitors |
| US6048877A (en) | 1997-02-21 | 2000-04-11 | Bristol-Myers Squibb Company | Tetralone derivatives as antiarrhythmic agents |
-
1999
- 1999-01-13 US US09/229,315 patent/US6333337B1/en not_active Expired - Fee Related
- 1999-01-26 ZA ZA9900550A patent/ZA99550B/xx unknown
- 1999-01-27 TR TR2000/02191T patent/TR200002191T2/xx unknown
- 1999-01-27 IL IL13721999A patent/IL137219A0/xx unknown
- 1999-01-27 BR BR9907236-0A patent/BR9907236A/pt not_active IP Right Cessation
- 1999-01-27 DE DE69916792T patent/DE69916792D1/de not_active Expired - Lifetime
- 1999-01-27 CA CA002317457A patent/CA2317457A1/en not_active Abandoned
- 1999-01-27 EP EP99902443A patent/EP1051394B1/en not_active Expired - Lifetime
- 1999-01-27 WO PCT/US1999/001663 patent/WO1999037607A1/en not_active Ceased
- 1999-01-27 HU HU0101269A patent/HUP0101269A3/hu unknown
- 1999-01-27 CN CN99804373A patent/CN1294577A/zh active Pending
- 1999-01-27 AU AU22419/99A patent/AU745845B2/en not_active Ceased
- 1999-01-27 ID IDW20001654A patent/ID25853A/id unknown
- 1999-01-27 AT AT99902443T patent/ATE265426T1/de not_active IP Right Cessation
- 1999-01-27 KR KR1020007008128A patent/KR20010034377A/ko not_active Withdrawn
- 1999-01-27 JP JP2000528531A patent/JP2002501041A/ja active Pending
- 1999-01-27 NZ NZ505666A patent/NZ505666A/xx unknown
- 1999-01-27 TW TW088101240A patent/TW542823B/zh not_active IP Right Cessation
- 1999-01-27 PL PL99341859A patent/PL341859A1/xx not_active Application Discontinuation
- 1999-01-27 RU RU2000122451/04A patent/RU2218330C2/ru not_active IP Right Cessation
-
2000
- 2000-07-13 NO NO20003600A patent/NO20003600L/no unknown
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